Browsing by Author "Yaman, Mehmet"

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Akut Koroner Sendrom Hastalarında Syntax Skoru İle Epikardiyal Yağ Doku Arasındaki İlişki
(2021) Kilinc, Ali Yasar; Öztürk, Fatih; Atıcı, Adem; Okudan, Yunus Emre; Sımsek, Hakkı; Demir, Koray; Yaman, Mehmet
Amaç: Çalışmanın amacı akut koroner sendromlu (AKS) hastalarda epikardiyal yağ dokusu (EYD) kalınlığı ile SyntaxSkoru arasındaki ilişkiyi değerlendirmektedir. Yöntemler: Çalışmaya AKS geçiren 200 ve AKS geçirmemiş olan 150 hasta dahil edilmiştir. Her hasta için sistolik(S-EYD)ve diyastolik(D-EYD) EYD kalınlığı ölçülmüştür. EYD kalınlığı ve EYD ile Syntax Skoru arasındaki ilişki hastalar ve kontrolgrupları arasında karşılaştırılmıştır. Bulgular: Hastalar ve kontrol grubu karşılaştırıldığında yaş, vücut kitle indeksi, hipertansiyon ve diyabet varlığı anlamlıolarak farklı iken, tütün kullanımı ve hiperlipidemi varlığı açısından her iki grup arasında farklılık saptanmamıştır. HemS-EYD hem de D-EYD kalınlığı her iki grup arasında farklı olarak bulunmuştur (5.57±1.15 vs. 4.47± 0.60, p<0.001; 3.18±0.81 vs. 2.71±1.90, p=0.014, sırasıyla). Hasta grubunda EYD kalınlığı Syntax Skoru ile önemli bir korelasyon göstermiştir (p<0.001; r=0.740). Sonuç: EYD kalınlığı hasta grubunda daha fazla bulunmuş ve Syntax Skoru ile anlamlı bir korelasyon göstermiştir. Budurum bize hastalara koroner anjiografi yapmadan önce hastalığını ciddiyetini, noninvaziv bir yöntemle belirleme fırsatısunmaktadır.
Compliance With Dyslipidemia Guidelines in Daily Practice: How Effective Is Cardiovascular Risk Prevention
(Elsevier, 2018) Guntekin, Unal; Gumrukcuoglu, Hasan Ali; Yaman, Mehmet; Ozturk, Fatih; Akyol, Aytac; Gumrukcuoglu, Fatma Nur; Kandemir, Yasemin Behram
Purpose: Cardiovascular disease (CVD) due to atherosclerosis is the leading cause of early mortality and morbidity. The current European guidelines on CVD prevention in clinical practice recommend the use of the Systematic Coronary Risk Estimation (SCORE) system. The current American Heart Association guidelines recommend the use of the new pooled cohort risk assessment equations to estimate the 10-year atherosclerotic CVD risk. The purpose of this article was to investigate the compliance of dyslipidemia guidelines in daily practice in patients with dyslipidemia or who have risk factors for CVD. Methods: The study group consisted of 500 outpatients who had dyslipidemia or risk factors for CVD. The risk level was computed according to the European and American Heart Association guidelines. Therapeutic LDL-C targets were identified based on the calculated risk level. Therapeutic target levels were compared based on the dosage of statins used and achievement of the LDL-C goal in daily practice according to the risk levels. Findings: According to the European dyslipidemia guidelines, 231 patients were in the very-high/high-risk group, and 106 patients (45.9%) achieved the LDL-C target (<100 mg/dL); 210 patients were in the moderate-risk group, and 156 (74.3%) patients achieved the LDL-C target (<115 mg/dL); and 59 patients were in the low-risk group, and 55 (93.2%) patients achieved the LDL-C target (<155 mg/dL). Univariate and multivariate logistic regression analyses revealed that the LDL-C level and presence of coronary artery disease were significantly reverse associated with achievement of the LDL-C goal (both, P < 0.001). (C) 2018 Elsevier Inc. All rights reserved.
