Browsing by Author "Tuncer, O."

Now showing 1 - 20 of 43

Acute Peritoneal Dialysis in Critically Ill Newborns
(Springer, 2016) Ustyol, L.; Peker, E.; Demir, N.; Agengin, K.; Tuncer, O.
Acute Respiratory Distress Syndrome Due To Overdose Desferrioxamine: Report of a Child
(2005) Atas, B.; Caksen, H.; Tuncer, O.; Oner, A.F.; Kirimi, E.; Akbayram, S.
In this article, we present an 18-month-old girl with acute iron poisoning who died from acute respiratory distress syndrome due to overdose of desferrioxamine. Our purpose is to emphasize the importance of close follow-up of children with acute iron poisoning for desferrioxamine toxicity.
Assessing of Term Newborns Hospitalized in Our Neonatal Unit With the Diagnosis of Indirect Hyperbilirubinemia
(Anatolian Journal of Clinical Investigation, 2015) Demir, N.; Peker, E.; Aslan, O.; Ceylan, N.; Tuncer, O.
The one of most common problems of the newborn baby is indirect hyperbilirubinemia. In this retrospective study; the etiology, clinical and demographic features, treatment methods, and the complications in pathological indirect hyperbilirubinemia and prolonged jaundice were evaluated. 237 cases of pathological indirect hyperbilirubinemia and prolonged jaundice that were viewed in Yüzüncü Yıl University Hospital Neonatology Unit between January 2013 - December 2014 were included in this study. All neonates in the study with following characteristics: 57.8% of patients were male, the mean gestational age of 38.4 ± 1 weeks, mean birth weight of 2870 ± 505 g , mean bilirubin level on admission of 21.6 ± 5.6 mg/dL (13–49), vaginal delivery ratio of 55.7%, first time mother ratio of 34.2%, breastfeeding ratio of 98%. While in 95 (40.1 %) neonates the etiology of hyperbilirubinemia could not be found, urinary tract infection in 34 (14.3%), ABO incompatability in 72 (30.4%) and Rh incompatability in 24 (% 10.1) patients were found. The average length of stay in the hospital and duration of phototherapy were 4 ± 2.9 days and 37.2 ± 14.2 hours, respectively. All of the cases were given phototherapy, but 44 infants were done exchange transfusions. We found that bilurubin induced neurological disorder in 23 newborn had undergone exchange transfusion, and its the most important risk factorwas ABO incompatability (43.2 %). Urinary tract infection (30.8%), and idiopathic causes (42.3 %) were found as the most important risk factors for prolonged jaundice.Pathological indirect hyperbilirubinemia is a major cause of morbidity and mortality in the newborn period. We think that newborns with jaundice should be diagnosis, treatment, and close follow-up in order to prevent development of bilirubin-induced neurologic dysfunction. © 2015, Anatolian Journal of Clinical Investigation. All rights reserved.
Association of Down Syndrome and Morgagni Hernia
(Medecine Et Hygiene, 2014) Taskin, G. Alpaslan; Tuncer, O.; Demir, N.; Bilici, S.; Aktar, F.; Peker, E.; Uner, A.
Baller-Gerold Syndrome Associated With Dextrocardia
(Medecine Et Hygiene, 2011) Ceylan, A.; Peker, E.; Dogan, M.; Tuncer, O.; Kirimi, E.
Baller-Gerold syndrome associated with dextrocardia: Baller-Gerold Syndrome (BGS) is a rare autosomal recessive disorder that is apparent at birth. The disorder is characterized by distinctive malformations of the skull and facial area and bones of the forearms and hands. We report a 4 year old boy in whom the clinical features of craniosynostosis and bilateral absent thumbs and radii led to a diagnosis of Baller-Gerold syndrome. Physical examination revealed that the heart was localized to the right side. Echocardiography confirmed dextrocardia. Dextrocardia has not previously been reported with Baller-Gerold syndrome. To the best of our knowledge, this is the first reported case of Baller-Gerold syndrome associated with dextrocardia.
Candida Albicans Outbreak Associated With Total Parenteral Nutrition in the Neonatal Unit
(Elsevier, 2016) Guducuoglu, H.; Gultepe, B.; Otlu, B.; Bektas, A.; Yildirim, O.; Tuncer, O.; Berktas, M.
