Browsing by Author "Turel, Idris"

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Anthelmintic Activity of Urtica Dioica L. in Mice Naturally Infected With Aspiculuris Tetraptera
(Medwell online, 2008) Turel, Idris; Oto, Gokhan; Ayaz, Erol; Yilmaz, Orhan; Mercan, Ufuk
The aim of present study was to investigate the anthelmintic activity of Urtica dioica L. (nettle) in Swiss albino mice naturally infected with Aspiculuris tetraptera. Methanolic extracts obtained from leaves and seeds of U dioica were evaluated for their in vivo anthelmintic activity. The 250 mu L (175 mg mL(-1)) extracts were administered orally on daily basis. Results showed that methanolic extract of U. dioica seeds possessed only a slight anthelmintic activity. In contrast, methanolic extract of leaves exhibited potent anthelmintic activity.
Drug Interaction Between Ivermectin and Etomidate: Investigation on the Effect of Ivermectin on Etomidate Anaesthesia
(Soc Stiinte Farmaceutice Romania, 2020) Yucel, Ufuk Mercan; Oner, Ahmet Cihat; Turel, Idris; Yilmaz, Orhan
The present study aims to determine the effect of ivermectin on the duration of anaesthesia performed with etomidate and to find out if there are any interactions between these two drugs at the central nervous system level. For this purpose, 25 Sprague-Dawley female rats were divided into 5 groups with 5 rats in each group. Group I received only subcutaneous saline at a dosage of 0.1 ml/100 g bw. Group II received the intraperitoneal injection of propylene glycol at a dosage of 1 mL/100 g bw. Group III received the subcutaneously 0.2 mg/kg bw ivermectin. Two hours after these treatments, neuropharmacological tests (rotarod and open field) were performed. Also, Group IV received 20 mg/kg bw etomidate intraperitoneally. Group V received subcutaneously 0.2 mg/kg bw ivermectin and 2 hours after the ivermectin administration, 20 mg/kg bw etomidate was given intraperitoneally. In these two groups, anaesthesia was monitored and the sleep duration was calculated based on rectal reflexes. Once the animals were fully awake, neuropharmacological tests were performed. Ivermectin that was administered two hours before the etomidate anaesthesia prolonged etomidate sleeping duration strongly. Also, ivermectin increased motion and decreased motor coordination, in association with etomidate it potentiates CNS depression (with prolonged sleep duration and decreased motor coordination).
Effect of Urtica Dioica L. on Selected Trace Elements Levels and Serum Protein Patterns in the Rabbits Treated With 7,12-Dimethylbenz(a)anthracene
(Asian Journal of Chemistry, 2008) Ekin, Suat; Oto, Gokhan; Berber, Ismet; Turel, Idris; Kusman, Tuba
In the present study, the effect of Nettle (Urtica dioca L.) on trace elements and serum protein patterns in female rabbits administrated to 7,12-Dimethylbenz(a)anthracene (DMBA) was investigated. Rabbits were divided into equal four groups. Group I was control group (n = 8), group 11 (n = 8), treated with DMBA (1 mg/kg.d), group III treated with DMBA (I mg/kg.d) and methanol extract of U. dioica 35 mg/kg/d and group IV (n = 8) treated with DMBA (1 mg/kg.d) and aqueous extract of U. dioica 35 mg/kg/d. The results show that on 60th day DMBA-treated group were compared with the control group levels, a significant decrease (p < 0.05) was observed in the Zn. DMBA and methanol extract of U. dioica treated group were compared with the control group levels, a significant increase (p < 0.05) was observed in the Cu. Serum Fe and Mn levels among groups were determined not to be statistically significant (p > 0.05). It was found that U. dioica not affected on trace elements level and serum protein patterns in rabbits subjected to DMBA.
Effects of Plantago Major Extract on Serum Protein Fractions in Broiler Diet
(Agricultural Research Communication Centre, 2017) Bingol, Nuriye Tugba; Dede, Semiha; Karsli, Mehmet Akif; Yilmaz, Orhan; Turel, Idris; Yuksek, Veysel
The aim of this study was to determine the effects of Plantago major's (P.major) water extract added into broiler diets at different levels on serum protein fractions. A total of 112 Ross 308 broiler chicks were used in the study. Experiment consisted of control and 3 treatment groups with a 28 chicks within each group. Each experimental group was divided into four subgroups consisting of4 chicks. A basal (control) diet was prepared and three experimental diets were established by addition of P.major into basal diet; P.major 1 (5 g/kg feed), P.major 2 (10 g/kg feed), P.major 3 (15 g/kg feed). Broiler chicks were fed with these diets for 42 days ad libitum. Total protein levels of P.major 3 group were lower than other groups and controls. It was determined that the albumin percentages and levels became decreased in a significant ratio in the P.major 1 and P.major 2, (P<0,05), Alpha 1 globulin percentage and concentration were found significantly high in P.major 2 group than the other groups (P<0.05), Alpha 2 level and percentage in P.major 1 group was seen significantly higher than the control group, the A/G ratio in P.major 1 and P.major 2 was seen significantly lower than the control group. There was no significant difference between groups for beta and gamma globulins as percentage.
Hepatoprotective and Anti-Inflammatory Activities of Plantago Major L
(Wolters Kluwer Medknow Publications, 2009) Turel, Idris; Ozbek, Hanefi; Erten, Remzi; Oner, Ahmet Cihat; Cengiz, Nureddin; Yilmaz, Orhan
Objective: The aim of this study was to investigate anti-inflammatory and hepatoprotective activities of Plantago major L. (PM). Materials and Methods: Anti-inflammatory activity: Control and reference groups were administered isotonic saline solution (ISS) and indomethacin, respectively. Plantago major groups were injected PM in doses of 5 mg/kg (PM-I), 10 mg/kg (PM-II), 20 mg/kg (PM-III) and 25 mg/kg (PM-IV). Before and three hours after the injections, the volume of right hind-paw of rats was measured using a plethysmometer. Hepatoprotective Activity: The hepatotoxicity was induced by carbon tetrachloride (CCl4) administration. Control, CCl4 and reference groups received isotonic saline solution, CCl4 and silibinin, respectively. Plantago major groups received CCl4 (0.8 ml/kg) and PM in doses of 10, 20 and 25 mg/kg, respectively for seven days. Blood samples and liver were collected on the 8th day after the animals were killed. Results: Plantago major had an anti-inflammatory effect matching to that of control group at doses of 20 and 25 mg/kg. It was found that reduction in the inflammation was 90.01% with indomethacin, 3.10% with PM-I, 41.56% with PM-II, 45.87% with PM-III and 49.76% with PM-IV. Median effective dose (ED50) value of PM was found to be 7.507 mg/kg. Plantago major (25 mg/kg) significantly reduced the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels when compared to the CCl4 group. The histopathological findings showed a significant difference between the PM (25 mg/kg) and CCl4 groups. Conclusion: The results showed that PM had a considerable anti-inflammatory and hepatoprotective activities.