Decreased Risk of Ventricular Arrhythmias With Treatment of Nebivolol in Patients With Coronary Slow Flow
(Via Medica, 2016) Simsek, Hakki; Yaman, Mehmet; Babat, Naci; Akdag, Serkan; Akyol, Aytac; Demirel, Koray Celal; Gunes, Yilmaz
Background: Coronary slow-flow (CSF) is an angiographic phenomenon characterised by delayed opacification of vessels in the absence of any evidence of obstructive epicardial coronary disease. QT interval dispersion (QTD) reflects regional variations in ventricular repolarisation and cardiac electrical instability and has been reported to be longer in patients with CSF. Aim: To examine QT duration and dispersion in patients with CSF and the effects of nebivolol on these parameters. Methods: The study population included 67 patients with angiographically proven normal coronary arteries and CSF, and 38 patients with angiographically proven normal coronary arteries without associated CSF. The patients were evaluated with 12-lead electrocardiography, and echocardiography before and three months after treatment with nebivolol. Results: Compared to the control group QTcmax and QTcD were significantly longer in patients with CSF (p = 0.036, p = 0.019, respectively). QTcD significantly correlated with the presence of CSF (r = 0.496, p < 0.001). QTcmax (p = 0.027), QTcD (p = 0.002), blood pressure (p = 0.001), and heart rate (p < 0.001) values significantly decreased after treatment with nebivolol. Conclusions: Coronary slow flow is associated with increased QTD. Nebivolol reduced increased QTD in patients with CSF after three months.
The Effect of Low-Sodium Dialysate on Ambulatory Blood Pressure Measurement Parameters in Patients Undergoing Hemodialysis
(Dove Medical Press Ltd, 2015) Akdag, Serkan; Akyol, Aytac; Cakmak, Huseyin Altug; Tosu, Aydin Rodi; Asker, Muntecep; Yaman, Mehmet; Gumrukcuoglu, Hasan Ali
Background: End stage renal disease is related to increased cardiovascular mortality and morbidity. Hypertension is an important risk factor for cardiovascular disorder among hemodialysis (HD) patients. The aim of this study was to investigate the effect of low-sodium dialysate on the systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels detected by ambulatory BP monitoring (ABPM) and interdialytic weight gain (IDWG) in patients undergoing sustained HD treatment. Patients and methods: The study included 46 patients who had creatinine clearance levels less than 10 mL/min/1.73 m(2) and had been on chronic HD treatment for at least 1 year. After the enrollment stage, the patients were allocated low-sodium dialysate or standard sodium dialysate for 6 months via computer-generated randomization. Results: Twenty-four hour SBP, daytime SBP, nighttime SBP, and nighttime DBP were significantly decreased in the low-sodium dialysate group (P<0.05). No significant reduction was observed in both groups in terms of 24-hour DBP and daytime DBP (P=NS). No difference was found in the standard sodium dialysate group in terms of ABPM. Furthermore, IDWG was found to be significantly decreased in the low-sodium dialysate group after 6 months (P<0.001). Conclusion: The study revealed that low-sodium dialysate leads to a decrease in ABPM parameters including 24-hour SBP, daytime SBP, nighttime SBP, and nighttime DBP and it also reduces the number of antihypertensive drugs used and IDWG.
