Browsing by Author "Tutuncu, M."

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Anti-Inflammatory Activities of Diethyl-Ether Extracts of Helichrysum Plicatum Dc. and Tanacetum Balsamita L. in Rats
(Academic Journals inc, 2009) Karaca, M.; Ozbek, H.; Akkan, H. A.; Tutuncu, M.; Ozgokce, F.; Him, A.; Bakir, B.
The aim of this study was to investigate anti-inflammatory activity of the diethyl ether extract of Tanacetum balsamita L. subsp. (TB) and Helichrysum plicatum DC. subsp. (HP) in carrageenan-induced inflammation in rats. Lambda carrageenan (0.05 mL) was injected into the subplantar region of the right hind paw to induce inflammation. Control group and the reference group were administered isotonic saline solution and indomethacin, respectively. TB extract was injected in doses of 25, 50 and 100 mg kg(-1) in the groups TB-25, TB-50 and TB-100, respectively. HP-25 HP-50 and HP-100 groups were injected HP extract in doses of 25, 50 and 100 mg kg(-1). Before the injections and 3 h after the injections the volume of right hind-paw of rats was measured using a plethysmometer. TB and HP had anti-inflammatory effects matching to that of the reference agent at all doses. It was found that reduction in the inflammation was 95.21% with indomethacin, 51.93% with TB-25, 52.55% with TB-50, 61.51% with TB-100, 70.73% with HP-25, 73.15% with HP-50 and 82.90% with HP-100. Median effective dose (ED50) value of TB and HP were found to be 81.484 and 73.030 mg kg(-1), respectively. The results showed that Tanacetum balsamita L. subsp. and Helichrysum plicatum DC. subsp. had a significant anti-inflammatory activity.
The Effects of Diethylether Extract of Helichrysum Plicatum Dc. Subsp Plicatum and Tanacetum Balsamita L. Subsp Balsamitoides (Sch Bip.) Grierson (Asteraceae) on the Acute Liver Toxicity in Rats
(Academic Journals inc, 2010) Tutuncu, M.; Ozbek, H.; Karaca, M.; Akkan, H. A.; Bayram, I.; Cengiz, N.; Him, A.
The aim of this study was to investigate the effects of the diethylether extract of Helichrysum plicatum DC. subsp. plicatum (HP) and Tanacetum balsamita L. subsp. balsamitoides (Sch. Bip.) Grierson (Asteraceae) (TB) in carbontetrachloride (CCl(4))-induced acute liver toxicity in rats. Acute liver toxicity was induced by injecting CCl(4) (0.8 mL kg(-1)) intraperitoneally for 7 days. The control group received isotonic saline only. The reference group received 50 mg kg(-1) silibinin. TB and HP extract was injected in doses of 25, 50 and 100 mg kg(-1). Body weights were measured daily during the experiment. On the 8th day of the experiments blood and liver samples were collected. Serum Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were measured in serum samples. Tissue samples were evaluated histopathologically. Some of the rats in TB and HP groups died during the experiments. Serum ALT levels were higher in the TB and HP groups than those in the CCl(4) group. Histopathological findings were similar in the CCl(4), TB and HP groups. The body weight loss was more in the TB and HP groups compared to that of the CCl(4) group. It is concluded that the diethylether extract of Helichrysum plicatum DC. subsp. plicatum and Tanacetum balsamita L. subsp. balsamitoides (Sch. Bip.) Grierson (Asteraceae) did not have a protective effect in carbontetrachloride (CCl(4))-induced acute liver toxicity in rats and even exacerbated the toxicity.
Haemobartonella Felis in Van Cats
(indian veterinary Journal, 2006) Yuksek, N.; Altug, N.; Agaoglu, Z.; Yuksel, H.; Kaya, A.; Tutuncu, M.
Investigation of the Lipid Peroxidation, Antioxidant Enzymes, Antioxidant Vitamins, Oxidation Products of Nitric Oxide and Some Biochemical Parameters in Chicken With Infectious Bursal Disease (Ibd)
(Eugen Ulmer Gmbh Co, 2016) Ertekin, A.; Yildirim, B. A.; Yildirim, S.; Yildirim, F.; Tutuncu, M.
In the current study, lipid peroxidation, antioxidant enzymes, antioxidant vitamins, oxidation products of nitric oxide and some biochemical parameter levels in chicken with infectious bursal disease were investigated. Thirty chicken were used in the study, 7 in a control group of healthy individuals and the other 23 chickens were infected naturally. The level of advanced oxidation protein products (AOPP) was not affected by the treatment. Vitamin C (P<0.01), nitrite (P<0.01), catalase (P<0.001) and superoxide dismutase (P<0.001) levels were significantly decreased. The levels of malondialdehyde and nitrate increased significantly (P<0.001), while the amounts of ALT (P<0.05) and Albumin (P<0.001) decreased. We also found that changes in glucose, AST, triglyceride and total protein levels were not affected. On the other hand, increases in the levels of LDL (P<0.01), cholesterol and HDL (P<0.05) were significant.
The Seroprevalance of Toxoplasma Gondii in Sheep, Goats and Cattle Detected by Indirect Haemaglutination (Iha) Test in the Region of Van, Turkey
(2003) Tutuncu, M.; Ayaz, E.; Yaman, M.; Akkan, H.A.
This study was carried out on sheep, goats and cattle in order to determine the seroprevalence of toxoplasmosis in the province of Van. Indirect Haemaglutination (IHA) test was used to detect Toxoplasma gondii antibodies in 305 ruminants (150 sheep, 104 cattle and 51 goats) obtained from the city center of Van and its region. The sera were tested for Toxoplasma gondii antibodies between 32 and 1024 titres. Samples with titres 64 and greater than this were considered as positive. The prevalaence of the positive sera were found to be 52 (34.6%) for sheep, 8 (7.6%) for cattle and 17 (33.3%) for goats. The results indicate that Toxoplasma gondii infection in ruminants in the province of Van is widespread.