Browsing by Author "Turkyilmaz, Gurcan"

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Comparison of Maternal B12 and Folate Status in Prenatally Diagnosed Neural Tube Defects: a Case-Control Study
(Istanbul Univ, Fac Medicine, Publ off, 2020) Turkyilmaz, Gurcan; Kucukbas, Gokce Naz; Erturk, Emircan; Turkyilmaz, Esebnem; Karaaslan, Onur; Sahin, Hanim Guler
Objective: To evaluate folate and B12 levels in fetuses who had been diagnosed with neural tube defects (NTDs) and healthy fetuses in Van Yuzuncu Yil University and Van State Education and Research hospitals between March-August 2019. Material and Method: Thirty-eight pregnant women who had been diagnosed with fetuses with NTDs prenatally, and 40 healthy controls were recruited. The chi-square test and Mann-Whitney U test were employed to compare variables. Results: None of the women had taken folic acid preconceptionally in the NTD group. However, 4 (10%) women had taken folic acid supplementation in the preconception period in the control group, and this was significantly different among the groups (p=0.04). The women who had taken folic acid in the first trimester of pregnancy were 9 (23.6%) and 32 (80%) in cases and controls, respectively, and it was significantly different (p=0.01). The mean B12 level was 248.7 +/- 65.4ng/ml in cases and 239.3 +/- 27.5 ng/ml in controls, and there was no significance between the groups (p=0.78). The mean folate level was 9.6 +/- 4.8 ng/ml in cases and 9.8 +/- 3.9 ng/ml in controls, and it was similar between the groups (p=0.62). Conclusion: We did not show difference in folate and B12 levels. However, folic acid intake in preconception or in the first trimester of pregnancy was significantly higher in women who have healthy babies compared to the NTD group.
Gebeliğin İntrahepatik Kolestazı; Üçüncü Basamak Referans Merkez Sonuçları
(2021) Turkyilmaz, Gurcan; Karaaslan, Onur
Giriş ve amaç: Çalışmamızda gebeliğin intrahepatik kolestazı tanısı ile kliniğimizde takip edilen 48 olgunun gebelik sonuçlarını sunmayı amaçladık. Gereç ve yöntem: Kliniğimizde takip edilen 48 hastanın tıbbi kayıtları retrospektif olarak incelendi. Gebelik kolestazı için tanı kriteleri: 1-dermatolojik patoloji olmaksızın, özellikle geceleri şiddetlenen yaygın kaşıntı 2-laboratuvar bulgularının gebelik kolestazını desteklemesi (ALT, AST>35 U/L, GGT>26 U/L, total bilurubin>1.2 mg/dl ve serum safra asitleri>10μmol/L). Tüm hastalar gebeliğin 37. haftasında doğurtuldu. Bulgular: Ortalama tanı haftası 30.4±5.4 hafta ve tanıdan doğuma kadar geçen süre ortalama 29.4±19.5 gündü. Hastaların ortalama ALT değeri 89.4±63.5 U/L, AST değeri 103.5±57.6 U/L ve serum safra asitleri değeri 37.8±21.1 μmol/L idi. Ortalama doğum haftası 37.1±2.1, ve doğum ağırlığı 3015±465 gramdı. 6 (%12.5) olguda preterm doğum gerçekleşti ve bunların hepsi spontan preterm doğumdu. Olguların %45.8’i vajinal yolla doğum yaparken %54.1 hastada sezaryen ihtiyacı görüldü. 15 hastada fetal distress nedeniyle sezaryen yapıldı. 11 vakada doğum sırasında mekonyumla boyalı amniyotik sıvı görüldü. Hiç bir olguda antepartum ölüm olmadı. Yenidoğanların birinci ve beşinci dakika ortalama Apgar skorları sırası ile 7.5±2.1 ve 8.1±1.6 idi. 7 (%14.5) bebeğin YDYBÜ ihtiyacı oldu. Sonuç: Gebeliğin intrahepatik kolestazı fetus ve yenidoğan için önemli riskler taşımaktadır. Yaygın kaşıntı şikayeti ile başvuran gebelerde gebelik kolestazı mutlaka tanıda akla gelmeli, bu hastalarda yakın fetal takip ve erken term doğum planlanmalıdır.
