Browsing by Author "Tuncer, I."

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Assay of Mycobacterium Tuberculosis in Biopsy Specimens Taken From Hepatic Granuloma Patients Using Polymerase Chain Reaction Method
(2001) Tuncer, I.; Köksalan, O.K.; Demir, K.; Dinçer, D.; Türkoǧlu, S.; Kaymakoǧlu, S.; Çakaloǧlu, Y.
Background/aims: In the diagnosis of hepatic tuberculosis, classical laboratory methods (including cultures and direct staining of the acid resistant bacilli) are insufficient. Diagnosis is commonly made by clinical and histological findings and then confirmed by response to antituberculous treatment. In the diagnosis of pulmonary and extra-pulmonary tuberculosis, the use of PCR to detect tuberculous bacilli is being evaluated and some authors consider it a very reliable and sensitive method. However, the use of PCR in the diagnosis of hepatic tuberculosis has not been sufficiently supported by clinical studies. The aim of this study was to assess the sensitivity of this method in demonstrating M. tuberculosis bacilli in liver tissue specimens of hepatic granuloma patients, which were fixed with formalin and imbedded in paraffin blocks. Methods: Thirty-two liver biopsy specimens taken from cases diagnosed with granulomatous hepatitis and fixed with formalin in paraffin blocks were included in the study. The specimens were divided into three groups according to clinical and laboratory findings, histopathological diagnosis of hepatic granuloma and the response to appropriate treatment: Group A (n=12): hepatic granuloma with caseification necrosis (liver tuberculosis), Group B (n=10): noncaseous hepatic granuloma (liver tuberculosis), Group C (n=10) nontuberculous hepatic granuloma patients. All biopsy materials were stained by the Ziehl-Neelsen method and with allocrom stain in a direct search for bacilli and the PCR study was then performed. DNA amplification of M. tuberculosis IS6110 gene was also done by PCR study Results: Direct stains were negative in all specimens. M. tuberculosis gene amplification was found to be positive with the first step PCR method in three (25%) of 12 patients in group A, while with nested PCR, four (33%) of 12 patients in group A, three (30%) of 10 patients in group B and one (10%) of 10 patients in group C were positive. Only seven (32%) of all 22 patients of groups A and B who were diagnosed with tuberculous granulomatous hepatitis had positive PCR tests. In the control group however, only one (10%) of the patients had a positive PCR test. Conclusion: The findings of this study show that in our patient groups, PCR is insufficiently sensitive in diagnosing TB. Possible explanations for this low sensitivity could be that DNA concentrations were low in our specimens that paraffin blocks used contained inhibitors or that the primers used were inappropriate.
The Association of Short Segment Barrett's Esophagus With Intestinal Metaplasia in Stomach
(2003) Tuncer, I.; Ugraş, S.; Uygan, I.; Türkdoǧan, K.; Kösem, M.
Background/aims: The aims of this study were to investigate the presence of short segment Barrett's esophagus in people found to have tongue-like columnar mucosal protrusions in the distal esophagus and to determine the relationship between short segment Barrert's esophagus and Helicobacter pylori, gastritis and intestinal metaplasia observed in other parts of the stomach. Methods: The study included 50 patients (32 male, 18 female). Two biopsy specimens were taken from the antrum, at least 2 cm away from the pylorus, from the incisura angularis, corpus and cardia and four biopsy specimens were taken from tongue-like columnar protrusions (<3 cm long) above the gastroesophageal junction. Tissue samples were stained with hematoxyline-eosine, HID-Alcian blue pH 2.5 and modified Giemsa. Results: Of the 50 subjects who were found to have tongue-like columnar protrusions above the gastroesophageal junction, short segment Barrett's esophagus was detected in nine (18%). Whereas all short segment Barretti's esophagus cases were associated with chronic gastritis, Helicobacter pylori was found to be positive in five (55.5%) of them and there was intestinal metaplasia in other parts of the stomach (antrum in two patients, incisura angularis in three, antrum and cardia in one) in six (66.6%) cases. In 41 patients without short segment Barrett's esophagus 33 (80%) had chronic gastritis, 27 (66%) had Helicobacter pylori infection and eight had intestinal metaplasia in different locations (there in antrum, four in incisura angularis, one in the antrum and cardia) of the stomach. Conclusions: An association between short segment Barrett's esophagus and intestinal metaplasia was found in different parts of the stomach. The link between intestinal metaplasia in the stomach and these metaplastic changes in the tubular esophagus requires evalation in larger and more comprehensive studies.
