Browsing by Author "Tuncer, I"

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Anti-Fibrogenic Effects of Captopril and Candesartan Cilexetil on the Hepatic Fibrosis Development in Rat - the Effect of At1-R Blocker on the Hepatic Fibrosis
(Elsevier Gmbh, 2003) Tuncer, I; Ozbek, H; Ugras, S; Bayram, I
Background/Aim: Angiotensin converting enzyme (ACE) and angiotensin II (AT-II) have been suggested to play an important role in liver fibrogenesis. There is a significant relationship between inheritance of hightened expression of transforming growth factor beta1 (TGF-beta1) and AT-II and the development of progressive hepatic fibrosis. The purpose of this study was to investigate the effects of captopril. an ACE inhibitor and candesartan cilexetil, an AT-II type I receptor (AT1-R) blocker, on liver fibrosis induced in rats by carbon tetrachloride (CCl4) administration. Methods: rats were divided into 4 experimental groups: The first group was given CCl4 alone; the second was given both CCl4 and captopril (100 mg(.)kg(-1.)day(-1)); the third was given both CCl4 and candesartan cilexetil (8 mg(.)kg(-1.)day(-1)); fourth group was given 0.9% NaCl only. Seven weeks after initiating the treatment. indices of fibrosis were assessed. Results: Candesartan cilexetil treatment significantly reduced the fibrosis development. These inhibitory effects were not observed in the captopril-treated group. The mean fibrosis score was significantly lower in the CCl4/candesartan group compared with the group applied to CCl4 alone and the group applied to CCl4/captopril. Similarly, the number of alpha-smooth muscle actin positive cells was markedly suppressed by candesartan treatment. Conclusions: The results suggest that AT-II plays a pivotal role in hepatic fibrogenesis and candesartan significantly attenuates the progression of liver fibrosis. This drug may provide an effective new strategy for prevention of liver fibrosis. Its effectiveness should be investigated in chronic liver disease associated with progressive fibrosis.
Chronic Hepatitis Delta Virus Infection in Eastern Turkey
(Elsevier Science Bv, 2003) Turkdogan, MK; Bozkurt, H; Tuncer, I; Uygan, I; Irmak, H; Buzgan, T; Akdeniz, H
Effect of Estrogen on Fibrinogen Clotting Time in Rabbits
(Scientific Technical Research Council Turkey, 1998) Ercan, M; Yegin, E; Akdeniz, H; Irmak, H; Bayiroglu, F; Tuncer, I
The aim of this study was to examine the effect of estrogen on fibrinogen clotting time in rabbit model experimentally, The study was performed on 14 white New Zealand race female prepubertary rabbits at two months old weighing meanly 1.4+/-0.3 kg. Blood samples was taken from ear veins of the rabbits and first fibrinogen clotting time levels were measured to obtain control values. Next day, female sex hormone preparate estradiol valerinate at a dose of 0.3 mg/kg were injected to the rabbits IM. In their examinations made on 10(th) day of injection, they were evaluated as in oestrus and under the maximal effects of estrogen, acid their blood samples were taken again to measure their fibrinogen clotting time levels. Fibrinogen clotting time levels were determined from blood samples taken before and after female sex hormone administration. Samples taken from ear veins of the rabbits were used for measurement of fibrinogen clotting time. In the study, fibrinogen clotting time values were found meanly 18.13+/-1.00 sec. from blood samples taken before estrogen injection versus 18.87+/-0.61 sec. from blood samples after 10 days of estrogen injection, in statistical assessment performed, there were not statistically significant differences (t=0.94, p>0.05) between fibrinogen clotting time values before and after estrogen administration. Our data revealed that estrogen administration caused a silghtly but insignificantly increase in fibrinogen clotting time values in the rabbits.
Epidemiological Aspects of Endemic Upper Gastrointestinal Cancers in Eastern Turkey
(H G E Update Medical Publishing S A, 2005) Türkdogan, MK; Akman, N; Tuncer, I; Uygan, I; Kösem, M; Özel, S; Memik, F
Background/Aims: The aim of our study was to present the epidemiological aspects of endemic upper gastrointestinal (esophageal and gastric) cancers in the Van region of Eastern Turkey. Methodology: The patients were diagnosed by esophagogastroscopy, biopsy and histopathological analysis. The control group consisted of 73 healthy subjects. Epidemiological characteristics (age, sex, dietary habits, educational status, life style) were evaluated by questionnaires. Helicobacter pylori infection was diagnosed in nontumoral gastric mucosal biopsy specimens by Giemsa staining. Results: 298 esophageal Ca and 384 gastric Ca patients were diagnosed in seven years (1994-2001). Most of the patients (90%) were of rural origin. Endoscopic prevalence rate of upper gastrointestinal (UGI) Ca was the highest (1 Ca per 7 esophagogastroscopy) in the Van region compared to other parts of Turkey. Esophageal Ca were 1.5 times more common in females whereas gastric Ca were 1.6 times more common in males. Ninety per cent of esophageal cancers were epidermoid and the remaining 10% were adenocarcinomas. Ninety-seven per cent of gastric Ca were adenocarcinomas. Helicobacter pylori infection was not significantly increased in gastric Ca patients compared to controls. Conclusions: Low educational and socioeconomic status, consumption of smoked, salted, hot, fatty foods, overdrinking hot tea and well water, cigarette smoking, poor intake of fresh fruits and vegetables and poor hygienic conditions were probable culprit factors.