Background: The most frequently isolated fungi in patients using TPN belongs to the Candida genus. Various infections including venous catheter infections, fungemia, endocarditis and ophthalmitis may be encountered. Objective: Upon growth of Candida in the blood cultures from the pediatric (neonatal) unit of our hospital, a surveillance was performed in this unit and involving the health care workers. Clonal relationships of the isolates were investigated with molecular tests. Methods: Blood samples obtained from the patients in pediatric neonatal unit were studied with automatized blood culture [BacT/Alert (Bio Merioux, France)]. Yeast isolates from environmental surveillance cultures (TPN solutions, hands of healthcare personnel, etagere, etc) and patients were identified as C. albicans with conventional methods and ID 32 C and ATB (TM) Fungus 3 (Biomerieux, France) kits. Clonal similarity was determined by using AP-PCR as initial method and we have also typified all strains by the method of REP-PCR (diversilab system, bioMerieux). Finally; Pulsed Field Gel Electrophoresis (PFGE) was used for confirmation. Results: C. albicans was isolated in blood cultures of seven patients. Similar antifungal susceptibility patterns were observed in all isolates. AP-PCR and REP-PCR showed that the C. albicans isolates grown in the TPN solution and from the patients' blood cultures were clonally same strains. PFGE analysis further confirmed this clonality. Conclusion: According to results of the molecular methods, we thought that a C. albicans outbreak had occurred in the neonatal pediatric unit, due to contamination of TPN solution.
A Case of Bartter’s Syndrome Associated With Nephrocalcinosis Presenting With Tetany
(2004) Ataş, B.; Çaksen, H.; Tuncer, O.; Kirimi, E.; Arslan, S.; Erol, M.; Yuca, S.A.
A 10-year-old boy was admitted to hospital with a 3 month history of intermittent spasms of the wrists and ankles, and twitching of the eyelids. He also had polyuria, polydipsia, nocturnal enuresis, fatigue and constipation since he was a toddler. Physical examination revealed normal blood pressure, myokymia on the right eyelid and bilateral carpopedal spasms. Laboratory investigation revealed hypocalcemia, hypokalemia, increased plasma renin and aldosterone, hypercalciuria, metabolic alkalosis, and bilateral medullary nephrocalcinosis. Cranial computed tomography was normal. Based on the clinical and laboratory findings he was diagnosed as having Bartter’s syndrome, which is characterized by hypochloremia, hypokalaemia and metabolic alkalosis associated with potassium renal leakage, with normal blood pressure despite increased plasma renin activity. It is well known that tetany is not uncommon in the neonatal form of Bartter’s syndrome and nephrocalcinosis is usually not present in the classic form. Interestingly, our patient had both the clinical manifestations of the neonatal form and of the classic form of Bartter’s syndrome. In conclusion, we would like to emphasize that both the clinical manifestations of neonatal and classic forms of Bartter’s syndrome (as an overlapping syndrome) might be seen in children and that Bartter’s syndrome should also be considered in children with tetany as in our case. © 2004, IOS Press. All rights reserved.
A Case of Langerhans Cell Histiocytosis With Anal Fistula
(Kurume University School of Medicine, 2010) Akbayram, S.; Akgun, C.; Ozen, S.; Kaya, A.; Tuncer, O.; Yuca, S.A.; Oner, A.F.
Langerhans cell histiocytosis (LCH) is an uncommon clinically heterogeneous disorder characterized by the proliferation and accumulation of Langerhans cells with local infiltration of tissues and organ destruction. LCH takes many clinical forms, affecting different systems and different sites in the same system with variable outcomes. Bone, skin, lymph node, pituitary, liver, lung, bone marrow and spleen involvement can be seen in patients with LCH. Involvement of the perianal site is rare. In this article, a 16-month-old boy with multiple organ involvement including skin, liver, lung, and bone is presented. Aside from these systemic involvements, he also had a simple anal fistula. According to our best knowledge, this case of LCH with anal fistula is only the second to be reported in childhood. We would like to emphasize that LCH may be associated with anal fistula; therefore, we suggest that patients with LCH should be examined for this condition.
