Browsing by Author "Yasar, Tekin"

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Anterior Lens Capsule and Iris Thicknesses in Pseudoexfoliation Syndrome
(Taylor & Francis inc, 2017) Batur, Muhammed; Seven, Erbil; Tekin, Serek; Yasar, Tekin
Purpose: The aim of this study was to evaluate anatomic properties of the lens capsule and iris by anterior segment optical coherence tomography (AS-OCT) in patients with pseudoexfoliation (PEX).Methods: This prospective study included 62 eyes of 62 patients with PEX syndrome and 43 eyes of 43 age- and gender-matched controls. All subjects underwent full ophthalmologic examinations including AS-OCT. Pupillary diameter, midperipheral stromal iris thickness, central and temporal lens capsule thicknesses, and peripheral pseudoexfoliation material thickness on the anterior lens capsule surface were measured and recorded.Results: Mean age was 66.8 9.3 years in the PEX group and 65.5 +/- 8.9 years in the control group (p = 0.44). The PEX group consisted of 62 patients: 38 men (61.3%) and 24 women (38.7%); the control group included 43 subjects: 25 men (58.1%) and 18 women (41.9%). Pupillary diameter after pharmacologic mydriasis was 21% smaller in the PEX group than controls. Mean midperipheral iris thickness was 36 +/- 7.2 m (7.8%) thinner in the PEX group than that of control group (p = 0.047). The central anterior capsule was a mean of 3.40 +/- 0.51 m (18%) thicker in the PEX group compared to the control group (p = 0.0001). The temporal anterior lens capsule was a mean of 0.17 +/- 0.15 m thicker in the PEX group compared to the control group (p = 0.81).Conclusions: With high-resolution OCT imaging, it has become possible to evaluate the anterior lens capsule without histologic examination and demonstrate that it is thicker than normal in PEX patients.
Brucellosis and Uveitis
(Amer Soc Contemporary Medicine Surgery & Ophthalmology, 2008) Karahocagil, Mustafa Kasim; Demirok, Ahmet; Kilic, Adil; Cinal, Adnan; Caksen, Hueseyin; Yasar, Tekin
A 30-year-old-lady, (Case 1) was found to have brucella uveitis in her left eye. Serum agglutination (SAT) and SAT/Coombs titers were positive at 1:320 and 1:160, respectively. In Case 2, a 12-year-old-girl diagnosis of left brucellosis uveitis was made. Both SAT and SAT/Coombs titers were positive at 1:1280. This report confirms that Brucellae organisms as a cause of uveitis.
Causes of Visual Impairment in the Van City Area According To the Health Committee's Reports
(Turkish Ophthalmological Soc, 2012) Ceyhan, Dogan; Yasar, Tekin; Demirok, Ahmet; Cinal, Adnan; Esmer, Oktay; Batur, Muhammed
Purpose: In this study, disability reports of the Health Committee of the Hospital of the Yiiziincii Yil University School of Medicine will be evaluated. The demographic characteristics, causes and degree of visual loss, visual system impairment rating and whole body impairment rating of the people with visual impairment will be determined. Material and Method: Health committee disability reports of our hospital, between September 2006 and August 2010, were evaluated. Relevant variables of each patient were recorded and evaluated. Results: 415 health committee reports for visual impairment were found to be prepared during the period of the study. One hundred fifty three (36,9%) of the cases were female and 262 (63.1%) were male and the mean age was 41.8 +/- 22.4 years. The most frequent causes of visual impairment were macular diseases, evisceration and phitisis, amblyopia, optic nerve diseases, degenerative myopia, acquired corneal and hereditary retinal diseases. The patients who had a disability report had a mean of 41.69 +/- 25.92% visual system impairment rating and 60,76 +/- 24,67% whole body impairment rating. Discussion: This research was planned for contributing to the epidemiologic information about visual impairment in our country. This data may serve to compute the cost of visual disability reports. The information is also expected to contribute to determine the causes and measures for the prevention of diseases and conditions leading to visual disability.
