Browsing by Author "Yürektürk, E."

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Carotid Intima-Media Thickness and Lipid Profile in Children Patients With Hypothyroidism
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Çetin, M.; Eren, A.; Bitkin, E.Ç.; Yürektürk, E.; Goya, C.; Karaman, K.
Hypothyroidism is a condition where there is a decrease or absence of thyroid hormone production as a result of a disorder occurring anywhere in the hypothalamo-pituitary-thyroid axis. There are very few studies in the literature reporting on the effect of hypothyroidism on lipid metabolism and carotid intima-media thickness (CIMT) in children. The present study was designed to determine whether hypothyroidism is associated with an increase in the CIMT and lipid levels in patients under thyroid hormone replacement therapy. The study included 30 children (under thyroid hormone replacement therapy) diagnosed with hypothyroidi and a control group comprising 30 healthy, euthyroid children. All the patients were examined for clinical characteristics, and the serum lipid levels and the CIMT were measured. Mean age was 8.47 ± 5.22 years in the patient group and 8.82 ± 4.91 years in the control group. Patient group TSH value was significantly higher than control group (9.95 ± 18.43, 1.93 ± 1.04, p = 0.021, respectively). The t otal cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and TG values were similar in both group (p = 0.065, p = 0.429, p = 0.219, and 0.391, respectively). CIMT values of the patient and control groups did not differ significantly ( 0.40 ± 0.08 and 0.39 ± 0.07, p = 0.920, respectively) In this study, contrary to the rare studies in the children's age group in the literature, no significant changes in lipid pr ofile and CIMT were detected in patients with hypothyroidism. Further prospective studies are needed to substantiate these findings in children with hypothyroidism. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Case Series: 11 Cases of Hemolytic Disease of the Fetus and Newborn Due To Kell Blood Group Incompatibility
(Yuzuncu Yil Universitesi Tip Fakultesi, 2024) Yürektürk, E.; Aycan, N.; Başaranoğlu, M.; Arslan, B.; Tuncer, O.
Hemolytic disease of the fetus and newborn (HDFN) results from the destruction of the newborn's red blood cells or the fetus by the mother's immune globulin G antibodies. Although HDFN is often caused by RhD and ABO incompatibility, it can also be seen due to minor blood groups such as Kell, Kidd, Duffy, P, MNS, or Rh subgroup (C, c, E, e) alloantibodies. Our study aims to share our experiences regarding a rare cause of HDFN. The files of patients who were followed up with the diagnosis of jaundice in a third-level Neonatology Unit of a university hospital between January 2014 and September 2023 were retrospectively examined. Eleven patients with Kell incompatibility were included in the study. There was no ABO/RhD incompatibility in any case. RhD subgroup incompatibility and Kell incompatibility were present in four cases. Phototherapy was applied to all patients. The patient, whose total bilirubin level was high despite phototherapy, was treated with an exchange transfusion. No complications were observed due to treatment or high total bilirubin. No significant difference was observed between the parameters evaluated according to the gender variable. It should be kept in mind that severe hemolysis and related deaths may occur due to Kell incompatibility. In order to reduce and prevent severe hemolysis due to Kell and other minor blood groups in newborns, transfusing blood products suitable for minor blood groups to women of childbearing age (especially pregnant women) may be a correct approach as a country policy. © 2024, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.