Heavy Metals in Soil, Vegetables and Fruits in the Endemic Upper Gastrointestinal Cancer Region of Turkey
(Elsevier Science Bv, 2003) Türkdogan, MK; Kilicel, F; Kara, K; Tuncer, I; Uygan, I
The environmental exposure to heavy metals is a well-known risk factor for cancer. We investigated levels of seven different heavy metals, (Co, Cd, Pb, Zn, Mn, Ni and Cu) in soil, fruit and vegetable samples of Van region in Eastern Turkey where upper gastrointestinal (GI) cancers are endemic. Heavy metal contents of the samples were determined by flame atomic absorption spectrometer. Four heavy metals (Cd, Pb, Cu and Co) were present in 2- to 50-fold higher concentrations whereas zinc levels were present in 40-fold lower concentrations in soil. The fruit and vegetable samples were found to contain 3.5- to 340-fold higher amounts of the six heavy metals (Co, Cd, Pb, Mn, Ni and Cu) tested. The volcanic soil, fruit and vegetable samples contain potentially carcinogenic heavy metals in such a high levels that these elements could be related to the high prevalence of upper GI cancer rates in Van region. (C) 2002 Elsevier Science B.V. All rights reserved.
Hepatic Cavernous Hemangiomas -: Patterns of Contrast Enhancement on Mr Fluoroscopy Imaging
(Elsevier Science inc, 2002) Ünal, Ö; Sakarya, ME; Arslan, H; Tuncer, I; Etlik, Ö
Purpose: The purpose of this study was to assess the patterns of contrast enhancement of hepatic hemangiomas on gadolinium-enhanced MR fluoroscopy imaging prospectively. Method: Investigation was performed on a 0.3-T open MR unit. Gadolinium-enhanced MR fluoroscopy images were obtained in 24 patients with 28 hepatic hemangiomas. Each MR fluoroscopy image was obtained in 2 s and MR fluoroscopy lasted for 10-25 min for each investigation. Results: Three patterns of contrast enhancement were observed in 24 patients on MR fluoroscopy images. Four small lesions were not detected on MR fluoroscopy images. Uniform enhancement was seen in nine lesions (29%), peripheral nodular enhancement progressing centripetally to uniform enhancement was seen in nine lesions (29%), and peripheral nodular enhancement with persistent central hypointensity was seen in six lesions (22%). Conclusion: Enhanced MR fluoroscopy technique could obtain dynamic images of hepatic hemangiomas. It can be suggested as a useful technique for the showing of enhancement of hepatic hemangiomas, keeping in mind its low sensitivity in the diagnosis of small hemangiomas. (C) 2002 Elsevier Science Inc. All rights reserved.
Hepatoprotective Effect of Foeniculum Vulgare Essential Oil
(Elsevier Science Bv, 2003) Özbek, H; Ugras, S; Dülger, H; Bayram, I; Tuncer, I; Öztürk, G; Öztürk, A
Hepatoprotective activity of Foeniculum vulgare (fennel) essential oil (FEO) was studied using carbon tetrachloride (CCl4) induced liver injury model in rats. The hepatotoxicity produced by acute CCl4 administration was found to be inhibited by FEO with evidence of decreased levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin. The results of this study indicate that FEO has a potent hepatoprotective action against CCl4-induced hepatic damage in rats. (C) 2003 Elsevier Science B.V. All rights reserved.
