Browsing by Author "Yilmaz, Cahide"

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Activity of Mannitol and Hypertonic Saline Therapy on the Oxidant and Antioxidant System During the Acute Term After Traumatic Brain Injury in the Rats
(Elsevier Science Bv, 2007) Yilmaz, Nebi; Dulger, Haluk; Kiymaz, Nejmi; Yilmaz, Cahide; Gudu, Burhan O.; Demir, Ismail
In this study, our objective is to investigate the effects of mannitol and 7.5% hypertonic saline (HS) therapy on the levels of malondialdehyde (MDA), catalase and glutathione peroxidase (GSH-Px) in the early stages of experimental head traumas in rats. Rats included in the study were divided into four groups: Group I Control, Group II Trauma, Group III Mannitol, and Group IV 7.5% Hypertonic Saline. Rats in Group 11 were subject to head trauma only. Mannitol was injected intraperitoneally to rats in Group III after head trauma and 7.5% HS was injected intraperitoneally to rats in Group IV after head trauma. Rats were sacrificed 4 h after administration of mannitol. or 7.5% HS, and the levels of MDA catalase and GSH-Px in brain tissues extracted from rats were determined. MDA levels in the trauma group were significantly increased compared with the control group (p<0.01), whereas there was a reduction in catalase and GSH-Px levels, although these differences were not significant. By contrast, in the mannitol group, MDA, catalase and GSH-Px levels were lower than the levels in the trauma group, and these reductions were statistically significant (p<0.05). The MDA, catalase and GSH-Px levels of the 7.5% HS group were lower than those of the trauma group; however, this reduction was not statistically significant. It was concluded that mannitol and 7.5% HS therapies that are used to reduce intracranial pressure and to increase the use of catalase, an antioxidant enzyme, and GSH-Px, are likely to reduce cellular damage by reducing the formation of MDA, the levels of which are known to be indicative of cellular level oxidant damage. (c) 2007 Elsevier B.V. All rights reserved.
Alstrom Syndrome Associated With Cerebral Involvement: an Unusual Presentation
(Modestum Ltd, 2006) Yilmaz, Cahide; Caksen, Huseyin; Yilmaz, Nebi; Guven, Ahmet Sami; Arslan, Derya; Cesur, Yasar
Alstrom syndrome (AS) is a rare autosomal recessive disorder, characterized by retinal degeneration, progressive hearing impairment, truncal obesity and non-insulin dependent diabetes mellitus. A 6-year-old girl was admitted with aphasia, deafness, strabismus, abdominal distention, and weakness on the right body side. The physical and laboratory examination revealed psychomotor retardation, right hemiparesis, sensorioneural hearing loss, aphasia, eye and teeth abnormalities, hyperpigmentation, truncal obesity, hepatosplenomegaly, severe iron deficiency anemia, delayed bone age, and cerebral hemiatrophy. Based on these abnormal findings she was diagnosed as AS. According to our knowledge this is the first case of AS with cerebral involvement. This last finding may be a component of the syndrome.
Arachnoid Cyst Causing Subfalcine Herniation in a Child Failure To Thrive
(Nobel Ilac, 2011) Dogan, Murat; Yilmaz, Cahide; Ustyol, Lokman; Caksen, Huseyin
Arachnoid cysts represent only 1% in all intracranial masses. The signal and density of arachnoid cysts are mostly the same as cerebrospinal fluid unless be complicated. They do not have calcification and do not retain contrast material but they are benign lesions. Although they can be seen in all ages, they are mostly detected in children. Male-female ratio is In this case report., 18 months-old-boy with subfalcine herniation because of an arachnoid cyst who was brought to our hospital only with complaint of failure to thrive was presented due to its atypical and rare presentation.
