Browsing by Author "Yaşar, S."

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Effect of Exercise on Erythrocyte Osmotic Fragility in High Fat Diet Fed Rats During Intermittent Fasting
(Yuzuncu Yil Universitesi Tip Fakultesi, 2017) Yaşar, S.; Günbatar, N.; Yüksek, S.; Arıhan, O.; Oto, G.
Exercise is an important component of a healthy lifestyle. High fat diets are blamed for various health problems such as cardiovascular diseases. Intermittent fasting is a way of increasing longevity and decreasing certain adverse health conditions. In this study effect of exercise, intermittent fasting and high fat diet on erythrocyte osmotic fragility which is an important marker of erythrocyte integrity was investigated. 42 Wistar albino male rats were used in this study. Rats were divided into 7 groups in which each were composed of 6 animals. Exercise was administered 3 times a week. Intermittent fasting was administered 2 times a week (24 without any food in those two days). High fat was given in a high fat diet. Combination of applications was also administered in different groups. Results state an increase in erythrocyte osmotic fragility due to exercise. High fat or intermittent fasting did not cause in increase in fragility however they did not alleviate increased fragility due to exercise where they are concomitantly administered with exercise. Intermittent fasting administered solely or with high fat did not change erythrocyte osmotic fragility therefore stating no negative impact of intermittent fasting on this studied parameter. However no protective effect was observed in IF+Exe group. This result can also be interpreted with high impact of Exe in this study on the rats. Studies including molecular mechanism focusing on erythrocyte membrane lipid alterations should be performed to clarify current findings. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
A Novel Biosensor for Gabapentin Drug Detection Based on the Pd-Decorated Aluminum Nitride Nanotube
(Springer, 2021) Yaşar, S.; Hosseinian, A.; Ebadi, A.; Ahmadi, S.; Ebrahimiasl, S.; Kumar, A.
Density functional theory calculations were performed to inspect the potential application of pristine AlN nanotube (AlNNT) as well as Pd-decorated AlNNT (Pd@AlNNT) in recognition of gabapentin (GB) drug. The sensing response of AlNNT to the GB drug is very small (~ 5.2 at 298 K) attributed to the small adsorption energy (AE) of −0.16 eV. Molecular orbital energy decomposition method (EDA) showed that the contributions of electrostatic attraction, Pauli repulsion, orbital relations, and dispersion forces in the AE are about −0.21, 0.19, −0.11, and −0.09 eV, respectively. A Pd atom preferentially adsorbed over an Al–N bond of the AlNNT, releasing the energy of 2.93 eV. We found that the GB strongly adsorbed on the Pd@AlNNT with AE of −1.29 eV and the sensing response increased to 524.6 by the Pd decoration. Based on the results, the main stabilization contribution to the AE of GB on the Pd@AlNNT comes from the electrostatic attraction based on the EDA analysis. The recovery time was achieved to be 1.8 s for the GB desorption from the Pd@AlNNT surface. Finally, we concluded that the Pd@AlNNT can transform the presence of GB molecules into electrical signal, and it may potentially be applied as an electronic sensor for GB drug detection. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Retraction Note: a Novel Biosensor for Gabapentin Drug Detection Based on the Pd-Decorated Aluminum Nitride Nanotube (Structural Chemistry, (2021), 32, 5, (1961-1971), 10.1007/S11224-021-01771-5)
(Springer, 2023) Yaşar, S.; Hosseinian, A.; Ebadi, A.; Ahmadi, S.; Ebrahimiasl, S.; Kumar, A.
The Editor-in-Chief and Publisher have retracted this article because they have been unable to validate the content of this article. An investigation by the Publisher found evidence suggestive of attempts to inappropriately obtain or allocate authorship. The article also appears to contain inappropriate or irrelevant references. Akram Hosseinian does not agree to this retraction. Semih Yaşar, Abdolghaffar Ebadi, Sheida Ahmadi and Saeideh Ebrahimiasl have not responded to any correspondence from the editor or publisher about this retraction. Ajit Kumar has not explicitly stated whether they agree to this retraction notice. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.