Browsing by Author "Ural, K."

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Comparative Clinical Efficiency of Resveratrol, Allopurinol, and Resveratrol Plus Allopurinol in Canine Visceral Leishmaniasis
(American Veterinary Medical Association, 2025) Erdogan, S.; Erdogan, H.; Ural, K.; Pasa, S.; Gultekin, M.; Balikci, C.; Gunal, I.
Objective To assess the clinical and immunological effectiveness of resveratrol alone or combined with allopurinol for treating canine visceral leishmaniasis (CVL). Methods This study included 50 dogs, 30 diagnosed with CVL and 20 healthy controls. Dogs were classified based on their treatment regime (receiving resveratrol [200 mg/dog/d] and/or allopurinol [10 mg/kg/d]). Clinical scores, anti-leishmanial antibody titers, and routine blood parameters were evaluated on days 0, 15, and 30 after treatment. Results Dogs treated with the combination therapy showed the most substantial improvements, with a 75.77% reduction in clinical scores and an 81.25% reduction in antibody titers. Dogs receiving allopurinol exhibited a 56.25% reduction in clinical scores, while those treated with resveratrol showed a 42.82% reduction. Antibody titers were less significantly reduced in the resveratrol group (67.5%) compared to the allopurinol group (45%). Conclusions Combining resveratrol with allopurinol enhances the therapeutic efficacy for CVL, leading to significant clinical improvements and reductions in antibody titers. Resveratrol alone also demonstrates promising anti-leishmanial effects. Clinical Relevance Resveratrol, either alone or in combination with allopurinol, offers a feasible and effective alternative for improving clinical outcomes in CVL. Its incorporation into standard protocols may enhance treatment strategies in veterinary medicine. ©The authors.
D-Dimer Level as a Potential Marker of Cutaneous Disease Activity in Canine Leishmaniosis and Demodicosis
(Herman Otto Intezet, 2020) Ayan, A.; Ural, K.; Erdoǧan, H.; Gültekin, M.
Biochemical markers for detecting disease activity allow a clinician to monitor severity of illness, progression, and response to therapy. D-dimer is a breakdown/degradation product of cross-linked fibrin, increasing with clot formation and fibrinolysis and its testing is non-invasive. The aim of this study was to measure D-dimer concentrations and assess their value in the diagnosis of cutaneous disease activity in dogs with canine visceral leishmaniosis (CVL) and demodicosis, besides the strengths of the latter marker in identifying early diagnosis. D-dimer analyses were performed in two groups of dogs; (ll) 13 dogs with CnVL, (III) 16 dogs with demodicosis, then were compared to those of healthy dogs (n = 11) as (l) control group. The D-dimer range in clinically healthy dogs was < 0.1 mg/L. In dogs with CVL and demodicosis, the D-dimer concentrations were higher than those of healthy dogs (p < 0.05) and (p < 0.01), respectively. In both groups, D-dimer level increased with clinical evidence of disease. D-dimer concentration may be considered as an indicator for cutaneous disease activity during selected diseases and may be useful as a potential biochemical marker of disease activity in certain cutaneous inflammatory conditions. © 2020 Herman Otto Intezet. All rights reserved.
Effect of Curcumin Enema Dosage Regimes on the Reduction of Giardia Cyst Among Calves
(Pusat Penelitian Dan Pengembangan Peternakan, 2023) Ural, K.; Erdogan, H.; Ural, Da; Pasa, S.; Erdogan, S.; Ayan, A.; Balikci, C.
Giardiasis is one of the most significant and neglected parasitic infestations among calves, resulting in intestinal infections. This protozoan agent gained diagnostic and therapeutical importance because of its zoonotic potential, in which novel alternative/substitute therapeutical interventions are important, and this is because commonly used anti-parasitic drugs for control and eradication for battling this infection commonly presented side effects. Therefore, the present project evaluated the antiprotozoan activity of curcumin at different dose regimes used via the rectal route, the main constituent of turmeric. Rectal enema groups [Group I: 2 gr/kg, Group II: 80 mg/kg, and Group III: 10 mg/kg] and oral treatment Group IV: 2 gr/calf consisted of curcumin treatment at appropriate dosages showed herein in which the control group V were untreated. All treatment groups showed a statistically significant decrease in cyst counts on day 10, compared to day 10 values of the control group (p<0.005). Among the treatment groups, the highest cyst reduction was evident at 99.86% in curcumin 10 mg/kg rectal enema-administered calves (Group III), which received the lowest dose of the study. Curcumin at all dosages, primarily used in the rectal route at the lowest dosage regimen of 10 mg/kg, could have hastened clinical and parasitological efficacy via probable inhibition of Giardia proliferation and adhesion, as described previously. This treatment modality via the rectal route can change the game, highlighting novel treatment protocols.
May Citrus Extract Provide Anti-Giardial Therapeutic Efficacy
(Ataturk Universitesi, 2021) Aliç Ural, D.; Erdoğan, S.; Balikçi, C.; Ayan, A.; Erdoğan, H.; Ural, K.
In this study, it was aimed to investigate the therapeutic efficacy of the bitter orange extract in goat kids with giardiasis. A total of sixteen goat kids detected to be infected with Giardia duodenalis at the age of 12 to 68 days were enrolled in the study. Goat kids were randomly assigned into two groups, whereas goat kids in the control group (n= 8) without receiving any drug and group (n=10) received oral bitter orange extract at a dosage of 10 ml/goat kids for seven days. Anti-giardial therapeutic efficacy of bitter orange extract was determined by oocyst shedding interpreted with a microscopical examination of fecal samples on days 0 and 10. It was revealed that the therapeutic efficacy of orange bitter extract as compared with control was 99.9% on day 10. In conclusion, this significant decrease of oocyst shedding supports the anti-giardial activity of bitter orange extract and shows that it might be an alternative in the treatment of giardiasis. © 2021 Ataturk Universitesi. All rights reserved.
Serum Thiol Disulphide Levels Among Sheep With Sarcoptic Mange
(Veteriner Fakultesi Dergisi, 2019) Çamkerten, İ.; Çamkerten, G.; Erdoğan, H.; Ayan, A.; Erdoğan, S.; Ural, K.
Sarcoptic mange, a notable parasitic disease, causes dermatological alterations among ruminants. Thiol-disulphite hemostasis is a novel oxidative stress parameter. The aim of this study was to evaluate dynamic thiol/disulfide homeostasis in sheep with sarcoptic mange. Total of thirty-six sheep (n=15 female, n=21 male) with sarcoptic mange (Group I), and twelve healthy sheep (Group II) were used in the study. A novel method was used to determine the thiol disulphide parameters. Native thiol, total thiol and Disulphide values were statistically lower in Group I. Disulphide/native thiol, Disulphide/total thiol, and Native thiol/ total thiol proportions had no statistical differences in groups. Sarcoptic mange was probably affected by the thiol Disulphide hemostasis in infected sheep. Thus, the data obtained in this study might form base for further studies to include antioxidant molecules in the treatment protocols. © 2019, Veteriner Fakultesi Dergisi. All rights reserved.