Assessment of Nutritional Status: Triceps and Subscapular Skin-Fold Thickness in Turkish Children and Adolescent
(Professional Medical Publications, 2011) Yuca, Sevil Ari; Cesur, Yasar; Yilmaz, Cahide; Mazicioglu, Mumtaz; Kurtoglu, Selim
Objectives: To determine the mean and percentile values and constitute the percentile curves of the triceps and subscapular skin-fold thickness (SFT) for obtaining a measure to be used in evaluating nutritional status of children and adolescents for age and gender to determine the threat of adiposity in Turkish children. Methodology: This cross-sectional study was carried out between October 2006 and May 2007 with 6917 students selected among those with pre-defined socio-economic criteria and attending primary schools in Van city center. Based on these data, the subjects were distributed to age groups in 6-month intervals, beginning from the age of 7 up to the age of 17. Results: Analysis of mean values of the thickness of triceps and subscapular SFT according to age in boy subjects demonstrated that these values generally increased with age up to thirteen years of age where peak values were observed, and the thickness decreased between 14 and 15 years of age, increasing again thereafter. A comparison of our data with the data reported from other countries revealed lower than median values of triceps and subscapular SFT in our study for both girls and boys regardless of the age group. Conclusions: Subcutaneous fat accumulation is lower in Turkish children compared to those in other countries and no risk of obesity is imminent, at least in the region where this study was carried out.
A Case of Carbamazepine Intoxication in A Young Boy
(Elsevier Science inc, 2010) Dogan, Murat; Yilmaz, Cahide; Temel, Hayrettin; Caksen, Huseyin; Taskin, Gokmen
A Case of Congenital Hypothyroidism Presented With Dysmyelinization Findings
(Elsevier Science Bv, 2014) Yuca, Sevil An; Yilmaz, Cahide; Kaya, Avni; Ustyol, Lokman; Sal, Ertan; Cesur, Yasar; Caksen, Huseyin
The central nervous system is one of the most crucial targeted systems of hyphotiroidism where tissues undergo various broad developmental processes such as neuronal and glial cellular differentiation, migration and myelinization. However brain images are mainly normal. In this articlel. we present findings related to a 1-year-old girl who has been referred to our outpatient he clinic with complaints of slowing of movement and lack of interest. She was diagnosed with hypothyroidism. Her brain magnetic resonance image obtained during diagnosis displayed dysmyelinization. It showed improvement after Na-L thyroxin therapy during follow up.
A Child With Incomplete Kluver-Bucy Syndrome Developed During Acute Encephalitis
(Elsevier Science inc, 2008) Yilmaz, Cahide; Cemak, Fatma; Guven, Ahmet Sami; Caksen, Hueseyin; Atas, Buelent; Tuncer, Oguz
Clinical Outcome and Magnetic Resonance Imaging Findings in Infants With Hypoglycemia
(Sage Publications inc, 2011) Caksen, Huseyin; Guven, Ahmet Sami; Yilmaz, Cahide; Unal, Ozkan; Basaranoglu, Murat; Sal, Ertan; Kaya, Avni
The authors examined clinical outcome and cranial magnetic resonance imaging (MRI) findings in infants with hypoglycemia to determine the effects of hypoglycemia on the developing brain. A total of 110 infants with hypoglycemia were included in the study. Of the patients, 36 were females and 74 were males. The age of the infants was between 1 day and 22 months. Of the 110 infants, 47 were preterm neonates, 40 were term neonates, and 23 were older than 28 days. No difference in serum glucose level was noted between symptomatic and asymptomatic infants. The most common observed abnormal findings were hyperintense lesions, encephalomalacia, and cerebral atrophy. Abnormal MRI findings were found in 4% of preterm infants, in 32.5% of term infants, and in 43.5% of older infants. Abnormal MRI findings were statistically significantly more common in symptomatic infants than in asymptomatic infants. Of the infants, 45.5% of hypoglycemic infants had cerebral palsy and/or cerebral palsy plus epilepsy.
