Browsing by Author "Uygan, I."

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The Association of Short Segment Barrett's Esophagus With Intestinal Metaplasia in Stomach
(2003) Tuncer, I.; Ugraş, S.; Uygan, I.; Türkdoǧan, K.; Kösem, M.
Background/aims: The aims of this study were to investigate the presence of short segment Barrett's esophagus in people found to have tongue-like columnar mucosal protrusions in the distal esophagus and to determine the relationship between short segment Barrert's esophagus and Helicobacter pylori, gastritis and intestinal metaplasia observed in other parts of the stomach. Methods: The study included 50 patients (32 male, 18 female). Two biopsy specimens were taken from the antrum, at least 2 cm away from the pylorus, from the incisura angularis, corpus and cardia and four biopsy specimens were taken from tongue-like columnar protrusions (<3 cm long) above the gastroesophageal junction. Tissue samples were stained with hematoxyline-eosine, HID-Alcian blue pH 2.5 and modified Giemsa. Results: Of the 50 subjects who were found to have tongue-like columnar protrusions above the gastroesophageal junction, short segment Barrett's esophagus was detected in nine (18%). Whereas all short segment Barretti's esophagus cases were associated with chronic gastritis, Helicobacter pylori was found to be positive in five (55.5%) of them and there was intestinal metaplasia in other parts of the stomach (antrum in two patients, incisura angularis in three, antrum and cardia in one) in six (66.6%) cases. In 41 patients without short segment Barrett's esophagus 33 (80%) had chronic gastritis, 27 (66%) had Helicobacter pylori infection and eight had intestinal metaplasia in different locations (there in antrum, four in incisura angularis, one in the antrum and cardia) of the stomach. Conclusions: An association between short segment Barrett's esophagus and intestinal metaplasia was found in different parts of the stomach. The link between intestinal metaplasia in the stomach and these metaplastic changes in the tubular esophagus requires evalation in larger and more comprehensive studies.
A Brucellosis Case With Ascites, Hearing Loss and Pancytopenia
(2003) Tuncer, I.; Akdenis, H.; Uygan, I.; Turkdogan, K.; Cekici, S.; Durmus, A.
Objectives- To report a rare case of brucellosis in a previously healthy 25-year-old woman who presented with fever, bilateral hearing loss, non-portal hypertensive type ascites and pancytopenia. Design- Case study. Setting- Departments of Gastroenterology and Infectious Diseases, Yuzuneu Yil University Medical Faculty, Van. Results- Cultures from bone marrow and ascites yielded growth of Brucella melitensis and Brucella standard tube agglutination was found to be positive at a titer of 1/1280. The patient completely recovered by the sixth week following combined antibacterial treatment of ciprofloxacin, rifampin and doxychline. Conclusion- Brucellosis is a multisystemic disease, which may be manifested by various symptoms. Our case is the first case of brucellosis to be reported in the literature with the rare association of severe complications of hearing loss, ascites and pancytopenia.
Chronic Hepatitis Delta Virus Infection in Van Region of Eastern Turkey
(2005) Türkdoǧan, M.K.; Bozkurt, H.; Uygan, I.; Tuncer, I.; Irmak, H.; Buzgan, T.; Akdeniz, H.
Background/aims: Hepatitis delta virus infection is an important cause of liver morbidity and mortality worldwide. In Eastern Turkey, hepatitis B virus infection is the major cause of chronic liver diseases. We aimed to research the role of hepatitis delta virus infection in chronic liver diseases related to hepatitis B virus infection in the Van region of Eastern Turkey. Methods: Serological markers of hepatitis B virus and hepatitis delta virus infection [HBsAg, HbeAg, Anti-HBe and Anti- hepatitis delta virus total (IgM+IgG)] were determined by ELISA test in patients with chronic hepatitis and cirrhosis. Serum hepatitis B virus DNA was determined by polymerase chain reaction (PCR) method in chronic hepatitis B patients. Results: Hepatitis delta virus infection was detected in 5% (7/138) of asymptomatic hepatitis B virus carriers, in 16% (24/148) of chronic hepatitis B patients and in 45% (34/75) of cirrhotic hepatitis B virus patients, hepatitis delta virus infection showed a three-fold increase in chronic hepatitis (p<0.01) and nine-fold increase in cirrhosis (p<0.001) compared to hepatitis delta virus carriers. Also, it was three times more frequent in cirrhosis (p< 0.001) compared to chronic hepatitis. Chronic hepatitis delta virus infection was equally distributed between sexes in patients with chronic hepatitis B virus infection, whereas chronic hepatitis B virus infection alone was three times more frequent in males (p<0.001). Mean ages of hepatitis delta virus carriers, chronic hepatitis D and hepatitis delta virus cirrhosis patients were 30.7±8 (14-65), 36±13 (19-70) and 44±16 (25-55), respectively. Conclusions: The higher prevalence of hepatitis delta virus infection in more severe form of hepatitis B virus infection suggests that hepatitis delta virus infection increases the severity of chronic hepatitis B virus infection in the Van region, hepatitis delta virus infection remains a second major cause of chronic liver diseases in Eastern Turkey in spite of its decreasing prevalence in Western countries and in Western Turkey.
