Browsing by Author "Yoruk, Ibrahim"

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An Analysis on the Roles of Angiogenesis-Related Factors Including Serum Vitamin D, Soluble Endoglin (Seng), Soluble Fms-Like Tyrosine Kinase 1 (Sflt1), and Vascular Endothelial Growth Factor (Vegf) in the Diagnosis and Severity of Late-Onset Preeclampsia
(Taylor & Francis Ltd, 2017) Cim, Numan; Kurdoglu, Mertihan; Ege, Serhat; Yoruk, Ibrahim; Yaman, Gorkem; Yildizhan, Recep
Aim: The aim of this study was to evaluate the roles of proangiogenic factors including serum vitamin D and vascular endothelial growth factor (VEGF) and anti-angiogenic factors including soluble endoglin (sEng) and soluble fms-like tyrosine kinase 1 (sFlt1) in the diagnosis and severity of late-onset preeclampsia. Materials and methods: The study was conducted at Yuzuncu Yil University Research and Education Hospital Department of Gynecology and Obstetrics. The study included a patient group of 40 women with late-onset preeclampsia who were pregnant at >= 32 weeks of gestation according to the last menstrual period (LMP) or ultrasonographic fetal biometric measurement and a control group of 40 healthy pregnant women who presented to our clinic for routine pregnancy examination and were at the same age and gestational period with those in the patient group. The two groups were compared in terms of maternal age, gravida, parity, week of gestation, systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, white blood cell (WBC), hemoglobin (Hgb), platelet count, urea, creatinine, liver function tests (AST, ALT, LDH), vitamin D-3, 25(OH) vitamin D-3, 1,25(OH) vitamin D-3, sEng, sFlt1, and VEGF levels, mode of delivery, the infant APGAR score at 1 and 5 min after delivery, and infant weight at delivery. Results: The groups were similar in terms of age, gravida, parity, week of gestation, serum vitamin D-3, 25(OH) vitamin D-3, 1,25(OH)(2) vitamin D-3 and VEGF levels, and infant weight at delivery (p > 0.05). Systolic/diastolic blood pressure, total protein in spot urine sample, 24-h urine protein, WBC, Hgb, serum urea, creatine, AST, ALT, and LDH were significantly higher in the preeclamptic group compared to the healthy group (p < 0.05). However, thrombocyte level and the APGAR score at 1 and 5 min after delivery were significantly lower in the preeclamptic group compared to the healthy group (p < 0.05). No significant correlation was found between serum sEng, sFlt1, VEGF, vitamin D-3, 25(OH) vitamin D-3, and 1,25(OH)(2) vitamin D-3 levels. The sEng level was higher in the women with severe preeclampsia compared to the women with mild preeclampsia (p < 0.05) and no significant difference was observed in serum sFlt1, VEGF, vitamin D-3, 25(OH) vitamin D-3, and 1,25(OH)(2) vitamin D-3 levels between the subgroups of preeclampsia (p > 0.05). Conclusion: Both sEng and sFlt1 levels are remarkably high in patients with late-onset preeclampsia; however, only sEng may be a useful tool in the determination of the severity of preeclampsia.
Determination of Vitamin E Levels in Walnuts (Juglans Regia L.) Grown in the Lake Van Basin by Hplc
(Kastamonu Univ, 2021) Demirkan, Faruk; Bilici, Mustafa; Yoruk, Ibrahim
Aim of study: The present study describes determination of vitamin E levels in Walnuts (Juglans regia L.) Grown in the Lake Van basin. Area of study: Adilcevaz, Bahcesaray, Catak, Edremit, Gevas regions in the Lake Van basin and in the center of Van. Material and methods: Walnuts were collected regions and stored in a deep freezer for analysis. On the day of analysis, 10 pieces of fresh and dried walnut samples belonging to each region were taken and broken, and a homogeneous mixture was obtained by pulverizing them and determined by HPLC. Main results: The amounts of alpha-Tocopherol of the samples in fresh walnuts were found to be 2.36 +/- 0.01 mu g/g, 5.01 +/- 0.31 mu g/g, 6.23 +/- 0.15 mu g/g, 7.20 +/- 0.28 mu g/g, 3.99 +/- 0.46 mu g/g, 5.05 +/- 0.30 mu g/g, respectively, and the amounts of gamma-Tocopherol were found to be 23.80 +/- 0.52 mu g/g, 16.54 +/- 1.08 mu g/g, 14.82 +/- 0.46 mu g/g, 17.34 +/- 0.78 mu g/g, 11.91 +/- 0.40 mu g/g, 15.57 +/- 0.90 mu g/g, respectively, according to the regions. The amounts of alpha-Tocopherol in dried walnuts were found to be 5.13 +/- 0.26 mu g/g, 6.84 +/- 0.31 mu g/g, 7.58 +/- 0.40 mu g/g, 10.49 +/- 0.51 mu g/g, 8.65 +/- 0.34 mu g/g, 5.82 +/- 0.19 mu g/g, respectively, and the amounts of.-Tocopherol were found to be 33.10 +/- 1.65 mu g/g, 21.97 +/- 0.87 mu g/g, 20.98 +/- 0.83 mu g/g, 29.19 +/- 0.80 mu g/g, 21.09 +/- 0.24 mu g/g, 18.41 +/- 0.82 mu g/g, respectively, according to the regions. Highlights: The results obtained in the study are considered, it is observed that the walnuts grown in Adilcevaz, Bahcesaray, Catak, Edremit, Gevas and Van-Center regions are of high quality.
