Browsing by Author "Turk, Mustafa"

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Biocompatible and Biodegradable Poly(Tannic Acid) Hydrogel With Antimicrobial and Antioxidant Properties
(Elsevier, 2016) Sahiner, Nurettin; Sagbas, Selin; Sahiner, Mehtap; Silan, Coskun; Aktas, Nahit; Turk, Mustafa
A novel resourceful bulk poly(Tannic Acid) (p(TA)) hydrogel was prepared by crosslinking TA molecules with an epoxy crosslinker, trimethylolpropane triglycidyl ether (TMPGDE), in an autoclave at 90 degrees C for 2 h. The obtained p(TA) hydrogels were in disk form and have highly porous morphology. The swelling characteristics of p(TA) hydrogels were investigated in wound healing pH conditions of pH 5.4, 7.4, and 9 at 37.5 degrees C, and the hydrogels showed good swelling and moisture content behavior. Especially, p(TA) hydrogels were found to be sensitive to pH 9 with 1669% maximum swelling. P(TA) hydrogels were completely degraded at pH 9 hydrolytically in 9 days. Total phenol contents and the effects of scavenging ABTS radicals of degraded p(TA) hydrogels at pH 5.4, 7.4, and 9 were evaluated and calculated in terms of gallic acid equivalent and trolox equivalent antioxidant capacity, respectively, and found to be very effective. Moreover, degraded p(TA) hydrogels display strong antimicrobial behavior against gram positive Staphylococcus aureus, Bacillus subtilis, gram negative Pseudomonas aeruginosa bacteria strains and Candida albicans fungus strain. The WST-1 results indicated that bulk p(TA) hydrogels have no cyctotoxicity to the L929 fibroblast cell line in vitro. (C) 2015 Elsevier B.V. All rights reserved.
Characterization of P(Pmo), P(Lo) and P(Ro) Organoparticles, Their Bioactivity Properties and Their Effect on Pancreatic Cancer Capan-1 Cell
(Elsevier Science Sa, 2023) Alpaslan, Duygu; Turan, Abdullah; Dudu, Tuba Ersen; Bozer, Busra Moran; Aktas, Nahit; Turk, Mustafa
For the first time in the literature, p (PmO), p (LO) and p (RO) organo-particles were synthesized from Peppermint oil, Lemon oil and Rose oil. Of the organo-particles L-929 cell line viability/cytotoxicity and anticancer effect against Capan-1 pancreatic cancer cell line were investigated. p (PmO), p (LO) and p (RO) organoparticles were featured by thermogravimetry (TGA), Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron microscope (SEM), Particle size (DLS), and particle charge (zeta potential, Zeta) analyses. Antioxidant, biocompatible, and antimicrobial activities and in vitro cytotoxicity specialties were investigated. In studies on Capan-1 and L-929 cell lines, it was observed that p (PmO), p (LO) and p (RO) organo-particles were effective on L-929 fibroblast cell line on Capan-1 pancreatic cancer cell line. In addition, it was observed that p (PmO), p (LO) and p (RO) organo-particles were not toxic in L-929 cell lines at high doses. When the Capan-1 cell line MTT analysis results of p (PmO), p (LO) and p (RO) organo-particles were examined, a difference was observed between cell viability rates and apoptosis and necrosis values. The highest % apoptosis rate was observed in the p (RO) organo particle.
Fractional Order Pid and Application of Its Circuit Model
(Chinese inst Engineers, 2016) Atan, Ozkan; Chen, Diyi; Turk, Mustafa
In this paper, the circuit design of a fractional order proportional-integrated derivation (FO-PID) controller for synchronization between different FO chaotic systems has been described. Chaotic synchronization and control are used in different applications in nonlinear physical systems such as performance tests for controllers and chaotic communication systems. FO chaotic systems have been created, and the synchronization control of these two systems has been carried out using an FO-PID controller. The total square error should be minimized in order to determine the parameters and orders of the designed FO controller circuit. The results obtained using the FO controller are better than those obtained using classical control systems. Using an FO-PID controller, the time to reach synchronization decreased significantly.
