Browsing by Author "Turan, Kasim"

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Change of the Levels of Trace Elements and Heavy Metals in Threatened Abortion
(Lippincott Williams & Wilkins, 2019) Turan, Kasim; Arslan, Ayse; Uckan, Kazim; Demir, Halit; Demir, Canan
Backround: This study aimed to investigate the impact of changes in the serum levels of trace elements and heavy metals in threatened abortion, which is a common complication in early pregnancy. Earlier studies have shown that changes in the serum levels of some trace elements and increased serum concentrations of heavy metals are associated with spontaneous abortion; however, this relationship has not been fully clarified. Methods: The patient group consisted of 45 pregnant women diagnosed with threatened abortion. There were 40 healthy nonpregnant women in the control group. Blood samples were obtained from the patients and the healthy controls, and the concentrations of serum trace elements and heavy metals were measured using atomic absorption spectrophotometry. Results: Statistically significant decreases were found in the serum zinc (Zn), iron (Fe), magnesium (Mg) and manganese (Mn) levels, and significant increases were found in the serum copper (Cu), cadmium (Cd) and lead (Pb) levels in cases of threatened abortion in comparison to the controls (p < 0.001). However, there was no difference between the groups in terms of the serum cobalt (Co) levels (p > 0.001). Conclusion: Changes in the balance of some essential trace elements (especially decreases in Fe and Zn) and elevated concentrations of some toxic heavy metals in the blood may be important diagnostic and prognostic parameters for threatened abortion
Investigation of Prolidase, Adenosine Deaminase, Glutathione S-Transferase and Glutathione Reductase Activities in Patients With Abortus Imminens
(derman Medical Publ, 2017) Turan, Kasim; Uckan, Kazim; Sarikaya, Eren; Demir, Halit; Demir, Canan
Aim: Abortus Imminens is a pregnancy-related disease, the pathophysiology of which has not yet been thoroughly determined. The aim of this study was to investigate possible relations between prolidase (PR) enzyme activity and adenosine deaminase (ADA), glutathione S-transferase (GST) and glutathione reductase (GR) activities in Abortus Imminens patients. Material and Method: Fifty patients with Abortus Imminens were examined in Ipekyolu Women's and Children's Hospital between June 2015 and September 2015. The age range of the patients selected was between 18 and 50. Prolidase (PR) enzyme activity and adenosine deaminase (ADA), glutathione S-transferase(GST) and glutathione reductase (GR) activities were measured in Abortus Imminens serums. Prolidase (PR), adenosine deaminase (ADA), glutathione-S-transferase (GST) and glutathione reductase (GR) activities were determined by spectrophotometry. Results: Glutathione S-transferase and glutathione reductase activities were found to be significantly decreased in Abortus Imminens patients compared to healthy subjects. Discussion: Changes in antioxidant enzyme activities may play a very important role in the pathogenesis of Abortus Imminens. The serum ADA levels can be used as a biochemical marker in Abortus Imminens. This is the first large-scale study in the literature of the relationship between Abortus Imminens and antioxidants.
Reply To: "is Serum Level of Trace Elements and Heavy Metals Associated With Threatened Abortion
(Lippincott Williams & Wilkins, 2019) Turan, Kasim; Arslan, Ayse; Uckan, Kazim; Demir, Halit; Demir, Canan
Research of Some Trace Elements and Heavy Metal Levels at the Premature, Pre-Term and Term Births
(Parlar Scientific Publications (p S P), 2021) Turan, Kasim; Uckan, Kazim; Meydan, Ismet; Demir, Halit; Demir, Canan
The purpose of the study is to research some trace elements and heavy metal levels at the premature, preterm and term births. There are many genetic and environmental etiologic factors causing to the prematurity. This study was undertaken to understand how the unknown etiology is associated with heavy metal and trace element values in pre-term, preterm, and premature-preterm conditions. Measurement of the Zn, Cd, Fe, Mg, Mn, Pb, Co and Cu elements was determined with Atomic Absorption Spectrophotometer method. Fe, Co, Cu, Mg, Mn ve Zn levels of the premature preterm, preterm and term patients was found to be lower compared with the healthy control group (p<0.05). Pb and Cd levels were found higher at the premature preterm, preterm and term patients compared with the healthy control group (p<0.05). Some trace element and heavy metal levels at the premature preterm, preterm and term births may play an important role at the etiopathogenesy of the disease. This study is first and original at the literature.
Role of Oxidative Stress in Obese and Nonobese Pcos Patients
(Wiley, 2022) Uckan, Kazim; Demir, Halit; Turan, Kasim; Sarikaya, Eren; Demir, Canan
Objective. The aim of this study was to evaluate the relationship between the oxidant-antioxidant status, endothelial dysfunction, lipid metabolism, and metabolic syndrome risk in women with polycystic ovary syndrome (PCOS). Materials and Methods. Forty-five obese (BMI > 30 kg/m2) woman diagnosed with PCOS in the study, forty-five nonobese (BMI < 30 kg/m(2)) PCOS diagnosis working groups, and forty-nine healthy control groups were created with patients. Serum malondialdehyde (MDA) levels with antioxidant activities, such as SOD, GSH, GPx, and CAT activities, were measured by spectrophotometry. Results. There was a statistically significant difference in the mean serum MDA level in the obese PCOS group compared to the nonobese group and the control group (p < 0.001). When the antioxidant parameters, such as SOD, GPx, GSH, and CAT, were compared with the healthy control group, nonobese, and obese PCOS groups, the difference between the groups was statistically significant (p < 0.001). A positive correlation was observed between MDA and BMI, triglyceride, LDL, SBP, DBP, and HOMA-IR in the PCOS patient group. Conclusion. Oxidative stress and decreased antioxidant parameters in PCOS patients were correlated with hyperinsulinemia, hypertension, and dyslipidemia findings, and we think that this oxidative stress condition may contribute to metabolic syndrome and cardiovascular diseases in PCOS patients.