Browsing by Author "Uzun, M"
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Article Effects of Prolonged Intravenous of Flunixin Meglumine in Healthy Dogs(veterinarni A Farmaceuticka Univerzita Brno, 2003) Erdogan, HM; Gunes, V; Gokce, HI; Uzun, M; Citil, M; Yuksek, NThis study was designed to evaluate possible side effects on liver and kidney functions and haematological indices, associated with long-term intravenous (IV) administration of flunixin meglumine in healthy dogs. For this purpose, 12 dogs were divided into 2 equal groups. Group 1 was intravenously given flunixin meglumine at the dose of 1.1 mg/kg/day for 5 days and g-roup 11 received 2.2 mg/kg/day IV for 5 days. Blood samples were withdrawn before treatment (day 0), 2 h post injection on each day of treatment and one day after the last injection for biochemical (glucose, sodium-Na, potassium-K, chloride-Cl, creatinine, urea, alkaline phosphatase-AP, alanine amino transferase-ALT and total protein) and haematological (bleeding time, coagulation time, red blood cell, white blood cell, platelet count, differential leukocyte count, haematocrit and haemoglobin) analyses. Faecal and urine samples were collected on the same days as blood samples for the presence of any abnormalities. The results revealed a significant increase in bleeding (P < 0.001) and coagulation time (P < 0.001) and a decrease in platelet count (P < 0.001) in both groups. There was also a significant increase in the concentration of Na and Cl in group 1 and an elevation in AP (P < 0.00 07 ALT (P < 0.001) and glucose (P < 0.001) in group II. Blood in urine and faeces was also evident in both groups. The results may suggest that the dose of 1.1 mg/kg IV for 5 d does not cause any significant side effects provided that no bleeding disorder exists. and the dose of 2.2 mg/kg IV for 5 d should not exceed 3 d as liver enzymes began to increase significantly afterwards.Article The Electrocardiogram of the Pekin Duck(Amer Assoc Avian Pathologists, 1996) Cinar, A; Bagci, C; Belge, F; Uzun, MIn this study, standard limb lead electrocardiograms (EGG) were recorded in 50 Pekin ducks. The ECG exhibited P, R, S, and T waves. A Q wave was observed in 30% of leads aVR aVL. All waves in lead I were of very low amplitude or almost isoelectric. The P wave was 20% negative, 80% positive in lead aVR and always positive in other leads. The duration and amplitude of P wave were 0.025 sec and 0.17 mV, respectively and the P-R interval was 0.06 sec in lead II. A Q wave was observed in 30% of leads aVR and aVL but was invisible in other leads. The duration of QRS complex was 0.036 sec and its amplitude was 0.069 mV. The S wave (rS) was greater than the R wave in leads III and aVE The R and S waves were equal in lead III (66%). The mean duration and amplitude of T wave were 0.05 sec and 0.22 mV, respectively. The T wave was negative in leads aVR and aVL and positive in other leads. The Q-T interval was 0.10 sec. The mean heart rate was 281.3 (220-375) beats/min. The average value of the mean electrical axis was +147 degrees (+95 degrees to -160 degrees).