Poly(CnO) and Poly(CcO) Organo-Particles Produced from Coconut Oil (CnO) and Cocoa Oil (CcO): Synthesis, Characterization, Bio and Anticancer Activity
(Horizon Research Publishing, 2025) Alpaslan, Duygu; Dudu, Tuba Ersen; Bozer, Busra Moran; Aktas, Nahit; Turk, Mustafa
With the increasing number of cancer cases in recent years, the solution methods suggested for these cases are also of great importance. Within the scope of the presented study, we aimed to develop an alternative material in cancer immunotherapy by synthesizing poly(coconut oil) (p(CnO)) and poly(cacao oil) (p(CcO)) organo-particles from coconut and cocoa oils. The structural features of these particles synthesized using the redox polymerization technique were elucidated by various characterization methods. The chemical structure and functional groups of p(CnO) and p(CcO) organo-particles were determined by Fourier Transform Infrared Spectroscopy (FT-IR). Organo particle size and zeta potential values were determined by the dynamic light scattering (DLS) method using Zetasizer device. The morphological features of the particles were determined by Scanning Electron Microscopy (SEM). Bioactivity properties were determined by antioxidant, antimicrobial and biocompatibility analyses. In this study, the effects of p(CnO) and p(CcO) organo-particles on cytotoxicity and apoptotic processes against L-929 fibroblast and Capan-1 pancreatic cancer cell lines were also investigated. p(CnO) and p(CcO) organo-particles Capan-1 cell lines were determined to have significant cytotoxic activity at all doses studied. An increase in cell number was observed in L-929 fibroblast cells treated with p(CnO) and p(CcO) organo-particles. As a result, findings have been obtained that the p(CcO) organo particle triggers the apoptotic mechanism. On Capan-1 pancreatic cancer cells, p(CcO) was found to have a fatal impact akin to that of doxorubicin. It is anticipated that combining p(CcO) with doxorubicin could potentially lead to better outcomes than using doxorubicin alone.
Synthesis, Characterization and Modification of Gum Arabic Microgels for Hemocompatibility and Antimicrobial Studies
(Elsevier Sci Ltd, 2017) Farooq, Muhammad; Sagbas, Selin; Sahiner, Mehtap; Siddiq, Mohammad; Turk, Mustafa; Aktas, Nahit; Sahiner, Nurettin
Gum Arabic (GA) microgels were successfully prepared via reverse micellization method with high yield (78.5 +/- 5.0%) in 5-100 mu m size range using divinyl sulfone (DVS) as a crosslinker. The GA microgels were degraded hydrolytically 22.8 +/- 3.5% at pH 1 in 20 days, whereas no degradation was observed at pH 7.4 and pH 9 at 37 degrees C. By using diethylenetriamine (DETA), and taurine (TA) as chemical modifying agents, GA microgels were chemically modified as GA-DETA and GA-TA, and the zeta potential values of 5.2 +/- 4.1 and -24.8 +/- 1.3 mV were measured, respectively in comparison to -27.3 +/- 4.2 mV for GA. Moreover, blood compatibility of GA, GA-TA, and GA-DETA microgels was tested via in vitro protein adsorption, % hemolysis ratio, and blood clotting index. All the microgels were hemocompatible with% hemolysis ratio between 0.23 to 2.05, and the GA microgels were found to be highly compatible with a blood clotting index of 81 +/- 40. The biocompatibility of GA, GA-DETA and GA-Taurine microgels against L929 fibroblast cells also revealed 84.4, 89.1, and 67.0% cell viability, respectively, at 25.0 mu g/mL concentration, suggesting great potential in vivo biomedical applications up to this concentration. In addition, 5 and 10 mgImL minimum inhibition concentrations of protonated GA-DETA microgels (GA-DETA-HCl) were determined against E. coli and S. aureus, respectively. (C) 2016 Elsevier Ltd. All rights reserved.