Effect of Rhizobacteria Application on Nutrient Content, Bioactive Compounds, Antioxidant Activity, Color Properties and Fruit Characteristics of Strawberry Cultivars
(Mdpi, 2024) Elikara, Alper Umut; Popescu, Gheorghe Cristian; Demirel, Serap; Sumbul, Ahmet; Yaman, Mehmet; Demirel, Fatih; Gunes, Adem
The aim of this study was to determine the effects of single and combined applications of plant-growth-promoting rhizobacteria (PGPR) bacteria on plant nutrition, biochemical content and fruit characteristics in Albion and Monterey strawberry cultivars. Bacillus subtilis OSU-142, Bacillus megaterium M3 and Paenibacillus polymyx were the PGPR used in the experiment. For each bacterial treatment, 10 mL of a 108 CFU mL-1 suspension was applied to the soil where Albion and Monterey cultivars were grown. PGPR bacteria were applied as single treatments and a mixture of equal amounts of these three bacterial species was applied as a mixed treatment. This study was carried out with a total of four different bacterial treatments and one control group. The highest fruit weight was obtained in the Monterey cultivar with 12.67 g in the Mix treatment and in the Albion cultivar with 11.79 g in the Bacillus megaterium M3 treatment. Regarding biochemical properties, Paenibacillus polymyxa was effective in influencing nutrient element content in fruits, while Bacillus subtilis OSU-142, Paenibacillus polymyxa and Bacillus megaterium M3 applications were more effective in leaf nutrient element content. It has been observed that the Mix treatment resulting from the combined use of bacteria, rather than their separate use, has a greater impact on fruit weight. Consequently, it has been understood that PGPR bacteria are potentially effective in improving the agronomic, pomological, and biochemical characteristics of strawberry cultivars and can be used in studies and breeding programs aimed at increasing strawberry yield and quality.
Effects of Trimetazidine on T Wave Alternans in Stable Coronary Artery Disease
(Korean Soc Cardiology, 2016) Yaman, Mehmet; Arslan, Ugur; Gumrukcuoglu, Hasan Ali; Sahin, Musa; Simsek, Hakki; Akdag, Serkan
Background and Objectives: Studies reveal that the microvolt T wave alternans (MTWA) test has a high negative predictive value for arrhythmic mortality among patients with ischemic or non-ischemic cardiomyopathy. In this study, we investigate the effects of trimetazidine treatment on MTWA and several echocardiographic parameters in patients with stable coronary artery disease. Subjects and Methods: One hundred patients (23 females, mean age 55.6 +/- 9.2 years) with stable ischemic heart disease were included in the study group. Twenty-five age- and sex-matched patients with stable coronary artery disease formed the control group. All patients were stable with medical treatment, and had no active complaints. Trimetazidine, 60 mg/day, was added to their current treatment for a minimum three months in the study group and the control group received no additional treatment. Pre- and post-treatment MTWA values were measured by 24 hour Holter testing. Left ventricular systolic and diastolic functions were assessed by echocardiography. Results: After trimetazidine treatment, several echocardiographic parameters related with diastolic dysfunction significantly improved. MTWA has been found to be significantly improved after trimethazidine treatment (63 +/- 8 mu V vs. 53 +/- 7 mu V, p<0.001). Abnormal MTWA was present in 29 and 11 patients pre- and post-treatment, respectively (p< 0.001). Conclusion: Trimetazidine improves MTWA, a non-invasive determinant of electrical instability. Moreover, several echocardiographic parameters related with left ventricular functions also improved. Thus, we can conclude that trimetazidine may be an effective agent to prevent arrhythmic complications and improve myocardial functions in patients with stable coronary artery disease.