Color Vision and Health Committee Procedures
(Turkish Ophthalmological Soc, 2011) Ceyhan, Dogan; Yasar, Tekin
Besides the diagnosis, follow-up and treatment of some ophthalmic pathologies, color vision examination is used to determine the eligibility for certain professions. Color vision is affected by factors, such as genetic structure of the person, characteristics of the eye and some mental processes, which have not been elucidated exactly yet. Therefore, there is no test which can be easily applied and can evaluate in details and "measure" the color vision ability. Screening tests like Ishihara, which are common in Turkey, do not range the exact color vision ability of the people. In health committees of the hospitals, the necessity to determine conditions like "color blindness/dyschromatopsia" with these tests, makes color vision evaluation harder. When supported by some other color vision tests, the Ishihara test becomes more useful in assessing color vision. Including the terminology, the standards for examination and evaluation of color vision can be further improved in Turkey; thus, the examinations for eligibility for occupation and driving license can be more appropriate for the conditions of the country. This review was intended to make proposals for improvement of color vision examinations and practices for eligibility for some occupations.
Comparasion of Optic Nerve Head With Stereophotometric and Scanning Laser Ophthalmoscopic Imaging
(derman Medical Publ, 2015) Tekin, Serek; Yasar, Tekin
Aim: To compare theevaluation results of two experienced clinicians about examination of optic discs in glaucoma patients and healthy inidividuals by stereophotometry and scanning laser ophthalmoscopy. Material and Method: We studied 116 individuals (217 eyes) who were divided as normal, glaucoma and suspected glaucoma in numbers of 54, 42 and 20 respectively. Stereo-photometric photographs of optic disc were examined with fundus camera (Zeiss, FF 450 plus). Optic disc was also evaluated with HRT-3 in the same visit. Two experienced clinicians evaluated the cup/disc ratios and whether the optic discs were glaucomatous or not. Evaluation results were analysed and compared with HRT-3 examinations. Results: There were no significant age and gende rdifferences between the groups(p>0.05). Stereophotographic C/D ratio correlations between the clinicians were 0.79 (p<0.001) in theright-eyesand 0.82 (p<0.001) in thelefteyes. Correlationbetween C/D ratios of the-firstclinicianexaminationand HRT-3 was 0.57 (p<0.001) in therighteyesand 0.50 (p<0.001) in thelefteyes. Correlationratios of thesecondclinicianwas 0.66 (p<0.001) in therighteyesand 0.68 (p<0.001) in thelefteyes. Consistency of thefirstclinician in means of correlation of stereographyand HRT-3 C/Dratioswas %51.2 (p<0.001) in therighteyesand % 47.5 (p<0.001) in thelefteyes. Consistencyforthesecondclinicianwas 0.40 (p<0.001) in therighteyesand % 62.7 (p<0.001) in thelefteyes. Discussion: Although the consistency between the clinician was well, consistency between the clinicians and HRT-3 was in lower rates. Imaging methods were insufficient in glaucoma suspected eyes despite both of methods was effective in the discrimination of normal and glaucomatous eyes.
Comparing Biometry in Normal Eyes of Children With Unilateral Cataract/Corneal Disease To Age-Matched Controls
(Nepal Ophthalmic Soc, 2015) Gul, Adem; Cinal, Adnan; Caglar, Cagatay; Yasar, Tekin; Kilic, Adil
Objective: To compare ocular biometry and central corneal thickness of unaffected healthy eyes of pediatric patients with monocular cataracts/corneal opacities and age-matched controls. Materials and methods: We studied 329 eyes of 329 children who were between 1 and 12 years old. The study group (n: 164) consisted of healthy fellow eyes of children operated for unilateral congenital/traumatic cataract and corneal laceration. Axial length, anterior chamber depth, lens thickness, vitreous chamber depth, and central corneal thickness were measured by ultrasound biometry/pachymetry. Results: Axial length was 22.16 mm in the study group and 21.99 mm in the control group. Anterior chamber depth, lens thickness, and vitreous chamber depth results were 3.35; 3.64 and 15.20 in the treatment group and 3.20; 3.63, and 15.15 mm in the control group, respectively. The axial length and all the components, i.e. anterior chamber depth, lens thickness, and vitreous chamber depth are higher in the unaffected healthy eyes of the pediatric patients than that of the control group but only the difference in the anterior chamber depth was statistically significant. The central corneal thickness was 548 microns and 559 microns in the study and the control groups, respectively, and the difference was found to be significant. Conclusion: Greater anterior chamber depth was chiefly responsible for the overall increase in the axial length in the study group. The central corneal thickness was significantly thinner in the study group than that of the control group.
