Browsing by Author "Turkdogan, M.K."

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Helicobacter Pylori Infection in Gastric Carcinoma in the Van Region of Turkey
(1999) Turkdogan, M.K.; Alici, S.; Ilhan, M.; Dilek, H.; Akman, E.; Ayakta, H.; Karakok, M.
The prevalence of Helicobacter pylori (H. pylori) infection was assessed in endoscopic biopsies of 39 patients with gastric cancer (23 male, 16 female). Biopsies were taken both from the cancerous and peripheal sites of the cancer (Ca) tissues and evaluated with Giemsa staining method. In a control group of 59 patients (34 male, 26 female), endoscopic biopsies were evaluated by the same method. H. pylori was positive in 56.4 % (22/39) of gastric Ca patients at the peripheral site biopsies while it was only 25.6 % positive (10/39) in the cancer tissues. H. pylori positivity was 36.6 % (22/60) in the control group. Thus, the prevalance of H. pylori infection was evaluated as significantly high (p<0.05) in the peripheal site biopsies of gastric Ca patients. The cumulation of H. pylori was 47.6 % in the cardia, 55.5 % in the corpus and 66.6 % in the antrum. In conclusion, gastric Ca is significantly related to H. pylori infection in the Van region. Public health education, the recognition of transmission routes and successful eradication therapy are the cornerstones of future prevention of gastric carcinogenesis.
Hepatitis Delta Virus Infection in Van Region of Eastern Turkey
(1999) Turkdogan, M.K.; Akdeniz, H.; Berktas, M.; Hekim, H.
The High Prevalence of Esophageal and Gastric Cancers in Eastern Turkey
(1998) Turkdogan, M.K.; Akman, N.; Tuncer, I.; Dilek, F.H.; Akman, E.; Memik, F.; Aksoy, H.
Background/Aims: Gastrointestinal cancers (G.I Ca) are important causes of mortality in Eastern Turkey. We purposed to reveal the epidemiological characteristics and the regional risk factors of the upper G.I (esophageal and gastric) cancers. Materials and Methods: 203 G.I Ca patients were diagnosed in our Gastroenterology Department with endoscopic, radiological and histopathological methods in two and half years. Their age, sex, nutritional habits and the histopathologic types of cancers were determined. Results: Esophageal and gastric cancers were ninety percent (183/203) of all the G.I Ca. Gastric and esophageal cancers were ninety percent (90%) of all these GI cancers. Both of cancer groups have been generally diagnosed after fifty years of age, and gastric Ca was twice frequent in males, whereas esophageal Ca was one and half times frequent in females. Drinking hot tea and family history of cancer were significant in the esophageal Ca group, although cigarette smoking was not significantly different in both cancer groups than the control group. Daily dietary habits were generally consumption of hot, salted, fatty, smoked and fried foods (meat, cereals etc.) without sufficient intake of fresh fruits and vegetables. Histopathologically, ninety percent (90%) of esophageal Ca were epidermoid carcinoma and ten percent (10%) were adencarcinoma whereas all gastric Ca were adenocarcinoma. Conclusions: There are many carcinogen risk factors including mainly dietary and ecological factors such as stagnant ditch water, animal manure and peat in rural areas and volcanic soil properties in the Van region.
Nitric Oxide Oxidation Products in the Serum of Patients With Gastric and Esophageal Cancer and Helicobacter Pylori
(1999) Turkdogan, M.K.; Testereci, H.; Kahraman, T.; Dilek, F.H.; Akman, E.
Nitric oxide (NO) oxidation products (nitrate and nitrite) were analysed in the serum of 12 gastric cancer (Ca), (12 gastric Ca, 12 esophageal Ca) and 12 healthy controls with modified Stahr's method. Helicobacter pylori (H. pylori) infection was diagnosed histopathologically in the gastric cancer and control groups. In the gastric Ca group mean, serum nitrate and nitrite levels (11.65 ppm and 3.40 ppm) were significantly higher than the esophageal Ca and control groups (p<0.05 and p<0.001). In the esophageal Ca group the mean serum nitrate level (7.16 ppm) was higher than the control group (4.73 ppm, p<0.05) while the nitrite level (1.53 ppm) was not significantly different from the control group (1.70 ppm). H. pylori infection was significantly higher in the gastric Ca group (56.40%) than the control group (36.66%, p<0.05). In conclusion, we observed the highest serum NO product levels in the gastric Ca group although the dietary intake of nitrated foods was similar in both of the Ca groups. This observation indicates the important role of H. pylori infection in the etiopathogenesis of gastric cancer related to the synthesis of NO and consequent the carcinogen nitroso compounds.
Serum and Tissue Levels of Vitamin a and E in Gastric and Esophageal Cancer
(1996) Turkdogan, M.K.; Testereci, H.; Kahraman, T.; Tuncer, I.; Algun, E.; Yoruk, I.H.
Vitamin A and Vitamin E have antioxidant properties and their role in the prevention of gastrointestinal cancers by way of scavenging lipid peroxidation products is very important. Vitamin A ester (retinol acetate) and vitamin E isomers (alpha, gamma and total tocopherols) have been investigated in the serum samples and tissue biopsies of 7 esophageal, 12 gastric cancer patients and a control group consisting of 12 healthy subjects. The serum mean retinol acetate level was significantly higher in the gastric cancer group but not in patients with esophageal cancer when compared to the control group. Serum mean tocopherol levels were low in both cancer groups when compared to the control group but this did not reach biological significance. Tissue mean retinol acetate and tocopherol levels were found significantly low in both of the cancer groups (p<0.03 and p<0.08). These findings suggest that the low tissue levels of the antioxidant vitamin A and E may be related to the etiopathogenesis of the gastrointestinal cancers.
Value of Fibrinogen as a Marker in Gastrointestinal Cancers
(1997) Turkdogan, M.K.; Akman, N.; Ercan, M.; Tuncer, I.; Algun, E.
Increase of some coagulation factors and tendency to venous thrombosis have been reported in gastrointestinal cancers. In this study, plasma fibrinogen levels have been investigated in 24 patients with gastrointestinal cancer (esophageal, gastric and pancreatic cancer). Significant increase has been found in the esophageal cancer group (p < 0.01). Plasma fibrinogen levels were also elevated in two pancreatic cancer patients (9.52 and 6.45 gr/lt) but they were normal in gastric cancer patients. These results suggest that fibrinogen may be a useful tumor marker in some gastrointestinal cancers and further investigations are required in a large number of patients.