A Case of Nephrotic Syndrome Associated With Relapsing Hepatitis A
(IOS Press, 2007) Ataş, B.; Tuncer, O.; Çaksen, H.; Arslan, Ş.
Viral hepatitis A infection is a self-limited infection occurring predominantly among children usually as an anicteric often-subclinical illness. Almost all patients with hepatitis A virus infection recover completely. However, a relapsing course can occur with clinical signs, symptoms and biochemical findings of hepatic inflammation one or four months after the acute phase. In this article, we report a case of nephrotic syndrome associated with relapsing hepatitis A. Although it has been reported that hepatitis A can lead to nephrotic syndrome, an association of relapsing hepatitis A and nephrotic syndrome has not been reported in the literature to the best of our knowledge. © 2007 IOS Press. All rights reserved.
Case Series: 11 Cases of Hemolytic Disease of the Fetus and Newborn Due To Kell Blood Group Incompatibility
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Yürektürk, E.; Aycan, N.; Başaranoğlu, M.; Arslan, B.; Tuncer, O.
Hemolytic disease of the fetus and newborn (HDFN) results from the destruction of the newborn's red blood cells or the fetus by the mother's immune globulin G antibodies. Although HDFN is often caused by RhD and ABO incompatibility, it can also be seen due to minor blood groups such as Kell, Kidd, Duffy, P, MNS, or Rh subgroup (C, c, E, e) alloantibodies. Our study aims to share our experiences regarding a rare cause of HDFN. The files of patients who were followed up with the diagnosis of jaundice in a third-level Neonatology Unit of a university hospital between January 2014 and September 2023 were retrospectively examined. Eleven patients with Kell incompatibility were included in the study. There was no ABO/RhD incompatibility in any case. RhD subgroup incompatibility and Kell incompatibility were present in four cases. Phototherapy was applied to all patients. The patient, whose total bilirubin level was high despite phototherapy, was treated with an exchange transfusion. No complications were observed due to treatment or high total bilirubin. No significant difference was observed between the parameters evaluated according to the gender variable. It should be kept in mind that severe hemolysis and related deaths may occur due to Kell incompatibility. In order to reduce and prevent severe hemolysis due to Kell and other minor blood groups in newborns, transfusing blood products suitable for minor blood groups to women of childbearing age (especially pregnant women) may be a correct approach as a country policy. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Chondrodysplasia Punctata Associated With Tetralogy of Fallot in a Newborn Infant
(Medecine Et Hygiene, 2010) Akgun, C.; Akbayram, S.; Tuncer, O.; Taskin, G.; Ceylan, A.
Chronic Mercury Poisoning: Report of Two Siblings
(2010) Yilmaz, C.; Okur, M.; Geylani, H.; Caksen, H.; Tuncer, O.; Ataş, B.
Mercury exists as organic inorganic and elementary forms in nature and is one of the most toxic metals that are poisonous for human beings. Mercury is commonly used in many different sectors of industry such as in insects formulas, agriculture products, lamps, batteries, paper, dyes, electrical/electronic devices, jewelry, and in dentistry. In this study, two siblings (one a 7-year-old boy and the other a 13 years old girl) are reported who developed chronic mercury poisoning as a result of long-term contact with batteries. Our aim is to emphasize the importance of mercury poisoning that is extremely rarely seen in childhood.
Comparison of Cerebral Oximeter and Pulse Oximeter Values in the First 72 Hours in Premature, Asphyctic and Healthy Newborns
(Univ West indies Faculty Medical Sciences, 2014) Kaya, A.; Okur, M.; Sal, E.; Peker, E.; Kostu, M.; Tuncer, O.; Kirimi, E.