Congenital Hypothyroidism With Isolated Fibula Agenesis
(Nobel Ilac, 2010) Dogan, Murat; Yilmaz, Cahide; Caksen, Hueseyin; Cesur, Yasar; Akpinar, Fuat; Gueven, Ahmet Sami
Although congenital hypothyroidism is seen often as an isolated case, it can also be seen as a part of some syndromes like Schinzel-Giedion, Aicardi-Goutieres-like, cleidocranial dysplasia and deletion of 18q. It is also well known that congenital hypothyroidism may be associated with other congenital malformations, especially with cardiac heart diseases, skeletal abnormalities, Central nervous system and eye malformations. In this article, 11-years-old-girl with fibula agenesis associated with congenital hypothyroidism because of thyroid gland hypoplasia is presented. In our knowledge, both congenital hypothyroidism and isolated fibula agenesis have not been published before in the literature.
Congenital Primary Hypothyroidism Diagnosed at Advanced Ages
(Nobel Ilac, 2010) Yuca, Sevil Ari; Cesur, Yasar; Yilmaz, Cahide
Objective: Aim of this study was to investigate that clinical and laboratory findings of sixteen cases who were referred to our endocrinology outpatient clinic due to a complaint of growth and developmental delay and who were diagnosed with primary congenital hypothyroidism at advanced ages. Material and Method: Sixteen cases of which the youngest was minimum six and the oldest was 23 years old were enrolled into the study. Anthropometrical measures, chrono-logical, height and bone ages of the patients were recorded. Hypothyroidism was diagnosed by the decrease in free thyroxin (sT4) levels and the elevated in serum thyroid stimulating hormone (TSH) levels. To clarify the etiology, thyroglobulin (TG) level and thyroid ultrasonography were studied from the patient. Also thyroid scintigraphy was performed to the patients without a thyroid tissue at a normal anatomical localization. Results: The mean diagnostic age in our cases was 12.6 +/- 4.3 years and female were predominant was present (female/male: 4/14). Height, weights and bone ages of patients were severely retarded. Ectopia was determined in two patients while in twelve patients the thyroid gland was hypoplastic. The thyroid gland was within normal borders in one patient for age and gender and hyperplasic in another case. Conclusion: We wanted to emphasize that congenital hypothyroidism should be kept in mind in cases with developmental delay and mental retardation as these may be non-diagnosed congenital hypothyroidism also infant or early childhood outside. It must be remember, diagnose of these patients may delay until the pre-adolescence and even prior the adulthood. We wish attract attention to the national screening program for congenital hypothyroidism by this study.
Evaluation of Auditory Brainstem Potentials in Children With Acute Herpes Simplex Encephalitis
(Taylor & Francis Ltd, 2009) Caksen, Hueseyin; Yilmaz, Cahide; Tombul, Temel; Guven, Ahmet Sami; Ozen, Ozlem
Objective: In this study, auditory brainstem potentials (ABPs) were studied in children with Herpes simplex encephalitis (HSE) to determine the ABP abnormalities in HSE during childhood. We also wished to determine whether or not to use ABP in early diagnosis of HSE. Method: The study includes 28 children; eight children with acute HSE, nine with nonspecific encephalitis, and 11 healthy age-matched control subjects. The diagnosis of HSE was confirmed by the demonstration of Herpes simplex virus type 1 in CSF by polymerase chain reaction. Recordings of ABPs were performed by using Nihon Kohden Neuropack 2 device. Results: The study includes eight children (four females and four males) with acute HSE, nine children (five males and four females) with nonspecific encephalitis, and 11 healthy age-matched control subjects (six males and five females). Age ranges of the patients and controls were between six months and 12 years. There was not statistically significant difference between the groups for age and gender (p>.05). There were significant differences in the mean latencies of the wave IV on the right ear and in the mean interpeak latencies (IPLs) of the waves III-V on the right and left ears between the nonspecific encephalitis group and the control group (p<.05). However, there were no statistically significant differences between the HSV and control groups (p>.05). In addition, there was no significant difference between HSV and nonspecific groups (p>.05). Conclusions: Our findings revealed that there were mild ABP abnormalities in children with nonspecific encephalitis, but no ABP abnormality in patients with HSV encephalitis. However, we think that more extensive and detailed studies should be performed to determine whether or not there were ABP abnormalities in childhood HSV encephalitis.
