Browsing by Author "Yilmazer, G."

Now showing 1 - 2 of 2

The Comparison of Dose Distribution of Different 3d Conformal and Conventional Radiotherapy Plans for Gastric Cancer
(Ijrr-iranian Journal Radiation Res, 2016) Izmirli, M.; Yilmazer, G.; Cakir, T.; Palabiyik, Z. A.; Nart, M.
Aims: It was aimed to investigate postoperative conformal radiotherapy planning that provides the best target volume and the least dose for critical organs in cancers of stomach. Methods: This study was conducted on the CT simulation images of thirty patients diagnosed with gastric cancer. Target volumes and the organs at risk were contoured. AP-PA reciprocal parallel field conventional plan and three- and four-field 3D conformal plans were created using linear accelerator. Target volumes and doses consumed by organs at risk were compared by dose-volume histograms. Results: While a sufficient dose could be applied to target volumes in all plans with conformal planning, average figures showed that 95% of porta hepatis area failed to take the prescribed dose (D95) in some plans by using AP-PA reciprocal parallel zone conventional plans. The most convenient protection for spinal cord, heart and kidneys was obtained by conformal four-field technique and the liver doses were increased in conformal four-field plans but did not exceed the tolerance dose. And also, in the conventional AP-PA reciprocal parallel field plans, tolerance dose of spinal cord (4500 cGy) was exceeded. Conclusion: In this study, conformal four-field technique was superior considering target volume dose distributions, and especially spinal cord doses in all localizations and heart doses in cardia tumors. Kidney doses were also reduced in conformal four-field planning, but failed to reach statistical significance. There was a not exceeding tolerance limits dose increase in liver.
Effect of Radiotherapy on Erythrocyte Catalase, and Carbonic Anhydrase Activities, Serum Levels of Some Trace Elements and Heavy Metals (Zn, Cu, Pb, Cd, Mn, Fe, Mg and Co) in Cancer Patients
(Ijrr-iranian Journal Radiation Res, 2022) Tuncer, G. Seven; Demir, H.; Izmirli, M.; Cakir, T.; Yilmazer, G.; Demir, C.
Background: We tried to reveal the relationship between the levels of some important minerals, rare elements and heavy metals by measuring serum cobalt (Co), lead (Pb), zinc (Zn), iron (Fe), copper (Cu), cadmium (Cd), magnesium (Mg), manganese (Mn), catalase (CAT) and carbonic anhydrase (CA) levels in head and neck, CNS, esophagus, stomach and breast cancers receiving radiotherapy. Materials and Methods: Serum Cu, Fe, Pb, Zn, Co, Mg, Mn and Cd levels were measured using atomic absorption spectrophotometry. Carbonic anhydrase activity (CA), CO2 hydration measurements were made using bromothymol blue method as indicator. Results: Catalase activity, carbonic anhydrase activity and serum copper, lead, zinc, iron, cobalt, cadmium, manganese, magnesium measurements for baseline and post-radiotherapy values differ greatly in cancer patients compared to healthy subjects (p<0.05). Conclusion: As a result, these findings have a significant impact on the pathophysiology of cancer. It can be argued that this paper shows a preliminary study for examining the effect of radiotherapy treatment on the activity of erythrocyte catalase, carbonic anhydrase and serum levels of cobalt, lead (Pb), zinc, iron, copper, cadmium, magnesium and manganese in the head and neck, CNS, stomach, esophagus and breast cancers receiving radiotherapy treatment.