Browsing by Author "Yildiz, Hanifi"

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Analysis of Endogenous Oxidative Damage Markers and Association With Pulmonary Involvement Severity in Patients With Sars-Cov Pneumonia
(Elsevier France-editions Scientifiques Medicales Elsevier, 2021) Yildiz, Hanifi; Alp, Hamit Hakan; Ekin, Selami; Arisoy, Ahmet; Gunbatar, Hulya; Asker, Selvi; Haylu, Mine
Introduction: The SARS-CoV-2 virus affects many organs, especially the lungs, with widespread inflammation. We aimed to compare the endogenous oxidative damage markers of coenzyme Q10, nicotinamide dinucleotide oxidase 4, malondialdehyde, and ischemia-modified albumin levels in patients with pneumonia caused by SARS-CoV-2 and in an healthy control group. We also aimed to compare these parameters between patients with severe and non-severe pulmonary involvement. Methods: The study included 58 adult patients with SARS-CoV-2 pneumonia and 30 healthy volunteers. CoQ10 and MDA levels were determined by high-pressure liquid chromatography. NOX4 and IMA levels were determined by ELISA assay and colorimetric method. Results: Higher levels of CoQ10, MDA, NOX4, and IMA and lower levels of COQ10H were observed inpatients with SARS-CoV-2 pneumonia than in the control group. MDA, IMA, NOX4, and CoQ10 levels were significantly higher in patients with severe pulmonary involvement than in patients with non-severe pulmonary involvement, but no significant difference was observed in CoQ10H levels. CoQ10 levels were significantly and positively correlated with both ferritin and CRP levels. Conclusion: SARS-CoV-2 pneumonia is significantly associated with increased endogenous oxidative damage. Oxidative damage seems to be associated with pulmonary involvement severity.
Blood Prestin Levels in Covid-19 Patients
(Lippincott Williams & Wilkins, 2023) Turan, Mahfuz; Alp, Hamit Hakan; Yildiz, Hanifi; Baran, Ali Irfan; Ekin, Selami; Akin, Ramazan; Bozan, Nazim
Background: Many studies have found that viral infections affect different tissues, including the inner ear. Coronavirus disease 2019 (COVID-19), a viral infection, is a significant health problem worldwide. Prestin is a motor protein with important functions both in the outer hair cells of the inner ear and in cardiac tissue. In addition, prestin is promising as an early biomarker in the detection of ototoxicity. To determine the severity of infection in COVID-19 patients and to determine whether other tissues are affected by the infection, lactate dehydrogenase (LDH), C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase MB (CK-MB), biochemical markers such as ferritin and D-dimer are used. This study aimed to compare prestin levels in patients with COVID-19 and healthy volunteers.Methods: In blood samples taken from 45 patients diagnosed with COVID-19 and 40 healthy volunteers, prestin levels were determined with the kit that used an enzyme-linked immunosorbent assay method and was commercially available. At the same time, LDH, CRP, ALT, AST, CK-MB, ferritin, and D-dimer levels were also detected in both patients and healthy control groups and correlations with prestin levels were examined.Results: The main result of our study is that serum prestin levels in COVID-19 patients are significantly higher than in healthy controls (p < 0.001). In addition, a statistically significant strong positive correlation was found between prestin-LDL (r = 0.537, p = 0.001), prestin-CRP (r = 0.654, p = 0.001), and prestin-D-dimer (r = 0.659, p = 0.001).Conclusion: The levels of prestin, a motor protein in inner ear outer hair cells and cardiac myocytes, were found to be higher in COVID-19 patients than in healthy volunteers. It also showed a positive correlation with CRP and D-dimer. This may be associated with systemic dysfunction.
A Case of Miliary Tuberculosis, Pneumothorax, and Pulmonary Thromboembolism: Original Image
(Ortadogu Ad Pres & Publ Co, 2009) Ozbay, Bulent; Sertogullarindan, Buenyamin; Asker, Selvi; Ekin, Selami; Yildiz, Hanifi; Sunnetcioglu, Mahmut
A 30 years old woman complained of high fever and dyspnea. She delivered her 7(th) child 4 weeks ago. Symptoms had started after delivery and increased during the last 3 days. PA chest roentgenogram showed diffuse and bilateral miliary nodules. Physical examination revealed temperature 39.2 degrees C, pulse 130/min, arterial tension 90/60 mmHg, respiratory rate 35/min, and lung sounds normal. Deep venous thrombosis was detected in the right leg. SaO(2) was 69% and PaO2/FiO(2) was 86 while on 6 L/min O-2 inhalation. Computed tomography of thorax showed filling defects as well as miliary nodules. The tuberculin skin reaction was positive. Bilateral tuberculosis foci were seen in the choroid of retina. Treatment consisted of antituberculous drugs, anticoagulants, fluid and nutritional support. PaO2/FiO(2) rapidly improved. Recurrent pneumothorax developed. A tube thoracostomy was inserted. This case was interesting regarding the coexistence of miliary tuberculosis, recurrent pnomothorax, and venous thromboembolism.
