Browsing by Author "Yalcin, S."

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Dietary Vitamin E (α-Tocopherol Acetate) and Selenium Supplementation From Different Sources: Performance, Ascites-Related Variables and Antioxidant Status in Broilers Reared at Low and Optimum Temperatures
(Taylor & Francis Ltd, 2007) Ozkan, S.; Malayoglu, H. Basmacioglu; Yalcin, S.; Karadas, F.; Kocturk, S.; Cabuk, M.; Ergul, M.
1. This study compared the effect of dietary supplementation with organic or inorganic selenium (Se) sources plus control amounts or large amounts of vitamin E (alpha- tocopherol acetate) in broilers raised at control ( 20 to 24 degrees C) or low ( 14 center dot 5 to 16 center dot 8 degrees C) temperatures after 2 weeks of age. 2. The following dietary treatments were used from one day old. Diet 1, the control diet, comprised a commercial diet containing 0 center dot 15 mg/ kg inorganic Se and 50 mg vitamin E/kg feed. Diet 2 was the same as diet 1, supplemented with 0 center dot 15 mg/ kg inorganic Se. Diet 3 was the same as diet 2 but was supplemented with 200 mg/ kg vitamin E. Diet 4 was the same as diet 1, but inorganic Se was replaced with 0 center dot 30 mg/ kg organic Se. Diet 5 was the same as diet 4, supplemented with 200 mg/ kg vitamin E. 3. Low temperature reduced the growth rate of broilers; however, at 6 weeks, there were no differences in the body weights of birds fed on organic Se supplemented diets housed at low or control temperature. The feed conversion ratio was significantly affected by low temperature but not by diet. The heterophil/ lymphocyte ratio was higher in chicks after one week in the cold, indicating mild stress. Blood triiodothyronine levels were significantly higher in birds after 1 and 4 weeks in the cold but thyroxin was not affected. 4. Organic Se supplementation increased relative lung weight at the control temperature, which might lead to greater respiratory capacity. Relative spleen weight significantly decreased in broilers fed diets supplemented with inorganic Se under cold conditions, a possible indication of chronic oxidative stress. 5. At the low temperature, supplementation with organic Se alone, or with inorganic Se and vitamin E increased glutathione peroxidase ( GSHPx) activity and glutathione ( GSH) concentration in the liver of broilers, which may indicate increased activity of birds' antioxidant defence against suboptimal environments.
End-Of Results of Turkish Gastric Cancer Patients From the Global Regate Study
(Zerbinis Publications, 2014) Yalcin, S.; Gumus, M.; Kilickap, S.; Alkis, N.; Ilhan, M.; Oksuzoglu, B.; Demir, G.
Purpose: Registry of Gastric Cancer Treatment Evaluation (REGATE) study was an international, prospective study including over 10000 patients from 22 countries, designed to describe the pattern of care in gastric cancer globally. The aim of this study was to summarize the data of the Turkish arm and compare them with the global results. Methods: Ten centers from Turkey took part in the REGATE registry. Between 2004 and 2008, 395 patients (median age, 60 years; range, 18-91, 67.6% men) with newly diagnosed primary adenocarcinoma of the stomach were followed at initial visit and 8-10 months later, at the time of treatment completion. Data on patient demographics, medical history, histopathology, cancer stage, planned and realized treatments was prospectively collected. Data processing and analysis were conducted centrally. Results: In Turkey, the majority of patients were diagnosed at an advanced stage, while the rate of surgery was lesser compared with the rest of the world. Realized treatment included more palliative-only therapy than initially planned (63.3%), while no therapy was recommended in 21.8%. Surgery involved total gastrectomy (46.3%) or distal subtotal gastrectomy (51.9%), with 87% R0 resection, 51.0% D1 and 44.9% D2 lymph node dissection. Combination chemotherapy was administered in more than half of the patients receiving palliative therapy (57.9%). Chemoradiotherapy was used in 66.7% of the cases receiving adjuvant therapy. Radiotherapy was applied to 32% of the cases receiving palliative therapy. Conclusion: Advanced stage gastric cancer is highly prevalent in Turkey. Increasing public awareness and implementing screening programs in high risk groups may help identify gastric cancer at earlier stages.
First-Line Anti-Egfr Agents (Panitumumab or Cetuximab) Plus Chemotherapy in Patients With Metastatic Colorectal Cancer: Onco-Colon Turkey Study Subgroup Analysis
(Elsevier, 2022) Isikdogan, A.; Turk, H.; Bilir, C.; Sendur, M.; Karabulut, B.; Artac, M.; Yalcin, S.
The Nutritive Value of Modified Dried Vinasse (Pro Mass) and Its Effects on Growth Performance, Carcass Characteristics and Some Blood Biochemical Parameters in Steers
(Ecole Nationale veterinaire Toulouse, 2010) Yalcin, S.; Eltan, Oe; Karsli, M. A.; Yalcin, S.