Evaluation of Lymphocyte Subgroups in Children With Down Syndrome
(Sage Publications inc, 2015) Yilmaz, Cahide; Dogan, Murat; Basarslan, Fatmagul; Yilmaz, Nebi; Yuca, Sevil; Bulan, Keziban; Caksen, Huseyin
In this study, lymphocyte subgroups including blood CD3, CD4, CD8, CD4/CD8, CD19, and CD16.56 values were analyzed in children with Down syndrome (DS). The study includes 85 children with DS, followed at Department of Pediatrics, Faculty of Medicine, Yuzuncu Yil University and 64 healthy age-matched control participants. Blood CD3, CD4, CD8, CD4/CD8, CD19, and CD16.56 values were examined in both the groups. Significantly decreased blood CD3, CD4, and CD19 values were found in the study group (P < .05) when compared with the control group. In conclusion, we would like to emphasize that blood CD3, CD4, and CD19 levels were found to be decreased in children with DS. Based on these finding, we think that these decreased lymphocyte subgroups might be responsible for increased susceptibility to infections in children with DS.
Guillain-Barre Syndrome Following Bee Sting
(Georg Thieme verlag Kg, 2005) Yilmaz, Cahide; Caksen, Huseyin; Anlar, Omer; Odabas, Dursun
Hemiplegic Migraine: a Case Report
(Galenos Yayincilik, 2010) Yilmaz, Cahide; Sonmez, Bulent; Basaranoglu, Murat; Kaya, Avni; Acikgoz, Mehmet; Caksen, Hueseyin
The girl patient aged twelve had been brought to the hospital having weakness at her left side. After having fallen from a balcony, her paroxysmal headeche accompanying nause and vomiting had began. This case was cured by valproic acid. Electroencephalography showed focal slowing and deep wave discharge. This case was presented to remind that hemiplegic migraine can seldomly begin, after minor head trauma. (Turk Arch Ped 2010; 45: 153-4)
Hypernatremia in Hospitalized Children
(Modestum Ltd, 2017) Yuca, Sevil; Cesur, Yasar; Caksen, Huseyin; Arslan, Derya; Yilmaz, Cahide; Kaya, Avni
Objective: Hypernatraemia has serious complications such as brain injury, brain oedema and seizure. In this study, the incidence among children hospitalized hypernatremia, causes, development time, clinical features, and morbidity, and aimed to reveal the effect on mortality. Method: In this retrospective study, clinical and laboratory data from patients with hypernatremic were recorded. The study period was 33 months. The groups were separated into two groups; group I: Hypernatremia was present at hospital admission, group II: Hypernatremia was acquared after the hospitalization. Results: Overall incidence of hypernatraemia was 1.3% of all hospitalised children. While 42% of patients were from group I, 58% of patients had acquired hypernatremia during hospital stay. In group I, 61% of patients had infections on hospital admission. The most common cause of hypernatraemia in group II was neurological disorders (53%). The mortality rate was 30.5% (11/36) in patients with hypernatraemia on admission, 67.3% (33/49) in those with hospital-acquired hypernatraemia (P<0.05; significantly greater than for those with hypernatraemia on admission), and 51.7% (44/85) overall. Mean serum sodium level was higher in non-survivors than in survivors (161.7 +/- 8.3 mg/dL vs. 160 +/- 7.4 mg/dL), but the difference was not statistically significant. Similarly, there was no significant difference in peak serum sodium levels in survivors versus non-survivors, P>0.05. Conclusion: Hypernatraemia in pediatric age is associated with mortality and morbidity, and should be closely monitored in pediatric patients hospitalized for any reason in order to prevent complication.