A Brucellosis Case With Ascites, Hearing Loss and Pancytopenia
(2003) Tuncer, I.; Akdenis, H.; Uygan, I.; Turkdogan, K.; Cekici, S.; Durmus, A.
Objectives- To report a rare case of brucellosis in a previously healthy 25-year-old woman who presented with fever, bilateral hearing loss, non-portal hypertensive type ascites and pancytopenia. Design- Case study. Setting- Departments of Gastroenterology and Infectious Diseases, Yuzuneu Yil University Medical Faculty, Van. Results- Cultures from bone marrow and ascites yielded growth of Brucella melitensis and Brucella standard tube agglutination was found to be positive at a titer of 1/1280. The patient completely recovered by the sixth week following combined antibacterial treatment of ciprofloxacin, rifampin and doxychline. Conclusion- Brucellosis is a multisystemic disease, which may be manifested by various symptoms. Our case is the first case of brucellosis to be reported in the literature with the rare association of severe complications of hearing loss, ascites and pancytopenia.
Chronic Hepatitis Delta Virus Infection in Van Region of Eastern Turkey
(2005) Türkdoǧan, M.K.; Bozkurt, H.; Uygan, I.; Tuncer, I.; Irmak, H.; Buzgan, T.; Akdeniz, H.
Background/aims: Hepatitis delta virus infection is an important cause of liver morbidity and mortality worldwide. In Eastern Turkey, hepatitis B virus infection is the major cause of chronic liver diseases. We aimed to research the role of hepatitis delta virus infection in chronic liver diseases related to hepatitis B virus infection in the Van region of Eastern Turkey. Methods: Serological markers of hepatitis B virus and hepatitis delta virus infection [HBsAg, HbeAg, Anti-HBe and Anti- hepatitis delta virus total (IgM+IgG)] were determined by ELISA test in patients with chronic hepatitis and cirrhosis. Serum hepatitis B virus DNA was determined by polymerase chain reaction (PCR) method in chronic hepatitis B patients. Results: Hepatitis delta virus infection was detected in 5% (7/138) of asymptomatic hepatitis B virus carriers, in 16% (24/148) of chronic hepatitis B patients and in 45% (34/75) of cirrhotic hepatitis B virus patients, hepatitis delta virus infection showed a three-fold increase in chronic hepatitis (p<0.01) and nine-fold increase in cirrhosis (p<0.001) compared to hepatitis delta virus carriers. Also, it was three times more frequent in cirrhosis (p< 0.001) compared to chronic hepatitis. Chronic hepatitis delta virus infection was equally distributed between sexes in patients with chronic hepatitis B virus infection, whereas chronic hepatitis B virus infection alone was three times more frequent in males (p<0.001). Mean ages of hepatitis delta virus carriers, chronic hepatitis D and hepatitis delta virus cirrhosis patients were 30.7±8 (14-65), 36±13 (19-70) and 44±16 (25-55), respectively. Conclusions: The higher prevalence of hepatitis delta virus infection in more severe form of hepatitis B virus infection suggests that hepatitis delta virus infection increases the severity of chronic hepatitis B virus infection in the Van region, hepatitis delta virus infection remains a second major cause of chronic liver diseases in Eastern Turkey in spite of its decreasing prevalence in Western countries and in Western Turkey.
The Comparative Effects of Pentoxifylline and Ursodeoxycholic Acid on Il-1β, Il-6, Il-8 and Tnf-Α Levels in Nonalcoholic Fatty Liver
(2003) Tuncer, I.; Uygan, I.; Dülger, H.; Türkdoǧan, K.; Şekeroǧlu, R.; Kösem, M.
Objective: To investigate the comparative effects of the pentoxifylline (PTX) and ursodeoxycholic acid (UDCA) on IL-1β, IL-6, IL-8 and TNF-α in non-alcoholic fatty liver (NAFL) cases. Method: Twenty-eight cases diagnosed to have NAFL were included in our study. The cases were divided into 3 groups. 20 mg/kg/day PTX was given to the subjects in group A (6 male, 4 female), 15 mg/kg/day UDCA was given to the subjects in group B (5 males, 5 females) for 6 months. The cases in group C (5 male, 3 female) were followed as control group. The biochemical values and cytokine levels of the cases were evaluated before and at the end of the sixth month of the treatment. Results: When compared with the serum cytokine levels before and after the treatment, IL-8 and TNF-α levels were found to be significantly decreased both in group A and group B (p< 0.05), whereas there was no statistically significant change in IL-1β and IL-6 levels (p > 0.05). Conclusion: While PTX and UDCA significantly decreased the serum IL-8 and TNF-α levels in NAFL, their effects on IL-1β and IL-6 were not significant.