Evaluation of Genetic Diversity in Some Hybrid Individuals of Honeyberry (Lonicera Caerulea L.) Based on Fruit Characteristics, Leaf Morphology, Vitamin C, Antioxidant Activity, and Biochemical and Nutritional Contents
(Bmc, 2024) Gurcan, Kahraman; Yilmaz, Kadir Ugurtan; Tunc, Yazgan; Yaman, Mehmet; Gunes, Adem; Yildiz, Ercan; Khadivi, Ali
BackgroundGenetic diversity is a prerequisite for breeding programs, and one of the main goals here is to obtain quality products. Therefore, this study aims to evaluate the genetic diversity in some hybrid individuals of honeyberry (Lonicera caerulea L.) based on fruit characteristics, leaf morphology, vitamin C, antioxidant activity, biochemical, and nutritional content. In this context, superior quality individuals have been identified based on the 42 variables examined in our study. These hybrid individuals can be economically incorporated into production after the registration stages, and their sustainability for use in breeding programs can also be ensured.ResultsThe fruit weight ranged from 0.71 ('H11') to 1.66 g ('H6'). The ascorbic acid varied between 17.13 ('H7') and 20.64 mg AAE/100 g ('H15'). The antioxidant activity changed between 12.59 ('Store') and 15.03 mu mol Trolox g-1 ('Aurea'). The total anthocyanins were found to be highest in 'Borrel Beast' (163.79 mg cyn-3-gluc 100 g-1), followed by 'H8' (163.20 mg cyn-3-gluc 100 g-1). The highest nutrient levels in the fruits were found in the 'H10' individual, with calcium (2445.77 mg kg-1), potassium (2274.36 mg kg-1), phosphorus (2123.27 mg kg-1), magnesium (1263.95 mg kg-1), and sulfur (859.62 mg kg-1), respectively. The highest nutrient levels in the leaves were found in the 'H14' individual for calcium (19,493.21 mg kg-1), 'H5' for magnesium (5643.52 mg kg-1), 'H8' for sulfur (2312.11 mg kg-1), 'H6' for phosphorus (2007.51 mg kg-1), and 'H6' for potassium (1099.32 mg kg-1). In general, the nutrients in the fruit exhibited significant correlations among themselves at different levels (*, **, ***). Within the scope of principal component analysis, the first 8 principal components explained 80.69% of the total variance. According to the cluster and population analyses, it was determined that there was a high variation in subgroup B2. Additionally, although honeyberry is a relatively new fruit in T & uuml;rkiye, efforts have begun to develop new cultivars through hybrid breeding.ConclusionsWhen 42 variables were evaluated together to determine genetic diversity, hybrid individuals 'H14', 'H5', 'H8', and 'H1' were identified as superior individuals, respectively.
Hatay İlinde Bakısı Yapılan Kedi ve Köpeklerde Helmint Enfeksiyonları
(2006) Yaman, Mehmet; Ayaz, Erol; Gül, Abdurrahman; Muz, Mustafa Necati
Bu çalışmada 8 kedi ve 6 köpeğin otopsileri ve dışkı muayeneleri yapılmıştır. Dışkı muayenelerinde her iki hayvan grubunda %50,0 oranında enfeksiyon saptanmış olup, bir köpekte Trichuris sp. yumurtası, bir kedi ile bir köpekte de Ancylostoma sp. yumurtası bulunmuştur. Yapılan otopsi sonucunda kedilerin 7 (%87,5)'i, köpeklerin ise 2 (%33,4)'si çeşitli helmint türleri ile enfekte bulunmuştur. Otopsi bakılarında kedilerde Toxocara cati (%62,5), Joyeuxiella pasqualei (%50,0), Hydatigera taeniaformis (%25,0), Mesocestoides sp. (%12,5) ve Dipylidium caninum (%12,5); köpeklerde ise Toxocara canis (%16,7) ve D. caninum (%16,7) tespit edilmiştir. Bir kedinin karın boşluğunda çok sayıda Mesocestoides sp.'nin larvası olan tetrathyridium'lara rastlanmıştır. Kedi ve köpeklerde yüksek oranda askarit enfeksiyonlarının tespit edilmesi halk sağlığı açısından önemli bulunmuştur.
Hepatosteatosis and Carotid Intima-Media Thickness in Patients With Myocardial Infarction
(Springer Japan Kk, 2016) Ozturk, Hasan; Gumrukcuoglu, Hasan Ali; Yaman, Mehmet; Akyol, Aytac; Ozturk, Senay; Akdag, Serkan; Gunaydin, Zeki Yuksel
The aim of the study was to determine the involvement of non-alcoholic fatty liver disease (NAFLD) in myocardial infarction patients and its relation with carotid intima-media thickness (CIMT). This study consisted of 224 patients divided into three groups: those with myocardial infarction (MI), stable coronary artery disease (CAD), and normal coronary artery. Measurement of CIMT and abdominal ultrasonography for hepatosteatosis was performed in all participants. NAFLD was significantly more frequent among MI patients compared to the other groups. There was a significant difference between CAD and the presence of NAFLD (p < 0.05). Also, we found significant correlations between the severity of CAD and hepatosteatosis grade (r = 0.648, p < 0.001), CAD and CIMT (r = 0.594, p < 0.001), and NAFLD and CIMT (r = 0.233, p = 0.005). NAFLD was also significantly correlated with the severity of CAD (r = 0.607, p < 0.001), and the grade of NAFLD significantly correlated with CIMT (r = 0.606, p < 0.001). Patients with more severe CAD were more likely to have NAFLD. In addition, hepatosteatosis may be associated with coronary plaque instability and high fatty volume. Patients with NAFLD should be screened regularly for other cardiovascular risk factors, and the presence of fatty liver may help better classify these patients.