Aim: The monitoring of oxygenation is essential for providing patient safety and optimal results. We aimed to determine brain oxygen saturation values in healthy, asphyctic and premature newborns and to compare cerebral oximeter and pulse oximeter values in the first 72 hours of life in neonatal intensive care units. Methods: This study was conducted at the neonatal intensive care unit (NICU) of Van Yuzuncu Yil University Research and Administration Hospital. Seventy-five neonatal infants were included in the study (28 asphyxia, 24 premature and 23 mature healthy infants for control group). All infants were studied within the first 72 hours of life. We used a Somanetics 5100C cerebral oximeter (INVOS cerebral/somatic oximeter, Troy, MI, USA). The oxygen saturation information was collected by a Nellcor N-560 pulse oximeter (Nellcor-Puriton Bennet Inc, Pleasanton, CA, USA). Results: In the asphyxia group, the cerebral oximeter average was 76.85 +/- 14.1, the pulse oximeter average was 91.86 +/- 5.9 and the heart rate average was 139.91 +/- 22.3. Among the premature group, the cerebral oximeter average was 79.08 +/- 9.04, the pulse oximeter average was 92.01 +/- 5.3 and the heart rate average was 135.35 +/- 17.03. In the control group, the cerebral oximeter average was 77.56 +/- 7.6, the pulse oximeter average was 92.82 +/- 3.8 and the heart rate average was 127.04 +/- 19.7. Conclusion: Cerebral oximeter is a promising modality in bedside monitoring in neonatal intensive care units. It is complementary to pulse oximeter. It may be used routinely in neonatal intensive care units.
Comparıson of Pulse Oxymeter and Cerebral Oxymeter Values in Healthy Newborns in the First Five Mınutes of Life
(Nobelmedicus, 2014) Taskin, G.A.; Kaya, A.; Sal, E.; Üstyol, L.; Peker, E.; Tuncer, O.; Kırımi, E.
Objective: Practical approaches in delivery rooms have been discussed about oxygen usage in recent years. In this study, it was aimed to correlate preductal arterial oxygen saturation (SpO2), heart rate per minute and serebral oxygen saturation (SbO2) values of first five minutes of life and to try the pulse oxymeter (PO) and cerebral oxymeter (SO) usage practice in delivery room. Material and Method: A hundred healthy term uncomplicated newborn babies, who were born via normally spontan vaginal route, were included in the study. SpO2, SbO2, heart rate measurements and blood gase analysis of first five minutes of postnatal life were completed. Babies, who needed oxygen during measurements, were not taken in to the study.. Results: While postnatal 1st minute SpO2 value was 83.0±4.4 (74-94)%; at 5th minute these measurements reached to 92.9±3.5 (85-98)% with gradually increment. Except values of 4th and 5th minutes; SpO2 values were found statistically significant high with each other (p<0.05). At SbO2 measurements, suitable data was taken from 100% of the babies in first minute of life. While postnatal mean SbO2 value of the first minute was 48.9±9.9 (32-74)%; these measurements were reached to 69.9±9.5 (46-89)% at 5th minute gradually increment as like as SpO2 values. Conclusion: SO is complementary to PO in delivery room and can be used routinely. It was seen also in our study; oxygen need of newborns can be determined faster and more accurately with SO use in delivery room so unnecessary oxygen usage and its potential risks can be avoided.. © 2015, Nobelmedicus. All Rights Reserved.
Congenital Myasthenic Syndrome: a Case Report
(Medecine Et Hygiene, 2011) Ceylan, A.; Tuncer, O.; Sayin, R.; Peker, E.; Caksen, H.; Sari, S.
Congenital myasthenic syndrome: a case report: Congenital myasthenic syndromes (CMS) are diseases of the neuromuscular junction. They usually belong to the disease groups that begin in the infantile or childhood period and carry genetic characteristics. The following is important in establishing the diagnosis of this disease: clinical findings, electromyography, genetic tests, determination of serum acetylcholine receptor antibodies. Acetylcholine esterase inhibitor drugs are used in treatment of CMS. A seven-month old male patient was brought to our department with the complaints of difficult breathing, falling of the eyelids and swallowing difficulty. With clinical and laboratory findings, he was diagnosed with congenital myasthenia and treatment was started. CMS should be suspected in patients with no pathological findings on the physical examination, and normal chest X-rays.
Distribution, Optimum Detection Time and Antimicrobial Susceptibility Rates of the Microorganisms Isolated From Blood Cultures Over a 4-Year Time Period in a Turkish University Hospital and a Review of the International Literature
(Sage Publications Ltd, 2008) Kurtoglu, M. G.; Bozkurt, H.; Tuncer, O.; Kesli, R.; Berktas, M.