Delftia Acidovorans Pneumonia With Lung Cavities Formation
(Corporacion Editora Medica Valle, 2019) Yildiz, Hanifi; Sunnetcioglu, Aysel; Ekin, Selami; Baran, Irfan; Ozgokce, Mesut; Asker, Selvi; Akyuz, Sumeyye
Case Description: A 52-year-old female patient was admitted to our clinic with complaints of cough, sputum, fever and fatigue. The patient has been receiving immunosuppressive therapy for thrombocytopenic purpura for 5 years. Clinical Finding: Inspiratory crackles were heard on both hemithorax. Oxygen saturation measured with the pulse oximeter was 97%. Chest X-ray showed diffuse reticular opacities that were more prominent in the upper zones of both lungs. WBC counts were 17,600 mm(3) and Platelet counts were 29,000 mm3. Thorax CT showed that there were many thin-walled cavities and millimetric nodules accompanied by ground-glass infiltrates in the upper and middle lobes. Gram staining of bronchial fluid, taken by bronchoscopy, revealed Gram-negative bacilli and intense polymorphonuclear leukocytes. The bacteria were defined as Delftia acidovorans by BD Phoenix automated system. Treatment and outcomes: The patient was hospitalized with suspicion of opportunistic pulmonary infections and cavitary lung disease. After the empirical treatment of intravenous piperacillintazobactam and oral clarithromycin, her clinical and radiological findings significantly regressed, and she was discharged with outpatient follow-up. Clinical Relevance: This is the first example of cavitary pneumonia due to Delftia acidovorans in an immunocompromised patient. We would like to emphasize that Delftia pneumonia should be considered in the differential diagnosis of pulmonary cavitary involvement in such patients.
Effect of Combined Use of Tolterodine and Continuous Positive Airway Pressure Vs Continuous Positive Airway Pressure Only Treatment on Overactive Bladder Symptoms in Women With Moderate-To Obstructive Sleep Apnea Syndrome: a Randomized Clinical Trial
(Springer London Ltd, 2022) Ertas, Kasim; Yildiz, Hanifi; Demir, Murat; Aslan, Rahmi; Eryilmaz, Recep; Kirmizitoprak, Sevder; Taken, Kerem
Introduction and hypothesis Obstructive sleep apnea syndrome is associated with urological symptoms, including overactive bladder (OAB). This study aims to determine whether combined tolterodine and CPAP therapies are more effective for patients with OSAS than CPAP treatment only. Methods Women who underwent polysomnography test and were diagnosed with moderate-to-severe OSAS with apnea-hypopnea index (AHI) were included in the study. Data were collected on AHI, OAB awareness-8-item tool (OAB-V8), incontinence questionnaire-urinary incontinence short form (ICIQ-UI-SF), total daily urine volume (DUV), and the Benefit, satisfaction with treatment and willingness (BSW) tool. Eligible patients were randomized to receive either CPAP treatment only or combined CPAP and tolterodine treatment for 3 months. Results Among 103 participants, a total of 60 were included. Patients in both treatment arms showed significant improvements in OAB-V8, ICIQ-UI-SF, and total DUV compared to their baseline. The mean OAB-V8 was 15.7 at baseline and 5.6 at 3 months for the combined treatment arm and 16.6 and 7.6 at 3 months for the CPAP group only (mean baseline-adjusted between-group difference -1.1 [95% CI, -12.3 to -7.4]; p < 0.001). The improvement in the mean ICIQ-UI-SF was also statistically more significant in the combined therapy group than in the CPAP only arm (mean baseline-adjusted between-group difference -3.27 [95% CI, -4.6 to -1.59]; p < 0.001). No statistical significance was found in the improvement of total DUV between the groups. Conclusions In this study, combined use of tolterodine with CPAP provides beneficial effects to CPAP treatment only regarding OAB symptoms. Further research is required to confirm these findings in a large cohort.
