Browsing by Author "Yilmaz, C."

Now showing 1 - 20 of 22

Alström Syndrome Associated With Cerebral Involvement: an Unusual Presentation
(TIP ARASTIRMALARI DERNEGI, 2006) Yilmaz, C.; Çaksen, H.; Yilmaz, N.; Güven, A.S.; Arslan, D.; Cesur, Y.
Alström syndrome (AS) is a rare autosomal recessive disorder, characterized by retinal degeneration, progressive hearing impairment, truncal obesity and non-insulin dependent diabetes mellitus. A 6-year-old girl was admitted with aphasia, deafness, strabismus, abdominal distention, and weakness on the right body side. The physical and laboratory examination revealed psychomotor retardation, right hemiparesis, sensorioneural hearing loss, aphasia, eye and teeth abnormalities, hyperpigmentation, truncal obesity, hepatosplenomegaly, severe iron deficiency anemia, delayed bone age, and cerebral hemiatrophy. Based on these abnormal findings she was diagnosed as AS. According to our knowledge this is the first case of AS with cerebral involvement. This last finding may be a component of the syndrome.
Anal Protrusion of Ventriculo-Peritoneal Shunt Catheter: Report of Two Infants
(2004) Yilmaz, N.; Kiymaz, N.; Yilmaz, C.; Çaksen, H.; Yuca, S.A.
In general, treatment of hydrocephalus requires the application of a ventriculo-peritoneal shunt. Despite the peritoneal cavity being convenient for absorption of cerebrospinal fluid, multiple complications related to the shunt tends to develop within this area. The most frequent complications are abdominal. A rare complication can occurs with perforation of the organs located in peritoneal cavity by the catheter when infection occurs. Here we report two cases (because of unusual presentation) of shunt complication, they were operated for hydrocephalus. Acute traumatic anal protrusion of the peritoneal catheter occurred in the first case while a spontaneous anal protrusion during follow-up period, in the second case. The predisposing factors were thought to be previous abdominal infection and the use of trocar during operation in the first case and chronic irritative effect of the ventriculo-peritoneal catheter in the second case. © 2004, IOS Press. All rights reserved.
The Assessment of Anti-Cancer Potential of Macroalgae Alkaloid Tyramine on Colon Cancer Cell Lines
(Wiley, 2023) Babat, C. Fidan; Yilmaz, C.; Abdelsalam, A. H.; Arslan, S.
Bilateral Abducens Paralysis Following Head Injury: a Case Report
(2003) Yilmaz, N.; Arslan, M.; Kiymaz, N.; Demir, Ö.; Yilmaz, C.
Cranial nerve lesions often accompany head trauma. Olfactory, facial and vestibular nerves are the most commonly injured nerves. Optic and oculomotor nerve injuries are less frequently involved, and trigeminal, abducens and lower cranial nerves are rarely involved. The injury may occur in central nervous system or in the lower motor unit. Traumatic bilateral abducens paralysis is a very rare occurrence. It may follows cervical spine trauma and sixth nerve avulsion has been reported to complicate lumbar puncture. In this study, we describe an 11-year-old boy with bilateral abducens paralysis following hematoma in the left ponto-cerebellar angle and hemorrhage in the prepontine cisterns due to head trauma. Such hemorrhages might result in lesions in the supranuclear regions by traction on the nerve due to displacement of the pons and its nucleus as a result of direct pressure. © 2003, IOS Press. All rights reserved.
A Case of Benzydamine Hcl Intoxication
(2006) Doǧan, M.; Yilmaz, C.; Çaksen, H.; Güven, A.S.
Benzydamine HCl is a nonsteroidal anti-inflammatory drug (NSAID) and is available in mouthwash, dermal cream, aerosol and vaginal douche preparations, besides other compounds administered orally or by otic drops. Acute poisoning with benzydamine HCL is associated with agitation, hallucinations, seizures and rarely somnolence. In this study, we reported a rare case of benzydamine poisoning in a girl who presented with somnolence and visual hallucinations one hour after taking five benzydamine HCL dragees orally equal with 14.7 mg/kg for suicide. An 11 years old girl was brought to our hospital because of visual hallucinations. About 1,5 hours before the admission, she received five benzydamine HCL dragees orally for suicide. Visual hallucinations appeared one hour after ingestion of the drug. She especially mentioned to see snakes and her relatives such as her father who was not in the hospital. On laboratory examination complete blood count, serum electrolytes, renal and liver function tests were normal. The patient was hospitalized with the diagnosis of acute benzydamine HCl intoxication. Gastric lavage was performed and activated charcoal (1 g/kg/dose four doses daily) was given. The hallucinations were resolved and she became symptom and sign free two hours after hospitalization. We suggest that if a patient is presented with somnolence and visual hallucinations, drug intoxication should be considered in the differential diagnosis.
