Browsing by Author "Yarsan, E"

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Arsenic Residues in Grey Mullets Caught in Lake Van
(Scientific Technical Research Council Turkey, 1999) Bilgili, A; Yarsan, E; Türel, I
in this study, pollution caused by arsenic residues in grey mullets (Chalcarburnus tarichii, Pallas 1811) living in Van lake were investigated. A Total 120 samples, from the four seasons from 01.01.1994 to 01.01.1995 were collected. The organic parts of the muscles were washed with a mixture of magnesium oxide and magnesium nitrate according to the dry ash method and arsenic residues were measured by silver diethyl dithyocarbamate in a spectrophotometer. By analyzing the 120 fish samples, arsenic residues were calculated to be 0.009 - 0.347 ppm (average 0.051+/-0.046). In light of these results as the arsenic residues in grey mullets were below the level of 10 ppm, the accepted limit, it was concluded that arsenic intoxication poses no risk to human health.
Bioavailability and Pharmacokinetics of Oxytetracycline in Cultured Rainbow Trout Following Intramusicular Administration
(indian veterinary Journal, 2004) Dagoglu, G; Turel, L; Yilmaz, O; Yarsan, E; Oto, G; Kankaya, E
Aquaculture production of rainbow trout has increased in Turkey in the recent years. There is great concern over the use of drugs for fish production. Bacterial diseases, if untreated, may lead to great economic losses in the form of fish mortality and reduced growth. Thus aquafarming uses a wide variety of drugs for prevention and treatment of disease in cultured fish. Among these drugs, oxytetracycline (OTC) is a broad-spectrum antibiotic used for the treatment of a variety diseases including vibriosis, furunculosis, enteric redmouth, bacterial haemorrhagic septicemia, fin rot, gill disease columnaris and edwardsiellosis (Black et al., 1991; Unb, 1996). There is a paucity of information on the pharmacokinetics of OTC in farmed fish. The pharmacokinetics of OTC may be changed by parameters such as fish species, age, water temperature and salinity, route of administration and other conditions. Therefore the present study was performed to investigate the pharmacokinetics, i.e. absorption, distribution and elimination, of OTC in rainbow trout (Oncorhynchus mykiss) after intra-muscular administration.
Comparison of the Pharmacokinetics of Conventional and Long-Acting Formulations of Oxytetracycline in Sheep
(Scientific Technical Research Council Turkey, 2001) Kaya, S; Yarsan, E; Baydan, E; Akkaya, R; Aksoy, A
The pharmacokinetics of conventional and long-acting oxytetracycline (OTC) formulation were evaluated in sheep at a single dosage of 20 mg-kg(-1) body weight (bw). Conventional formulation was injected by intravenous (IV) route and long-acting formulation of oxytetracycline was administered by intramuscular (IM) route, Then blood samples were taken at 0.25, 0.5, 1, 2, 4, 8, 12, 24, 36, 48, 60, 72, 84 and 96 hours. Oxytetracycline analysis was performed by HPLC in plasma. The plasma drug concentration-time profile was characteristic of a two-compartment open model. Following IM administration, time to reach maximal plasma drug concentration was 2 hours and maximal plasma drug concentration was 5.13 +/-0.31 mug/ml. After IV and IM administration of oxytetracycline, the elimination times were 1.14 +/-1.13 and 18.92 +/-1.86 hours, respectively. Intramuscular bioavailability was found to be 73%. Also, AUC was found to be 106.24 +/-8.92 and 78.92 +/-5.07 mug- ml(-1) hours', respectively, IV and IM.
Heavy Metal Levels in Mussels (Unio Stevenianus Krynicki) Obtained From Van Lake
(Scientific Technical Research Council Turkey, 2000) Yarsan, E; Bilgili, A; Türel, I
The aim of this study was to evaluate heavy metal levels in mussels (Unio stevenianus Krynicki) obtained from Van Lake. A total of 120 samples representing each of the four seasons was collected between 01.01.1994 and 01.01.1995. The organic parts of the samples were ashed with a mixture of magnesium oxide and magnesium nitrate according to the dry ashing method and arsenic residues were measured by silver diethyldithyocarbamate in UV spectrophotometer; copper, cadmium, zinc and lead levels were also determined using an atomic absorption spectrophotometer. In the analysis of the 120 samples for residues of heavy mettals, the average values were found to be: 1.43+/-0.81 ppm for lead, 0.09+/-0.02 ppm for cadmium, 5.83+/-0.73 ppm for copper, 15.93+/-3.26 ppm for zinc and 0.06+/-0.05 ppm for arsenic. Evaluation of the study results showed that these heavy metal levels were within the normal ranges for our country and other country's acceptable limits.
Pharmacokinetics of Long Acting and Conventional Formulations of Oxytetracycline in Goats
(indian veterinary Journal, 2005) Turel, I; Dagoglu, G; Yilmaz, O; Yarsan, E; Irak, K
Oxytetracycline (OTC) is a broadspectrum antibiotic extensively used for the treatment of a variety disease and is active not only against a variety of gram (+) and gram (-) organisms, but also against mycoplasma, ehrlichia, rickettsiae, clarnydia and anaplasma. The pharmacokinetics of OTC may be changed by parameters such as species, age, health, route of administration and other conditions. There is a paucity of information on the pharmacokinetics of OTC in goats. Therefore the present study was performed to investigate the pharmacokinetics of OTC after intravenous and intramuscular administrations of both conventional (CF) and long-acting (LA) formulations in Colored Mohair goats of Turkey.