The Efficiency of Diffusion-Weighted Magnetic Resonance Imaging in the Differentiation of Malign and Benign Cavitary Lung Lesions
(Lippincott Williams & Wilkins, 2023) Durmaz, Fatma; Ozgokce, Mesut; Aydin, Yener; Yildiz, Hanifi; Ozkacmaz, Sercan; Dundar, Ilyas; Goya, Cemil
Purpose:The present study investigates the diagnostic efficiency of apparent diffusion coefficient (ADC) values in differentiating between malignant and benign cavitary lesions on diffusion-weighted magnetic resonance imaging (DWI). Materials and Methods:This prospective study included 45 consecutive patients identified with a cavitary lung lesion with a wall thickness of >= 5 mm on thoracic computed tomography in our clinic between 2020 and 2022, and who underwent thoracic DWI within 1 week of their original computed tomography. ADC measurements were made on DWI by drawing a region of interest manually from the cavity wall, away from the lung parenchyma in the axial section where the lesion was best demonstrated. The patients were then classified into benign and malignant groups based on the pathology or clinico-radiologic follow-up. Results:The sample included 29 (64.4%) male and 16 (35.6%) female patients, with a mean age of 59.06 +/- 17.3 years. Included in the study were 1 patient with 3 and 3 patients with 2 cavitary lesions each, with a total for the sample of 50 cavitary lesions. There were 23 (46%) malignant and 27 (54%) benign cavitary lung lesions. The mean ADC value (x10(-3) mm(2)/s) of the malignant and benign cavitary lesions was 0.977 +/- 0.522 (0.511 to 2.872) and 1.383 +/- 0.370 (0.930 to 2.213), respectively. The findings were statistically significant using an independent samples t test (P=0.002). The mean wall thickness of the malignant and benign lesions was 12.47 +/- 5.51 mm (5 to 25 mm) and 10.11 +/- 4.65 mm (5 to 22 mm), respectively. Although malignant cavities had a higher mean wall thickness than benign cavities, the difference was statistically insignificant (P=0.104). Conclusion:A significant difference was identified between the ADC values measured in DWI of the malignant and benign cavitary lung lesions. DWI, a noninvasive and rapid imaging method, can provide useful information for the differential diagnosis of cavitary lesions and can minimize unnecessary biopsies.
Evaluation of Neutrophil Gelatinase-Associated Lipocalin (Ngal), Hypoxia-Induced Factor-1 Alpha (hif-1α) and Apelin 13 Levels as New Potential Biomarkers for Pulmonary Thromboembolism: a Prospective Clinical Study
(W B Saunders Co Ltd, 2024) Baykal, Nuruban Delal; Mermit, Buket; Alp, Hamit Hakan; Yildiz, Hanifi
Aim: The objective was to evaluate the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1 alpha), and apelin 13 in patients with acute pulmonary thromboembolism (PE) and to investigate their diagnostic and prognostic role in PE patients with different mortality risk groups. Material and methods: This study was conducted in a tertiary referral center and included 124 subjects with 94 cases of PE and 30 cases of healthy control group. All subjects were 18 years of age or older. The diagnosis of PE was done with computed tomography angiography of the thorax. After the diagnosis of acute PE, the serum levels of neutrophil gelatinase-associated lipocalin (NGAL), hypoxia-induced factor-1 alpha (HIF-1 alpha), and apelin 13 levels were measured with a commercial enzyme-linked immunosorbent assay (ELISA) kit. Results: The median and IQR (interquartile range) age of patients and control groups were 68 (56-76) and 61.5 (56-67) years, respectively. The majority of patients with PE had risk factors (97.88 %), and only two (2.12 %) had no known risk factors. HIF-1 alpha level was found to be higher in the patient group than in the control group (p = 0.03). At the same time, the HIF-1 alpha level was found to be higher in the high mortality risk group than in the control group, low mortality risk group and intermediate-low mortality risk group (p = 0.000, 0.011, 0.002, respectively). While there was no significant difference in NGAL level between the patient group and the control group, a significant difference was observed between the mortality groups. NGAL level was found to be higher in the high mortality risk group than the control group, low mortality risk group, and medium-low mortality risk group (p = 0.001, 0.000, 0.010, respectively). Apelin 13 levels did not differ significantly in all groups. Conclusion: HIF-1 alpha is a promising biomarker in distinguishing between patients and control groups and in identifying those with high mortality risk in the patient group. At the same time, NGAL can be used as a successful biomarker in determining the group with high mortality risk in cases of PE.