A Case of Neurobrucellosis With Hydrocephaly
(Univ West indies Faculty Medical Sciences, 2013) Yilmaz, C.; Kaya, A.; Guven, A. S.; Yilmaz, N.; Caksen, H.
Central Nervous System Manifestations of Mycoplasma Pneumoniae: Report of Two Children
(IOS Press, 2005) Abuhammour, W.M.; Yilmaz, C.; Hurst, M.D.; Allarakhia, I.; Çaksen, H.
Mycoplasma pneumoniae is a common infection in the early adolescent period, presenting most commonly as an upper respiratory tract infection with variable severity. Extrapulmonary manifestations include neurologic, hematologic, hepatic, and cardiac involvement. Hemiparesis and dysarthria are frequently encountered in the setting of cerebrovascular accidents. We present two patients who had neurological complications secondary to Mycoplasma pneumoniae infection. The first patient was a 12-year-old boy who presented with recurrent episodes of transient hemiparesis and dysarthria. The second patient was a 3-year-old girl who presented with seizures and aphasia. Both patients had pneumonia and positive serum immunoglobulin M against Mycoplasma pneumoniae. Follow up revealed a full recovery in the first case and moderate articulation disorder in the second patient. © 2005 - IOS Press and the authors. All rights reserved.
Chronic Mercury Poisoning: Report of Two Siblings
(2010) Yilmaz, C.; Okur, M.; Geylani, H.; Caksen, H.; Tuncer, O.; Ataş, B.
Mercury exists as organic inorganic and elementary forms in nature and is one of the most toxic metals that are poisonous for human beings. Mercury is commonly used in many different sectors of industry such as in insects formulas, agriculture products, lamps, batteries, paper, dyes, electrical/electronic devices, jewelry, and in dentistry. In this study, two siblings (one a 7-year-old boy and the other a 13 years old girl) are reported who developed chronic mercury poisoning as a result of long-term contact with batteries. Our aim is to emphasize the importance of mercury poisoning that is extremely rarely seen in childhood.
Comparison of Various Treatments in Childhood Brucellosis
(2006) Yuca, S.A.; Ceylan, A.; Çaksen, H.; Kirimi, E.; Yilmaz, C.; Bay, A.
The aim of this study was to evaluate the effectiveness of different drug combinations for treatment of brucellosis in children. Sixty children (mean age 9.2 ± 3.1 years, range 10 months to 15 years) were treated with four different drug combinations. The diagnosis of brucellosis was established by positive serum agglutination titer, and/or the isolation of Brucella species from blood cultures. The most frequent findings were fever and arthritis in 12 (20%) and 13 (21.6%) patients respectively. The children under 8 years old comprised Group 1 and 2, and older than 8 years comprised Group 3 and 4 according to treatment regimens. Nine patients (Group 1) were treated with trimethoprim-sulfamethoxazole (TMP-SMZ) for 45 days plus ceftriaxone for 5 days and, rest nine patients (Group 2) were managed with TMP-SMZ for 45 days plus gentamicin for 5 days. Twenty-one patients (Group 3) were managed with doxycycline for 45 days and ceftriaxone for 5 days and, other 21 (Group 4) patients were managed with doxycycline for 45 days and gentamicin for 5 days. All patients recovered. Relapse and improvement rates were similar for all groups (P >0.05). Each regimen was effective in the treatment of childhood brucellosis. Using cheaper drugs such as doxycycline and gentamicin in children 8 years of age and older, and TMP-SMZ and gentamicin in children 7 years of age or younger for the treatment of brucellosis in children is a practical and useful approach in our region and in the developing countries. © 2006 - IOS Press and the authors.
Cranial Ct/Mri Findings in Children With Acute Herpes Simplex Encephalitis
(IOS Press, 2007) Çaksen, H.; Ünal, Ö.; Yilmaz, C.; Güven, A.S.; Özen, Ö.
