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Browsing by Author "Uraz, A."

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    Article
    Changes of Tumor Necrosis Factor-Α, Interleukin-10, and Tartrate-Resistant Acid Phosphatase5b in the Crevicular Fluid in Relation To Orthodontic Movement
    (Sage Publications inc, 2015) Karaduman, B.; Uraz, A.; Altan, G. N.; Balos Tuncer, B.; Alkan, O.; Gonen, S.; Cetiner, D.
    The aim of this study was to determine gingival crevicular fluid (GCF) expressions of tumor necrosis factor-alpha (TNF-), interleukin-10 (IL-10), and tartrate-resistant acid phosphatase (TRAP) 5b in the mechanism of orthodontic tooth movement. Nine adolescents requiring canine distalization participated in the study. A canine undergoing distal movement served as the test tooth, and the contra-lateral canine served as the control. The clinical parameters were recorded and GCF samples were collected from the mesial and distal gingival crevices of teeth at baseline, 1 h, 24 h, 7 days, and 28 days following force application. GCF samples were analyzed using ELISA. The data were analyzed using three-way repeated measures analysis of variance. TNF-alpha and TRAP5b levels in distal and mesial sites of the test teeth were significantly higher than that at both sites of the controls. When compared with baseline values, increase was prominent at 1 h and 24 h. The IL-10 concentration decreased during experimental period at both sites of the control and test teeth. The results demonstrated that orthodontic forces evoke changes in the levels of TNF-alpha, IL-10, and TRAP5b during the initial stages of force application. The changes in local host response in periodontal tissues may be one of the triggers in regulating alveolar bone resorption during orthodontic tooth movement.
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    Article
    Immunoexpression of P38 Mitogen-Activated Proteinkinase in Patients With Aggressive and Chronic Periodontitis
    (Biolife Sas, 2013) Uraz, A.; Ayhan, E.; Yildirim, B.; Baris, E.; Pehlivan, S.; Eren, K.
    The influence of p38 mitogen-activated proteinkinase (MAPK) expression in the development and progression of periodontal disease is currently under investigation. The aim of the present study is to investigate whether the p38 MAPK expression in gingival tissues correlates with IL-1 beta levels in gingival crevicular fluid (GCF). Twenty patients with generalized aggressive periodontitis (GAgP), 15 patients with generalized chronic periodontitis (GCP) and 10 healthy subjects (H) were enrolled in the study. Clinical data, gingival tissue biopsies and GCF samples were collected. The expression of p38 was investigated by immunohistochemistry. The levels of IL-1 beta inGCF were measured using ELISA. Mean clinical parameters and GCF volumes were statistically higher in patients with GAgP and GCP compared to H subjects. Higher levels of IL-1 beta were found in both periodontitis groups. The p38 expression was significantly increased in inflamed gingival tissues. There were no statistically significant differences in levels of IL-1 beta and p38 expression between subjects with GAgP and GCP. Our data support the hypothesis that MAPK signaling pathway is an additional player in the pathogenesis of periodontitis. This is the first report to evaluate the involvement of p38 MAPK in patients with GAgP and GCP which might be, in part, considered of value in understanding disease mechanisms.