Oral Ciprofloxacin Versus Intravenous Cefotaxime and Ceftriaxone in the Treatment of Spontaneous Bacterial Peritonitis
(H G E Update Medical Publishing S A, 2003) Tuncer, I; Topcu, N; Durmus, A; Turkdogan, MK
Background/Aims: Cefotaxime or ceftriaxone were considered the first-choice antibiotic for empirical treatment in cirrhotic patients developing spontaneous bacterial Peritonitis. It has that ciprofloxacin could be an alternative to cefotaxime or ciprofloxacin in cirrhotic patients developing spontaneous bacterial peritonitis. The aim of the present study was to compare oral ciprofloxacin with cefotaxime and ceftriaxone in the treatment of-spontaneous bacterial peritonitis in cirrhotic patients. Methodology: Fifty-three hospitalized cirrhotic patients with spontaneous bacterial peritonitis were prospectively included and randomized into three groups: group A (n = 16); received orally 500mg ciprofloxacin every 12 h, group B (n = 18); received intravenous cefotaxime. 2g every 8 h and group C (n = 19) received intravenous ceftriaxone 2g every 24h. Results: 15 patients from the ciprofloxacin group, 17 from the cefotaxime group and 17 patients from the ceftriaxone group were finally analyzed. Spontaneous bacterial peritonitis resolution in three groups was found to be 80%, 76%, and 83%, respectively (p = NS). Incidence of complications and hospital mortality was similar in the three groups. No adverse events were observed in any of the three groups. The cost of the treatment was statistically lower in the ciprofloxacin group than in the cefotaxime group and ceftriaxone group (p < 0.001). Conclusions: These results suggest that orally ciprofloxacin is as effective as cefotaxime and ceftriaxone in the empirical treatment of spontaneous bacterial, peritonitis in cirrhotic patients, and is also less expensive and can be administered orally.
Possible Role of Helicobacter Pylori in the Etiopathogenesis of Chronic Otitis Media
(Lippincott Williams & Wilkins, 2005) Kutluhan, A; Yurttas, V; Akarca, US; Aydin, A; Tuncer, I; Ugras, S
Objective: To investigate a possible contribution from Helicobacter pylori to the etiopathogenesis of chronic otitis media. Study Design: Prospective clinical trial. Methods: Tympanomastoidectomy, radical mastoidectomy, and modified radical mastoidectomy procedures were performed according to the pathology of ear disease. Biopsy specimens were taken from middle ear, mastoid antrum, and tympanic orifice of eustachian tube. Helicobacter pylori DNA was extracted from these biopsy specimens by using nested polymerase chain reaction. Results: Helicobacter pylori DNA was detected in 3 (7.9%) of 38 chronic otitis media patients. Conclusion: Even though it is possible to detect Helicobacter pylori in middle ear cleft in chronic otitis media, its role in the etiopathogenesis of the issue is controversial.
Primary Malignant Fibrous Histiocytoma Presenting as an Intussusception: Report of the Small Intestine of a Case
(Springer, 2002) Kotan, C; Kosem, M; Alici, S; Ilhan, M; Tuncer, I; Harman, M
Malignant fibrous histiocytoma occurs most commonly in the extremities and trunk, but rarely in the visceral organs. Malignant fibrous histiocytoma of the small intestine is an extremely rare condition. To our knowledge, only ten cases of primary tumors involving the small intestine have been described up to now. Among them only one case has been reported to lead to intussusception. This case report documents the appearance of a storiform-pleomorphic type primary malignant fibrous histiocytoma of the ileum, which led to intussusception, in a 58-year-old man with a 3-month history of dyspepsia, weight loss, general fatigue, and nonspecific abdominal pain. The patient was well with no sign of disease at 8 months after surgery. The clinical and pathologic characteristics of malignant fibrous histiocytoma of the small intestine as found in the literature are also reviewed.
The Role of Urtica Dioica and Nigella Sativa in the Prevention of Carbon Tetrachloride-Induced Hepatotoxicity in Rats
(Wiley, 2003) Türkdogan, MK; Ozbek, H; Yener, Z; Tuncer, I; Uygan, I; Ceylan, E
The role of Nigella sativa L. (Ranunculaceae) (NS) and Urtica dioica L. was investigated (UD) in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis and cirrhosis. Fifty Sprague-Dawley rats were allocated into five groups (I, IIA and B, IIIA and B) and CCl4 was injected biweekly to all groups. Group I (control, CCl4 only), group IIA and B (NS fixed oil and volatile oil), group IIIA and B (UD fixed oil and UD decoction extract) rats were killed at the end of week 12 and histopathological and immunohistochemical examinations of liver tissues were performed. In the control group, coagulation necrosis and hydropic degeneration were marked in the periacinar regions (zone 3) associated with fibrosis in the periacinar regions and in the portal tracts. In groups IIA-B and IIIA-B (NS and UD), none of the serious histopathological findings were detected except for sparse coagulation necrosis in the periacinar regions. ASMA-positive perisinusoidal cells with myofibroblastic transformation and lysosomal enzyme activity suggesting fibrogenesis were also significantly more common in the control group than in the NS and UD groups. UD and NS seem to be significantly effective in the prevention of carbon tetrachloride induced hepatotoxicity in rats. Copyright (C) 2003 John Wiley Sons, Ltd.
Salmonella Myocarditis in a Patient With Wolf-Parkinson Syndrome That Was Confused With an Inferior Myocardial Infarction
(Univ Chicago Press, 1997) Akdeniz, H; Tuncer, I; Irmak, H; Demiroz, AP