The Comparative Effects of Pentoxifylline and Ursodeoxycholic Acid on Il-1β, Il-6, Il-8 and Tnf-Α Levels in Nonalcoholic Fatty Liver
(2003) Tuncer, I.; Uygan, I.; Dülger, H.; Türkdoǧan, K.; Şekeroǧlu, R.; Kösem, M.
Objective: To investigate the comparative effects of the pentoxifylline (PTX) and ursodeoxycholic acid (UDCA) on IL-1β, IL-6, IL-8 and TNF-α in non-alcoholic fatty liver (NAFL) cases. Method: Twenty-eight cases diagnosed to have NAFL were included in our study. The cases were divided into 3 groups. 20 mg/kg/day PTX was given to the subjects in group A (6 male, 4 female), 15 mg/kg/day UDCA was given to the subjects in group B (5 males, 5 females) for 6 months. The cases in group C (5 male, 3 female) were followed as control group. The biochemical values and cytokine levels of the cases were evaluated before and at the end of the sixth month of the treatment. Results: When compared with the serum cytokine levels before and after the treatment, IL-8 and TNF-α levels were found to be significantly decreased both in group A and group B (p< 0.05), whereas there was no statistically significant change in IL-1β and IL-6 levels (p > 0.05). Conclusion: While PTX and UDCA significantly decreased the serum IL-8 and TNF-α levels in NAFL, their effects on IL-1β and IL-6 were not significant.
Comparison of Serum Cytokeratin-18, Cea and Ca 19-9 Levels in Esophageal and Gastric Cancers
(2004) Tuncer, I.; Dülger, H.; Uygan, I.; Öztürk, M.; Kotan, Ç.; Şekeroǧlu, R.
The aim of this study was to determine clinical value of alone and combined use of serum cytokeratin (CK)-18, carcinoembryonic antigen (CEA) and CA 19-9 in esophageal squamous cell carcinoma and gastric adenocarcinoma. Serum tumor markers were measured in 60 patients who had esophageal squamous cell carcinoma or gastric adenocarcinoma. Thirty healthy subjects served as controls. In patients with gastric adecarcinoma serum CK-18 levels were significantly increased compared to both esophageal squamus cell carcinoma and control groups (p<0.01, p<0,05 respectively). But there was no significant difference in CK-18 levels between esophageal squamous cell carcinoma patients and healthy subjects (p>0.05). On the other hand, serum CEA and CA 19-9 levels did not differ between groups (p>0.05). The sensitivity of serum CK-18, CEA and CA19- 9 in esophageal squamous cell carcinoma were 53%, 70% and 66%, respectively. For gastric adenocarcinoma, the sensitivity of each tumor marker was similar 70%, 70% and 70%, respectively. CK-18/CA19-9 combination in the esophageal (83%) and gastric carcinomas (93%) were found to be more sensitive than other tumor markers when these markers were evaluated in combination. CEA exhibited the highest sensitivity for esophageal squamous cell carcinoma compared to CK-18, and CA19-9. However, the sensitivity of all tumor markers in gastric adenocarcinoma were similar. The combination of CK-18 and CA19-9 could increase the diagnostic sensitivity in esophageal and gastric carcinomas.
Dietary Benzo(A)pyrene and 1,2-Benzanthracene Levels in an Endemic Upper Gastrointestinal (Oesophageal and Gastric) Cancer Region of Turkey
(2003) Türkdoǧan, M.K.; Daǧoǧlu, G.; Akman, N.; Alişarli, M.; Tuncer, I.; Uygan, I.
Background: In eastern Turkey, upper gastrointestinal (oesophageal and gastric) cancers are endemic and dietary factors play an essential role in carcinogenesis. Design: Laboratory analysis of benzo(a)pyrene (BP) and 1,2-benzanthracene (BA) levels in a range of cooked foods in use in the Van region. Materials and Methods: BP and BA levels (ppb) in bread and cooked meat samples were determined by high performance liquid chromatography. An analysis of variance and the multitest were used. Results: The mean BP level was highest in bread baked in a bakery using fuel oil (3.32 ppb), followed by bread baked in an oven burning dried dung, fatty pizza cooked using a wood fire and meat roasted on a liquid petroleum gas (LPG) fire (2.51, 2.37 and 2.32 ppb, respectively; p>0.05). The mean BP level in bread baked in a bakery using fuel oil was significantly higher than that in meat roasted in an oven burning dried dung, bread baked in an oven using wood fire and meat cooked using a wood fire (2.03, 1.54 and 1.39 ppb, respectively, p<0.01). Mean BA levels were highest in bread baked in an oven burning dried dung and bread baked in a bakery using fuel oil (1.06 and 1.04 ppb, respectively), followed by meat roasted using a LPG fire, fatty pizza cooked using a wood fire and meat roasted in an oven burning dried cow dung (0.91, 0.77 and 0.73 ppb, respectively, p>0.05). The mean BA levels in bread baked in an oven burning dried dung and bread baked in a bakery using fuel oil were significantly higher than those in bread baked in an oven using a wood fire and meat cooked using a wood fire (0. 55 and 0.55 ppb, respectively, p<0.01). The mean BP levels were two to three times more elevated than the mean BA levels in all food samples. Conclusions: These findings reveal the carcinogenic role of traditional foods baked or cooked using animal manure or fuel oil in the Van region because of high BP and BA levels.
