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Browsing by Author "Yavuzer, B."

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    Article
    Effect of Taxifolin on Doxorubicin-Induced Oxidative Cardiac Damage in Rats: a Biochemical and Histopathological Evaluation
    (Pakistan Agricultural Scientists Forum, 2024) Aldemir, M. N.; Kara, A., V; Mammadov, R.; Yazici, G. N.; Cicek, B.; Yavuzer, B.; Suleyman, H.
    Doxorubicin is a widely used anthracycline-derived broad-spectrum antitumoral antibiotic drug. However, cardiotoxicity due to doxorubicin treatment has warranted dose reduction or complete discontinuation in certain cases. The role of oxidative stress in the pathogenesis of doxorubicin-induced cardiotoxicity has been previously demonstrated. Against this background, this study aimed to investigate the protective effect of the potent antioxidant flavone taxifolin against possible oxidative heart damage biochemically and histopathologically induced by doxorubicin. Albino Wistar male rats were divided into three groups: healthy controls (HG), a group given doxorubicin alone (DG), and a group given taxifolin + doxorubicin ( TDG). Taxifolin was administered orally at a dose of 50 mg/kg via gavage. Doxorubicin was injected intraperitoneally at a dose of 5 mg/kg. This procedure was repeated for 7 days. The results of the biochemical experiment showed that taxifolin significantly inhibited doxorubicin-induced malondialdehyde increases and glutathione decreases in heart tissues. In addition, taxifolin significantly suppressed the increases in cardiac damage markers, such as serum troponin I, creatine kinase, and creatine kinase-MB, induced by doxorubicin. Taxifolin treatment has also been histopathologically shown to alleviate doxorubicin-induced heart tissue damage. Accordingly, the results of the present study suggest that taxifolin may be useful in the treatment of doxorubicin-induced oxidative heart damage.
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    Article
    The Effects of Corneal Edema on the Intraocular Pressure Measurements
    (Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Seven, E.; Tekin, S.; Batur, M.; Yavuzer, B.; Yaşar, T.
    We aimed to evaluate the possible effects of corneal edema on intraocular pressure (IOP) measurements obtained with three different tonometers on the first day after cataract surgery. Sixty-four eyes of the 64 patients underwent phacoemulsification and IOP measurements using Goldmann applanation tonometer (GAT), Tono-Pen applanation tonometer (TAT), and Pascal digital contour tonometer (DCT) the first day after surgery. Central corneal thickness (CCT) measurements were used to quantify the postoperative corneal edema. Intraclass correlation coefficient and Bland-Altman plot were used to assess the compatibility of IOP measurements among three method pairs. TAT and DCT IOP measurements were found to be compatible with each other (p=0.141) in the corneal edema group. The GAT and TAT IOP measurements in the eyes with corneal edema were inversely proportional to the CCT values (p=0.011 and p=0.033, respectively), but the DCT relationship was not statistically significant (p=0.44). The lack of a significant relationship between DCT and CCT in edematous corneas may suggest that DCT, as in normal corneas, can perform CCT-independent measurements. However, there is still no gold standard method for IOP measurement in edematous corneas. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.