Browsing by Author "Yilmaz, B."

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Evaluation of Relationship Between Aerobic Fitness Level and Range of Isocapnic Buffering Periods During Incremental Exercise Test
(C M B Assoc, 2017) Algul, S.; Ozcelik, O.; Yilmaz, B.
The purpose of this study is to examine the relationship between the amount of O-2 uptake (VO2) in the range of isocapnic buffering (ICB) periods and aerobic fitness levels of subjects with different exercise tolerance levels. A total of 50 young male subjects (20.8 +/- 0.4 years) performed an incremental exercise test using a cycle ergometer to determinetheir anaerobic threshold (AT), respiratory compensation point (RCP) and maximal exercise capacity (Wmax). The ICB period is defined as the region between AT and RCP. Pulmonary gas exchange parameters were measured breath-by-breath using a respiratory gas analyser. The subjects' fitness levels, as indicated by peak O-2 uptake to body weight ratios (VO(2)peak/BW), ranged from 28 ml/min/kg to 58 ml/min/kg, and Wmax capacity to body weight ratio (Wmax/BW) ranged from 1.94 W/min/kg to 3.96 W/min/kg. The VO2 in the range of ICB periodsranged from 101 ml to 793 ml (with an average of 295 +/- 157 ml). There was a positive linear correlation between VO(2)peak/BW, Wmax/BW and range of ICB: R= 0.76542 (p< 0.0001), and R= 0.92135 (p< 0.0001), respectively. The results of this study suggest that the range of ICB periods may be related to aerobic fitness. Importantly, aerobic fitness levels should be evaluated and considered important data, in addition toAT, VO(2)peak/BW and Wmax/BW.
The Impact of Physical Exercise Performed at Different Times of Day on Serum Nesfatin-1 and Irisin Levels in Trained and Untrained Young Male Subjects
(Wiley, 2017) Ozcelik, O.; Algul, S.; Yilmaz, B.
The Preparation of Various Shapes and Porosities of Hydroxyethyl Starch/P(hema-co-nvp) Ipn Hydrogels as Programmable Carrier for Drug Delivery
(Taylor and Francis Inc., 2020) Ozay, O.; Ilgin, P.; Ozay, H.; Gungor, Z.; Yilmaz, B.; Kıvanç, M.R.
This study used biocompatible and biodegradable hydroxyethyl starch (HES), 2-hydroxyethyl methacrylate (HEMA) and N-vinyle-2-pyrrolidone (NVP) monomers for hydrogel synthesis with the aim of use as a drug carrier system. As a result of the synthesis reactions using the redox polymerization technique, hydrogels were produced in both film and cylindrical form. The morphological characterization and structural characterization of hydrogels were performed using scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FT-IR), respectively. In addition, swelling characterizations of hydrogels to be used for drug release in various media were examined. The release properties of sodium diclofenac (NaDc) and trimethoprim (TMP) loaded into hydrogels produced in order to use as drug carrier material for controlled drug release were examined in media with pH = 1.2 and 7. It was determined that the hydrogels performed controlled release according to the type of drug and the pH values of the medium. Drug release mechanisms deviated from Fickian mode according to determined drug release rate constants, diffusion exponent (n) and regression values at different pH values. In addition, antibacterial properties of drug-loaded hydrogels against B. subtilus, S. aureus and E. coli were investigated. © 2019, © 2019 Taylor & Francis Group, LLC.