This study was conducted to determine the chemical composition and rumen degradability characteristics of modified dried vinasse (ProMass) originating from bakers yeast production and to investigate its effects on steer performance, carcass characteristics and some blood parameters. This additive compound with an elevated metabolizable energy (2 800 kcal/g) contained a marked proportion of crude proteins which were remarkably rich in glutamic acid. The degradation of dry matter and organic matter measured in rumens from 4 crossed sheep was very high (about 900 g/kg) during the first 4 hours and the ProMass crude protein was markedly soluble. Forty-five steers were randomly allotted in 3 equal groups according to the mixed diet regimen (concentrates plus forage): concentrates supplemented with 40 g/kg or 80 g/kg ProMass were distributed to assay groups for 24 weeks whereas one group was not supplemented and served as negative control. Growth performance and food efficiency was slightly increased but not significantly in supplemented steers and faecal moisture and serum biochemical profiles (urea, protein and cholesterol concentrations and AST, ALT and ALP activities) were unchanged compared to controls. ProMass supplementation has induced significant reductions of the heart and pelvic fat weights whereas the dressing percentages and the other carcass characteristics remained unaffected. These results showed that ProMass supplies highly soluble proteins, can be included in the steer ration up to 80 g/kg without adverse effects and would promote fat utilization.
Photoperiodic Lighting (16 Hours of Light:8 Hours of Dark) Programs During Incubation: 1. Effects on Growth and Circadian Physiological Traits of Embryos and Early Stress Response of Broiler Chickens
(Oxford Univ Press, 2012) Ozkan, S.; Yalcin, S.; Babacanoglu, E.; Kozanoglu, H.; Karadas, F.; Uysal, S.
This study was conducted to evaluate the effect of a 16L:8D photoperiod during incubation, either during the whole incubation period (Inc(0-21d)) or the last week of incubation (Inc(14-21d))1 on embryo growth, incubation performance, and light:dark rhythm of plasma melatonin and corticosterone in relation to early stress responses of newly hatched chicks to the posthatching environment. A dark incubation condition (Inc(Dark)) served as control. Three batches of eggs (n = 1,080, 1,320, 720) from Ross 308 broiler breeders were used in the experiment. Embryos from Inc(0-21d) presented a daily rhythm of melatonin at internal pipping and hatching, but Inc(Dark) embryos did not. The Inc(14-21d) group had rhythmic plasma melatonin at hatching only. A L:D rhythm of corticosterone was apparent at hatching. A significant incubation x sampling time interaction suggested that a lower increment in blood corticosterone level in Inc(0-21d) at 8 h posthatching (light period), as compared with hatching (dark period) values, might be associated with probable changes in the hypothalamic-pituitary-adrenal axis in Inc(0-21d) through incubation lighting. This finding may also suggest improved adaptation to the posthatching environment. Incubation lighting did not consistently affect brain malondialdehyde concentration; the only difference between groups was higher concentrations at hatching in Inc(14-21d), whereas incubation groups at the internal pipping stage had similar values. Mean relative asymmetry (RA) did not differ with incubation lighting. The malondialdehyde and RA results indicate that neither lighting nor darkness during the overall incubation exacerbated embryo oxidative and developmental stress. An increased breast muscle weight was observed at hatching only in Inc(14-21d). The Inc(0-21d) group had increased embryo weights relative to egg weight and decreased residual yolk but had no effect on chick weight, relative heart and liver (% of embryo weight), hatch-ability, embryo mortality, incubation time, oxidative stress, or mean RA. In conclusion, these results provide further evidence that photoperiodic lighting during incubation (Inc(0-21d)) may improve adaptation of chicks to a novel environment at hatching, possibly giving birds a better start for early posthatching development.
Photoperiodic Lighting (16 Hours of Light:8 Hours of Dark) Programs During Incubation: 2. Effects on Early Posthatching Growth, Blood Physiology, and Production Performance in Broiler Chickens in Relation To Posthatching Lighting Programs
(Oxford Univ Press, 2012) Ozkan, S.; Yalcin, S.; Babacanoglu, E.; Uysal, S.; Karadas, F.; Kozanoglu, H.
Photoperiodic incubation lighting might improve bird adaptation to a novel environment at hatching for a better start in early posthatching development. We evaluated the effect of 16L:8D lighting for either the whole incubation period (Inc(0-21d)) or the last week of incubation (Inc(14-21d) on early posthatching growth, blood melatonin, and corticosterone at 6 d as well as malondialdehyde levels in brain tissue, relative asymmetry, and overall broiler performance as an interaction with the posthatching lighting programs. Dark incubation conditions (Inc(Dark)) served as control. There were 3 incubation batches in the experiment. Chicks from 2 of 3 batches were reared either at 16L:8D or under continuous lighting (24 h) through 6 d posthatching. Batch 3 chicks were reared to 35 d under either 16L:8D or 23L:1D. The main finding was a significant incubation x posthatching lighting interaction for 35-d BW in broilers. Although groups had similar BW under continuous lighting, Inc(0-21d) and Inc(14-21d) broilers were respectively 94 and 78 g heavier than Inc(Dark) birds under 16L:8D at 35 d. Lighted incubation groups increased 0 to 6 d of gain and had higher d-6 breast muscle weights with no effect on other traits measured. Posthatching 16L:8D reduced the gain and d-6 breast muscle. Significant incubation x posthatching lighting and posthatching lighting x sampling time interactions for blood melatonin may indicate that Inc(0-21d) affects melatonin diurnal rhythms even at 6 d under continuous light. Lower blood corticosterone levels on d 6 in Inc(0-21d) chicks reared under 16L:8D posthatching may support our hypothesis that incubation lighting can modify the bird stress response, probably affecting the hypothalamic-pituitary-adrenal axis during ontogeny, and may improve adaptation to a similar environment posthatching. The lower malondialdehyde concentration in brain tissue of Inc(0-21d) birds on d 6 may indicate lower lipid peroxidation and thus lower oxidative stress compared with Inc(Dark). These results provide further evidence that Inc(0-21d) may improve both bird adaptation to a similar photoperiodic environment and growth, probably through early entrainment of circadian physiology.