In this study, cranial computerized tomography (CT) and/or magnetic resonance imaging (MRI) findings were investigated in nine children with acute herpes simplex encephalitis (HSE). HSE was confirmed by polymerase chain reaction. Our purpose was to evaluate the diagnostic value of CT and MRI in the diagnosis of HSE and to determine the widespread of the cranial abnormalities in HSE in childhood. Cranial CT was examined in all children and found to be normal in four children. Cranial MRI was examined in seven children, of whom, three was normal. Temporal involvement was diagnosed in only two children. Our findings revealed that the range of cranial involvement was fairly variable in childhood HSE; aside from typical temporal involvement, cranial images may be normal or widespread involvement including basal ganglia, thalamus, frontal and parietal lobes may be seen in children with HSE. © 2007 IOS Press. All rights reserved.
Cyanide Intoxication With Encephalitis Clinic: a Case Report
(2006) Dogan, M.; Yilmaz, C.; Kaya, A.; Caksen, H.; Taskin, G.
Cyanide intoxication is one of the most dangerous poisonings and may occur by oral, respiratuary and dermal routes. Central nervous system is the most susceptible region to acute cyanide intoxication. A 3.5-yearsold-girl was brought to our pediatric emergency polyclinic with complaints of fever, dullness and convulsion. On physical examination, lethargy and agitation, increased deep tendon reflexes and bilateral extensor plantar response were determined. On brain magnetic resonance imaging, increased signal intensity and decreased diffusion in bilateral basal ganglia on T2-fluid-attenuated inversion-recovery sequences were determined. The patient diagnosed as intoxication or encephalitis was taken to intensive care unit. Gastric lavage was performed and activated charcoal and acyclovir were given. After these managements, it was learnt that she had eaten a lot of apricot, plum and seed of apricot before the complaints. Therefore, she was diagnosed as cyanide intoxication and hydroxycobalamin treatment was given for five days. Our aim is to emphasize that in patients who were brought with symptoms and signs of encephalitis, intoxications also should be thought in differential diagnosis; therefore, we want to underline once again that taking detailed anamnesis is very important.
Evaluation of Lymphocyte Subgroups in Children With Subacute Sclerosing Panencephalitis
(Sage Publications Ltd, 2009) Yilmaz, C.; Yuca, S. A.; Yilmaz, N.; Oner, A. F.; Caksen, H.
The aetiology of subacute sclerosing panencephalitis (SSPE) remains to be fully elucidated, although it follows infection with a hypermutant defective M-protein measles virus. This study analysed peripheral blood lymphocyte subgroups to determine their role in the pathophysiology of SSPE. It included 22 children with SSPE aged 2 - 15 years (patient group) and 22 age- and gender-matched healthy children (control group). In children < 6 years old, there were no statistically significant differences between the two groups in the proportions of lymphocytes expressing the surface markers CD3, CD8, CD19 or CD16/56, or in CD4/CD8 ratio. The proportion of CD4(+) lymphocytes in SSPE patients < 6 years of age was significantly lower compared with the control group. In children >= 6 years old, there were no significant differences in the lymphocyte subgroups. In conclusion, these findings suggest that a low CD4(+) lymphocyte count might be responsible for SSPE in younger children.
Histopathological and Biochemical Alterations in the Adrenal Gland of Male Rats Exposed To Bisphenol F
(Pleiades Publishing inc, 2024) Kaptaner, B.; Dogan, A.; Yilmaz, C.; Aykut, H.; Dogan, E.; Babat, C. Fidan; Donmez, F.
Bisphenol F (BPF) is a bisphenol A derivative that is widely used in the manufacturing of industrial and consumer products. The presented study was conducted to explore the adverse effects of BPF on the adrenal glands of rats. Toward this aim, twenty-eight male albino Wistar rats were randomly divided into four groups, each containing seven individuals. The animals were administered a vehicle (control) or BPF at 3 different doses comprising 20, 100, and 500 mg/kg of body weight (bw) via oral gavage for 28 days. Next, the effects of BPF on the gland were evaluated in terms of histopathological alterations, serum adrenocorticotropic hormone (ACTH) and cortisol levels, and the contents of reduced glutathione (GSH) and malondialdehyde (MDA). The zona fasciculata of the adrenal cortex showed prominent histopathological lesions such as vacuolar degeneration and necrotic degeneration in the experimental groups. BPF caused noticeable elevations in the serum ACTH and cortisol levels. Moreover, decreases in levels of GSH and increments in the contents of MDA were determined, indicating oxidative stress. In conclusion, BPF showed toxic effects on the adrenal gland that may result in disruptions in its vital functions in the body. The results herein suggest that attention should be paid to the utilization of BPF in manufacturing processes due to its harmful effects and risks to the health of organisms.