Is Conventional Cardiac Examination Adequate for Obese Pregnant Women? a Prospective Case-Control Study
(Elsevier Taiwan, 2022) Sarikaya, Remzi; Turkyilmaz, Gurcan
Objective: Obesity in pregnancy shows short- and long-term adverse effects for both mother and baby. We aimed to investigate the effects of obesity on cardiac functions in the third trimester of pregnancy. Materials and methods: A prospective caseecontrol study where the pregnant women at the third trimester of pregnancy were divided into two groups: obese (BMI >= 30) and the controls (BMI<30). All participants underwent conventional 2D and speckle-tracking echocardiography, while structural and functional cardiac parameters were measured. The unpaired t-test or the Mann-Whitney-U test were used to compare values between the two groups. p <= 0.05 was outlined to be statistically significant. Results: Forty-one obese pregnant women and 41 healthy and normal-weight pregnant controls were recruited. The mean BMI was 24.6 +/- 2.4 kg/m(2) in the controls and 38.5 +/- 5.4 kg/m(2) in the obese group. SV was significantly higher in obese patients (p = 0.02). SVI was markedly lower in the obese group (p < 0.01). CO and Cardiac Index were significantly higher in obese patients compared to the controls (p < 0.01). TVRI was significantly higher in the obese group than the controls. EF was similar between the two groups (p = 0.33). LVM and LVMI were significantly higher in obese patients than the controls (p = 0.024 and p = 0.01). Diastolic dysfunction was present in 3 (7.3%) controls; 21 (51.2%) of the obese women demonstrated diastolic dysfunction, and it was significantly higher than the controls (p < 0.01). LV-GLS and LV-GCS were substantially lower in the obese group (p < 0.01). RV-FAC and RV-GS were markedly lower in the obese group (p < 0.01). TAPSE was similar in obese and control groups (p = 00.17). Conclusion: Obesity in pregnancy is associated with increased subclinical systolic and diastolic dysfunction, which cannot be detected by standard 2D methods. (C) 2022 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.
Psychological Reactions in Women With Pregnancy Termination\rdue To Fetal Anomaly
(2021) Turkyilmaz, Gurcan; Atan, Yavuz Selim; Turkyilmaz, Sebnem Erol; Ertürk, Emircan
OBJECTIVE: We aimed to determine and compare grief, depression, and post-traumatic stress scores\rin women who underwent termination of pregnancy due to fetal anomaly in the first vs. second-trimester\rof pregnancy.\rSTUDY DESIGN: Forty-three women who underwent termination of pregnancy for fetal anomaly were\rsubdivided into two categories in this prospective-cohort study: First-trimester group, which was defined\ras termination of pregnancy performed <14 weeks of gestation, and Second-trimester termination of\rpregnancy who underwent termination of pregnancy between 20 and 28 weeks of pregnancy. Eight\rweeks after the termination of pregnancy, the Beck Depression Inventory, Perinatal Grief Scale-short\rversion, and Impact of Event Scale-Revised were performed with face-to-face interviews.\rRESULTS: Twenty-four women in the first-trimester group and 19 women in the second-trimester group\rwere enrolled. The mean Beck Depression Inventory score was 7.3±4.2 in the first-trimester group and\r11.1±4.6 in the second-trimester group (p=0.033). The mean Perinatal Grief Scale-short scores were\r86.3±17.2 and 101.4±29.2 in the first and second-trimester groups, respectively (p=0.014). Impact of\rEvent Scale-Revised scores of the first trimester and second-trimester groups were 22.5±8.6 and\r35.3±17.1, respectively (p=0.022). Depression was detected in 29.1% of women in the first-trimester\rgroup and 57.8% in the second-trimester group (p=0.023). Perinatal grief was significantly higher in the\rsecond-trimester group (45.8% vs. 84.2% p<0.01). Post-traumatic stress was significantly higher in the\rsecond-trimester group (41.6% vs. 73.6%, p=0.031).\rCONCLUSION: Our study indicates that termination of pregnancy for fetal anomaly causes severe psychiatric problems in most women. Depression, grief, and post-traumatic stress are more prominent in\rwomen who underwent termination of pregnancy in the second trimester of pregnancy than in the first\rtrimester.