This study retrospectively examined 8986 blood cultures from patients over a 4-year time period in an eastern Turkish university hospital to determine the detection times and distribution of isolated microorganisms using the automated BACTEC (TM) 9050 and BACTEC (TM) 9120 systems. A total of 1914 (21.3%) blood cultures contained pathogenic microorganisms and 252 (2.8%) positive cultures were considered contaminated. Of all the cultures, 18 (0.2%) were false positives and 224 (2.5%) were false negatives. In cultures containing pathogenic microorganisms, Gram-positive and Gram-negative bacterial isolation rates were 436 (22.8%) and 1440 (75.2%), respectively, and yeasts (all Candida sp.) were found in 38 (2.0%) cultures. Coagulase-negative staphylococci occurred in 936 (48.9%) cultures and Staphylococcus aureus occurred in 302 (15.8%) cultures. The mean detection time for all of the pathogens was 21 h and Brucella spp were isolated within 10 days. This study helps in understanding the epidemiology of the region and in providing positive therapeutic approaches. A review of the international literature helps to place this understanding into a global context.
Does Growth Hormone Therapy Enlarge Pituitary Adenomas
(Galenos Publishing House, 2022) Bitkin, E.Ç.; Kara, C.; Karaman, S.; Başaranoğlu, M.; Yokuş, A.; Tuncer, O.
Objective: Pituitary adenomas are detected incidentally in some cases of childhood growth hormone deficiency. Growth hormones may affect tumor growth. This study analyzed the reliability of growth hormone therapy in patients with non-functioning pituitary adenomas. Methods: The study group included 16 hypopituitary patients with incidentally detected non-functioning pituitary adenoma and treated with recombinant growth hormone. Age- and sex-matched 16 healthy children with incidental pituitary adenoma detected during investigation of chronic headache were selected as the control group. The data of the two groups were retrospectively reviewed and compared regarding the change in adenoma size over time. Results: Changes in adenoma size in the patient and control groups were -0.1 (-0.8-0.3) mm and -0.1 (-0.5-0.3) mm, respectively (p=0.664). Adenoma size growth was detected in 3 patients in the patient group and 5 patients in the control group (p=0.685). Conclusion: Our data suggest that recombinant growth hormone therapy does not produce pituitary adenomas, and thus its use is safe in growth hormone deficient children with incidentally detected non-functioning pituitary adenomas. © Copyright 2022 by Medical Journal of Bakırköy published by Galenos Yayınevi.
Efficacy and Safety of Rectal Ibuprofen for Ductus Arteriosus Closure in Very Low Birth Weight Infants
(Springer, 2016) Demir, N.; Peker, E.; Ece, I.; Balahoroglu, R.; Tuncer, O.
Esophageal Atresia Concomitant With Congenital Hypothyroidism and Phenylketonuria in a Newborn
(Walter de Gruyter GmbH, 2010) Peker, E.; Tuncer, O.; Cagan, E.; Dogan, M.; Kaya, A.; Aveu, S.; Kirimi, E.
Evaluation of the Effect of Sound Intensity on Vital Signs in Neonatal Intensive Care Unit
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Başaranoğlu, M.; Karaman, S.; Sönmez, B.; Tuncer, O.
Newborns, and especially prematures, suffer acute and chronic damage from noise during hospitalization. Therefore, it is important to monitor the noise levels of both the in-tub and out-of-tub environment. In this study we aimed to evaluate the effects of sound level measurement, noise sources and sound level on the vital signs of infants in Neonatal Intensive Care Unit. We measured the sound levels at three different time point and two different sites during the day to determine the sources of the noise using the Benetech Sound Level Meter GM1352. During each measurement, the number of people in two sections of the NICU, the number of devices working, and the vital signs of the patients were recorded. The average noise level in the first region was 58.58±10.7 dB and the average noise level in the second region was 50.17±6.407 db. There was a significant decrease in SaO2 values, especially during periods when the volume was high (p<0.01). It was also determined that the number of breaths, pulse and sleeplessness levels increased during periods when the sound level rose above a certain level. As a source of noise the number of people working devices used and the presence of the nurse desk in the section were found. İt was determined that the recommended sound level in our unit was generally exceeded and that these levels had various adverse effects on infants. It is necessary to take measures to reduce the negative effects of noise on babi es. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.