Levosimendan Accelerates Recovery in Patients With Takotsubo Cardiomyopathy
(Via Medica, 2016) Yaman, Mehmet; Arslan, Ugur; Kaya, Ahmet; Akyol, Aytac; Ozturk, Fatih; Okudan, Yunus Emre; Bektas, Osman
Background: The aim of this study was to determine the efficacy and safety of levosimendan in takotsubo cardiomyopathy (TC). Methods: The study was conducted in a retrospective design and 42 consecutive patients were enrolled in 6 cardiovascular centers in Turkey. The records of TC patients having left ventricular ejection fraction (LVEF) <= 35% were examined at admission, discharge and recovery period including their clinical and echocardiographic data. Results: Of these 42 TC patients, 17 were treated with loading dose and i.v. infusion of levosimendan (group 1) and 25 were treated without levosimendan (group 2). Echocardiographic findings at admission and at discharge were similar and no serious complications were observed in either group. However recovery period including the interval of 50% increase in LVEF, time to achieve the baseline troponin values and hospitalization were significantly lower in patients taking levosimendan. Conclusions: This is the first study using loading dose and subsequent continuous intravenous administration of levosimendan demonstrating accelerated recovery in patients with TC.
Morpho-Genetic Characterization of Fig (Ficus Carica Var. Rupestris (Hausskn.) Browicz) Genotypes To Be Used as Rootstock
(Springer, 2024) Yildiz, Ercan; Aglar, Erdal; Sumbul, Ahmet; Yaman, Mehmet; Caliskan, Oguzhan; Popescu, Gheorghe Cristian; Gonultas, Metin
With its enormous genetic pool, Turkiye is the homeland of the fig and many plant species. The common fig species in the country's natural population are Ficus carica var. caprificus (male figs), Ficus carica var. domestica (female figs; edible figs), and Ficus carica var. rupestris. In this study, the morphological and molecular characterization of 42 genotypes, including those obtained by selection from the Ficus carica var. rupestris (Hausskn.) Browicz population, which is naturally spread in a limited area in Tunceli province, was performed. This study evaluated the qualitative and quantitative characteristics of 23 fig genotypes. These results showed that tree growth habit, lateral shoot formation, apical dominancy, and leaf length characteristics were highly discriminant variables for phenotypic description in wild fig genotypes. The genetic relationship between the genotypes was demonstrated with 12 SRAP and 9 ISSR primers. As a result of the study, it was determined that the genetic similarity values ranged between 0.52 and 0.94. It was determined that the first five essential components (PCA) contributed 20.87%, 13.21%, 10.66%, 9.58%, and 7.11% of the total variation, respectively, and their cumulative rate corresponded to 61.43% of the total variation. Very detailed results on the genetic variation in the fig population in the region were obtained by morphological features and molecular methods. The seven genotypes selected were propagated to determine their potential for dwarf rootstocks. The results of the present study may provide significant leads for further research on this subject. The potential of dwarf rootstocks in figs can be an essential tool for modern fruit growing.