Comparison of Serum Cytokeratin-18, Cea and Ca 19-9 Levels in Esophageal and Gastric Cancers
(2004) Tuncer, I.; Dülger, H.; Uygan, I.; Öztürk, M.; Kotan, Ç.; Şekeroǧlu, R.
The aim of this study was to determine clinical value of alone and combined use of serum cytokeratin (CK)-18, carcinoembryonic antigen (CEA) and CA 19-9 in esophageal squamous cell carcinoma and gastric adenocarcinoma. Serum tumor markers were measured in 60 patients who had esophageal squamous cell carcinoma or gastric adenocarcinoma. Thirty healthy subjects served as controls. In patients with gastric adecarcinoma serum CK-18 levels were significantly increased compared to both esophageal squamus cell carcinoma and control groups (p<0.01, p<0,05 respectively). But there was no significant difference in CK-18 levels between esophageal squamous cell carcinoma patients and healthy subjects (p>0.05). On the other hand, serum CEA and CA 19-9 levels did not differ between groups (p>0.05). The sensitivity of serum CK-18, CEA and CA19- 9 in esophageal squamous cell carcinoma were 53%, 70% and 66%, respectively. For gastric adenocarcinoma, the sensitivity of each tumor marker was similar 70%, 70% and 70%, respectively. CK-18/CA19-9 combination in the esophageal (83%) and gastric carcinomas (93%) were found to be more sensitive than other tumor markers when these markers were evaluated in combination. CEA exhibited the highest sensitivity for esophageal squamous cell carcinoma compared to CK-18, and CA19-9. However, the sensitivity of all tumor markers in gastric adenocarcinoma were similar. The combination of CK-18 and CA19-9 could increase the diagnostic sensitivity in esophageal and gastric carcinomas.
Demographic and Clinicopathological Characteristics of Nonalcoholic Fatty Liver Disease in the East-Southeastern Anatolia Regions in Turkey
(2005) Bahcecioglu, I.H.; Koruk, M.; Yilmaz, O.; Bolukbas, C.; Bolukbas, F.; Tuncer, I.; Ozercan, I.H.
Objective: To identify the demographic and clinicopathological characteristics of patients diagnosed with non-alcoholic fatty liver disease (NAFLD) and the risk factors for fibrosis based on histopathological findings in East-Southeastern Anatolia regions in Turkey. Subjects and Methods: The study included a total of 93 patients diagnosed with NAFLD from 5 different centers. Histopathological findings were evaluated by dividing them into four categories using Matteoni classifications. Cases with fibrosis were further evaluated using Brunt classifications. Results: The patients with a nonalcoholic fatty liver were in the 3rd and 4th decade age groups. The mean age was 38 years, 76% of the patients were male, 85% were overweight, 37% were obese, 18% had type 2 diabetes mellitus, and 80.6% had hyperlipidemia. A multiple regression analysis showed that age, type 2 diabetes mellitus, and aspartate aminotransferase (AST) levels were linked with the severity of the disease. Of the 93 patients, 55 (59.1%) had fibrosis, of which 10.8% were classified as severe. The severity of fibrosis was significantly higher in obese patients. Conclusions: The risk factors for severity of NAFLD included advanced age, type 2 diabetes mellitus and serum AST level, while the risk factor for the severity of fibrosis was obesity. Copyright © 2006 S. Karger AG.
Dietary Benzo(A)pyrene and 1,2-Benzanthracene Levels in an Endemic Upper Gastrointestinal (Oesophageal and Gastric) Cancer Region of Turkey
(2003) Türkdoǧan, M.K.; Daǧoǧlu, G.; Akman, N.; Alişarli, M.; Tuncer, I.; Uygan, I.
