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Browsing by Author "Yazici, Ahmet"

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    6-Methylthiouracil and 6-Methyluracil Derivatives Synthesized by Reaction of Acetylketene With Thiourea and Urea Compounds in Presence of Yb(Tfa)3
    (Taylor & Francis inc, 2023) Aslanoglu, Furgan; Yazici, Ahmet
    Thiouracil and uracil derivatives are among the bioactive molecules used in the treatment of many diseases, such as 6-propylthiouracil and 5-fluorouracil. A new synthesis method of 6-methylthiouracil and 6-methyluracil was developed in this study. Various 6-methylthiouracil and 6-methyluracil derivatives were obtained by reacting 2,2,6-trimethyl-4H-1,3-dioxin-4-one with thiourea and urea compounds in the presence of Yb(TFA)(3) according to this new method. Optimization of this new method was performed. The structures of 6-methylthiouracil and 6-methyluracil derivatives were characterized.