Evaluation Serum Levels of Ykl-40, Periostin, and Some Inflammatory Cytokines Together With Il-37, a New Anti-Inflammatory Cytokine, in Patients With Stable and Exacerbated Asthma
(Mosby-elsevier, 2021) Yildiz, Hanifi; Alp, Hamit Hakan; Sunnetcioglu, Aysel; Ekin, Selami; Cilingir, Buket Mermit
Introduction: As asthma has a wide range of inflammatory pathways, the researchers were focused on the markers that may be associated with exacerbation and stability in asthma. Objective: Our aim is to investigate the serum levels of some inflammatory markers and cytokines in stable and exacerbated asthmatic patients. Methods: The study included in 59 non-smoker asthma patient (Exacerbated=25, Stable=34) and 30 healthy volunteers. The serum level of periostin, YKL-40, IL-4, IL-5, IL-37, and TNF-alpha were detected by enzyme-linked immunosorbent assay. Results: Except for IL-37, the periostin, YKL-40, IL-4, IL-5, and TNF-alpha level in asthmatic patients were significantly higher than those of healthy control. In the exacerbated group, the periostin, YKL-40, IL-5, and TNF-alpha level were significantly higher than stable asthma and healthy control groups. The serum levels of IL-4 in exacerbated and stable asthma groups were significantly higher than healthy control group. There was a significant difference between IL4 levels, in stable asthma and healthy control groups. In exacerbated asthma group, IL-37 level was significantly lower than stable and healthy control groups. The highest area under the ROC curve (AUC) was found for IL-4. While there was a significant negative correlation between these parameters and FEV1, there was a positive correlation between IL-37 and FEV1, but not significant. Conclusions: This study showed that increased serum periostin, YKL-40, IL-5, IL-4, and TNF-alpha and decreased serum IL-37 were associated with exacerbation showing uncontrolled asthma. (C) 2020 Elsevier Inc. All rights reserved.
Ewing's Sarcoma of the Lung: a Rare Case
(Turkish Assoc Tuberculosis & Thorax, 2019) Ekin, Selami; Cobanoglu, Ufuk; Goya, Cemil; Erten, Remzi; Yildiz, Hanifi
The Ewing's sarcoma family of tumors (ESFT) incorporates both the well-recognized primary bone and the extraskeletal soft tissue sarcomas. Primitive neuroectodermal tumors (PNET) and ESFT have a similar neural phenotype and can be considered in the same entity. Here, we will present 28 years old patient with Ewing Sarcoma. Patient was admited chest pain. Chest radiograph showed a suspicious lesion in the left paracardiac area. Computed tomography (CT) scan and positron emission tomography (PET)/CT result were compatible with malignant tumor. The patient was underwent surgical resection as the bronchoscopic result couldn't a malignant finding and pathological finding was detected as Ewing's sarcoma. Ewing's sarcoma should be considered in patients who are very fast growing in the lungs, are properly confined and suspected of malignancy in FDG-PET/CT.
Factors Determining the Therapeutic Level of Positive Airway Pressure in Patients With Obstructive Sleep Apnea Syndrome
(Wolters Kluwer Medknow Publications, 2023) Sunnetcioglu, Aysel; Cilingir, Buket Mermit; Gunbatar, Hulya; Yildiz, Hanifi; Dogan, Hediye Ulker
Objectives: In daily practice, we encounter with obstructive sleep apnoea syndrome (OSAS) patients who require different levels of positive airway pressure (PAP) despite having a similar apnoea-hypopnea index (AHI). We aimed to determine the parameters contributing to the determination of the therapeutic level of PAP. Methods: Data on 548 patients who underwent polysomnography and PAP titration were analysed retrospectively. Patients were divided into groups according to OSAS severity (mild, moderate, and severe) and the mean pressure in each group was determined, after which patients were further divided into those who required a PAP below the mean and those who required a PAP above the mean. Results: The mean optimal PAP level in the mild, moderate, and severe OSAS groups was 7.4 +/- 2.3, 8.6 +/- 2.4, and 9.8 +/- 2.9 cm H2O, respectively. In the moderate and severe OSAS group, the subgroup that needed high pressure had a higher supine AHI, a longer apnoea time, and a longer SaO(2) <90% time as compared with the subgroup that needed low pressure. Conclusion: A longer apnoea duration and a higher supine AHI are associated with a higher PAP level in patients with moderate and severe OSAS.