Background: In eastern Turkey, upper gastrointestinal (oesophageal and gastric) cancers are endemic and dietary factors play an essential role in carcinogenesis. Design: Laboratory analysis of benzo(a)pyrene (BP) and 1,2-benzanthracene (BA) levels in a range of cooked foods in use in the Van region. Materials and Methods: BP and BA levels (ppb) in bread and cooked meat samples were determined by high performance liquid chromatography. An analysis of variance and the multitest were used. Results: The mean BP level was highest in bread baked in a bakery using fuel oil (3.32 ppb), followed by bread baked in an oven burning dried dung, fatty pizza cooked using a wood fire and meat roasted on a liquid petroleum gas (LPG) fire (2.51, 2.37 and 2.32 ppb, respectively; p>0.05). The mean BP level in bread baked in a bakery using fuel oil was significantly higher than that in meat roasted in an oven burning dried dung, bread baked in an oven using wood fire and meat cooked using a wood fire (2.03, 1.54 and 1.39 ppb, respectively, p<0.01). Mean BA levels were highest in bread baked in an oven burning dried dung and bread baked in a bakery using fuel oil (1.06 and 1.04 ppb, respectively), followed by meat roasted using a LPG fire, fatty pizza cooked using a wood fire and meat roasted in an oven burning dried cow dung (0.91, 0.77 and 0.73 ppb, respectively, p>0.05). The mean BA levels in bread baked in an oven burning dried dung and bread baked in a bakery using fuel oil were significantly higher than those in bread baked in an oven using a wood fire and meat cooked using a wood fire (0. 55 and 0.55 ppb, respectively, p<0.01). The mean BP levels were two to three times more elevated than the mean BA levels in all food samples. Conclusions: These findings reveal the carcinogenic role of traditional foods baked or cooked using animal manure or fuel oil in the Van region because of high BP and BA levels.
Dietary Nitrate and Nitrite Levels in an Endemic Upper Gastrointestinal (Esophageal and Gastric) Cancer Region of Turkey
(2003) Türkdoǧan, M.K.; Testereci, H.; Akman, N.; Kahraman, T.; Kara, K.; Tuncer, I.; Uygan, I.
Background/aims: The aim of this study was investigate nitrate and nitrite levels in some traditional foods and drinking water in Van, an endemic upper gastrointestinal (esophageal and gastric) cancer region of Eastern Turkey. Methods: Cheese with added herbs, drinking; water, bread baked by wood fire and bread baked by burning animal manure specimens collected in the Van region were analyzed by Stahr's modification method. Nitrite was reduced to nitrate by the following three reagents: hydrazine sulphate ((NH2) 2SO4), CuSO4 and NaOH. Nitrate was then determined by coupling reagent containing sulphanlyamide, phosphoric acid and N-1-naphtyl ethylendiamine dihydrochloride. Results: Nitrate and nitrite levels of all traditional foods and nitrite levels of drinking water were very significantly elevated compared to standard values (p<0.001-0.01). Conclusions: These findings suggest that the influence of a traditional diet rich in nitrate and nitrite is significant in the development of endemic upper gastrointestinal (esophageal and gastric) cancers in the Van region of Turkey.
The Effects of Ursodeoxycholic Acid Alone and Ursodeoxycholic Acid Plus Low-Dose Acetylsalicylic Acid on Radiolucent Gallstones
(2003) Tuncer, I.; Harman, M.; Mercan, R.; Öztürk, M.; Arslan, I.; Meral, C.; Türkdoǧan, M.K.
Background/aims: Mucin, a high molecular weight glycoprotein secreted by the gallbladder and biliary duct epithelium, is a pronucleating agent in experimental and human gallstone disease. Blockage of mucin release with aspirin inhibits the formation of primary gallstones in animal models. The aim of this study was to compare the effects of ursodeoxycholic acid alone and plus low-dose aspirin on dissolution of solitary or multiple gallstones. Methods: There were three treatment groups comprising 43 patients with cholesterol gallstones: Group I (n=16, 13 females, three males) was givenursodeoxycholic acid (15 mg. kg. day) alone and Group II (n=14, 12 females, two males) was treated with aspirin (100 mg/day) in addition to ursodeoxycholic acid cholic. Group III was a control group of 13 cases (11 females, two males) who were monitored without medical treatment. Stone dissolution rates were evaluated sonographically in all patients at three month intervals during the treatment period. Results: After 12 months of treatment, stone dissolution was found in six (37.5%) of the patients in Group I and six (42.8%) of the patients in Group II. The difference in both treatment groups was significant compared to controls (p<0.05) but there was no significant difference between the two treatment groups (p>0.05). Of the cases in whom dissolution was achieved, all patients had multiple gallstones except for one with a solitary stone in Group I. Gallstones were not dissolved of any subject of group III. Conclusions: The results showed that ursodeoxycholic acid cholic therapy is more effective in the dissolution of multiple gallstones than of solitary ones. Combination with aspirin did not potentiate the efficacy of ursodeoxycholic acid cholic.