Hyponatremia in Hospitalized Children: Review of 400 Cases
(Karger, 2009) Cesur, Yasar; Yuca, Sevil Ari; Dogan, Murat; Yilmaz, Cahide; Kaya, Avni; Akgun, Cihangir
Intracranial Foreign Bodies Causing Delayed Brain Abscesses: Intracranial Sewing Needles - Case Illustration
(Amer Assoc Neurological Surgeons, 2007) Yilmaz, Nebi; Kiymaz, Nejmi; Yilmaz, Cahide; Bay, Ali; Mumcu, Cigden
Intracranial Lipomas - a Clinical Study
(Elsevier, 2006) Yilmaz, Nebi; Unal, Ozkan; Kiymaz, Nejmi; Yilmaz, Cahide; Etlik, Omer
Objective: This study aimed to investigate the localization of the lipoma, as well as associated intracranial and extracranial lesions in 14 patients immediately following hospital admission. The pathological findings from the neurological examinations of these patients are also investigated. Methods: Fourteen patients who were admitted to our clinic with a variety of symptoms and diagnosed with intracranial lipoma were included in the study. Problems presented upon admission, neurological findings, and other existing system abnormalities were evaluated. Localization of the lipomas and accompanying pathologies were determined by using computerised tomography and magnetic resonance imaging. Results: The most frequent reasons for admission of patients with intracranial lipomas were: headache 7 (50%), trauma 3 (21.5%), epilepsy 3 (21.5%) and one with symptoms due to the local mass effect of tumor (7%). Although the pericallosal region is accepted as the region where lipomas commonly occur, this study found the most frequent occurrence in the quadrigeminal cistern. Intracranial lipoma calcification was only evident in 1 of the 14 patients. In addition, contrary to the expectations, intracranial and extracranial lesions accompanying lipomas were rare. All patients received systematic treatment. Conclusion: This study showed that intracranial lipomas are more frequent in the quadrigeminal region of the brain; most are asymptomatic, generally caught incidentally; and accompanying intracranial and extracranial pathologies are less common than expected. (c) 2005 Elsevier B.V. All rights reserved.
Late Onset Arginine Succinate Lyase Deficiency With Normal Plasma Ammonia Level
(Nobel Ilac, 2011) Yilmaz, Cahide; Dogan, Murat; Cesur, Yasar; Caksen, Huseyin; Yuca, Sevil Ari; Atas, Bulent; Tuncer, Oguz
Arginine succinate lyase (ASL) deficiency is one of the most common cause of urea cycle defect and shows all characteristics of this disorders. This disease is presented with hyperammonemia, abnormally kinky hair and mental retardation. 6-years-old-girl was brought to our hospital because of skin eruption, weight loses, abdominal pain, having no appetite, polydipsia and pollakiuria. In physical examination, especially occipital balding, mental retardation, hepatomegaly, ataxia and articulation defect were found. She, who was diagnosed as ASL deficiency after the laboratory examinations, had normal blood ammonia levels. Finally in this study, we emphasize; ASL deficiency must be thought when a child has mental retardation and cerebellar ataxia, even if normal ammonia levels.
Lipid Peroxidation in Patients With Brain Tumor
(Taylor & Francis Ltd, 2006) Yilmaz, Nebi; Dulger, Haluk; Kiymaz, Nejmi; Yilmaz, Cahide; Bayram, Irfan; Ragip, Balahoroglu; Oger, Muzaffer
Molecular and genetic signatures may predict brain tumor behavior and may soon guide tumor classification, diagnosis, and tumor-specific treatment strategies. Free oxygen radicals ( FOR) are thought to take part in oncogenesis and cellular differentiation. This article explored the state of FORs and antioxidant system in patients with cerebral tumor. The serum concentrations of malondialdehyde (MDA), catalase, and glutathione peroxidase (GSH-Px) enzyme activities were measured in the serum of 35 patients with cerebral tumors ( 21 glioma, 14 meningioma) and 11 controls. MDA measurement was done with fluorometric method and catalase and GSH-Px enzyme activities were done with photometric method. Mean serum MDA levels, catalase, and GSH-Px enzyme activities were significantly higher for both glial and meningiomal tumor cases when compared to controls (p < .05). There is no significant difference between glioma and meningioma groups in terms of the aforementioned parameters ( p > .05). In conclusion, lipid peroxidation and antioxidant enzymes as assessed by MDA, catalase, and GSH-Px were increased in patients with brain tumors, for this respect there is no difference between gliomas and meningiomas.