Comparison of Heidelberg Retina Tomograph-3 Glaucoma Probability Score and Moorfields Regression Analysis of Optic Nerve Head in Glaucoma Patients and Healthy Individuals
(Springer, 2017) Caglar, Cagatay; Gul, Adem; Batur, Muhammed; Yasar, Tekin
To compare the sensitivity and specificity of Moorfields regression analysis (MRA) and glaucoma probability score (GPS) between healthy and glaucomatous eyes with Heidelberg Retinal Tomograph 3 (HRT-3). The study included 120 eyes of 75 glaucoma patients and 138 eyes of 73 normal subjects, for a total of 258 eyes of 148 individuals. All measurements were performed with the HRT-3. Diagnostic test criteria (sensitivity, specificity, etc.) were used to evaluate how efficiently GPS and MRA algorithms in the HRT-3 discriminated between the glaucoma and control groups. The GPS showed 88 % sensitivity and 66 % specificity, whereas MRA had 71.5 % sensitivity and 82.5 % specificity. There was 71 % agreement between the final results of MRA and GPS in the glaucoma group. Excluding borderline patients from both analyses resulted in 91.6 % agreement. In the control group the level of agreement between MRA and GPS was 64 % including borderline patients and 84.1 % after excluding borderline patients. The accuracy rate is 92 % for MRA and 91 % for GPS in the glaucoma group excluding borderline patients. The difference was nor statistically different. In both cases, agreement was higher between MRA and GPS in the glaucoma group. We found that both sensitivity and specificity increased with disc size for MRA, while the sensitivity increased and specificity decreased with larger disc sizes for GPS. HRT is able to quantify and clearly reveal structural changes in the ONH and RNFL in glaucoma.
Comparison of the Efficacy of Accelerated Corneal Cross-Linking Therapy in Different Pediatric Age Groups Having Progressive Keratoconus
(Springer, 2020) Ozer, Muhammet Derda; Batur, Muhammed; Mesen, Selma; Tekin, Serek; Seven, Erbil; Yasar, Tekin
Purpose To report a comparison analysis of accelerated corneal cross-linking (A-CXL) treatment for progressive keratoconus patients in different pediatric age groups. Study design Retrospective, cross-sectional. Methods Patients with progressive keratoconus aged <= 18 were retrospectively reviewed. Forty-one eyes of 41 patients were included in the study. Patients were divided into two groups according to their age (<= 14 years and 15-18 years). All patients underwent epithelium-off A-CXL protocol. Acquired data were compared between the two groups. Results The mean age was 14.3 +/- 1.8 (10-18) years. Twenty-five (61%) of the participants were male, and 16 (39%) were female. Twenty (49%) patients were separated into group 1 (<= 14 years of age), and 21 (51%) were in group 2 (15-18 years). Age at presentation was found to be the only factor in anticipating the progression of keratoconus at the second postoperative year visit (p < 0.001). Progression in keratometric values was detected in seven (35%) of the 20 eyes in group 1, and one (4%) of the 21 patients in group 2 (Z = - 2.44, p = 0.014). Conclusion Even if proper treatment is applied, the progression of keratoconus is likely in patients younger than 14 years of age. Instead of evaluating pediatric patients as a whole, closer follow-up and early treatment may be useful in younger age groups (<= 14 years).
Conjunctival Lymphangiectasis: Successful Surgical Resection of an Idiopathic Case
(Ophthoscience Publ, 2019) Seven, Erbil; Batur, Muhammed; Tekin, Serek; Bulut, Gulay; Yasar, Tekin
Conjunctival lymphagiectasis is a topical ocular condition characterized by swelling of conjunctiva as a result of dilated lymphatics of the bulbar conjunctiva. In this case report, a 51-year-old man presented with conjunctival swelling in the left eye. Conjunctival lymphangiectasis was diagnosed and a conjunctival resection was performed. No recurrence was found in follow-up examination at 9 months.
