Browsing by Author "Ulkevan, Tuba"

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Malignant Catatonia Triggered by Acute Psychological Traumatic Experience in a Patient with Schizophrenia: A Case Report
(Klinik Psikiyatri dergisi, 2025) Ulkevan, Tuba; Altindag, Hulya; Celikkaleli, Suheda Tapan
Malignant catatonia is defined as catatonia accompanied by hyperthermia and/or autonomic instability. Catatonia can develop in association with psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder, as well as various medical and neurological conditions. However, our knowledge regarding the role of acute traumatic experiences in the development of catatonia remains limited. This case report discusses a presentation of malignant catatonia triggered by an acute psychological trauma in a patient with schizophrenia in remission. A 41-year-old male patient has been followed with a diagnosis of schizophrenia since 2003. Following an acute psychological traumatic event, the patient developed withdrawal, reduced speech, refusal to eat and drink, and generalized rigidity. Upon examination, the patient exhibited catatonic stupor, rigidity, mutism, negativism, and vital signs indicating hyperthermia and hypertension. Based on these findings, a diagnosis of malignant catatonia was considered. The patient was administered electroconvulsive therapy. After eight sessions of electroconvulsive therapy, a significant improvement in the patient's clinical symptoms was observed. Traumatic experiences may contribute to the development of malignant catatonia through mechanisms such as acute threat perception, inflammatory responses, autonomic instability, and dysregulated dopaminergic signaling
Vortioxetine-Induced Amenorrhea: a Case Report
(Lippincott Williams & Wilkins, 2022) Isik, Mesut; Kurhan, Faruk; Ulkevan, Tuba; Ozdemir, Pinar Guzel
Background: Vortioxetine is a novel multimodal antidepressant for the treatment of major depressive disorders and is widely used in clinical practice. Vortioxetine has a safe profile. However, there are case reports of other adverse effects in the literature. In this article, a case of amenorrhea due to vortioxetine is presented. Case: The patient is 36 years old, married, female, and is an anesthesiologist. She applied to the psychiatric outpatient clinic with symptoms of major depression. Vortioxetine was initiated at 10 mg/d and then gradually increased to 20 mg/d. She had regular menstruation until now. However, she did not menstruate after taking vortioxetine. The patient used vortioxetine for 3months and never had a period. Pregnancy test and other tests to investigate organic etiology were normal. Twoweeks after discontinuation of vortioxetine, the patient had a menstrual period. Conclusions: Further research is needed on the relationship and possible mechanisms between vortioxetine and amenorrhea.