Browsing by Author "Yardim, Yavuz"

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Adsorptive Stripping Voltammetric Determination of Higenamine on a Boron-Doped Diamond Electrode Improved by the Use of an Anionic Surfactant
(Elsevier Science Sa, 2020) Allahverdiyeva, Shabnam; Pinar, Pinar Talay; Keskin, Ertugrul; Yunusoglu, Oruc; Yardim, Yavuz; Senturk, Zuhre
The present work describes the first electroanalytical investigation and a new voltammetric method for a cheap, rapid and simple determination of higenamine at a surface of mildly-oxidized boron-doped diamond electrode (at +1.6 V during 180 s). The oxidation of compound was strongly dependent on pH. The sensitivity of method was significantly improved in the presence of anionic surfactant, sodium dodecyl sulfate (SDS). The first oxidation peak was chosen for the electroanalytical determination of higenamine due to its higher sensitivity compared to the other two ones. By employing square-wave stripping mode, there was a linear dependence of the oxidation peak current at +0.75 V and higenamine concentration in the range of 0.5-30.0 mg L-1 (1.84 x 10(-6)-1.11 x 10(-4) M), with a detection limit of 0.13 mg L-1 (4.79 x 10(-7) M) in BR buffer pH 2.0 containing 2 x 10(-4) M SDS (after 30 s accumulation at open-circuit condition). As an example, the practical applicability of the proposed method was tested with the quantification of higenamine in the commercial dietary supplement formulations, with results in good agreement to those obtained declared by high-performance liquid chromatography with diode-array detection as a reference method.
An Anodically Pretreated Boron-Doped Diamond Electrode Surface for Square-Wave Adsorptive Stripping Voltammetric Quantification of the Non-Absorbable Antibiotic Rifaximin in the Pharmaceutical Formulation
(Elsevier Science Sa, 2023) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Yardim, Yavuz
This study presents an electroanalytical examination with the voltammetric technique for quantitatively evaluating rifaximin (RFX) using the non-modified boron-doped diamond (BDD) electrode. By utilizing cyclic voltammetry (CV) method, RFX illustrated only one well-defined, irreversible, adsorption-controlled by oxidation and reduction peak at about +0.64 V and +0.21 V, respectively, (vs Ag/AgCl) in 0.1 M HNO3 solution. The square-wave (SW) voltammetric technique examined the dependence of potentials and current intensities on the BDD electrode pretreatment, the nature of a supporting electrolyte, pH, and another characteristic. When the SW mode was used, a satisfactory linear response was achieved in 0.1 M HNO3 solution at +0.56 V (vs Ag/AgCl). The dynamic range is observed from 0.5 to 20.0 mu g mL-1 (6.36 x 10-7-2.54 x 10- 5 M) via a low limit of detection of 0.14 mu g mL-1 (1.7810-7 M). The applicability of the developed method for detecting RFX was exhibited in pharmaceutical formulation samples.
Cathodic Adsorptive Stripping Voltammetry of Abscisic Acid Using Pencil-Lead Bismuth-Film Electrode
(Walter de Gruyter Gmbh, 2011) Yardim, Yavuz
In this study, electrochemical behavior of phytohormone abscisic acid (ABA) at the bismuth-film electrode (BiFE) has been investigated using square-wave cathodic stripping voltammetry. BiFE was prepared ex situ on a supporting pencil-lead graphite electrode. ABA yielded a well-defined voltammetric response in phosphate buffer, pH 3.0 at -1.08 V (vs. Ag/AgCl) (a pre-concentration step being carried out at a fixed potential of -0.80 V for 120 s). The process could be used to determine ABA concentrations in the range 0.756-15.08 mu m, with a detection limit of 0.209 mu m (55.24 ng/ml). As an example, the practical applicability of pencil-lead BiFE was tested with the measurement of ABA in seed samples of maize plant (Zea mays L.).
