Browsing by Author "Uner, A."

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Assessment of Cardiac Functions in Infants With Cow's Milk Allergy
(International Scientific Literature Inc., 2014) Ece, I.; Demirören, K.; Demir, N.; Uner, A.; Balli, S.
Background: Cow's milk allergy is the most common food allergy in children, with rates estimated at 1.9% to 4.9%. Clinical phenotypes of cow's milk allergy are varied and involve 1 or more target organs, with the main targets being the skin, respiratory system, and gastrointestinal tract. To date, no studies have investigated detailed cardiac function in children with cow's milk allergy. The current study aimed to investigate cardiac function in infants with cow's milk allergy. Material/Methods: We studied 42 infants with cow's milk allergy and 30 age- and sex-matched healthy subjects. Cardiac functions were evaluated by M-mode, pulsed-wave, and tissue Doppler echocardiography. Results: There were no significant differences in ejection fraction or mitral and tricuspid annular plane systolic excursion between the 2 groups. Pulsed-wave Doppler-derived E/A ratios in mitral and tricuspid valves were similar in both groups. Ea/Aa ratios in the left ventricle posterior wall and right ventricle free wall were lower in patients with cow's milk allergy than in the control group. The E/Ea ratio in the left ventricle, isovolumic relaxation time, deceleration time, and right and left ventricular myocardial performance indices were higher in patients in the study group. Conclusions: Our study identified reduced early diastolic tissue Doppler velocities in infants with cow's milk allergy. © Med Sci Monit, 2014.
Association of Down Syndrome and Morgagni Hernia
(Medecine Et Hygiene, 2014) Taskin, G. Alpaslan; Tuncer, O.; Demir, N.; Bilici, S.; Aktar, F.; Peker, E.; Uner, A.
Comparison of Nifedipine and Captopril in Children With Pulmonary Hypertension Due To Broncopneumonia
(Oxford Univ Press, 2008) Uner, A.; Dogan, M.; Demirtas, M.; Acikgoz, M.; Temel, H.; Kaya, A.; Caksen, H.
This study included 40 children, who were diagnosed with pneumonia and pulmonary hypertension (from the radiographic and clinical features), was performed at Yuzuncu Yil University Faculty of Medicine, Department of Pediatrics, from September 2003 to July 2005. Patients who had pneumonia and congenital heart disease or systemic hypertension or renal and liver disease together were excluded from the study. Blood gas analysis and oxygen concentration, measured with pulse oximetry, were performed in all patients. Besides chest X-ray, electrocardiography and echocardiographic search was also carried out. Echocardiographic examination was performed by using M mode, two-dimensional echocardiography and colored Doppler sonotron Vingmed CFM 725. At echocardiographic examination, pulmonary hypertension is defined as above 35 mmHg of pulmonary artery pressure. For echocardiographic examination, patients with pulmonary hypertension were divided into two groups. Captopril (2 mg/kg/day, three doses a day) and nifedipine (0.5 mg/kg/day, three doses a day) were given to the first and the second group, respectively. Echocardiography was performed daily until normal pulmonary artery pressure was achieved. At the beginning of the treatment, the patients were treated with double antibiotics and antibiotic change was carried out in needed cases at the follow up. Digoxin was administered to the cases of respiratory infection with heart failure.
The Evaluation of Serum N-Terminal Prohormone Brain-Type Natriuretic Peptide, Troponin-I, and High-Sensitivity C-Reactive Protein Levels in Children With Congenital Heart Disease
(Sage Publications Ltd, 2014) Uner, A.; Dogan, M.; Ay, M.; Acar, C.
Although advanced diagnostic and treatment methods are available, congenital heart disease (CHD) holds an important place among the causes of death within the first year of age. Therefore, several prognostic factors are needed for diagnosis and monitoring of these patients. In this study, which includes 66 CHD patients and 38 healthy control children, serum cardiac troponin-I (cTnI), high-sensitivity C-reactive protein (Hs-CRP), and N-terminal prohormone brain-type natriuretic peptide (NT-proBNP) levels were analyzed for their prognostics values. The patient groups were categorized and then evaluated as cyanotic (n = 16), acyanotic (n = 50), symptomatic (n = 23), asymptomatic (n = 43), and isolated ventricular septal defect (VSD)-isolated atrial septal defect (ASD) groups. Cyanotic group was statistically compared with acyanotic group, symptomatic group with asymptomatic group, and VSD group with ASD group. Between the cyanotic, acyanotic, and control groups; between symptomatic and asymptomatic groups; and between the VSD and ASD groups, significant difference was not showed for age (p > 0.05). NT-proBNP was found to be significantly higher in the cyanotic group than acyanotic and control group, in the symptomatic group than asymptomatic group; and in the patient group than healthy control group (p < 0.05). Between the groups of VSD and ASD, significant difference was not showed (p > 0.05). The same comparison results for TnI and Hs-CRP were not significant (p > 0.05). TnI and Hs-CRP were only found significantly higher in the patient group than healthy control group (p < 0.05). Eventually, we think that NT-proBNP, Hs-CRP, and TnI might be used for clinical management and estimation of outcome of these disorders in the future and these also might be able to modify existing strategies, but much more studies are needed.
