Browsing by Author "Unsal, Mustafa"

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Adjuvant Treatment Results and Prognostic Factors in Patients With Stage I-Iii Operated Breast Cancer
(Kare Publ, 2006) Izmirli, Mustafa; Donmez Yilmaz, Binnur; Alan, Omur; Yalciner, Mehmet; Berberoglu, Elif; Unsal, Mustafa
OBJECTIVES We evaluated the adjuvant treatment results and prognostic factors in patients with breast cancer. METHODS A total of 197 stage I-III breast cancer patients (mean age 51; range 18 to 80 years) treated and followed up by Okmeydam Training Hospital, Department of Radiation Oncology in 1995 were evaluated retrospectively. RESULTS The 41.1% of patients were premenopausal and the remaining were postmenopausal. Invasive ductal carcinoma was encountered as the most frequent (85.8%) histopathologic type of tumor and most frequent (%49.7) stage was IIB. Modified radical mastectomy was performed on 65% of patients. In adjuvant treatment, cyclophosphamide-methotrexate-fluorouracil combinations and anthracycline containing combinations were given to 46.7% and 23.4% of patients respectively. In addition, endocrine therapy and radiotherapy was carried out on the 75.6% and 69.0% of patients. Local recurrences was occurred in a rate of 13.2% and distant metastases were observed in a rate of 26.4% and 7.1% of patients had both local recurrences and distant metastases. The 60.9% of patients were disease free and 1% with local recurrences also they were followed-up for a median time of 89 months (4-108). The overall survival rate and disease free survival rates for 5 and 8 years were as follows; 68%, 61%, 66%, and 60% respectively. With one variable analysis increased number of involved axillary lymph nodes, tumor size and stage gave rise to reduced overall survival rate and disease free survival rate. With multiple variable analysis, number of involved axillary lymph nodes (p=0.001) and tumor size (p=0.001) had significant effect on overall survival rate and disease free survival rate. CONCLUSION The tumor size and number of involved axillary lymph nodes were found to be statistically significant prognostic factors in breast cancer patients in our study.
Cancer Statistics of Ssk Okmeydani Training and Research Hospitals Department of Oncology From 1999 To 2004
(Kare Publ, 2007) Izmirli, Mustafa; Altin, Suleyman; Dernek, Berna Olcum; Unsal, Mustafa
OBJECTIVES In this study, we evaluated the cancer incidence and demographic characteristics in people have social insurance after from digital registration date. Evaluation was done using 6 years data after that time. METHODS We investigated the 52.214 patients having diagnosed as cancer between 1st January 1999 and 31st December 2004. Final diagnosis was evaluated with considering he patient's age, sex, admit time, county, and stage of illness. RESULTS 28.830 patients were males (55.2%) and 23.384 were females (44.86%) an median age at the time of admission was 56 (range 098). The frequency of disease was 0.7% in 0-14 years old age group, 20.5% 15-44 years old age group, 24.3% 45-54 years old age group, 27.1% 55 to 64 years old age group, and 27.4% 65 years and older age group. The 81.7% of the cases were having with local-regional disease and the remaining 18.3% were having distant metastasized disease. The detected most frequent 10 types of cancer were as follows; lung cancer 22.1%, breast cancer 15.2%, colorectal cancer 8.6%, gastric cancer 6.0%, thyroid cancer 4.0%, non-Hodgkin lymphoma 3.7%, central nervous system cancers 3.5%, ovary cancer 2.7%, corpus uteri cancer 2.5%, and larynx cancer 2.5%. The most frequent 5 cancers only for females were breast (33.4%), colorectal (8.3%), thyroid (6.9%), ovary (6.0%), and corpus uteri cancer (5.5%), and for males lung (36.1%), colorectal (8.8%), stomach (7.2%), larynx cancer (4.1%) and non-Hodgkin lymphoma (4.0%). The number of patients showed significant increase from 1999 (7.014) to 2004 (10.823). CONCLUSION We present the statistical data for cancer patients who admitted to the SSK Okmeydani Training and Research Hospital Department of Radiation Oncology before the time of revolution from SSK to Healthy ministry. That data can give us some opinion for frequency of cancer in Marmara and west of Karadeniz region.
The Results of Palliative Intensive Hypofractionated Radiotherapy From Patients Having Brain Metastases With Unknown Primary Tumour
(Kare Publ, 2006) Izmirli, Mustafa; Altin, Sulayman; Buyukpolat, M. Yakup; Adatepe, M. Ferhan; Unsal, Mustafa
OBJECTIVES We retrospectively examined the results of hypofractionated radiotherapy from 24 patients having brain metastases with unknown primary. METHODS Radiotherapy was administered to 24 patients (20 males (83.4%), 4 females (16.6%), age range 24-75 years) as 10 Gy fraction doses with 10 days intervals for a total of 30 Gy tumour dose in 3 fractions. Antiedema treatment was given to all patients. Karnofsky performance status was 70 for one patient and below 70 for the rest of the patients. Multiple metastases were present in 79.2% of the patients, in 20.8% of the patients there was single lesion and histophatologic diagnosis was present only for this group. 50% of the patients had hemiplegia, 45.8% had hemiparesia, 4.2 % had quadriplegia and 6 patients (25%) had other additional pathologies. Treatment was started at the day of admission for 13 patients. RESULTS The total and partial reliefs in neurological symptoms were seen in 8.3% and 37.5% of patients, respectively. Median survival from diagnosis of brain lesions was 2.87 months. The six months, 1 and 2 years survival rates were 33.3%, 8.33%, and 8.33%, respectively. The prognosis of patients with brain metastases is poor and have similar survival rates from the other poor performance patients (KPS<70). CONCLUSION As a conclusion, short course hypofractionated radiotherapy might be adviced to the patients with poor prognosis.