Determination of 7,12-Dimethylbenz[a]anthracene in Orally Treated Rats by High-Performance Liquid Chromatography and Transfer Stripping Voltammetry
(Bentham Science Publ Ltd, 2012) Yardim, Yavuz; Levent, Abdulkadir; Ekin, Suat; Keskin, Ertugrul; Oto, Gokhan; Senturk, Zuhre
A number of polycyclic aromatic hydrocarbons (PAHs) have been shown to be toxicants, and induce carcinogenic and immunotoxic effects. As a model PAH agent, 7,12-dimethylbenz[a]anthracene (DMBA) was the strongest one tested in terms of its biological activities and biotransformation. A new and simple high-performance liquid chromatographic (HPLC) method with diode-array detection at 290 nm was developed and validated for monitoring of DMBA in different matrices (serum, liver and kidney) of rats orally treated with DMBA. Furthermore, the applicability of adsorptive transfer stripping voltammetry (AdTSV) on the pencil-lead graphite electrode to these samples was illustrated using our previously reported data for bulk aqueous solutions of DMBA. HPLC and AdTSV methods, which were compatible with each other, allowed DMBA to be detected down to the levels of 3.82x10(-9) M (0.98 ppb) and 6.73x10(-9) M (1.73 ppb), respectively. Olive oil solutions of DMBA in dose 50 mg/kg were orally administered. 60 days after a single dose of DMBA, its concentrations in these biological samples from rats were measured by means of both methods. Because of rapid biotransformation, DMBA could not be detected in serum. Only low levels of the compounds were deposited unchanged in kidney whereas its levels were considerably higher in liver. These methods were also applied to the assay whether there is an influence of the intake of aqueous extracts of Hypericum Perforatum L. plant on the parent DMBA levels accumulated in rat tissues.
Determination of Indacaterol From Inhaler Capsules by Square-Wave Voltammetry at the Surface of the Boron-Doped Diamond Electrode
(Serbian Chemical Soc, 2025) Barzani, Hemn Abdulazeez H.; Ali, Hoshyar Saadi; Yardim, Yavuz
This research paper presents an electroanalytical investigation using the voltammetric method to quantify indacaterol maleate (IND) employing an unmodified boron-doped diamond (BDD) electrode. IND exhibited a distinct, irreversible oxidation peak at approximately 1.06 V (vs. Ag/AgCl) in a 0.1 mol L-1 phosphate buffer solution (PBS) with a pH of 2.5, as demonstrated by cyclic voltammetry (CV). A hypothetical mechanism for the electro-oxidation of IND, based on data gathered from CV investigations, was suggested. The square wave-adsorptive stripping voltammetric technique achieved acceptable linearity in PBS (pH 2.5) at approximately 0.90 V. The methodology demonstrated linearity within the concentration range of 1.0 to 30.0 mu g mL-1 (equivalent to 1.97x10-6-5.89x10-5 mol L-1) and yielded a limit of detection (LOD) of 0.22 mu g mL-1 (equivalent to 4.33x10-7 mol L-1). The proposed method's applicability was assessed through the sensing of IND in drug formulations.
Determination of Trace Metal and Mineral Levels in the Tobacco and Cigarette Samples Using by Fass
(Chem Soc Pakistan, 2013) Levent, Abdulkadir; Yardim, Yavuz; Demir, Cengiz
Cigarettes and tobacco products are consumed in large amounts by human beings in the world. Also, tobacco is one of the most important agricultural products in Turkey. The accumulation of heavy metals in tobacco leaves in accordance with a possible risk of transferring them to people by smoke is well known. This study was carried out to estimate trace metal and mineral levels in tobacco and cigarettes from Eastern and South-eastern Anatolia, Turkey. The analysis was done by flame atomic absorption spectrometry using dry ashing or wet digestion. Results obtained are in agreement with data reported in the literature.
Determination of Tramadol in Pharmaceutical Forms and Urine Samples Using a Boron-Doped Diamond Electrode
(Serbian Chemical Soc, 2020) Keskin, Ertugrul; Allahverdiyeva, Shabnam; Seyho, Esma; Yardim, Yavuz
The present work describes the electroanalytical investigation and a novel voltammetric method for the cheap, fast and simple quantification of tramadol (TRH) using a boron-doped diamond electrode. TRH displayed one well-defined, irreversible and adsorption-controlled oxidation peak at about 1.58 V (vs. Ag/AgCl) in Britton-Robinson buffer (BR, 0.1 mol L-1, pH 3.0) using the cyclic voltammetry technique. The voltammetric responses of the oxidation peaks are dependent on pH and their sensitivity was significantly enhanced in the presence of surfactant media (sodium dodecyl sulphate, SDS). Under the optimized experiment conditions, employing the square-wave stripping mode, it was found that there was an excellent correlation between oxidation peak current and the TRH concentration in the range 0.25 to 50.0 mu g mL(-1) (8.34 x 10(-7)-1.67 x 10(-4) mol L-1), with a detection limit of 0.072 mu g mL(-1) (2.40 x 10(-7) mol L-1) in 0.1 mol L-1 BR buffer (pH 3.0) solution comprising 8 x 10(-4) mol L-1 SDS at 1.52 V (after 30 s accumulation at open-circuit conditions). The developed approach could be used for the quantification of TRH in pharmaceutical formulations and spiked human urine samples with acceptable recoveries.