Natural Diversity of Crataegus Monogyna Jacq. in Northeastern Türkiye Encompassing Morphological, Biochemical, and Molecular Features
(Mdpi, 2025) Erkek, Bora; Yaman, Mehmet; Sumbul, Ahmet; Demirel, Serap; Demirel, Fatih; Coskun, Omer Faruk; Eroglu, Ayten
Hawthorn (Cratageus monogyna Jacq.), one of the important wild fruit species in Turkey, is an important fruit species in many countries due to its use in traditional medicine, landscaping studies, and the food and beverage industry. In this study, morphological characterization revealed significant variation among genotypes, with fruit weight ranging from 0.55 g to 2.87 g, fruit width from 9.74 mm to 18.39 mm, and leaf width from 19.53 mm to 41.19 mm. Genotype-dependent variations were observed in the total phenolic content (151.34 mg-491.88 mg GAE 100 g-1 flesh), the total flavonoid content (16.74-48.13 mg CAE 100 g-1 flesh), the total anthocyanin content (26.34-79.79 mg cyn-3 gluc 100 g-1 flesh), and the antioxidant activity (29.20% to 56.70%). HPLC-based phenolic profiling identified substantial variations in key bioactive compounds, with the highest levels of chlorogenic acid (16.16 mg 100 g-1 fw), caffeic acid (10.21 mg 100 g-1 fw), epicatechin (13.83 mg 100 g-1 fw), rutin (74.05 mg 100 g-1 fw), and protocatechuic acid (2.00 mg 100 g-1 fw). ISSR marker-based molecular analysis revealed a high degree of genetic polymorphism (89.12%), with 55 out of 62 bands classified as polymorphic. The polymorphic information content values ranged from 0.34 to 0.44. The Jaccard similarity coefficient ranged from 0.04 (M9 and M16) to 0.63 (M17 and M3), indicating substantial genetic variability. The tanglegram analysis comparing genetic and morphological-biochemical dendrograms yielded an entanglement score of 0.714, indicating an alignment between molecular and phenotypic data. These findings show that hawthorn genotypes from the Kelkit Valley exhibit extensive genetic and biochemical diversity, which is critical for conservation efforts, breeding programs, and the development of high-value medicinal and functional food products.
A New Echocardiographic Parameter of Arterial Stiffness in End-Stage Renal Disease
(Elsevier Science inc, 2013) Sahin, Musa; Simsek, Hakki; Akyol, Aytac; Akdag, Serkan; Yaman, Mehmet; Inan, Bekir; Gumrukcuoglu, Hasan Ali
Refinement of Surface Sterilization Protocol for in Vitro Olive (Olea Europaea L.) Shoot Proliferation and Optimizing by Machine Learning Techniques
(Korean Soc Horticultural Science, 2025) Palaz, Esra Bulunuz; Demirel, Serap; Popescu, Gheorghe Cristian; Demirel, Fatih; Ugur, Remzi; Yaman, Mehmet; Tunc, Yazgan
The olive tree (Olea europaea L.) is one of the most ancient fruit species grown throughout history. Given the challenges and costs associated with propagating olive cultivars by cuttings and grafting, it is crucial to identify a method for efficient and widespread propagation. Micropropagation is especially advantageous for propagating plants that are conventionally challenging to propagate or for producing virus-free seedlings or plants with specified traits. This work aimed to improve the in vitro shoot proliferation of O. europaea L. 'Sultani' cultivated in T & uuml;rkiye. Machine learning (ML) techniques were used to predict the efficiency of surface sterilization treatments. The explants were subjected to varied concentrations and durations of five disinfectants: hydrogen peroxide (H2O2), silver nitrate (AgNO3), mercuric chloride (HgCl2), sodium hypochlorite (NaOCl), and chlorine dioxide (ClO2). Each disinfectant was assigned three treatment levels (T1, T2, T3), which varied in concentration and exposure duration. The measured variables were contamination rate, survival rate, growth rate, shoot diameter, shoot length, and leaf number. ClO2 and NaOCl were the most efficient disinfection agents for the growth of explants. ClO2 showed particularly excellent results in terms of shoot diameter (0.765 mm), shoot length (43.733 mm), and leaf number (14.578). NaOCl treatment resulted in the greatest growth percentage (70.55%). AgNO3 treatment performed moderately performance in most parameters, but the lowest contamination rate (13.556%) was observed. Ultimately, the selection of chemical and treatment techniques substantially impacted the efficacy of in vitro olive shoot proliferation. The support vector regression, random forest, extreme gradient boosting (XGBoost), elastic net, and Gaussian processes algorithms were used to model and forecast the optimal sterilizing settings. The XGBoost provided the most accurate (R2) for survival rate, growth rate, shoot diameter, shoot length, and leaf number variables; 0.587, 0.959, 0.843, 0.894, and 0.900, respectively. The XGBoost algorithm was used to predict and optimize surface sterilization. The optimal circumstances for survival and development were projected to include explants sterilized with a 30% solution of NaOCl for 20 min. Moreover, it was projected that explants treated with a 15% concentration of ClO2 for 30 min would be possibly ideal in terms of shoot diameter, shoot length, and leaf number values. ML algorithms could further optimize these protocols for better outcomes, reducing the number of treatments needed and improving efficiency.