Conjunctival Myxoma: a Clinicopathologic Report
(Slack inc, 2008) Kilic, Adil; Kosem, Mustafa; Demirok, Ahmet; Cinal, Adnan; Yasar, Tekin
A conjunctival myxoma was identified in a specimen obtained from a 45-year-old woman via excisional biopsy. The patient presented with a slowly growing painless epibulbar mass. The paucicellular tumor included stellate and spindle-shaped cells, mast cells, and dilated lymphatic channels embedded in a loose collagenous matrix. The differential diagnosis of conjunctival myxoma should include tumors that have myxoid patterns and richly myxoid malignant neoplasms. [Ophthalmic Surg Lasers Imaging 2008;39:514-516.]
Could Visual Impairment in the Pediatric Age Group Be Reduced
(Turkish Ophthalmological Soc, 2013) Ceyhan, Dogan; Yasar, Tekin; Caglar, Cagatay
Pediatric age is the most important period for preventive eye care services and research. Vision loss in this period could cause a long life without sight and also significant financial and moral losses, in terms of people and society. Rational screening programs may reduce vision loss in childhood and this issue increases the value of the subject. Retinopathy of prematurity, congenital/infantile cataracts and glaucoma, optic nerve and retinal pathologies, refractive errors, amblyopia, and strabismus are the major clinical pictures causing visual loss in childhood. Using the epidemiological data, it could be estimated that every year approximately two to three thousand children suffer an ophthalmologic disease that causes significant visual loss. Regarding the refractive errors and amblyopia, it could be estimated that hundreds of thousands of children need ophthalmological follow-up in the country. For the timely treatment of these pathologies, a couple of short eye examination programs seem more realistic. Childhood vision loss in the country could be reduced, by informing pediatricians and family physicians and by proper guiding of the public opinion. Effective eye screening could be achieved with the implementation of simple methods like red reflex/Bruckner test with ophthalmoscopy, or simultaneous ( binocular) retinoscopy and ophthalmoscopy of both eyes. Screening programs could be spread throughout the country by appropriate training of the physicians in the health institutions of the country. Screening programs will contribute to reduce the rate of visual disability by disseminating ophthalmologic practices throughout the country.
Effect of Insulin Therapy on Ocular Biometric Parameters in Diabetic Patients
(Mary Ann Liebert, inc, 2020) Seven, Erbil; Yildiz, Saliha; Tekin, Serek; Altas, Ahmet Serkan; Ozer, Muhammet Derda; Batur, Muhammed; Yasar, Tekin
Purpose: To evaluate effects of insulin on ocular parameters in patients with type 2 diabetes mellitus who start insulin therapy. Methods: In this prospective study, ocular biometric parameters were obtained using optical biometer (Lenstar LS900; Haag-Streit AG) and refraction test (ARK-510A Auto refracto-keratometer; Nidek Co. Ltd, Aichi, Japan) before and at 3 months after initiating insulin therapy. In addition, patients' fasting blood glucose (FBG), glycosylated hemoglobin (HbA1C), and blood lipid levels were measured at the same time points. Pretreatment and post-treatment results were compared. In addition, associations between ocular parameters with initial dose and type of insulin treatment regimen, HbA1C, and FBG levels were evaluated. Results: The patients' mean age was 51.2 +/- 12.9 (18-73) years. Post-treatment HbA1C and FBG levels (8.5% +/- 2.5% and 188.1 +/- 111.2 mg/dL, respectively) were significantly lower than pretreatment values (12% +/- 1.4% and 325.3 +/- 95.7 mg/dL, respectively; P < 0.001 for both). There was a significant positive correlation between the change in HbA1C and the change in lens thickness (P = 0.03), and a significant negative correlation between the change in FBG and the change in the spherical equivalent refraction (P = 0.045). Insulin dose and treatment regimen type were not significantly correlated with ocular parameters (P > 0.05). Conclusion: HbA1C-lowering glycemic effect of insulin was correlated with a small decrease in lens thickness. Long-term, randomized controlled trials including larger patient numbers are needed to shed light on the long-term effects of insulin use and glycemic control on ocular parameters.