Hospital and 1-Year Mortality Outcomes in Covid-19 Pneumonia
(Bayrakol Medical Publisher, 2024) Askar, Selvi; Askar, Muntecep; Bilgin, Mehmet Hakan; Yildiz, Hanifi; Beyzaei, Rasa; Keskin, Siddik
Aim: COVID-19 caused many deaths, and its socioeconomic impact continues. Hospital mortality is generally known, but information on 1 -year mortality is limited. This study aimed to measure all -cause mortality rates in hospitalized and 1 -year follow-up COVID-19 patients and to evaluate the factors affecting these rates. Material and Methods: PCR-positive patients' demographic, clinical, and laboratory characteristics were retrospectively analyzed. Hospitalization duration and mortality data were recorded. Discharged patients' polyclinic, follow-up, and mortality status within one-year were evaluated. Results: The study included 201 patients, with a mean age of 63.12 +/- 14.5 years, and 59.2% were male. Logistic regression analysis identified several factors affecting hospital mortality, including male gender, smoking, lactate-dehydrogenase, and ferritin. Further analyses indicated that advanced age, low -oxygen saturation, high -sodium levels, low -potassium levels, low -hemoglobin), elevated -white -blood cell count, reduced -platelet count, increased INR and D-Dimer count, and elevated -CRP (C -reactive protein) levels were significant factors influencing hospital mortality. Mortality within 1 -year was associated with factors including male gender, diabetes, low -oxygen saturation, elevated -AST levels, elevated -ALT levels, elevated-ferritin levels, and hospitalization length. Those who died within one year were more likely to have been hospitalized in intensive -care unit, required oxygen support, and were smokers. Discussion: Hospital mortality was associated with impaired laboratory parameters and smoking, whereas 1 -year mortality was associated with intensivecare, oxygen requirements, and diabetes.
Implications of Obstructive Sleep Apnea on Reproductive Health: a Study on Anti-Mullerian Hormone Levels
(Springer Heidelberg, 2024) Yildiz, Hanifi; Alp, Hamit Hakan; Ucler, Rifki; Bilgin, Mehmet Hakan
PurposeThis study aimed to explore the association between anti-mullerian hormone (AMH) levels and obstructive sleep apnea (OSA) severity.MethodsA cross-sectional design was employed to evaluate AMH levels in 68 premenopausal women diagnosed with OSA at Van Yuzuncu Yil University Faculty of Medicine. OSA severity was scored according to the 2018 AASM guidelines using a 16-channel Embla device. AMH levels were measured from blood samples using a commercially available kit.ResultsThe study found that AMH levels in OSA patients were significantly lower than those in the healthy control group. A statistically significant negative correlation between AMH and AHI levels was observed. When stratified by OSA severity, the lowest AMH levels were found in the severe OSA group.ConclusionOSA may have potential endocrine implications, especially concerning reproductive health. Decreased AMH levels in OSA patients could indicate future risks of infertility or early menopause.
Investigation of Lung Involvement With Dlco in Women Exposed To Biomass Smoke
(European Respiratory Soc Journals Ltd, 2012) Arisoy, Ahmet; Sertogullarindan, Bunyamin; Ozbay, Bulent; Ekin, Selami; Yildiz, Hanifi
Is There a Relationship Between Obstructive Sleep Apnea (Osa) and Hearing Loss
(int Scientific Literature, inc, 2016) Ekin, Selami; Turan, Mahfuz; Arisoy, Ahmet; Gunbatar, Hulya; Sunnetcioglu, Aysel; Asker, Selvi; Yildiz, Hanifi
Background: Obstructive sleep apnea (OSA) is a common disorder with an estimated prevalence in the general population of 2-5%. Its main clinical features are loud snoring and breathing stoppage during sleep. Ischemia could be a consequence of noise-induced hearing loss because cochlear oxygen tension is reduced during and after noise exposure. In this study, we evaluated auditory function in patients affected by OSA and simple snoring. Material/Methods: A total of 66 participants (male to female ratio: 40: 26) were included in the study, of which 21 were in the control group, 18 were in the simple snoring group, and 27 were in the OSA patient group. Polysomnography and audiometric examination were performed in all participants. Results: The mean ages of the participants in the control, simple snoring, and OSA groups were 39.14 +/- 9.9, 37.28 +/- 8.2, and 41.56 +/- 8.99 years, respectively. There were no statistically significant differences among groups regarding age or sex; however, there were statistically significant differences among groups in body mass index, apnea-hypopnea index scores, mean saturation, and duration under 90% saturation. In addition, statistically significant differences were found between the patient group and the control and simple snoring groups concerning the mean saturation, duration under 90% saturation, and the extended high frequency of hearing. Conclusions: These data show that snoring may cause hearing loss at extended high frequencies.