Relationship Between Uric Acid To Hdl Ratio and Extent and Severity of Coronary Artery Disease
(Termedia Publishing House Ltd, 2024) Yaman, Mehmet; Kilinc, Ali Y.; Ozturk, Fatih; Coskun, Mehmet; Duz, Ramazan; Gunes, Yilmaz
Introduction: Coronary artery disease (CAD) is common worldwide and is a significant cause of morbidity and mortality. CAD is a chronic and inflammatory disease mainly caused by atherosclerosis. SYNTAX and Gensini scoring systems are used to evaluate CAD extent and severity. Uric acid to high-density lipoprotein (HDL) ratio (UHR) increases in inflammatory conditions. Aim: To investigate the relationship between UHR and the extent and severity of CAD and its correlation with SYNTAX and Gensini scoring systems. Material and methods: 894 patients who underwent angiography were included in the study. 612 participants with critical coronary stenosis were designated as the patient group, and 282 participants without stenosis were designated as the control group. Characteristic features and laboratory parameters of the groups were compared. The relationship between the SYNTAX and Gensini scores of the patient group and UHR was analyzed. Results: Baseline characteristics and laboratory parameters were similar in both groups, except for uric acid and UHR levels. Both uric acid levels (7.58 +/- 2.55 mg/dl vs. 5.71 +/- 1.46 mg/dl, p < 0.01) and UHR (0.2016 +/- 0.094 vs. 0.1461 +/- 0.05, p < 0.01) were significantly higher in the patient group. UHR levels were found to be correlated significantly with both scoring systems. In the ROC curve analysis the UHR cut-off value of 0.1567 was able to predict CAD moderately (AUC = 0.669 (0.634-0.704), sensitivity 61.1%, specificity 38.7%). Conclusions: UHR is an easy-to-use parameter that can be used before invasive evaluation to predict the presence, severity, and extent of CAD.