Intracranial Hemorrhage Due To Vitamin K Deficiency in Infants: a Clinical Study
(Taylor & Francis Ltd, 2009) Yilmaz, C.; Yuca, S. A.; Yilmaz, N.; Bektas, M. S.; Caksen, H.
The hospital records of 30 infants with a diagnosis of intracranial hemorrhage (ICH) due to late onset of vitamin K deficiency, seen during a 5-year period (2001-2005) were retrospectively evaluated. Signs and symptoms of the patients were convulsions (80%), poor sucking (50%), irritability (40%), vomiting (47%), acute diarrhea (33%), and fever (40%). On physical examination there were bulging or full fontanel in 19 patients (63%), collapsed fontanel in one (3%), diminished or absent neonatal reflexes in 11 (37%), pallor in 14 (47%), and cyanosis in one (3%) patient. Gastrointestinal disorder, skin hemorrhagic findings, and epistaxis each were noted in two (7%) patients. All the infants had prolonged prothrombin time (PT) and seven had prolonged activated partial thromboplastin time (APTT), both of which were corrected by the administration of vitamin K. All the infants had ICH, with the most common being intraparenchymal hemorrhage, followed by multiple type ICH (27%). Neurosurgical intervention was performed in five patients (17%). The overall case fatality rate was 33%. In conclusion, we would like to stress that ICH due to vitamin K deficiency in infants is still an important health problem in Turkey resulting in high mortality rate.
Kluver-Bucy Syndrome Developed After Convulsion: a Case Report
(2011) Okur, M.; Yilmaz, C.; Epçaçan, S.; Üstyol, L.; Kaya, A.; Çaksen, H.
Kluver-Bucy syndrome is characterized by increased appetite, hypersexuality, hypermetamorphosis, memory disorders, visual agnosia, stagnancy, aphasia, bulimia, polyuria, and polydipsia. A 14 year old girl had generalized tonic-clonic convulsions at admission, and an incomplete Kluver-Bucy syndrome with hypersexuality, recent memory disturbance, hypermetamorphosis, speech disturbance, hyperactivity, agitation, aggressiveness, and hallucinations, developed the following day. Here in, we report a case of KBS in a child with epilepsy.
Prevalence of Overweight and Obesity in Children and Adolescents in Eastern Turkey
(2010) Yuca, S.A.; Yilmaz, C.; Cesur, Y.; Doǧan, M.; Kaya, A.; Başaranoǧlu, M.
Objective: The aim of this study was to estimate the prevalence of overweight and obesity in school children in Eastern Turkey. Methods: This study included 9048 school children aged 6-18 years. The subjects were classified as overweight and obese, according to the International Obesity Task Force. Results: We found prevalence of overweight of 11.1% in the studied population. It was detected that 2.2% of the population in the study was obese; 2.1% of males and 2.3% of females. While the prevalence of obesity was extremely low before 9 ages and after 15, it reached to high values at puberty and just before pubertal period in boys. The prevalence of overweight was higher in girls and reached to peak point at pubertal ages. Generally, the prevalence of obesity and overweight was slightly higher in girls than in boys, although the boys were more obese in prepubertal ages. Conclusion: Overweight and obesity are concerns for children and adolescents in low socio-economic status regions as well. © Journal of Clinical Research in Pediatric Endocrinology.
The Role of Glutation-S Mu1 and Teta1 Polymorphisms in Chronic Obstructive Pulmonary Disease
(University of Ankara, 2021) Hayat, B.; Yavuz, M.S.; Sahin, E.; Dirican, O.; Sarialtin, S.Y.; Yilmaz, C.; Oguztüzün, S.