The High Prevalence of Esophageal and Gastric Cancers in Eastern Turkey
(1998) Turkdogan, M.K.; Akman, N.; Tuncer, I.; Dilek, F.H.; Akman, E.; Memik, F.; Aksoy, H.
Background/Aims: Gastrointestinal cancers (G.I Ca) are important causes of mortality in Eastern Turkey. We purposed to reveal the epidemiological characteristics and the regional risk factors of the upper G.I (esophageal and gastric) cancers. Materials and Methods: 203 G.I Ca patients were diagnosed in our Gastroenterology Department with endoscopic, radiological and histopathological methods in two and half years. Their age, sex, nutritional habits and the histopathologic types of cancers were determined. Results: Esophageal and gastric cancers were ninety percent (183/203) of all the G.I Ca. Gastric and esophageal cancers were ninety percent (90%) of all these GI cancers. Both of cancer groups have been generally diagnosed after fifty years of age, and gastric Ca was twice frequent in males, whereas esophageal Ca was one and half times frequent in females. Drinking hot tea and family history of cancer were significant in the esophageal Ca group, although cigarette smoking was not significantly different in both cancer groups than the control group. Daily dietary habits were generally consumption of hot, salted, fatty, smoked and fried foods (meat, cereals etc.) without sufficient intake of fresh fruits and vegetables. Histopathologically, ninety percent (90%) of esophageal Ca were epidermoid carcinoma and ten percent (10%) were adencarcinoma whereas all gastric Ca were adenocarcinoma. Conclusions: There are many carcinogen risk factors including mainly dietary and ecological factors such as stagnant ditch water, animal manure and peat in rural areas and volcanic soil properties in the Van region.
Oesophageal Involvement During Attacks in Pemphigus Vulgaris Patients
(Wiley, 2006) Calka, O.; Akdeniz, N.; Tuncer, I.; Metin, A.; Cesur, R. S.
Pemphigus vulgaris (PV) is a rare autoimmune bullous skin disorder characterized by frequent involvement of the mucous membranes, usually beginning at the mouth. To investigate the oesophageal involvement in patients with PV and to explore the primary relationship of the disease with symptoms such as dysphagia, odynophagia and retrosternal burning. Oesophageal involvement was investigated by upper gastrointestinal endoscopy and biopsy during the early phase of the attacks in 26 patients with PV (12 men, 14 women, age range 24-63 years). Histopathological examination and direct immunofluorescence of the oesophageal biopsy specimens revealed pemphigus involvement in 12 of 26 patients (46.15%). The oesophagus is an important predilection zone for PV, thus care must be taken to detect these lesions at an early stage.
P-35 the Efficacy of Cisapride in Managing Nausea Produced by Selective Serotonin Reuptake Inhibitors: a Placebo Controlled Study
(Elsevier B.V., 1996) Kara, H.; Agargün, M.Y.; Algün, E.; Türkdoan, M.K.; Tuncer, I.
Rheumatic Findings in Hyperparathyroidism. a Case Report
(1996) Adak, B.; Tuncer, I.; Tekeoglu, I.
Hyperparathyroidism is a general term indicating an increased level of parathyroid hormone in the blood. The condition is generally divided into three types: primary, secondary, and tertiary. A number of rheumatic findings are associated with parathyroid hormone excess. In this study a case is presented of a woman with primary hyperparathyroidism and its rheumatic manifestations due to an intrathymic parathyroid adenoma.
Serum and Tissue Levels of Vitamin a and E in Gastric and Esophageal Cancer
(1996) Turkdogan, M.K.; Testereci, H.; Kahraman, T.; Tuncer, I.; Algun, E.; Yoruk, I.H.
Vitamin A and Vitamin E have antioxidant properties and their role in the prevention of gastrointestinal cancers by way of scavenging lipid peroxidation products is very important. Vitamin A ester (retinol acetate) and vitamin E isomers (alpha, gamma and total tocopherols) have been investigated in the serum samples and tissue biopsies of 7 esophageal, 12 gastric cancer patients and a control group consisting of 12 healthy subjects. The serum mean retinol acetate level was significantly higher in the gastric cancer group but not in patients with esophageal cancer when compared to the control group. Serum mean tocopherol levels were low in both cancer groups when compared to the control group but this did not reach biological significance. Tissue mean retinol acetate and tocopherol levels were found significantly low in both of the cancer groups (p<0.03 and p<0.08). These findings suggest that the low tissue levels of the antioxidant vitamin A and E may be related to the etiopathogenesis of the gastrointestinal cancers.
