Browsing by Author "Uslu, A."

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Fluorouracil and Folinic Acid Bolus Schedule (Nordic Regimen) Combined With Irinotecan as a First-Line Chemotherapy in Metastatic Colorectal Cancer
(2010) Küçükzeybek, Y.; Karabulut, B.; Yetiş, H.; Uslu, R.; Sanli, U.A.; Uslu, A.; Göker, E.
The recent incorporation of irinotecan (CPT-11) for the management of advanced colorectal cancer has generated further improvement in survival. The goal of this retrospective analysis was to evaluate the efficacy and toxicity of irinotecan plus bolus FU/FA (Nordic regimen) as first-line therapy in patients with advanced colorectal cancer. A total of 43 patients with metastatic colorectal cancer treated with irinotecan plus bolus FU/FA (Nordic regimen) as first-line chemotherapy were reviewed. Patients with metastatic adenocarcinoma of the colon or rectum and who had measurable disease and WHO performance status of 2 or less were treated with irinotecan 210 mg/m2 as a 30-90 min intravenous infusion on day 1, followed by 5-FU 500 mg/m2 and FA 60 mg/m2 bolus on days 1 and 2, every 2 weeks, until disease progression or unacceptable toxicity. Patients were evaluated for response rates, survival and toxicity. Median patient age was 56 (29-76) years. Response rates were 72% as a carcino embryogenic antigen (CEA) level and 45% as a clinic evaluation. Disease control rates were 76% as a CEA level and 80% as a clinic evaluation. Median duration of response was 5,8 (2-9) months as a clinic evaluation and median duration of response was 6,6 (2-11) months as a CEA level. Median progression free interval was 9 (2-13) months and median overall survival was 16 (3-18) months. Grade 3-4 neutropenia occurred in 30% of the patients. Non-haematological toxicities were mild. There was no treatment-related death. Irinotecan - Nordic regimen is considered as a reasonable option for first-line treatment of patients with metastatic colorectal cancer.
Non-Invasive Evaluation of Liver Fibrosis Using Real-Time Elastography and Comparison of Intercostal and Subcostal Approaches
(TIP ARASTIRMALARI DERNEGI, 2015) Uslu, A.; Batur, A.; Bıyık, M.; Acıkgozoglu, S.
In patients with chronic liver diseases, the identification of significant fibrosis is of special interest, because the presence of fibrosis is an important parameter for the estimation prognosis, for survelliance and for treatment decisions in patients with Chronic Liver Diseases. Although percutaneous liver biopsy is the gold standart method for assessing liver fibrosis, it has some limitations including its invasive nature, inconvenience, sampling errors, inadequate specimen size and interobserver variability in pathology interpretation. Therefore many studies have focused on the evaluation of noninvasive methods for the assessment of liver fibrosis stage. One of these methods is real time elastography which measures tissue elasticity. In the present study, we assessed intercostal and subcostal measurement methods to discriminate between normal and fibrotic liver. © 2015, TIP ARASTIRMALARI DERNEGI. All rights reserved.
Prevalence of Dermatophytosis in Cats and Dogs in Türkiye: Dominance of Microsporum Canis and First Detection of Trichophyton Rubrum
(BioMed Central Ltd, 2025) Sanioglu Golen, G.S.; Balevi, A.; Uslu, A.; Akar, K.; Taşmertek, M.; Aras, Z.
Background: Dermatophytosis is a fungal infection that can be zoonotic, with transmission occurring in both directions between humans and companion animals, particularly in settings involving close contact. This study aimed to determine the prevalence and identify the causative agents of dermatophytosis in dogs and cats using conventional and molecular diagnostic methods. A total of 150 animals with dermatological lesions were sampled, including 105 cats and 45 dogs from both household and shelter environments. This cross-sectional study employed direct microscopy and fungal culture as the initial diagnostic methods. PCR targeting the CHS1 gene was subsequently performed on fungal isolates obtained from 38 culture-positive samples, followed by species-specific amplification to identify Microsporum canis and Trichophyton rubrum. For molecular identification, DNA was extracted from pure cultures derived from hair, skin scrapings, and nail specimens. ITS region sequencing was also performed on two of the PCR-confirmed T. rubrum isolates. Prevalence was compared across animal species, age groups and living environments. Results: Dermatophytes were detected in 25.3% (38/150) of samples. In cats, only M. canis 76% (19/25) was identified. In dogs, both M. canis (5/13) and T. rubrum (2/13) were found. This represents the first report of T. rubrum in a dog in Türkiye, with ITS sequencing confirming > 99% identity to reference strains. Infection rates were significantly higher in animals under one year of age (p = 0.0097), while no statistically significant difference was observed between dogs and cats (p = 0.529). PCR and sequencing provided rapid and accurate identification. Conclusions: Dermatophyte infections are more prevalent among juvenile animals and pose a growing zoonotic threat. Molecular diagnostics improve early detection and control strategies. These findings highlight the need for routine surveillance and reflect the critical importance of the One Health approach, which integrates human, animal, and environmental health to prevent and manage zoonotic disease transmission. © 2025 Elsevier B.V., All rights reserved.
Testing a Structural Model on Impulse Buying Tendency, Fear of Covid-19, Economic Anxiety, Household Income and Quality of Life
(Inderscience Publishers, 2024) Çelik, Z.; Türkyılmaz, C.A.; Uslu, A.
Based on impulse buying and fear theory, the study examines which factors affect consumers’ impulse buying tendencies. Data were collected from 546 participants through the survey. The research model was tested with process macro. The fear of COVID-19 decreases the quality of life while increasing the economic anxiety and impulse buying tendency. While economic anxiety and life quality factors separately have a negative mediating role in the effect of COVID-19 fear on impulse buying tendency, these two factors together have a positive mediating role. Because while economic anxiety reduces the impulse buying tendency, quality of life increases the impulse buying tendency. Economic anxiety and its interaction with household income cut down life quality. However, the conditional effects of economic anxiety on quality of life at different levels of household income are not significant. The negative effect of household income on life quality is insignificant. The study provides implications. Copyright © 2024 Inderscience Enterprises Ltd.