Browsing by Author "Tuncay, I."

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A Comparison of Effects of Floroquinolones on Fracture Healing (An Experimental Study in Rats)
(2005) Tuncay, I.; Özbek, H.; Köşem, M.; Ünal, Ö.
BACKGROUND: The objective of the present study was to test and compare the effect of floroquinolones on fracture healing as assessed histopathologically. METHODS: A total of twenty five Wistar rats were arbitrarily assigned to five groups with five animals each. Bilateral closed femoral fracture was constructed manually in all groups. The first group did not receive any drug as control (C). The 2nd, 3rd, 4th, and the last group were treated with norfloxacin (N), ofloxacin (O), pefloxacin (P) and ciprofloxacin (Ci) respectively. Antibiotic administration was started on the 7th day after the fracture incident. All the treatments were discontinued twenty days after the incident all the rats were sacrificed, and the fracture calluses together with affected femurs were resected en bloc at the fourth week after fracture. RESULTS: Average healing grades of control group was higher than all the other antibiotic groups. Mean healing grades of control (5 ; n:8), ofloxacin (4.1; n:7), ciprofloxacin (3.9; n:8), norfloxacin (3.4; n:9) and pefloxacin groups (2.6; n:10) were recorded.. Statistically significant differences between antibiotherapy groups (excluding, norfloxacin) and the control group were detected. CONCLUSIONS: The current histopathological study has shown that all the studied floroquinolones retarded fracture healing in rats.
Effects of Hyaluronic Acid on Postoperative Adhesion of Tendo Calcaneus Surgery: an Experimental Study in Rats
(2002) Tuncay, I.; Ozbek, H.; Atik, B.; Ozen, S.; Akpinar, F.
Adhesions are a significant problem after tendon surgery. The effects of hyaluronic acid on adhesion formation of the tendo calcaneus were investigated in this study. Twenty Wistar rats were utilized. Both tendo calcanei were incised transversely, and then repaired. Hyaluronic acid (0.2 cc) was injected into peritendinous tissue on the right side, while the same amount of normal saline was injected to the left side as a control. The animals were sacrificed 40days after the experiment. Both the right and left tendon adhesions were evaluated both macroscopically and microscopically for the presence of adhesions (grading scale 0-4). Throughout the experimental period, there was no difference in range of motion of the ankle between the two groups. Macroscopically, there were fewer adhesions in the experimental group (mean 0.6 ± 0.8) compared to the controls (mean 1.1 ± 0.2). This difference was not statistically significant (p =. 096). Histopathologically, these parameters were similar in both the experimental (mean 1.15 ± 0.98) and the control groups (mean 1.9 ± 1.25). This difference was significant (p =. 043). Hyaluronic acid may be effective for prevention of adhesions in the tendo calcaneus though this effect could not be demonstrated experimentally.
The Effects of Nicotine on Fracture Healing: an Experimental Study
(2002) Agca, M.; Tuncay, I.; Tosun, N.; Akpinar, F.
This study is aimed to evaluate treatment research the effects of nicotine on fracture healing. Thirty rats were used. Nicotine was injected subcutaneously at a dosage of 2 mg/kg/day to group A and 4 mg/kg/day to group B. Control group (group C) received 0.5 ml/kg/day saline solution. Three weeks later, transverse fractures were performed on to the left ulnar and radial bones for each animal. Animals were designed to one of two follow-up groups which were euthanized either 2 or 3 weeks. On the 14th day of fracture, randomly chosen five rats from each group of A, B and C were sacrificed. At the 21st day of fracture, same procedure performed for all remaining rats. Both had surgical and histopathological evaluation were performed. Transverse fractures performed on the 21st day of study were confirmed by direct radiograms. One rat died spontaneously before completing the study was therefore excluded from the final analysis. The results indicate that healing process proceeds in each group. There was no significant difference in fracture healing between groups A and B two weeks after the fracture. However, fracture healing was significantly delayed in nicotine treated group comparing to control group. We continue to support the notion that nicotine has a negative effect on fracture healing.
Rice Bodies in Knee Joint: a Case Report
(2002) Tuncay, I.; Tosun, N.; Uǧraş, S.; Ince, Ö.
Rice bodies with synovial origin resemble cartilage and they are usually sourced of fibrin. They are supposed as synovial chondromatosis wrongly. Tuberculosis, rheumatoid arthritis or other seronegative arthropathies may exist in the etiology. Twenty-one years old patient with complainted of occasional swelling and pain, underwent diagnostic arthroscopy. Massive rice bodies with synovitis in the joint were observed in the knee arthroscopy under local anesthesia. Afterward, open surgical extirpation with subtotal synovectomy was performed. Fibrinous structure was observed histopathologically. No recurrence was found during follow up period, also no underlying tuberculosis or rheumatologic pathology was detected.