Determination of Vanillin in Commercial Food Product by Adsorptive Stripping Voltammetry Using a Boron-Doped Diamond Electrode
(Elsevier Sci Ltd, 2013) Yardim, Yavuz; Gulcan, Mehmet; Senturk, Zuhre
A method for the determination of food additive vanillin was developed by adsorptive stripping voltammetry. Its determination was carried out at the anodically pre-treated boron-doped diamond electrode in aqueous solutions. Using square-wave stripping mode, the compound yielded a well-defined voltammetric response in phosphate buffer, pH 2.5 at +1.14 V (vs. Ag/AgCl) (a pre-concentration step being carried out at open-circuit condition for 60 s). A linear calibration graph was obtained in the concentration range of 0.5-15.0 mu g mL(-1) (3.3 x 10(-6)-9.8 x 10(-6) mol L-1) with a detection limit of 0.024 mu g mL(-1) (1.6 x 10(-7) mol L-1). As an example, the practical applicability of the proposed method was tested for the determination of this flavouring agent in commercial pudding powder of Keshkule (Turkish milk pudding with almond flour). (C) 2013 Elsevier Ltd. All rights reserved.
Developing an Electroanalytical Procedure for the Determination of Caffeic Acid Phenethyl Ester at a Boron-Doped Diamond Electrode by the Use of Cationic Surfactant Media
(Elsevier Science Sa, 2022) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Ozok, Hande Izem; Yardim, Yavuz
The aim of the present work is to describe voltammetric analysis of caffeic acid phenethyl ester (CAPE) by using a boron-doped diamond (BDD) electrode in the presence of the cationic surfactant. Using cyclic voltammetry, CAPE demonstrated a single well-defined, quasi-reversible, adsorption-controlled by oxidation and reduction peak at approximately +0.44 V & +0.22 V respectively, (vs. Ag/AgCl) in the Britton-Robinson buffer (BR, 0.04 mol L-1, pH 5.0). The obtained results showed that the oxidation peaks of CAPE are pH dependent (ranging from 2.0 to 6.0). The oxidation peak currents of CAPE were significantly increased by using cetyltrimethylammonium bromide (CTAB, cationic surfactant) in the selected supporting electrolyte. Under the optimum parameters of experiment, the linear relationship was found for CAPE determination in 0.04 mol L-1 BR buffer solution (pH 5.0) including 1 x 10(-4) mol L-1 CTAB at +0.41 V (vs. Ag/AgCl) (after 30 s accumulation at the open-circuit condition). The linear range was found with 0.01 to 1.0 mu g mL(-1) (3.5 x 10(-8)-3.5 x 10(-6) mol L-1) via the detection limit 0.0028 mu g mL(-1) (9.8 x 10(-9) mol L-1). The developed approach was used successfully to detect CAPE concentration in the model urine samples. To our knowledge, this is the first approach for electrochemically analyzing of CAPE.
The Effect of Ctab, a Cationic Surfactant, on the Adsorption Ability of the Boron-Doped Diamond Electrode: Application for Voltammetric Sensing of Bisphenol a and Hydroquinone in Water Samples
(Elsevier, 2021) Hoshyar, Saadi Ali; Barzani, Hemn A. H.; Yardim, Yavuz; Senturk, Zuhre
The present study introduces for the first time the effect of the cationic surfactant, cetyltrimethylammonium bromide (CTAB) on the adsorption capability of the boron-doped diamond (BDD) electrode for the sensing of environmental pollutants bisphenol A (BPA) and hydroquinone (HQ). Cathodic pretreatment of the electrode surface after an anodic pretreatment exhibited a best electrochemical response for these two phenolic compounds. The electrochemical characteristics of BPA and HQ were first sufficiently documented by cyclic voltammetry in aqueous solutions without the addition of surfactant over a shorter and longer potential range. Square-wave voltammetry was employed for a detailed study depending on the operational conditions (e.g., pH and nature of supporting electrolyte, concentration of CTAB, accumulation variables, instrumental parameters, etc.). The sensitivity of the voltammetric measurements for BPA and HQ was increased when CTAB was present in strong acidic media (more effective for BPA) due to its interaction with the neutral forms of the selected compounds on the hydrophobic surface of BDD electrode. Besides, a significant increase in the detecting sensitivity of BPA in CTAB-containing solutions could be obtained after applying an accumulation process. Using square-wave stripping mode (after 30 s accumulation at open-circuit condition) in 0.1 M H2SO4 containing 1 x 10(-4) M CTAB, the limits of detection were found to be 0.05 mu g/mL (2.19 x 10 M), and 0.23 tig/mL (2.09 x 10(-6) M) for the simultaneous determination of BPA and HQ, respectively. In this way, modification-free BDD electrode could introduce an alternative to chemically modified electrodes for the analysis of environmental samples.
