Browsing by Author "Yildirim, N."

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Adenoid Hypertrophy in Adults: Clinical and Morphological Characteristics
(Sage Publications Ltd, 2008) Yildirim, N.; Sahan, M.; Karslioglu, Y.
This study compared the aetiology and pathological characteristics of adult and childhood adenoid hypertrophy (AH). Clinical and morphological features and accompanying otolaryngological pathologies were recorded in 40 adults and 23 children undergoing adenoidectomy for obstructive AH. Both AH forms were similar in terms of symptomatology and associated inflammations. There were, however, significant differences in otitis media rate, with effusion and dullness, and retraction in the eardrum both more prevalent in childhood AH. Adult AH was associated with nasal septum deviation in 25.0% of patients. Histopathological features of adenoidal lymphoid tissue were dissimilar in the two groups: numerous lymph follicles with prominent germinal centres was the chief finding in childhood adenoids, whereas adult adenoids showed chronic inflammatory cell infiltration and secondary changes (e.g. squamous metaplasia). These results underline the importance of considering AH as a cause or contributing factor in nasal obstruction and related pathologies in adults and supports the theory that it represents a long-standing inflammatory process rather than being a novel clinical entity.
Allelopathic Effects of Plants Extracts on Physiological and Cytological Processes During Maize Seed Germination
(Allelopathy Journal, 2008) Turker, M.; Battal, P.; Agar, G.; Gulluce, M.; Sahin, F.; Erez, M. E.; Yildirim, N.
The methanol extracts (3.3, 5.6 and 10.0%) of Berberis vulgaris L., Mentha longfolia (L) Huds., Salvia limbata C.A. Mey., Artemisia absinthium L., Achillea biebersteinii Afan., Origanum vulgare L., Medicago sativa L., Vicia cracea (Desf.) B. Fedtsch were applied to maize (Zea mays L.) seeds to determine their effects on radical, plumule growth, contents of phytohormones [giberellic acid equivalents (GAs), indole-3-acetic acid (IAA), trans-zeatin (t-Z) and abscisic acid (ABA)], carbohydrates (glucose, fructose and sucrose), fatty acids, (palmitic acid and oleic acid), mitotic index and chromosome abnormalities as compared to control. The 5.0 and 10.0 % extracts inhibited the germination. The extracts also decreased the length of plumule and radicals. However, there were variable effects on plant hormones, fatty acids and sugar levels. Plant extracts decreased the mitotic index and also caused abnormalities in chromosomes.
Delayed Surgical Treatment of Traumatic Hearing Loss Due To Ossicular Disruption
(Royal Belgian Soc Ear, Nose, Throat, Head & Neck Surgery, 2008) Yildirim, N.; Sahan, M.
Delayed surgical treatment of traumatic hearing loss due to ossicular disruption. Objective: Surgical treatment of dislocation and fracture of the middle ear ossicles is recommended to be carried out within months of the initial injury. Here we present 6 patients with traumatic ossicular injury whose surgery was delayed over I year. We evaluated the clinical and pathological changes that occurred over time and assessed the surgical outcomes in delayed cases. Methodology: Histories of the causative traumas, computerized tomography (CT) and tympanometry findings, pre- and postoperative hearing thresholds, and ossicular damages assessed at the tympanotomies were evaluated. Results: The time lapse between the trauma and the surgery varied from I to 6 years. The resultant hearing losses were moderate or moderately severe, conductive, mixed or sensorineural type. Tympanometry and CT revealed ossicular discontinuity in only two cases. In operations, various types of ossicular abnormalities in the form of absence, displacement, fracture and/or fixation were identified. Continuity and mobility of the ossicular chains were restored with various techniques. Air-bone conduction gap was brought to within 20 dBHL in all cases, and within 10 dB in 3 (50%) of the cases. Gains in the bone conduction were also notable. Conclusion: Trauma to the middle ear may result in an elevation in the air and/or bone conduction thresholds due to ossicular disruption and fixation. Our findings confirmed that tympanotomy is superior to methods such as CT and tympanometry in delineating the type and extent of the traumatic ossicular damage, and usually gives favorable results even in delayed cases.
Sensorineural Hearing Loss After Ossicular Manipulation and Drill- Generated Acoustic Trauma in Type I Tympanoplasty With and Without Mastoidectomy: a Series of 51 Cases
(Medquest Communications LLC, 2015) Kazikdas, K.C.; Onal, K.; Yildirim, N.
Recognized causes of high-frequency sensorineural hearing loss (SNHL) after tympanoplasty with and without mastoidectomy include acoustic trauma from manipulation of the ossicles, the noise generated by suctioning and, in the case of mastoidectomy, the noise generated by temporal bone drilling. We conducted a retrospective study to identify the effects of ossicular manipulation and mastoid drilling on high-frequency SNHL. Our study population was made up of 51 patients-20 males and 31 females, aged 10 to 59 years (mean: 28.5). Of this group, 26 patients had undergone a unilateral over-under tympanoplasty only (tympanoplasty group) and 25 had undergone a unilateral tympanoplasty plus additional mastoid surgery (mastoidectomy group). Bone-conduction audiograms were obtained pre- and postoperatively; the latter were obtained within 24 hours after surgery and again at 6 months of follow-up. In the tympanoplasty group, a significant SNHL, primarily at 2 kHz, was seen in 6 patients (23%) at 24 hours, but at 6 months there was no depression of bone-conduction thresholds. In the mastoidectomy group, a significant SNHL, primarily at 2 and 4 kHz, occurred in 12 patients (48%) at 24 hours, and bone-conduction deterioration was still present in 4 patients (16%) 6 months after surgery. The difference between the preoperative audiograms and the 6-month audiograms in both groups was statistically significant (p = 0.034). We conclude that (1) over-under tympanoplasty, which requires significant manipulation of the ossicles, can cause temporary SNHL after surgery, and (2) prolonged exposure to the noise generated by mastoid drilling can result in permanent SNHL. © 2016 Vendome Group, LLC All rights reserved.