The Serum Levels of Il-1β, Il-6, Il-8 and Tnf-Α in Nonalcoholic Fatty Liver
(2003) Tuncer, I.; Özbek, H.; Topal, C.; Uygan, I.
Nonalcoholic fatty liver (NAFL) has an extensive clinical spectrum ranging from simple fatty liver to steatohepatitis and cirrhosis. Its pathogenesis is multifactorial. The aim of our study was to measure the serum levels of some cytokines (IL-1β, IL-6, IL-8 and TNF-α), which are thought to play a role in the pathogenesis of NAFL. Thirty subjects (18 males, 12 females) with clinical and laboratory features of hepatosteatosis were enrolled in the study as the patient group (group 1) and 30 healthy subjects (21 males, 9 females) served as controls (group 2). The levels of hepatic transaminases, gamma-glutamyltransferase, alkaline phosphatase, total cholesterol, IL-1β, IL-6, IL-8 and TNF-α were studied in both patients and controls. Serum IL-1β, IL-6, and TNF-α levels did not display significant differences between the patients and the controls (P > 0.05). On the other hand, the IL-8 level was significantly elevated in the patient group (P < 0.05). This increased level may play a more active role in the pathogenesis of fatty liver than IL-1β, IL-6 and TNF-α. Further studies are needed to elucidate to what extent the proinflammatory cytokines (especially IL-8 and TNF-α) are involved in the pathogenesis of NAFL.
Tissue Transglutaminase Expression in Duodenal Mucosa of Patients With Celiac Disease and of Normal Subjects
(2003) Tuncer, I.; Bayram, I.; Kaba, I.; Mercan, R.; Uǧraş, S.
Background/aims: Our aim in the present study was to investigate tissue transglutaminase expression by immunohistochemistry in duodenal mucosa of patients with celiac disease. Methods: A total of twelve patients with celiac disease were examined. The patients had different clinical and histopathologic degrees of severity and responded to gluten withdrawal with clinical improvement. Ten subjects with various unrelated diseases served as controls. Serum endomysium antibodies were measured by an indirect immunofluorescence method using a commercial kit. Duodenal biopsy specimens were stained with hematoxylin and eosin. Immunohistochemical staining for anti-tissue transglutaminase antibodies was performed using commercial kit. Results: Serum endomysium antibodies and evaluation of small bowel biopsy specimens were normal in all control subjects. However, serum endomysium antibodies were positive in all of the celiac patients. Immunohistochemical staining pattern of duodenal biopsy specimen performed using anti-tissue transglutaminase antibodies was similar in celiac patients and control subjects. Conclusion: Tissue transglutaminase expression by immunohistochemical methods in untreated celiac mucosa is not suitable for diagnosis of celiac disease.
Two Giant Cavernous Hemangioma Caused Cavernous Transformation of the Portal Vein in a Pregnant Woman
(2002) Tuncer, I.; Arslan, H.; Harman, M.
We report a case with two giant hemangiomas of the liver that caused cavernous transformation of the portal vein in a 45-yr-old full term pregnant woman. The patient had no serious complaints other than a mass and slight pain in the right upper quadrant and there were no abnormalities in laboratory values. Delivery was performed without complication. In the six month follow-up period, no changes were seen in the lesions.
Upper Esophageal Stenosis in a Case With Rothmund-Thomson Syndrome
(2001) Tuncer, I.; Metin, A.; Uǧraş, S.; Uygan, I.
Rothmund-Thomson Syndrome is an autosomal recessive disease that may be accompained by development abnormalities. Etiology of the disease has been postulated to DNA repair deficiency and intestinal anomaly has been very rarely. The case of RTS. admitted with dysphagia due to esophagus stenosis and his complaints disappeared completely after esophagus dilatation, was discussed ill the light of literature aknowledgement.
Value of Fibrinogen as a Marker in Gastrointestinal Cancers
(1997) Turkdogan, M.K.; Akman, N.; Ercan, M.; Tuncer, I.; Algun, E.
Increase of some coagulation factors and tendency to venous thrombosis have been reported in gastrointestinal cancers. In this study, plasma fibrinogen levels have been investigated in 24 patients with gastrointestinal cancer (esophageal, gastric and pancreatic cancer). Significant increase has been found in the esophageal cancer group (p < 0.01). Plasma fibrinogen levels were also elevated in two pancreatic cancer patients (9.52 and 6.45 gr/lt) but they were normal in gastric cancer patients. These results suggest that fibrinogen may be a useful tumor marker in some gastrointestinal cancers and further investigations are required in a large number of patients.