Browsing by Author "Yildiz, Ela"

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Microwave-Assisted Synthesis of New Dihydropyrimidine Derivatives and Mechanism of the Reactions
(Bentham Science Publ Ltd, 2013) Akbas, Esvet; Sahin, Ertan; Yildiz, Ela; Anil, Baris; Akyazi, Inci
5-benzoyl-4-aryl-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidines were synthesized via Biginelli cyclocondensation reaction. The diethyl 2-(4-aryl-5-benzoyl-6-phenyl-3,4-dihydropyrimidin-2(1H)-ylidene) malonates were prepared by the reaction of thioxopyrimidines with diethyl 2-bromomalonate in dioxane/pyridine (10/1 v:v) under microwave irradiation and conventional conditions. The reaction of diethyl 2-(5-benzoyl-4,6-phenyl-3,4-dihydropyrimidin-2(1H)ylidene) malonate with hydrazine hydrate and urea yielded the compounds of (E)-ethyl 2-(5-benzoyl-4,6-diphenyl-3,4-dihydropyrimidin-2(1H)-ylidene)-3-hydrazinyl-3-oxopropanoate and (E)-ethyl 2-(5-benzoyl-4,6-diphenyl-3,4dihydropyrimidin-2(1H)-ylidene)-3-oxo-3-ureidopropanoate, respectively. All of these new derivatives were characterized by analytical and spectroscopic studies. The structure of the diethyl 2-(5-benzoyl-4,6-diphenyl-3,4-dihydropyrimidin-2(1H)-lidene) malonate was identified by a single crystal X-ray diffraction analysis, and the reaction mechanism was also discussed.
Microwave-Assisted Synthesis of Tetrahydropyrimidines Via Multicomponent Reactions and Evaluation of Biological Activities
(Bentham Science Publ Ltd, 2011) Akbas, Esvet; Berber, Ismet; Akyazi, Inci; Anil, Baris; Yildiz, Ela
Various pyrimidine derivatives (1a-c) were synthesized using the Biginelli three component cyclocondensation reactions of a beta-diketone, arylaldehyde, and thiourea, under microwave irradiation and conventional conditions. The acetylation of compound 1a gave 3-acetyl thioxopyrimidin 2. Also, thiazolopyrimidine (3) and (4) derivatives were obtained by a simple one-pot condensation reaction of starting compounds 1a, and 1b with 2-bromopropionic acid. The prepared compounds were screened for their antimicrobial activities against Gram-positive, Gram-negative bacteria and fungi using micro dilution procedure. The results of the study showed that the compound 4 was effective and selective for antimicrobial activity against the tested bacteria and fungi. Thus, we suggested that the compound 4 might be a new potential antimicrobial substance for bacteria and fungi.
Synthesis, Characterization and Theoretical Studies of Novel Pyrimidine Derivatives as Potential Corrosion Inhibitors
(Serbian Chemical Soc, 2020) Akbas, Esvet; Yildiz, Ela; Erdogan, Ahmet
In this study, five new pyrimidine derivatives were synthesized and characterized by characterization methods such as H-1-NMR, C-13-NMR, FT-IR and elemental analysis. The corrosion inhibition activity of the synthesized compounds was examined by theoretical calculation using DFT method at the level of B3LYP/6-31G (d,p). According to the calculations, 4-(6-benzoyl-2-benzylidene-3-oxo-7-phenyl-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidin-5-yl)-benzoic acid (6) appears to be a good inhibitor for corrosion.