YYÜ GCRIS Basic veritabanının içerik oluşturulması ve kurulumu Research Ecosystems (https://www.researchecosystems.com) tarafından devam etmektedir. Bu süreçte gördüğünüz verilerde eksikler olabilir.

Browsing by Author "Ustunova, Savas"

Filter results by typing the first few letters
Now showing 1 - 2 of 2
  • Thumbnail Image
    Conference Object
    The Effects of Cichorium Intybus Extract on Cerebellar Apoptosis and Oxidative Stress in Pentylenetetrazole-Induced Kindling Model in Rats
    (Wiley-blackwell, 2016) Meral, Ismail; Gurevin, Ebru Gurel; Ustunova, Savas; Demirtas, Murat; Ozturk, Nilgun; Kiyan, Hulya Tuba; Erkec, Ozlem Ergul
  • Thumbnail Image
    Article
    Effects of Cichorium Intybus on Gabaa Receptors and Apoptosis in Pentylenetetrazole-Induced Kindling in Rats
    (Kare Publ, 2021) Ergul Erkec, Ozlem; Meral, Ismail; Kara, Mehmet; Esrefoglu, Mukaddes; Tok, Olgu Enis; Ustunova, Savas; Armagan, Metin
    Objectives: This study was designed to determine the effects of Cichorium intybus (CI) on apoptosis and GABA(A) receptor density in the brains of rats in pentyleneterazole induced kindling. Methods: The rats were divided into three groups: Control group, pentylenetetrazol administered (PTZ) group, and PTZ+CI extract administered (PTZ+CI) group. Control group received only physiological saline (0.5 ml). PTZ (35 mg/kg) injected to the animals in the PTZ and PTZ+CI groups. The CI extract (200 mg/kg) was also administered to the PTZ+CI group. A 75 mg/kg challenge dose of PTZ was administrated to the PTZ treated groups, on the 12th injection. Results: A significant increase was found in the number of neurons expressing the GABA(A) receptor in the brain tissue (hippocampus and cerebral cortex) of the PTZ group when compared to the control. The density of GABA(A) receptor of the neurons in the cerebral cortex significantly increased in PTZ administered groups compared to the control.The number of apoptotic neurons was found non-significant between groups in the brain. Conclusion: CI treatment prolonged the onset of the first seizure activity and seizure latency at a convulsive dose, and kept the number of GABA(A) receptors close to that of the control in the hippocampus.