YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.

Browsing by Author "Ugurlu, Pelin"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Article
    Content Analysis, Nanoparticle Forming Potential and Acaricidal Effects on Tick (Hyalomma Marginatum) of Essential Oils From Two Common Thymbra Species
    (Taylor & Francis Ltd, 2024) Kaya, Eda Cavus; Akdeniz, Mehmet; Ugurlu, Pelin; Yener, Ismail; Firat, Mehmet; Ertas, Abdulselam
    In this study, the fatty acid, essential oil and aroma composition of Thymbra sintenisii Bornm. & Aznav. subsp. sintenisii Bornm. & Aznav (TSS) and Thymbra sintenisii Bornm. & Azn. subsp. isaurica P.H.Davis (TSI) were determined by GC-MS. The cytotoxic activity was determined with MTT assay and antioxidant activities were determined with DPPH, ABTS, CUPRAC methods. Urease, acetyl, butyryl, angiotensin, alpha-amylase, tyrosinase, elastase, and collagenase enzyme inhibition activities of these species were also determined. The acaricidal effects of essential oils from aerial parts of TSS and TSI on ticks and the nanoparticle formation potential of their essential oils with AgNO3 were determined and compared. The main components of TSS essential oil and aroma were determined as carvacrol and o-cemen (66.78 and 35.44%, respectively), the major components of TSI essential oil and aroma were carvacrol and gamma-terpinene (63.78 and 31.44%, respectively). The species exhibited remarkably high antioxidant activity, particularly in the ABTS and CUPRAC methods. It was also determined that the butyrylcholinesterase and acetylcholinesterase enzyme inhibition activities (Inhibition%: 76.12 +/- 0.83 and 74.13 +/- 0.33, respectively) of the species were quite high. Moderate antimicrobial activity against the bacteria was observed for both essential oils, with MIC values ranging from 312 to 1250 mu g/mL. Moreover, essential oils of these species showed good acaricidal activity on Hyalomma marginatum (LC50: 11.82 mu g/mL for TSS; LC50: 57.64 mu g/mL for TSI). The high antioxidant, anticholinesterase, and acaracidal activities observed in both species are attributed to the presence of carvacrol in their essential oils. The species have potential to be used in food supplements-preservatives, pharmaceutical industry.
  • Thumbnail Image
    Article
    Nanoparticle Formation Capacity and Acaricidal Effect (Hyalomma Marginatum) of Essential Oil of Thymbra Spicata L. Subsp. Spicata L
    (Taylor & Francis Ltd, 2025) Kaya, Eda Cavus; Akdeniz, Mehmet; Ugurlu, Pelin; Yigitkan, Serkan; Toksoy, Mahmut Ozan; Firat, Mehmet; Ertas, Abdulselam
    The essential oil profile of Thymbra spicata L. subsp. spicata L. (Lamiaceae) was analyzed in this study using gas chromatography/mass spectrometry (GC-MS). Additionally, antioxidant and cytotoxic activities, along with inhibition activities for acetylcholinesterase, butyrylcholinesterase, urease, tyrosinase, elastase, collagenase, and angiotensin-converting enzymes, were assessed. Additionally, the acaricidal effects of the essential oil with strong antioxidant properties from T. spicata subsp. spicata, as well as the AgNO3 nanoparticles synthesized using this oil, were evaluated on Hyalomma marginatum nymphs. The main compounds present in the essential oil was identified as carvacrol (71.19%). The species exhibited remarkably high antioxidant activity, particularly in the ABTS cation radical scavenging activity and CUPRAC copper reducing capacity assays, with IC50 and A0.5 values of 1.80 +/- 0.053 and 1.30 +/- 0.12 mu g/mL, respectively. Additionally, the sample exhibited significantly high acetylcholinesterase and butyrylcholinesterase enzyme inhibition activities, with inhibition rates of 76.09 +/- 1.63% and 97.94 +/- 0.71%, respectively. It was also determined that the essential oil had moderate antimicrobial activity against the bacteria, and MIC values varied between 312 mu g/mL and 1250 mu g/mL. At the end of 24 hours, The LC50 values of essenttial oil and silver nanoparticles were determined to be 18.48 and 36.30 mu g/mL, respectively. The results of this study indicate that T. spicata may find application in dietary supplements due to its high carvacrol content and strong antioxidant, anticholinesterase, and acaricidal activities.