Browsing by Author "Yörük, M"

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Distribution of Mast Cells in Lung Tissues of Rats Exposed To Biomass Smoke
(Scandinavian Federation Laboratory Animal Science, 2004) Kanter, M; Yörük, M; Özbay, B; Karaca, T; Acar, S; Coskun, O
This study was designed to evaluate the distribution of mast cells in the lung tissues of rats exposed to biomass smoke. Fifty six female Wistar albino adult rats were used. They were divided into two experimental groups (control and biomass smoke-treated), each containing 28 animals. Control rats were not exposed to the biomass smoke at any time during the experiment. Rats in the treatment group were exposed daily (one hour) to biomass smoke for 3, 6 or 9 months. Lung tissues samples were obtained under deep anesthesia from the randomly selected 7 animals in both groups. Lung tissues were fixed in Mota's fixative (BLA) for 24 h and embedded in paraffin. Sections of 6 put thickness were cut and stained with 0.5% toluidine blue in 0.5 N hydrochloric acid at pH 0.5 for 30 min. The numbers of mast cell in lung tissues of the animals exposed to the biomass for 6 or 9 months were significantly (P<0.05) higher than controls. This study showed that long term exposure to biomass smoke was associated with the increased number of mast cells in the lung.
The Effects of Carbon Tetrachloride (Ccl4) Induced Experimental Acute and Chronic Intoxication on Histological Structure of Liver and Some Hematological Values and Electrocardiogram in Rabbits
(Scientific Technical Research Council Turkey, 1999) Çinar, A; Yörük, M; Meral, I; Kiliçalp, D; Koç, A; Ertekin, A
This paper reports an investigation of the effects of acute and chronic carbon tetrachloride intoxications on the histologic structure of the liver and hematological values and electrocardiograms in rabbits. The rabbits were divided into 3 groups of 7. The first group was the control group, the second group was acutely intoxicated and the third group was chronically intoxicated. In the acutely intoxicated group, caryorexsis, along with necrosis was observed in the hepatocyte of the centrolobular area of the liver. In the chronically intoxicated group, connective tissue mass around the V. centralis increased. This increase of connective tissue caused chirrosis. Hematological values of the groups were as follows: red blood cells 5.86+/-0.6, 5.95+/-1.5, 4.26+/-0.7 billion/mm(3); white blood cell: 6.9+/-1.35, 5.90+/-0.8, 4.0+/-2.44 thousand/mm(3); hemoglobin concentration: 12.7+/-0.9, 13.6+/-1.5, 11.8+/-1.2 gr/dl; hematocrit value: 41.8+/-3.3, 44.6+/-4.9, 33.0+/-4.4%; sedimentation: 5.2+/-1.6, 8.0+/-2.8, 10.2+/-1.3 45 degrees/1 hours respectively. The formula leukocyte was as follows: in the control group: neutrophil 34+/-5.3%, eosinophil 0.6+/-0.8%, basophil 0.2+/-0.4%, lymphocyte 62+/-5.02%, monocyte 3.2+/-0.97%. In the acutely intoxicated group: neutrophil 7.75+/-1.1%; eosinophil 1+/-0%; basophil 0+/-0%; lymphocyte 88.5+/-1.3%; monocyte 3.5+/-1.8%. In the chronically intoxicated group: neutrophil 60+/-8.51%; eosinophil 1+/-0.71%; basophil 0+0%: lymphocyte 35.75+/-7.33%; monocyte 3.2+/-0.83%. The extremity leads and 2 vertical and 1 horizontal chest leads were used in the electrocardiograph of the rabbits, All waves were observed in all derivations. The P and T waves were negative in the III and aR leads and positive in the other leads, The amplitudes of waves decreased (hypo voltage) as a result of intoxication. In the groups, the heart rates were 219+/-21 in the control. 215+/-17 in the acutaly intoxicated, 201+/-35 per minute in the chronically intoxicated and the mean electrical axes of the heart rate were 45 degrees+/-20, 50 degrees+/-27. 35 degrees+/-20 respectively. Statistical comparisons were carried out using analysis of variance and Q test.