Browsing by Author "Yaylali, Yalin Tolga"

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Acute Serious Thrombocytopenia Associated With Intracoronary Tirofiban Use for Primary Angioplasty
(Hindawi Ltd, 2014) Yurtdas, Mustafa; Yaylali, Yalin Tolga; Aladag, Nesim; Ozdemir, Mahmut; Atay, Memis Hilmi
Tirofiban, a specific glycoprotein IIb/IIIa inhibitor, may cause extensive thrombocytopenia with an incidence of 0.2% to 0.5%. We report the case of a 50-year-oldman who developed thrombocytopenia after tirofiban use (both intracoronary and peripheral) over hours and the successful management of this complication after primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.
Association of Heart Rate Recovery With Microalbuminuria in Non-Obstructive Coronary Artery Disease
(Elmer Press inc, 2017) Yurtdas, Mustafa; Ozdemir, Mahmut; Aladag, Nesim; Yaylali, Yalin Tolga
Background: Non-obstructive coronary artery disease (CAD) is associated with significantly increased risk for myocardial infarction. Heart rate recovery (HRR), a measure of autonomic function, is a strong predictor of all-cause mortality. Microalbuminuria, a marker of early arterial disease, is an independent risk factor for cardiovascular disease and mortality. We aimed to investigate HRR and determine its relationship with microalbuminuria in patients with non-obstructive CAD. Methods: We prospectively studied 565 patients who underwent elective coronary angiography. All participants underwent urinary analysis and then an exercise test. Microalbuminuria was defined as an urinary albumin-to-creatinine ratio (UACR) of 30 -299 mg/g. The HRR was abnormal if <= 12 beats/min during the first minute after exercise. First, all patients were divided into two groups, patients with microalbuminuria (n = 152) and patients without microalbuminuria (n = 413). Then, all patients were re-divided into two groups, those with lower HRR (<= 12 beats/min, n = 126) and those with higher HRR (> 12 beats/min, n = 439). Results: Patients with microalbuminuria had lower HRR and patients with lower HRR had higher UACR. While UACR was negatively correlated with HRR in patients with microalbuminuria (r = -0.424; P < 0.001) and in patients with lower HRR (r = -0.192; P = 0.042), there was no correlation of UACR with HRR in neither patients with normoalbuminuria nor patients with higher HRR, respectively. In the all study population, there was a significant inverse association between UACR and HRR (r = -0.445, P < 0.001), and UACR independently predicted the presence of lower HRR (P < 0.001). Conclusions: Our findings showed that there was a significant inverse association between UACR and HRR in patients especially with microalbuminuria, and that albuminuria might predict cardiac autonomic imbalance evaluated by HRR in patients with non-obstructive CAD.
The Effects of Baseline Heart Rate Recovery Normality and Exercise Training Protocol on Heart Rate Recovery in Patients With Heart Failure
(Turkish Soc Cardiology, 2015) Yaylali, Yalin Tolga; Findikoglu, Gulin; Yurtdas, Mustafa; Konukcu, Sibel; Senol, Hande
Objective: It is unclear which exercise training protocol yields superior heart rate recovery (HRR) improvement in heart failure (HF) patients. Whether baseline HRR normality plays a role in the improvement is unknown. We hypothesized that an exercise training protocol and baseline HRR normality would be factors in altering HRR in HF patients. Methods: In this prospective, randomized, controlled and 3 group parallel study, 41 stable HF patients were randomly assigned to 3-times-weekly training sessions for 12 weeks, consisting of i) 30 minutes of interval training (IT) (n=17, 63.7 +/- 8.8 years old) versus ii) 30 minutes of continuous training (CT) (n=13, 59.6 +/- 6.8 years old) versus iii) no training (CON) (n=11, 60.6 +/- 9.9 years old). Each patient had cardiopulmonary exercise testing before and after the training program. Maximum heart rates attained during the test and heart rates at 1 and 2 min (HRR1 and HRR2) during the recovery phase were recorded. Paired samples t-test or Wilcoxon signed-rank test was used for comparisons before and after training. One-way ANOVA or Kruskal-Wallis variance analysis was used for comparisons among groups. Results: HRR1 was unchanged after training. HRR2 improved in the IT group after training, and post-training HRR2 values were significantly faster in the IT group than in controls. Both HRR1 and HRR2 was significantly faster, irrespective of exercise protocol in patients with abnormal baseline values after training. Conclusion: HRR1 did not improve after training. HRR2 improved only in the IT group. Both HRRs in patients with abnormal baseline values improved after both exercise protocols. IT might be superior to CT in improving HRR2. Baseline HRR might play a role in its response to exercise.
Increased Plasma High-Sensitivity C-Reactive Protein and Myeloperoxidase Levels May Predict Ischemia During Myocardial Perfusion Imaging in Slow Coronary Flow
(Elsevier Science inc, 2014) Yurtdas, Mustafa; Yaylali, Yalin Tolga; Kaya, Yuksel; Ozdemir, Mahmut
Background and Aims. It is unclear whether changes in plasma levels of inflammatory markers could explain the link between ischemia and slow coronary flow (SCF). The aim of the study was to evaluate the plasma levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, and myeloperoxidase (MPO) during myocardial perfusion imaging (MPI) in SCF patients. Methods. The study population consisted of 53 SCF patients and 30 controls. Coronary flow rates were documented by TEVII frame count (TFC). Plasma levels of hsCRP, IL-6, MPO, and MPI were obtained in all participants. Results. hsCRP, IL-6 and MPO levels of SCF patients were higher than controls (hsCRP: 4.7 +/- 2.5 vs. 1.7 +/- 1.1 mg/L, p <0.001; IL-6: 8.2 +/- 4.3 vs. 5.2 +/- 2.1 pg/mL, p <0.001;. and MPO: 75.9 +/- 59.6 vs. 24.3 +/- 16.7 ng/mL, p <0.001). Twenty-one SCF patients exhibited myocardial perfusion defect (MPD) on MPI. In SCF patients, the highest hsCRP, IL-6 and MPO levels were observed in patients with both MPD and three-vessel slow flow. Mean TFCs were positively correlated with plasma levels of hsCRP (r = 0.424, p = 0.002), IL-6 (r = 0.367, p = 0.007), MPO (r = 0.430, p = 0.001), and reversibility score (r = 0.671, p <0.001) in SCF patients. HsCRP and MPO were the independent variables, which predicted positive MPI results (hsCRP: OR, 2.176; 95% CI, 1.200-3.943; p = 0.010, MPO: OR, 1.026; 95% CI, 1.007-1.046; p = 0.008). Conclusions. Inflammation may play a crucial role in both the pathogenesis and development of ischemia in SCF. Association of increased levels of inflammatory markers and ischemia suggests that endothelial inflammation may be largely responsible for clinical presentation. New combined treatment regimens should target endothelial activation and inflammation in SCF. (C) 2014 IMSS. Published by Elsevier Inc.
Increased Plasma Hscrp and Mpo Levels May Predict Ischemia During Mpi in Slow Coronary Flow
(Elsevier Science inc, 2013) Yurtdas, Mustafa; Yaylali, Yalin Tolga; Ozdemir, Mahmut; Kaya, Yuksel; Arin, Can Baba
Neutrophil-To Ratio May Predict Subclinical Atherosclerosis in Patients With Psoriasis Reply
(Wiley-blackwell, 2014) Yurtdas, Mustafa; Yaylali, Yalin Tolga; Ozdemir, Mahmut; Aladag, Nesim; Ozkan, Ilker; Kaya, Yuksel