Endophthalmitis Rate After Open-Globe Injuries in He Area of the City of Van
(Turkish Ophthalmological Soc, 2010) Gul, Adem; Yasar, Tekin; Caglar, Cagatay; Esmer, Oktay
Purpose: Endophthalmitis is an inflammation of the intraocular structures and is mostly associated with open-globe injuries and various surgical eye interventions. In this study, we investigated the endophthalmitis rate in patients who underwent primary repair of open-globe injury. Material and Method: We retrospectively reviewed the records of patients with open-globe injuries who had attended YOzUncti Yil University, Department of Ophthalmology between 1993 and 2009. We analyzed the data of 810 patients who had undergone primary repair; of those, 64 patients had developed endophthalmitis. Results: Endophthalmitis rate was 7,9% (64 patients). Perforating eye injury was commonly seen between 2 and 6 years of age; 56 cases (.1:0/0) were with corneal, 2 (3%-with scleral, and 6 cases (9%) were with corneoscleral perforation. Regarding the time between the onset of endophthalmitis and trauma, 11 (17%) patients developed endophthalmitis in the first 12 hours, 15 (23%)-between 12-24 hours, 13(20%)-on the second day, 13 (20%)-on the third day, and the remaining 12 patients-between the fourth and 30th day. The range of the follow-up period was 2 days-96 months. The most common agents in patients who developed posttraumatic endophthalmitis were metal objects such as fork, knife, needle, injector (39%), wood and thorn (23%) and the remaining were stone, glass, and animal-related factors like horn. Discussion: It was seen that 64 out of 810 patients (7,9%) in our clinic developed endophthalmitis after primary repair of penetrating eye injury.
Epidemiology of Adult Open Globe Injury
(Lippincott Williams & Wilkins, 2016) Batur, Muhammed; Seven, Erbil; Esmer, Oktay; Akaltun, Mahmut Nedim; Yasar, Tekin; Cinal, Adnan
Objective:The aim of this study was to evaluate the epidemiology and outcomes of adult open globe injuries (OGI) in the eastern part of Turkey.Methods:The retrospective study included all the patients who were diagnosed with OGI (436 eyes in 425 patients) at our clinic between 1997 and 2015. The OGI patients aged over 16 years were included into the study. Open globe injuries were classified according to the Ocular Trauma Classification. Age, gender, medical history, time between trauma and hospital admission, and mechanism of injury were recorded for each patient.Results:The incidence of OGI in adults was found to be 3.40/100,000, with 5.00/100,000 in males and 1.67/100,000 in females. Open globe injuries were mostly seen in the age group of 17 to 29 years and in October and November. The patients included 79.5% males and 20.5% females. Intraocular foreign body was detected in 99 (22.7%) eyes. A strong, linear, negative correlation was found between the Ocular Trauma Classification values and final visual LogMAR (r(p) = -0.602, P = 0.0001). The most common mechanism of injury was occupational accident (38.4%).Conclusion:Open globe injuries remain a serious public health problem, resulting in significant vision loss. Open globe injuries are mostly seen in the young, middle-aged, and male working population. Additional preventive measures should be taken for the individuals in these groups.
Epidemiology of Open Globe Injury in Children
(Lippincott Williams & Wilkins, 2017) Batur, Muhammed; Seven, Erbil; Akaltun, Mahmut Nedim; Tekin, Serek; Yasar, Tekin
Purpose: The purpose of this study was to evaluate the epidemiology and outcomes of pediatric open globe injury (OGI). Method: The medical records of all patients diagnosed with OGI in the authors' clinic between 1996 and 2015 were screened retrospectively. A total of 893 eyes of 892 patients aged 16 years or younger were included in the study. Open globe injury was classified according to the ocular trauma classification (OTS). Age, sex, history, cause and month of trauma, treatment received, visual acuity at presentation, final visual acuity, and cause of vision loss were recorded. Results: Children aged 16 years or younger comprised 67.7% of all OGI patients within the studied time period. The annual incidence of OGI in children was 5.16 per 100,000 overall, with 6.12 per 100,000 boys and 4.14 per 100,000 girls. Open globe injuries occurred most frequently in the 3 to 7 year age group and in the summer months. The most common scene of injury was playgrounds (50.2%). A strong, linear, negative correlation was found between OTS values and final visual acuity in logMAR (r(p)=-0.550, P=0.0001). Conclusion: The authors' study revealed that a high proportion of all OGIs in the authors' region occurred in children under 17 years old. As with adults, OGI in children often results in significant vision loss. However, considering the varying degrees of visual recovery demonstrated by some of the authors' patients, particularly those with no light perception at admission, the authors believe an eye-sparing approach is warranted in pediatric OGI.
