Browsing by Author "Yavuz, Mahmut"

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The Investigation of Hawthorn (Crataegus Orientalis) Plant's Inhibition Effect on Angiotensin Converting Enzyme and in Silico Studies
(Taylor & Francis Ltd, 2024) Yavuz, Mahmut; Celikezen, Fatih Caglar; Firat, Mehmet; Bas, Zehra; Turkoglu, Vedat
Hawthorn plant is used among people due to its cardiovascular, anti-inflammatory, and antihistamine properties. But no scientific study has been done about Crataegus orientalis (Mill.) M.Bieb. The presented study was planned to determine the effects of ethanol and n-hexane extracts of Crataegus orientalis leaves on human plasma ACE enzyme. In the study, the effect of plant extracts on ACE was studied by the spectrophotometric method. The chemical composition of the plant extracts was determined by HPLC-DAD analyses. In addition, molecular doking and ADME prediction studies were carried out. As a result, the obtained data showed that Crataegus orientalis could have an important place in the pharmaceutical industry and drug discovery studies, as it supports the traditional use of Crataegus orientalis as hypotensive. The results of the molecular docking studies revealed that the interactions of the selected compounds with the human ACE enzyme caused inhibition. [GRAPHICS]
One-Step Synthesis of Triarm Block Copolymers by Simultaneous Atom Transfer Radical and Ring-Opening Polymerization
(Springer, 2016) Ozturk, Temel; Yavuz, Mahmut; Goktas, Melahat; Hazer, Baki
One-step synthesis of poly(MMA-b-CL) triarm block copolymers was carried out by atom transfer radical polymerization of methyl methacrylate (MMA) and ring-opening polymerization of epsilon-caprolactone (CL) using 3-chloro-1,2-propanediol trifunctional initiator. The triarm block copolymers comprising one poly-MMA arm and two poly-CL arms were synthesized by changing some polymerization conditions such as monomer/initiator concentration, polymerization time. The effect of the reactions conditions on the polydispersity and molecular weights was also investigated. The block lengths of the block copolymers were calculated by using H-1-nuclear magnetic resonance (H-1-NMR) spectrum. It was observed that the block length could be altered by varying the monomer and initiator concentrations. The characterization of the products was achieved by using H-1-NMR, Fourier-transform infrared spectroscopy, gel-permeation chromatography, differential scanning calorimetry, thermogravimetric analysis and fractional precipitation techniques.