Objective: The aim of this study the investigation of "null" alleles in GSTM1 and GSTT1 gene regions in the development of COPD disease. Material and Method: There are 36 patients with COPD and 14 control cases, who received the Ethics Committee permission from Polatli Duatepe State Hospital Chest Diseases Department. DNA isolations were made from blood samples from the end of 2019 and the control group. Deletions in GSTM1 and GSTT1 gene regions were examined by qPCR method in COPD patient and control groups. The results of the study were evaluated comparatively by distributing the gene dose according to the Hardy-Weinberg. Result and Discussion: When seen from 36 COPD patients after qPCR analysis, it was found that deletion expressions due to gene doses in all patient groups; 23 individuals (63.8%) in the (+/-) genotype for GST-M1, 13 individuals (26.2%) in the (-/-) genotype. For GST-T1, 14 (%) in the (+/+) genotype 38.8), while deletion was observed with the highest rate, 4 individuals (11.1%) in the (+/-) genotype and 18 individuals (50.1%) in the (-/-) genotype were found. For GST-M1, deletion was observed in 19 individuals (63.3%) in the genotype (+/-) in male individuals, while it was observed in 4 individuals (66.6%) with the same genotype in women. While deletion was not observed in 11 (36.6%) male patients, this rate was observed as 2 (33.4%) in women. In the GST-T1 gene region, there were 10 (33.3%) males in male patients and 4 (66.6%) individuals in female patients with deletion occurring and the frequency of the "null allele" was high (+/+). In the (+/-) genotype, 3 (10%) in males and 1 (16.7%) in females were found. In the genotype where deletion was not observed and the gene was conserved (-/-), 17 (56.7%) individuals were observed in male patients and 1 (16.7%) in female patients. In the case that the gene "null" allele status in the GST-M1 gene region is slightly higher than the GST-T1 gene communication, this situation is thought to be a factor in obstructive pulmonary disease. © 2021 University of Ankara. All rights reserved.
Rubinstein-Taybi Syndrome and Crebbp C.201_202delta Mutation: a Case Presenting With Varicella Meningoencephalitis
(Medecine Et Hygiene, 2009) Caksen, H.; Bartsch, O.; Okur, M.; Temel, H.; Acikgoz, M.; Yilmaz, C.
Rubinstein-Taybi syndrome and CREBBP c.201_202delTA mutation: A case presenting with varicella meningoencephalitis: Rubinstein-Taybi syndrome (RTS) is a rare syndrome with a frequency of approximately 1 in 125,000 affected newborns, which is characterized by mental retardation, growth retardation, a particular dysmorphology and, in a subset of cases, immunodeficiency. RTS is typically caused by CREBBP deficiency, and heterozygous mutation or deletion of the CREBBP gene has been identified in 60-70% of patients. The inheritance is autosomal dominant but reports of vertical transmission are exceedingly rare; near-all cases are caused by de novo mutations. Here we present an 8-month-old boy with varicella meningoencephalitis, RTS, and a de novo deletion of the CREBBP gene of two base pairs at position 201-202 in exon 2, c. 201_202derr. The mutation has not been described previously but it predicts a protein truncation, and truncating CREBBP mutations are typical causes of RTS.
Scurvy Is an Important Problem in the East of Anatolia, Turkiye: Three Cases Report
(2010) Ari Yuca, S.; Yilmaz, C.; Cemek, M.; Cesur, Y.; Çaksen, H.
Scurvy is a multisystemic nutritional disorder which synthesis of collagen is destructed due to deficiency of vitamin C and its characteristic findings on hematological system and bone. Scurvy may occur at any age, frequently in infants aged 6-24 months. It is usually affected in children with severely developmental problems and suffered from malnutrition. Causes of inadequate ascorbic acid in infancy are usually starting weaning late, giving limited fresh fruits and vegetables, and mistakes in preparing foods. There is general tenderness, frog position at legs, edematous swelling along the shafts of legs, subperiosteal hemorrhage at the knees joints in with scurvy patients. Petechial hemorrhages may occur in skin and mucous membranes. The diagnosis of scurvy is usually based on the characteristic clinical picture, the roentgenographic changes in the long bones, and history of inadequate intake of ascorbic acid in infancy. We described here, three children with suffered from scurvy who had markedly vitamin C deficient in their diets. We wish to emphasize that, it is still a problem among malnutrition children in our country. Copyright © 2010 by Türkiye Klinikleri.
Synthesis, Optimization, Adme Analysis, and Antioxidant Activity of 2-(arylethynyl)
(Maik Nauka/interperiodica/springer, 2021) Kavak, E.; Algso, M. A. S.; Konus, M.; Yilmaz, C.; Lazoglu, A.; Karaagac, S. U.; Kivrak, A.
2,3-Dialkynylthiophene derivatives were synthesized by using regio- and stereocontrolled Pd-catalyzed Sonogashira coupling and desilylation reactions. The synthesized compounds were analyzed in silico for their pharmacokinetic parameters, general toxicity, and drug scores. In particular, 3-ethynyl-2-(phenylethynyl)thiophene and 3-ethynyl-2-[(4-methylphenyl)ethynyl]thiophene were found to have relatively high drug scores and low toxicities. The antioxidant activity of the title compounds were evaluated by five different assays. 3-Ethynyl-2-(naphthalen-1-ylethynyl)thiophene displayed significant reducing and free radical scavenging activities.