Evaluation of Successful and Failed Filtering Blebs After Trabeculectomy Using Anterior Segment Optical Coherence Tomography
(Wolters Kluwer Medknow Publications, 2021) Tekin, Serek; Seven, Erbil; Batur, Muhammed; Ozer, Muhammet Derda; Yasar, Tekin
Purpose: To evaluate filtering bleb characteristics using anterior segment optical coherence tomography (AS-OCT) and analyze correlations between these parameters and intraocular pressure (IOP). Methods: The study included 54 eyes of 43 patients who underwent trabeculectomy with mitomycin-C. The patients were divided into two groups based on mean postoperative IOP. The criterion for surgical success was mean unmedicated postoperative IOP <= 18 mmHg. Patients with IOP values >18 mmHg were prescribed anti-glaucoma drops and classified as a surgical failure. All patients underwent AS-OCT, and maximum bleb height, maximum bleb wall thickness, and maximum fluid-filled cavity height were measured. AS-OCT bleb parameters were compared between the successful and failed groups. Results: Of the 54 eyes, 37 (68.5%) were in the successful group, and 17 (31.5%) were in the failed group. Mean preoperative IOP values in the successful and failed groups were 26.9 +/- 6.5 mmHg and 22.9 +/- 4.9 mmHg, preoperatively, versus postoperative values of 13.3 +/- 2.1 mmHg and 22.8 +/- 2.8 mmHg, respectively. Mean postoperative follow-up time was 17.4 +/- 9.5 months in the successful group and 19.1 +/- 10.1 months in the failed group (P = 0.22). In the successful and failed groups, mean bleb height was 1473.7 +/- 150.6 mu m and 1165.4 +/- 217 mu m (P < 0.001), bleb wall thickness was 670.5 +/- 119.9 mu m and 538.8 +/- 144.3 mu m (P = 0.001), and fluid-filled cavity height was 736.5 +/- 196.8 mu m versus 532.5 +/- 226.2 mu m (P = 0.001), respectively. Conclusions: The results of this study showed that higher AS-OCT values for bleb height, wall thickness, and fluid-filled cavity height were associated with greater functional success. These parameters may be helpful in determining bleb functionality.
A Family With Congenital Cataract From Grandfather Throughout Grandchildren
(Turkish Ophthalmological Soc, 2009) Yener, Halil Ibrahim; Gul, Adem; Yasar, Tekin; Cinal, Adnan
Purpose: To report cataract cases along three generation in a large family. Introduce: Hereditary cataracts can be divided into two groups as congenital or developmental. Congenital cataracts can be seen with systemic diseases or as isolated in one third. Congenital cataract is still one of the most important treatable causes of blindness in childhood period. The proportion of blindness is 5-15/10 000 in developing countries and 1-4/10 000 in developed countries. The ratio of blindness related to cataract is 1-4/10 000 in developing versus 0,1-0,4/10 000 in developed countries. Case: A grandfather, his 10 children and five grandchildren were examined. Patients who have cataract were operated. All subjects were investigated in terms of systemic disases. Grandfather who was aphakic visited clinic for getting new glasses. Patient had operated in childhood period. He said that his two children were also operated in both eyes. We called other family members for ophthalmologic examination. We found posterior subcapsular cataract in four children and two grandchildren. None of these patients had systemic disases. conclusion: In cases of congenital or developmental cataracts, the relatives also must be examined and if needed intervention may be needed.