Extent and Burden of Allergic Diseases in Elementary Schoolchildren: a National Multicenter Study
(Esmon Publicidad S A, dept Allergy & Clin Immunol, Clin Univ Navarra, 2010) Civelek, E.; Cakir, B.; Boz, A. B.; Yuksel, H.; Orhan, F.; Uner, A.; Sekerel, B. E.
Background: Scarcity of standardized, comparable data on allergic diseases in schoolchildren in Turkey requires further multicenter studies based on the use of objective tools in addition to parent-completed questionnaires to improve the validity and reliability of results. Methods: Using International Study of Asthma and Allergies in Children (ISAAC) Phase II tools, elementary schoolchildren aged 9 to 11 years were surveyed in 5 city centers in different regions of Turkey. Results: We surveyed 6963 children from 70 schools and found that 35% had had at least 1 symptom of allergic diseases in the past year. Based on parental reports, the overall prevalence rates for wheezing, rhinoconjunctivitis, and eczema in the past year were 15.8%, 23.5%, and 8.1%, respectively. The overall frequencies of atopy, flexural dermatitis, and bronchial hyperreactivity were 18.9%, 3.6%, and 24.2%, respectively. There were large variations in the prevalence of both symptoms and objective signs between study centers. Absence from school for at least 1 day was reported for 34.2% of children with a diagnosis of asthma or allergic rhinitis. Conclusions: Approximately one third of elementary schoolchildren reported symptoms compatible with allergic diseases in the past year. The interregional differences in both symptoms and objective test results are possibly due to differences in environmental conditions. Unfortunately, serious problems are still encountered in the timely and proper diagnosis and treatment of allergic diseases.
Is Kawasaki Disease a Side Effect of Vaccination as Well
(OMICS Publishing Group, 2014) Ece, I.; Akbayram, S.; Demiroren, K.; Uner, A.
Different subtypes of vasculitis have been reported after vaccination in adults. However, only one case of Kawasaki disease in an infant after hepatitis B vaccination has been described. We report a case of Kawasaki disease in a 2 month-old infant who developed the Kawasaki disease 1 day after receiving his first dose of diphtheria tetanus-acellular pertussis, Haemophilus b and pneumococcal conjugate vaccine. © 2014 Ece I et al.
The Prevalance of Asthma and Allergic Diseases in Turkish School Children Using Isaac Phase Ii Protocol: Preliminary Findings of a National Study
(Blackwell Publishing, 2007) Civelek, E.; Cakir, B.; Uguz, A.; Yuksel, H.; Orhan, F.; Uner, A.; Sekerel, B.
Prevalence and Predictors of Current Wheezing in Turkish School Children, Using Isaac Phase Ii Protocol
(Blackwell Publishing, 2008) Civelek, E.; Cakir, B.; Uysal, Soyer O.; Orhan, F.; Bingol, Boz A.; Uner, A.; Sekerel, B.
Prevalence, Burden, and Risk Factors of Atopic Eczema in Schoolchildren Aged 10-11 Years: a National Multicenter Study
(Esmon Publicidad S A, 2011) Civelek, E.; Sahiner, U. M.; Yuksel, H.; Boz, A. B.; Orhan, F.; Uner, A.; Sekerel, B. E.
Background: Little is known about the epidemiology of atopic eczema (AE), and studies from the Mediterranean region and the Middle East are limited. Objective: We investigated the frequency, burden, and risk factors of AE in a developing country. Methods: The International Study of Asthma and Allergies in Childhood Phase II questionnaire was used to survey a representative sample of 10 to 11-year-old children in Turkey. Children were examined by allergists, and parents completed standardized questionnaires. Results: Among 6755 children, the prevalence of having eczema during one's lifetime or currently was 17.1% and 8.1%, respectively. The prevalence of visits to the doctor, nocturnal awakening, school absenteeism, and drug usage was 36.3%, 56%, 9.7%, and 28.7%, respectively. Associated factors were current rhinoconjunctivitis (odds ratio [OR], 2.53; 95% confidence interval [CI], 1.99-3.21), current wheezing (OR, 2.10; 95% CI, 1.58-2.79), family history of allergic disease (OR, 1.62; 95% CI, 1.21-2.18), low birth weight (OR, 1.79; 95% CI, 1.08-2.94), and exposure to animals in the first year of life (OR, 1.47; 95% CI, 1.06-2.03). Conclusions: In a developing Mediterranean country, the prevalence of AE is comparable to that of developed countries in the same region and lower than that observed in developed countries elsewhere. The course of the disease and risk factors of AE probably differ in developing countries.