Loeffler's Syndrome: an Interesting Case Report
(Wiley, 2016) Ekin, Selami; Sertogullarindan, Bunyamin; Gunbatar, Hulya; Arisoy, Ahmet; Yildiz, Hanifi
Loeffler's syndrome is an acute pneumonia with an unclear cause. One fourth of Loeffler's syndrome patients are idiopathic, although the most common etiologic causes include parasites. Asymptomatic form is usually a reversible, self-limited disease, which does not require a specific treatment regimen. We presented a 17-year-old young man with diagnosis of Loeffler syndrome.
Nox4, Mda, Ima and Oxidative Dna Damage: Can These Parameters Be Used To Estimate the Presence and Severity of Osa
(Springer Heidelberg, 2021) Ekin, Selami; Yildiz, Hanifi; Alp, Hamit Hakan
Purpose Obstructive sleep apnoea (OSA) involves recurrent obstructive apnoeas and hypopnoeas which cause cyclic hypoxia, reoxygenation and formation of reactive oxygen species (ROS). We aimed to investigate a member of the nicotinamide adenine dinucleotide phosphate oxidase (NOX) family of enzymes, specifically (NOX4), not previously studied in humans, as well as 8-OHdG/106dG, MDA and IMA, which are known to be associated with oxidative stress. We also evaluated these parameters in predicting the presence and severity of OSA. Methods All 120 subjects (90 with OSA, 30 healthy controls) underwent polysomnography and had blood serum samples taken at the same time of day. Subjects were grouped by presence and severity of OSA, and serum markers were compared among groups. Results Age and body mass index were not significantly different among groups. In the OSA group, the levels of NOX4, IMA, MDA and 8-OHdG/106dG were significantly higher than in the healthy control group. NOX4 and other parameters were positively correlated with the severity of OSA. For all parameters, the highest levels were detected in patients with severe OSA. Conclusions The repeated hypoxia of OSA is associated with increases in the serum levels of inflammatory mediators such as MDA, IMA and 8-OHdG/106dG and the ROS NOX4. In this study, NOX4 and other markers were associated with the presence and severity of OSA.
Pulmonary Physician Consultancy in Emergency Services in Turkey (Pupcest) - a Prospective Multicenter Study
(European Respiratory Soc Journals Ltd, 2018) Diken, Ozlem Ercen; Ekici, Aydanur; Bektas, Hayriye; Yildiz, Hanifi; Tabaru, Ali; Ogan, Nalan; Ozlu, Tevfik
A Rare Case of Mediastinal Cyst: Thoracic Duct Cyst
(derman Medical Publ, 2015) Mergan, Duygu; Cobanoglu, Ufuk; Yildiz, Hanifi; Sertogullarindan, Bunyamin; Sayir, Fuat
Thoracic duct cysts are very rarely observed cysts of the mediastinum. These cysts, which can become established in the costovertebral sulcus or the visceral compartment, have generally been reported at the level of the 10th and 11th vertebrae; however, they can be observed at any location along the ductus [11, A 37-year-old male patient complained of chest pain for the last 3 months that especially increased after meals. He complained of shortness of breath while walking or going up the stairs, for the last month. The lung graphy showed an increased darkening at a 5x6cm smooth (clean-cut, regular, orderly) bordered shadow just behind the heart shadow. The patient's computed thorax tomography showed a retrocardiac-paravertebral, middle line positioned, 8.5x7x6 cm proportioned, regular bordered, thin walled, homogenous cystic bulk at the subcarinal level. The patient, who could not be relieved with medical treatment, was taken to surgery. The lesion was reached by right posterolateral thoracotomy, and drainage of lymph-containing cystic fluid and excision of the cyst walls were performed by incising the thoracic duct cyst with a mediastinal pleura incision. Mass ligation was then performed to the thoracic duct. We wanted to present our thoracic duct cyst case in this article due to the currently limited number of actual cases reported in the literature.