Glaucoma Caused by Isolated Microspherophakia: a Long Story
(Medknow Publications & Media Pvt Ltd, 2014) Caglar, Cagatay; Yasar, Tekin
In Vivo Confocal Microscopy and Biomicroscopy of Filtering Blebs After Trabeculectomy
(Lippincott Williams & Wilkins, 2016) Caglar, Cagatay; Karpuzoglu, Nafiz; Batur, Muhammed; Yasar, Tekin
Purpose: The aim of this study is to analyze filtering blebs (FBs) after trabeculectomy with in vivo confocal microscopy (IVCM) and slit-lamp biomicroscopy. Materials and Methods: IVCM using the Heidelberg Retina Tomograph/Rostock Cornea Module and biomicroscopic examination were performed in 67 FBs in 55 patients 3 months to 30 years postoperatively (mean, 3.2 +/- 2.1 y). Although the blebs were evaluated by slit-lamp biomicroscopy, standardized FB classification was used. Results: Of the patients, 9 were female (16.3%) and 46 were male (83.7%), ranging in age from 32 to 81 (51.5 +/- 13.2) years. The absence of vascularization and tortuous vessels and the presence of epithelial microcysts on the bleb were significantly correlated with good bleb function (P = 0.001). IVCM findings significantly correlated with good bleb function, including the number of epithelial microcysts (P = 0.002), the stromal cysts without capsule (P < 0.001), minimal vascularization (P = 0.002), and the absence of tortuous conjunctival vessels (P = 0.003) and reticular and trabecular bleb patterns (P = 0.01 and < 0.01, respectively). In contrast, a hyperreflective condensed bleb stroma was significantly associated with bleb failure (P < 0.001). Conclusions: IVCM supports biomicroscopic evaluation as the mainstay for FB analysis and permits diagnostic imaging of FBs to evaluate and follow-up the bleb, differentiation between good and insufficient bleb function, and a microscopic analysis at a cellular level including the structural pattern of the bleb.
İntravitreal Deksametazon İmplantının Göz İçi Basıncına Etkisi
(2023) Batur, Muhammed; Seven, Erbil; Tekin, Serek; Eren, Sena Gülbay; Yasar, Tekin
Amaç: İntravitreal 0.7 mg deksametazon implantının göz içi basıncı (GİB) üzerine etkisini incelemek. Gereç ve Yöntem: Bu çalışmaya retina ven tıkanıklığı veya diyabetik retinopatiye bağlı makula ödemi olup intravitreal deksametazon implant uygulanan hastalar alındı. Glokomu, oküler hipertansiyonu ve açıda neovaskülarizasyonu olan hastalar çalışma dışı bırakıldı. GİB Applanasyon tonometrisi ile enjeksiyon öncesi ve enjeksiyon sonrası 1. gün, 1. hafta, 2. hafta, 1. ay, 3. ay ve 6. ay ölçüldü. Bulgular: Çalışmaya 55 (%54.45)’i erkek, 46 (%45.54)’sı kadın olmak üzere 101 hastanın 105 gözü dahil edildi. Hastaların ortalama yaşı 63.9±9,5 (32-85) yıl idi. Enjeksiyon öncesi ortalama GİB 14.43±2.53 mmHg olup, enjeksiyon sonrası ortalama GİB ve enjeksiyon öncesine göre p değerleri sırasıyla 1. gün 15.31±3.65 mmHg (p=0.132), 1. hafta 14.87±3.11 mmHg (p=0.371), 2. hafta 16.78 ±3.82 mmHg (p=0.001), 1. ay 17.38±4.30 mmHg (p=0.001), 3. ay 16.92±4.55 mmHg (p=0.001) ve 6. ay 15.59±2.78 mmHg (p=0.005) olarak saptandı. Enjeksiyon sonrası 5 (%4.8) hastada GİB artışı >21mmHg oldu, antiglokomatöz ilaçlar ile bu hastalarda GİB kontrol altına alındı. Sonuç: Retina ven tıkanıklığı veya diyabetik retinopatiye bağlı maküler ödem tedavisinde intravitreal deksametazon implantasyonu güvenli bir tedavi yöntemi olarak değerlendirilebilir. Ancak hastaların düzenli olarak GİB ölçümünün yapılması gerekir.