Electroanalytical Determination of Enrofloxacin Based on the Enhancement Effect of the Anionic Surfactant at Anodically Pretreated Boron-Doped Diamond Electrode
(Elsevier Science Sa, 2018) Donmez, Fatih; Yardim, Yavuz; Senturk, Zuhre
In this paper, a mercury-free and modification-free electroanalytical methodology based on anodically pretreated boron-doped diamond electrode is described for the quantification of enrofloxacin. The oxidation of compound was irreversible and presented an adsorption controlled process. The sensitivity of the stripping voltammetric measurements was significantly improved when the anionic surfactant, sodium dodecylsulfate (SDS) was present in the electrolyte solution. Using square-wave stripping mode, a linear response was obtained for enrofloxacin determination in 0.1 mol L-1 HNO3 solution containing 9 x 10(-4) mol L-1 SDS at +1.27 V (vs. Ag/AgCl) (after 60 s accumulation at open-circuit condition). Linearity was found within 0.025 to 1.0 mu g mL(-1) (6.96 x 10(-8)-2.78 x 10(-6) mol L-1) with a detection limit 0.0057 mu g mL(-1) (1.59 x 10(-8) mol L-1). The proposed method could be used for the determination of enrofloxacin in pharmaceutical formulations and the spiked human urine samples with acceptable recoveries.
Electroanalytical Determination of Salbutamol in Pharmaceutical Formulations Using Cathodically Pretreated Boron-Doped Diamond Electrode
(Marmara Univ, 2018) Talay Pinar, Pinar; Ali, Hoshyar Saadi; Abdullah, Abdullah Abdulwahed; Yardim, Yavuz; Senturk, Zuhre
This paper examined for the first time the possibilities of the usage of the cathodically pretreated borondoped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using square-wave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 mu g mL(-1) (1.73x10(-5) -3.47x10(-4) M). A detection limit of 1.21 mu g mL(-1) (5.06x10(-6) M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations.
Electroanalytical Investigation and Determination of Hepatitis C Antiviral Drug Ledipasvir at a Non-Modified Boron-Doped Diamond Electrode
(Elsevier Science Sa, 2020) Allahverdiyeva, Shabnam; Keskin, Ertugrul; Pinar, Pinar Talay; Yunusoglu, Oruc; Yardim, Yavuz; Senturk, Zuhre
This study is about the use of the boron-doped diamond electrode pretreated electrochemically (anodic and subsequent cathodic) in the voltammetric determination of hepatitis C antiviral drug ledipasvir. Cyclic voltammetric measurements revealed that the compound yielded two well-separated irreversible oxidation peaks (P-A1 and P-A2) in acidic medium. The dependence of intensities of currents and potentials on electrode pretreatment, pH and nature of the supporting electrolyte, and other variables was investigated by square-wave voltammetry. Determination of ledipasvir was performed in Britton-Robinson buffer (pH 2.0) on the basis of both P-A1 and P-A2, which offered linear concentration ranges 0.5-60.0 mu g mL(-1) (5.6 x 10(-7)-6.8 x 10(-5) mol L-1) and 5.0-60.0 mu g mL(-1) (5.6 x 10(-6)-6.8 x 10(-5) mol L-1), respectively, with detection limits of 0.12 mu g mL(-1) (1.4 x 10(-7) mol L-1) and 0.76 mu g mL(-1) (8.6 x 10(-7) mol L-1). The practical applicability of developed methodology was tested by the assay of a fixed-dose combination tablet with sofosbuvir.
