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Browsing by Author "Yalcin, Bahattin"

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    Synthesis of New Axially Coumarin Disubstituted Silicon(IV) Phthalocyanines, Investigation of Their Dna-Binding Properties and Inhibitory Activities on Ache and Buche
    (Bentham Science Publ Ltd, 2025) Gunes, Ahmet; Meletli, Furkan; Danis, Ozkan; Agirtas, Mehmet Salih; Yalcin, Bahattin
    Introduction In this study, we report on the synthesis and characterization of new silicon (IV) phthalocyanine compounds (SiPcs) axially substituted with coumarin-linked derivatives, designed for potential application in photodynamic therapy (PDT) due to their photophysical properties.Methods Characterization was carried out using FT-IR, UV-Vis, MALDI-TOF-MS, and 1H NMR spectroscopy. In dimethyl sulfoxide (DMSO), the SiPcs produced singlet oxygen with quantum yields of 0.17 to 0.19, assessed by the DPBF quenching method. DNA binding studies via UV-Vis spectroscopy and molecular docking suggested high binding affinities (Delta G0 values between -9.90 to -10.4 kcal/mol) and stable interactions with calf thymus DNA (ct-DNA).Results The compounds showed promising inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), with IC50 values indicating higher potency and selectivity compared to galantamine, a known cholinesterase inhibitor.Conclusion The combined singlet oxygen generation, DNA binding, and enzyme inhibition data underscore the potential of these SiPc-coumarin derivatives as multifunctional agents for PDT and neuroprotective applications such as Alzheimer's disease (AD).