Browsing by Author "Turan, Nedim"

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Cutaneous Metastases From Transitional Cell Carcinoma of the Bladder (In a Case With Two Primaries)
(Aves, 2010) Ugurluer, Gamze; Dogan, Erkan; Turan, Nedim
Cutaneous metastases from primary genitourinary malignancies are rare and, like all metastases, have a poor prognosis. Very few cases of skin metastases from urothelial carcinoma have been reported in the past and most of them were treated with chemotherapy. Here we present a case of cutaneous metastases from a primary bladder transitional cell carcinoma who was admitted to our clinic with pain and bleeding of the lesion on the dorsum of the hand which did not respond to chemotherapy and was treated with palliative radiotherapy.
Does the Efficacy of Regorafenib Differ in Chemotherapy Refractory Metastatic Colorectal Cancer Patients Who Had Mucinous Pathology Compared To Those Who Had Non-Mucinous Pathology
(Mosby-elsevier, 2021) Ayhan, Murat; Turan, Nedim; Kostek, Osman; Tufan, Gulnihal; Ozyukseler, Deniz Tataroglu; Odabas, Hatice; Yildirim, Mahmut Emre
Purpose: To investigate the importance of mucinous histopathology on the assessment of tumor response in patients with metastatic colorectal cancer (mCRC) receiving regorafenib. Materials and method: All pa-tients diagnosed with histologically confirmed mCRC in 2 oncology centers between 2013 and 2018 were retrospectively analyzed. Among 678 patients diagnosed with mCRC, 103 patients were treated with re-gorafenib. Ninety-four of these patients who had used at least 2 cycles of regorafenib and evaluable for treatment response were included in the analysis. Histopathologically, 18 patients with mucinous adeno-carcinoma and 76 patients with nonmucinous adenocarcinoma were compared in terms of response rate and survival durations. Results : Median follow-up duration of 6 months, median age of the patients was 61 (34-77) years. While 19.1% of the patients had mucinous histology, 80.9% had nonmucinous histology. The overall response rate was significantly lower in the mucinous subgroup than the nonmucinous subgroup (5.6% vs 43.4%, respectively, P = 0.003). Similarly, both progression-free survival (3.0 vs 4.0 months, respectively, P = 0.011) and overall survival duration were shorter in the mucinous subgroup (3.0 vs 7.0 months, P = 0.016, respectively) compared with the nonmucinous subgroup. Conclusion : The histological subgroup may predict tumor response in mCRC patients receiving regorafenib. Its efficacy on nonmucinous histology had significantly more favorable than mucinous subtype. (c) 2020 Elsevier Inc. All rights reserved.
Impact of Adjuvant Treatment Modalities on Survival Outcomes in Curatively Resected Pancreatic and Periampullary Adenocarcinoma
(Chinese Journal Cancer Research Co, 2015) Turan, Nedim; Benekli, Mustafa; Unal, Olcun Umit; Unek, Ilkay Tugba; Tastekin, Didem; Dane, Faysal; Buyukberber, Suleyman
Background: We examined the impact of adjuvant modalities on resected pancreatic and periampullary adenocarcinoma (PAC). Methods: A total of 563 patients who were curatively resected for PAC were retrospectively analyzed between 2003 and 2013. Results: Of 563 patients, 472 received adjuvant chemotherapy (CT) alone, chemoradiotherapy (CRT) alone, and chemoradiotherapy plus chemotherapy (CRT-CT) were analyzed. Of the 472 patients, 231 were given CRT-CT, 26 were given CRT, and 215 were given CT. The median recurrence-free survival (RFS) and overall survival (OS) were 12 and 19 months, respectively. When CT and CRT-CT groups were compared, there was no significant difference with respect to both RFS and OS, and also there was no difference in RFS and OS among CRT-CT, CT and CRT groups. To further investigate the impact of radiation on subgroups, patients were stratified according to lymph node status and resection margins. In node-positive patients, both RFS and OS were significantly longer in CRT-CT than CT. In contrast, there was no significant difference between groups when patients with node-negative disease or patients with or without positive surgical margins were considered. Conclusions: Addition of radiation to CT has a survival benefit in patients with node-positive disease following pancreatic resection.
A Patient With Pleural Effusion Related To Dasatinib
(Aves, 2013) Demir, Cengiz; Turan, Nedim; Sehitogullari, Abidin; Esen, Ramazan
Dasatinib is a tyrosine kinase inhibitor which is used for the treatment of patients with chronic myeloid leukemia (CML) resistant or intolerant to imatinib. Dasatinib can cause fluid retention in some patients, leading to peripheral edema and pleural effusion. Recognition of these symptoms as a potential complication of dasatinib will help prevent unnecessary investigations and facilitate adequate management. We report a patient with blastic phase CML. In patients with advanced phase CML an initial dose of dasatinib is recommended as 70 mg twice daily. We observed that 100 mg once daily dose of dasatinib could control the blastic phase of CML with less toxicity.
The Use of Plasmapheresis for Rapid Hormonal Control in Severe Hyperthyroidism Caused by a Partial Molar Pregnancy
(Springer Heidelberg, 2009) Adali, Ertan; Yildizhan, Recep; Kolusari, Ali; Kurdoglu, Mertihan; Turan, Nedim
The hormone human chorionic gonadotropin (hCG), secreted by molar tissue, is structurally similar to thyroid-stimulating hormone (TSH). Hyperthyroidism in trophoblastic disease is thought to be the result of TSH receptor activation by extremely elevated levels of hCG. Significant elevations in hCG levels are less common in cases of partial moles. We describe a patient with partial molar pregnancy in which the levels of hCG and thyroid hormones were significantly high. It was not possible to decrease the elevated thyroid hormone concentrations to safer levels using medical treatment strategies only. Since the patient's vaginal bleeding increased gradually, plasmapheresis was used to rapidly control the thyroid hormones during the preoperative preparation of the patient for anesthesia and surgery. After the evacuation of the molar tissue, the levels of the thyroid hormones detected after the plasmapheresis started to decrease even further. Plasmapheresis may be used as an alternative to antithyroid medication for the rapid control of thyroid hormones in cases of severe hyperthyroidism caused by molar pregnancy.