The Use of Trimetazidine in Patients With Stable Coronary Artery Effect on T Wave Alternans
(2013) Yaman, Mehmet; Gümrükçüoğlu, Hasan Ali
Kardiyovasküler mortalitede azalma olmasına rağmen iskemik kalp hastalığı halen batı dünyasında en önde gelen ölüm nedenidir. Gelişmiş ülkelerde AKÖ ise KVS öümlerin yarısından sorumludur. Tüm kardiyovasküler ölümlerin yaklaşık yarısını oluşturan ani kalp ölümü (AKÖ) gelişmiş ülkelerde halen en önde gelen ölüm nedenidir (4). Ani ölümde altta yatan ritim bozukluklarının %80'den fazlasını ventrikül taşiaritmileri oluşturmaktadır (5). Bu nedenle, AKÖ için risk altında bulunan hastaları önceden belirlemek amacıyla değişik klinik parametreler ve girişimsel olmayan testler geliştirilmeye çalışılmıştır Elektrokardiyografideki T-dalgasında vurudan vuruya ortaya çıkan mikrovolt düzeyindeki değişimlerin ölçümüne dayanan mikrovolt T-dalgası değişim (MTDD) testi, AKÖ riski bulunan hastaların risk derecelendirmesinde kullanılan girişimsel olmayan bir tanı yöntemidir. Trimetazidin enerji kaynağını yağ asidi metabolizmasından glukoz metabolizmasına kaydıran farmakolojik bir ajandır.Hücre enerji üretimini , Beta oksidasyonu inhibe ederek glikoliz yönüne kaydırır. Bu metaboliketkilerin koroner arter hastalığı ve AKÖ önleme tedavisinde ek fayda sağladığı gösterilmiştir (173). Çalışmaya iskemik kalp hastalığı olan 100 hasta (23 kadın, 77 erkek; ortalama yaş 55,6 +- 9,2) alındı. Tüm hastalar sinüs ritmindeydi ve koroner arter hastalıkları medikal tedavi altında stabil durumdaydı, aktif kardiyak şikayetleri yoktu. Almakta oldukları rutin tedaviye ek olarak trimetazidine 60 mg/gün dozunda en az 3 ay devam edilmek üzere başlandı. Kan örnekleri alındı, transtorasik ekokardiyografi yapıldı ve T dalga alternansı ölçebilen 24 saatlik ritim holter izlemi tedaviden önce ve sonra yapıldı. sol ventrikül sistolik ve diyastolik fonksiyonları, vital bulguları,T dalga alternansları ve labaratuar değerleri değerlendirildi Çalışma populasyonun çoğunu erkek cinsiyet (%77) oluşturuyordu. KAH risk faktörlerinden en sık sigara ikinci sırada HT bulunmaktaydı. En fazla uygulanan revaskülizasyon tipi stentleme (%96) idi. 3 aylık trimetazidin tedavisi sonrası LA volümünde anlamlı azalma (p:0,002), LVEF'da anlamlı olmayan artma (p:0,16) saptandı. EDZ, IVGZ ve Septal S'de anlamlı düzelme saptandı (p:0,01, p:0,00, p:0,02) . T max değerinde anlamlı değişiklik olmazken (p:0,319) T min ve T ort değerlerinde anlamlı azalma izlendi (p:0,000) ve (p:0,003) Sonuç olarak ; aritmi açısından düşük riskli stabil KAH olan (%96'sında EF:>%40) çalışma grubumuzda 3 aylık trimetazidin tedavisi ile AKÖ'ün noninvaziv göstergelerinden biri olan MTDD'de anlamlı azalma sağlandı. Diğer çalışmalardan farklı olarak MTDD'de sayısal olarak analiz edilmiş ve sayısal parametrelerde (TDmin, TDort) anlamlı düzelme saptanmıştır. Bunun yanında trimetazidin tedavisi ile önceki çalışmalara benzer olarak LV sistolik ve diyastolik parametrelerinde düzelme saptanmıştır. Anahtar kelimeler: İskemik kalp hastalığı, kardiyak enerji metabolizması, trimetazidin, T dalga alternansı, ani kardiyak ölüm.
Van Yöresi Phlebotominae (Diptera: Psychodidae) Türleri
(2005) Yaman, Mehmet; Değer, Mustafa Serdar
Bu araştırma Nisan - Ekim 2001 tarihleri arasında Van’ın Merkez, Edremit, Gevaş ve Erciş ilçelerinde bulunan Phlebotomus türlerinin tespiti amacıyla yapılmıştır. Araştırma süresince 185’i erkek, 113’ü dişi olmak üzere toplam 298 Phlebotomus örneği toplanmıştır. Erkek tatarcıklar (%62) dişilerden fazla bulunmuştur. Mikroskopik incelemeler sonucu yaygınlık sırasına göre P. balcanicus (%39), P. transcaucasicus (%34), P. papatasi (%22) ve P. jacusieli (%5) olmak üzere 4 tür tespit edilmiştir. Bulunan türler Van yöresinde ilk kez saptanmış, en fazla Temmuz ve Ağustos aylarında aktif oldukları görülmüştür.