Electroanalytical Investigation and Voltammetric Quantification of Antiviral Drug Favipiravir in the Pharmaceutical Formulation and Urine Sample Using a Glassy Carbon Electrode in Anionic Surfactant Media
(Tubitak Scientific & Technological Research Council Turkey, 2022) Akca, Zeynep; Ozok, Hande Izem; Yardim, Yavuz; Senturk, Zuhre
This work describes the electrochemical investigation of a promising antiviral agent, favipiravir (FAV) utilizing a nonmodified glassy carbon (GC) electrode, along with a unique voltammetric approach that can determine FAV with a good degree of accuracy, speed, and cost-effectiveness. Using cyclic voltammetry, the compound demonstrated a single well-defined and an irreversible oxidation peak at approximately +1.12 V (vs. Ag/AgCl) in Britton-Robinson (BR) buffer at pH 10.0. The synergistic effect of anionic surfactant, sodium dodecyl sulfate (SDS) on the adsorption ability of GC electrode remarkably increased the sensitivity of the stripping voltammetric measurements of FAV. Employing square-wave adsorptive stripping voltammetry at +1.17 V (vs. Ag/AgCl) (after 60 s accumulation at open-circuit condition) in BR buffer (pH 10.0) containing 3 x 10(-4) M SDS, the linear relationship is found for FAV quantification in the concentration from 1.0 to 100.0 mu g mL(-1) (6.4 x 10(-6)-6.4 x 10(-4) M) with a detection limit of 0.26 mu g mL-1 (1.7 x 10(-6) M). The proposed approach was used successfully to determine FAV in pharmaceutical formulations and model human urine samples.
Electroanalytical Sensing of Antidiabetic Drug Linagliptin by Using Square-Wave Voltammetry on the Boron-Doped Diamond Electrode
(Springer Wien, 2024) Barzani, Hemn A. H.; Ali, Hoshyar Saadi; Yardim, Yavuz
This research paper presents an electroanalytical investigation utilizing voltammetry to quantify the antidiabetic drug linagliptin with an unmodified boron-doped diamond electrode. Using cyclic voltammetry, linagliptin exhibited a single, distinct, irreversible oxidation peak at around + 1.03 V (vs. Ag/AgCl) in a 0.1 mol dm-3 phosphate buffer solution at pH 7.4. The square-wave voltammetry technique achieved acceptable linearity at approximately + 0.94 V in PBS (pH 7.4). The methodology demonstrated linearity within the concentration range of 1.0 and 50.0 mu g cm-3 (equivalent to 2.1 x 10-6-1.1 x 10-4 mol dm-3) and yielded a limit of detection of 0.28 mu g cm-3 (equivalent to 5.9 x 10-7 mol dm-3). The investigation of the proposed method's applicability was ultimately conducted through the sensing of linagliptin in drug formulations. The established methodologies can serve as viable alternatives to other analytical techniques due to their cost-effectiveness, user-friendliness, efficiency, and ability to yield reliable and repeatable results.
Electrochemical Behavior and Electroanalytical Determination of Indole-3 Acid Phytohormone on a Boron-Doped Diamond Electrode
(Wiley-v C H verlag Gmbh, 2011) Yardim, Yavuz; Erez, M. Emre
In this work, a boron-doped diamond (BDD) electrode was used for the electroanalytical determination of indole-3-acetic acid (IAA) phytohormone by square-wave voltammetry. IAA yielded a well-defined voltammetric response at +0.93 V (vs. Ag/AgCl) in Britton-Robinson buffer, pH 2.0. The process could be used to determine IAA in the concentration range of 5.0 to 50.0 mu M (n=8, r=0.997), with a detection limit of 1.22 mu M. The relative standard deviation of ten measurements was 2.09% for 20.0 mu M IAA. As an example, the practical applicability of BDD electrode was tested with the measurement of IAA in some plant seeds.
Electrochemical Behavior of Chlorogenic Acid at a Boron-Doped Diamond Electrode and Estimation of the Antioxidant Capacity in the Coffee Samples Based on Its Oxidation Peak
(Wiley, 2012) Yardim, Yavuz
In this study, an electroanalytical methodology for the determination of chlorogenic acid (CGA) was achieved at a boron-doped diamond electrode under adsorptive transfer stripping voltammetric conditions. The values obtained for CGA were used to estimate the antioxidant properties of the coffee sample based on CGA oxidation. By using square-wave stripping mode, the compound yielded a well-defined voltammetric response at +0.49 V with respect to Ag/AgCl in BrittonRobinson buffer at pH 3.0 (after 120 s accumulations at a fixed potential of 0.40 V). At the optimum experimental conditions, linear calibration curve is obtained within the concentration range of 0.25 to 4.0 mu g mL-1 with the limit of detection 0.049 mu g mL-1. The developed protocol was successfully applied for the analysis of antioxidant capacity in the coffee products such as Turkish coffee and instant coffee.