Red Cell Distribution Width and Uric Acid in Patients With Obstructive Sleep Apnea
(Wiley, 2018) Sunnetcioglu, Aysel; Gunbatar, Hulya; Yildiz, Hanifi
BackgroundObstructive sleep apnea (OSA), characterized by recurrent partial or complete pharyngeal closure, resulting in apnea or hypopnea, is closely associated with cardiovascular disorders (CVDs). Elevated red cell distribution width (RDW) and serum uric acid (SUA) levels have also been associated with CVDs and the consequent mortality. The aim of this study is to determine SUA levels and RDW in patients with OSA which is major a risk factor for CVDs. MethodsThis was a retrospective study involving 600 subjects evaluated by polysomnography. Patients were grouped according to the apnea-hypopnea index (AHI), expressed as control group or as mild OSA, moderate OSA, and severe OSA groups. ResultsThe mean RDW and the mean SUA were significantly higher in the severe OSA group than in all other groups (P<.015 and P<.003, respectively, for all). RDW was negatively correlated with minimum S-pO2 (r=-.142, P<.01) and positively correlated with mean oxygen desaturation time (r=.113, P<.05). SUA was negatively correlated with minimum S-pO2 (r=-.229, P<.01). The RDW was significantly higher in the OSA patients with CVDs than in those with OSA only (P<.05), although there was no significant difference between the OSA patients with and without CVDs in terms of the SUA in any of the groups (P>.05). ConclusionsElevated levels of SUA and RDW were associated with OSA severity, as defined by AHI. In addition, RDW was significantly higher in severe OSA with CVDs.
The Relationship Among Oxidative and Anti-Oxidative Parameters and Myeloperoxidase in Subjects With Obstructive Sleep Apnea Syndrome
(Daedalus Enterprises inc, 2016) Arisoy, Ahmet; Ekin, Selami; Sertogullarindan, Bunyamin; Gunbatar, Hulya; Sunnetcioglu, Aysel; Aksoy, Nurten; Yildiz, Hanifi
Obstructive sleep apnea (OSA) is a highly prevalent breathing disorder in sleep. It is characterized by intermittent hypoxia leading to hypoxemia, hypercapnia, sleep fragmentation, and increased respiratory efforts. We evaluated the relationship between OSA and myeloperoxidase activity, the oxidative stress index (OSI), total anti-oxidative capacity (TAC), and total oxidative capacity (TOC). METHODS: A total of 70 consecutive subjects (mean age +/- SD: 51.7 +/- 11.7 y) were diagnosed with OSA after a night polysomnography recording between January 2014 and June 2014 consecutively. The subjects in the OSA group were divided according to the severity of the disease into three subgroups, consisting of 11 mild, 17 moderate OSA, and 22 severe OSA subjects. Twenty subjects with simple snoring were considered as the control group. RESULTS: We included a total of 70 subjects: 50 with OSA (11 subjects 6.9% mild, 17 subjects 24.7% moderate, and 22 subjects 68.5% severe) and 20 subjects with simple snoring as control cases. The mean age of the mild OSA subjects was 44.5 +/- 11.7 y, moderate OSA subjects' mean age was 52.5 +/- 11.9 y, and severe OSA subjects' mean age was 52.1 +/- 10.1 y; 54.2% were male. There were statistically significant differences among the 4 groups' OSI, TAC, and TOC levels, but there was no statistically significant difference between the other values. The mean myeloperoxidase, TOC, OSI, and TAC levels were 55 +/- 12, 61.2 +/- 21.1, 3.04 +/- 1.04, and 2.03 +/- 0.4 in the mild OSA group; 58.7 +/- 17.2, 60 +/- 18.9, 3.05 +/- 1, and 2 +/- 0.33 in the moderate OSA group; 56.6 +/- 17.9, 52.1 +/- 17.9, 2.7 +/- 0.76, and 1.94 +/- 0.24 in the severe OSA group; and 49.8 +/- 12.5, 54.3 +/- 16.4, 3.08 +/- 0.88, and 1.78 +/- 0.26 in the control group, respectively. CONCLUSIONS: In our study, there were no differences in studied parameters between control and OSA groups. Furthermore, our low number of cases was a restrictive factor. Further studies should be undertaken to clarify this relation.