Dietary Nitrate and Nitrite Levels in an Endemic Upper Gastrointestinal (Esophageal and Gastric) Cancer Region of Turkey
(2003) Türkdoǧan, M.K.; Testereci, H.; Akman, N.; Kahraman, T.; Kara, K.; Tuncer, I.; Uygan, I.
Background/aims: The aim of this study was investigate nitrate and nitrite levels in some traditional foods and drinking water in Van, an endemic upper gastrointestinal (esophageal and gastric) cancer region of Eastern Turkey. Methods: Cheese with added herbs, drinking; water, bread baked by wood fire and bread baked by burning animal manure specimens collected in the Van region were analyzed by Stahr's modification method. Nitrite was reduced to nitrate by the following three reagents: hydrazine sulphate ((NH2) 2SO4), CuSO4 and NaOH. Nitrate was then determined by coupling reagent containing sulphanlyamide, phosphoric acid and N-1-naphtyl ethylendiamine dihydrochloride. Results: Nitrate and nitrite levels of all traditional foods and nitrite levels of drinking water were very significantly elevated compared to standard values (p<0.001-0.01). Conclusions: These findings suggest that the influence of a traditional diet rich in nitrate and nitrite is significant in the development of endemic upper gastrointestinal (esophageal and gastric) cancers in the Van region of Turkey.
Hepatoprotective Effect of Foeniculum Vulgare Essential Oil: a Carbon-Tetrachloride Induced Liver Fibrosis Model in Rats
(2004) Öbek, H.; Uǧraş, S.; Bayram, I.; Uygan, I.; Erdoǧan, E.; Öztürk, A.; Huyut, Z.
Hepatoprotective activity of Foeniculum vulgare (fennel) essential oil was studied using a carbon tetrachloride-induced liver fibrosis model in rats. The hepatotoxicity produced by chronic carbon tetrachloride administration was found to be inhibited by Foeniculum vulgare essential oil with evidence of decreased levels of serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and bilirubin. Histopathological findings also suggest that Foeniculum vulgare essential oil prevents the development of chronic liver damage. The changes in body weights in the rats assigned to the study groups supported these biochemical and histopathological findings. The results of this study clearly indicate that Foeniculum vulgare essential oil has a potent hepatoprotective action against carbon tetrachloride-induced liver fibrosis in rats.
The Serum Levels of Il-1β, Il-6, Il-8 and Tnf-Α in Nonalcoholic Fatty Liver
(2003) Tuncer, I.; Özbek, H.; Topal, C.; Uygan, I.
Nonalcoholic fatty liver (NAFL) has an extensive clinical spectrum ranging from simple fatty liver to steatohepatitis and cirrhosis. Its pathogenesis is multifactorial. The aim of our study was to measure the serum levels of some cytokines (IL-1β, IL-6, IL-8 and TNF-α), which are thought to play a role in the pathogenesis of NAFL. Thirty subjects (18 males, 12 females) with clinical and laboratory features of hepatosteatosis were enrolled in the study as the patient group (group 1) and 30 healthy subjects (21 males, 9 females) served as controls (group 2). The levels of hepatic transaminases, gamma-glutamyltransferase, alkaline phosphatase, total cholesterol, IL-1β, IL-6, IL-8 and TNF-α were studied in both patients and controls. Serum IL-1β, IL-6, and TNF-α levels did not display significant differences between the patients and the controls (P > 0.05). On the other hand, the IL-8 level was significantly elevated in the patient group (P < 0.05). This increased level may play a more active role in the pathogenesis of fatty liver than IL-1β, IL-6 and TNF-α. Further studies are needed to elucidate to what extent the proinflammatory cytokines (especially IL-8 and TNF-α) are involved in the pathogenesis of NAFL.
Upper Esophageal Stenosis in a Case With Rothmund-Thomson Syndrome
(2001) Tuncer, I.; Metin, A.; Uǧraş, S.; Uygan, I.
Rothmund-Thomson Syndrome is an autosomal recessive disease that may be accompained by development abnormalities. Etiology of the disease has been postulated to DNA repair deficiency and intestinal anomaly has been very rarely. The case of RTS. admitted with dysphagia due to esophagus stenosis and his complaints disappeared completely after esophagus dilatation, was discussed ill the light of literature aknowledgement.