Browsing by Author "Yilgör, A."

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Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786c and G894t and Ischaemic Stroke
(Yuzuncu Yil Universitesi Tip Fakultesi, 2019) Cilingir, V.; Donder, A.; Milanlioğlu, A.; Yilgör, A.; Tombul, T.
Endothelial nitric oxide synthase (eNOS) gene polymorphisms are suspected to increase the risk of ischaemic stroke (IS). eNOS-synthesized NO regulates vascular tone and inhibits the progression of atherosclero sis. The present study aimed to determine the association between eNOS polymorphisms G894T and T786C and IS. Sixty acute IS patients (32 male, 28 female) were included and classified in accordance with the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Genotypes of patients with eNOS G894T and eNOS T786C polymorphisms were determined through polymerase chain reaction. Significant differences were observed in the distribution of eNOS T786C polymorphism among IS subgroups. The eNOS T786C polymorphism heterozygote (TC) and homozygote (CC) genotypes more frequent in patients in the large artery atherosclerosis (LAA) subgroup. Considering a dominant model of inheritance for eNOS T786C polymorphism, the risk of IS was higher for the LAA subgroup than for other IS subgroups. Among potential haplotypes, the eNOS 786C+ eNOS 894G haplotype was associated with an increased risk of LAA; however, this finding was not statistically significant. eNOS gene polymorphisms are suspected to increase the risk of ischaemic stroke. Our results suggest that the eNOS T786C gene polymorphism is associated with LAA in IS patients. © 2019, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Comparison of Upper and Lower Extremity Functions in Primary and Secondary Progressive Multiple Sclerosis Patients
(Turkiye Klinikleri, 2019) Atilla, N.; Çilingir, V.; Milanlioğlu, A.; Yilgör, A.
Objective: The aim of this study was to find out whether upper extremity is relatively preserved and to what extent it is affected by Primary Progressive Multiple Sclerosis (PPMS) through the evaluation and comparison of upper extremity fine motor skills and walking ability in PPMS and Secodary Progressive Multiple Sclerosis (SPMS) patients with Expanded Disability Status Scale (EDSS) score of 4 and above. Material and Methods: A total of 65 progressive Multiple Sclerosis (MS) patients admitted to the Neurology Outpatient Clinic of Yüzüncü Yıl University Faculty of Medicine between January and December 2017 with EDSS scores ranging from 4.0 to 8.5 were included in our study. Expanded Disability Status Scale (EDSS), 9-Hole Peg Test (9-HPT) and Timed 25-Foot Walk (T25FW) Test were applied to the patients. Results: 9-Hole Peg Test right hand score of PPMS patients with EDSS score between 5.1 and 6.0 was 32.89±7.42 sec, whereas in SPMS patients within the same score range, it was 56.15±54.57 sec (p>0.05). 9-Hole Peg Test left hand score was found as 39.64±16.71 sec in PPMS patients and 47.51±27.32 sec (p>0.05) in SPMS patients. 9-Hole Peg Test mean score was 36.25±11.83 sec in PPMS patients and 51.83±38.18 sec in SPMS patients (p>0.05). The T25FW test was calculated only for 39 patients who were able to perform all tests. In 14 patients with PPMS, the first-stage T25FW test score was 35.62±22.2 sec, the second-stage score was 36.21±24.73 sec, and the mean T25FW test score was 35.92±22.81 sec. In 25 of SPMS patients, the first-stage T25FW test result was 36,12±32,84 sec, the second-stage T25FW test result was 32,77±26,11 sec, and the mean T25FW test result was 34,4±28,75 sec. Conclusion: In PPMS and SPMS patients with EDSS score of 5.1-6.0, the mean EDSS scores were observed to be closer to each other, and in PPMS patients in this group, the upper extremity function was relatively better, although not statistically significant. No significant difference was found between the groups in terms of lower extremity function. © 2019 by Türkiye Klinikleri.
Evaluation of Patients With Cerebral Venous Sinus Thrombosis
(Turkish Society of Cerebrovascular Diseases, 2014) Yilgör, A.; Tombul, T.; Milanlioǧlu, A.
OBJECTIVE: The aim of this article is to point out the etiology, risk factors, the rate of recanalization and mortality of cerebral venous sinus thrombosis patients. MATERIAL and METHODS: The current study was planned as retrospectively and fifty patients were included. All the patients were analyzed according to the clinical presentation, etiologic causes, risk factors, presence of MR lesion, the involvement of anatomic localization, recanalization and mortality. RESULTS: The most frequent risk factors of the cases were prothrombotic conditions (34%), pregnancy (14%) and puerperium (8%). The most frequent involvement was transverse sinus and secondly more than one sinüs thrombosis. As clinical application symptoms we detected headache (68%) and then focal neurologic deficiency (30%). On the other hand, at least 3 month's incidence rate of recanalization in the patients was 70.7%. Except for 2 cases that ended with death, the mortality of the cases was low. We could not find a significant association between risk factors and the presence of cerebral MR lesion or not (p=0.42) and also the presence of recanalization or not in the follow-up MR venography (p=0.625). CONCLUSION: We have concluded that, in the diagnosis and follow-up of cerebral venous sinus thrombosis, MR venography is the best method; through early diagnosis and proper treatment, the rate of recanalization will be fairly high and mortality will be low. In etiology, besides trombotic conditions, pregnancy and puerperium must be considered as one of the frequent risk factors.