Electrochemical Behavior of the Antineoplastic Agent Etoposide at a Graphene-Based Modified Electrode: Its Square-Wave Adsorptive Stripping Voltammetric Determination in the Pharmaceutical Formulations
(Editura Acad Romane, 2018) Talay Pinar, Pinar; Saka, Cafer; Yardim, Yavuz
An electrochemical sensor based on the graphene (GR) was prepared, and used for the determination of etoposide (ETO). The electrochemical behaviors of this compound on GR modified glassy carbon electrode (GR/GCE) were investigated by cyclic voltammetry and square-wave adsorptive stripping voltammetry (SWAdSV). Using SWAdSV, a linear calibration curve was obtained for ETO determination in 0.1 M Britton-Robinson (BR, pH 4.0) buffer solution at +0.56 V (vs. Ag/AgCl) (after 30 s accumulation at 0.1 V). A linear relationship was found between peak currents and the concentration of ETO within 0.025 to 0.5 mu g mL(-1), with a detection limit of 0.0023 mu g mL(-1). The developed method was successfully applied to the determination of ETO in the pharmaceutical formulations with good recoveries.
Electrochemical Determination of Flavonoid Fisetin in Commercial Dietary Supplements Using a Boron-Doped Diamond Electrode
(Wiley-v C H verlag Gmbh, 2023) Allahverdiyeva, Shabnam; Keskin, Ertugrul; Yoruk, Ibrahim; Yardim, Yavuz
For the first time, a boron-doped diamond electrode was utilized to quantitatively determine flavonoid fisetin (FST). Cyclic voltammetric studies have shown that the electrochemical oxidation of FST is irreversible and well-separated two peaks (P-A1 and P-A2) in 0.1 MHNO3 solution. The effects of electrode pretreatment, solution pH, nature of the supporting electrolyte, and instrumental variables on the peak current and potentials of the FST were investigated by square-wave voltammetry (SWV) and then optimum ones were determined. It was observed that the cathodically pre-treated BDD (CPT-BDD) electrode's performance was better than the other pre-treatment procedures for increasing the FST oxidation signal. Under optimized conditions and using the SWV technique, the response of the first anodic peak (P-A1) of the FST was proportional in a concentration range of 0.5-20.0 mu g mL(-1) (1.7x10(-6)-6.9x10(-5) mol L-1) with a detection limit of 0.08 mu gm L-1 (2.8 x 10(-7) mol L-1). Also, it was successfully demonstrated that the proposed method is applicable in commercial nutritional supplement formulations.
Electrochemical Determination of Fluoroquinolone Antibiotic Norfloxacin in the Presence of Anionic Surfactant Using the Anodically Pretreated Boron-Doped Diamond Electrode
(Wiley-v C H verlag Gmbh, 2020) Karahan, Fatih; Basi, Zehra; Keskin, Ertugrul; Pinar, Pinar Talay; Yardim, Yavuz; Senturk, Zuhre
In this article, a simple, fast and inexpensive methodology has been developed for the determination of fluoroquinolone class antibiotic norfloxacin (NFX) in anionic surfactant media (sodium dodecyl sulphate, SDS) using an anodically pretreated boron-doped diamond (APT-BDD) electrode. Cyclic voltammetric studies showed that the NFX gave an irreversible and adsorption controlled anodic oxidation signal at a potential of about +1.32 V on the APT-BDD electrode. The effects of parameters such as the electrode pre-treatment procedure, SDS concentration, and instrumental variables on the electrochemical sensitivity of NFX were evaluated. Under optimized conditions, the linearity was achieved in the range of 0.05 to 4.0 mu g mL(-1) (1.57x10(-7)-1.25x10(-5) mol L-1), with a detection limit of 0.013 mu g mL(-1) (4.07x10(-8) mol L-1) by using square-wave adsorptive stripping voltammetry (SW-AdSV). The feasibility of the developed approach for the quantification of NFX in urine samples was tested.