Effects of 900-Mhz Electromagnetic Field Emitted From Cellular Phone on Brain Oxidative Stress and Some Vitamin Levels of Guinea Pigs
(Elsevier, 2007) Meral, Ismail; Mert, Handan; Mert, Nihat; Deger, Yeter; Yoruk, Ibrahim; Yetkin, Aysen; Keskin, Siddik
This study was designed to demonstrate the effects of 900-MHz electromagnetic field (EMF) emitted from cellular phone on brain tissue and also blood malondialdehyde (MDA), glutathione (GSH), retinol (vitamin A), vitamin D3 and tocopherol (vitamin E) levels, and catalase (CAT) enzyme activity of guinea pigs. Fourteen male guinea pigs, weighing 500-800 g were randomly divided into one of two experimental groups: control and treatment (EMF-exposed), each containing seven animals. Animals in treatment group were exposed to 890- to 915-MHz EMF (217-Hz pulse rate, 2-W maximum peak power, SAR 0.95 w/kg) of a cellular phone for 12 h/day (11-h 45-min stand-by and 15-min spiking mode) for 30 days. Control guinea pigs were housed in a separate room without exposing EMF of a cellular phone. Blood samples were collected through a cardiac puncture and brains were removed after decapitation for the biochemical analysis at the end of the 30 days of experimental period. It was found that the MDA level increased (P < 0.05), GSH level and CAT enzyme activity decreased (P< 0.05), and vitamins A, E and D3 levels did not change (P > 0.05) in the brain tissues of EMF-exposed guinea pigs. In addition, MDA, vitamins A, D3 and E levels, and CAT enzyme activity increased (P < 0.05), and GSH level decreased (P < 0.05) in the blood of EMF-exposed guinea pigs. It was concluded that electromagnetic field emitted from cellular phone might produce oxidative stress in brain tissue of guinea pigs. However, more studies are needed to demonstrate whether these effects are harmful or/and affect the neural functions. (C) 2007 Elsevier B.V. All rights reserved.
Electrochemical Determination of Flavonoid Fisetin in Commercial Dietary Supplements Using a Boron-Doped Diamond Electrode
(Wiley-v C H verlag Gmbh, 2023) Allahverdiyeva, Shabnam; Keskin, Ertugrul; Yoruk, Ibrahim; Yardim, Yavuz
For the first time, a boron-doped diamond electrode was utilized to quantitatively determine flavonoid fisetin (FST). Cyclic voltammetric studies have shown that the electrochemical oxidation of FST is irreversible and well-separated two peaks (P-A1 and P-A2) in 0.1 MHNO3 solution. The effects of electrode pretreatment, solution pH, nature of the supporting electrolyte, and instrumental variables on the peak current and potentials of the FST were investigated by square-wave voltammetry (SWV) and then optimum ones were determined. It was observed that the cathodically pre-treated BDD (CPT-BDD) electrode's performance was better than the other pre-treatment procedures for increasing the FST oxidation signal. Under optimized conditions and using the SWV technique, the response of the first anodic peak (P-A1) of the FST was proportional in a concentration range of 0.5-20.0 mu g mL(-1) (1.7x10(-6)-6.9x10(-5) mol L-1) with a detection limit of 0.08 mu gm L-1 (2.8 x 10(-7) mol L-1). Also, it was successfully demonstrated that the proposed method is applicable in commercial nutritional supplement formulations.
Relationship Between Vitamin Composition and Spermatological Characteristics in Semen of Different Ram Breeds of Turkey
(Zoological Soc Pakistan, 2016) Karakus, Kadir; Mert, Nihat; Mert, Handan; Yoruk, Ibrahim; Aygun, Turgut; Tariq, Mohammad Masood
The aim of this study was to evaluate the vitamin levels of ram seminal plasma and the relationship between vitamins and spermatological characteristics. For this aim, nine 3-5 year old rams of Norduz, Karakas and Ile-de-France x Akkaraman (G1) genotypes were provided. Sperm of each ram was collected once per month from June to October of the year 2007 by artificial vagina. In each month, the concentrations of retinol acetate, alpha tocopherol, delta tocopherol, alpha tocopherol acetate and vitamin D-3 in seminal plasma were analyzed by using HPLC. Spermatological characteristics viz. sperm volume, pH, mass activity, sperm motility, abnormal spermatozoid, death/alive ratio and sperm concentration were evaluated. As testicular characteristics, scrotal circumference and testicular diameter were measured. Monthly changes and breed differences on the vitamin levels were statistically insignificant, whereas there was a positive correlation was obtained between testis diameter and retinol acetate levels (p<0.05) and a positive correlation was also estimated between analyzed vitamins. As a result, the relationships between the testicular, spermatological characteristics, and vitamin compositions should be taken into account in the breeding targets.
Some Biochemical Parameters and Vitamins Levels in the Hair Goats Naturaly Mix-Infested With Endo and Ectoparasities (Lice (Linognathus Africanus) and Trichostrongylidae Sp.)
(Medwell online, 2009) Tanritanir, Pinar; Ozdal, Nalan; Ragbetli, Cennet; Yoruk, Ibrahim; Ceylan, Ebubekir; Deger, Serdar
The aim of this study was to investigate the changes in the blood serum concentration of some biochemical parameters and lipid-soluble vitamin levels in the goats naturaly infested with lice and Trichostrongylidae sp. before and after treatment with moxidectin and effects of moxidectin treatment on these blood parameters. In this study, 20 hair goats naturaly infected with lice (Linognathus africanus) and Trichostrongylidae sp. and 10 healthy hair goats (control) were used as material. Blood samples were collected from infested and control groups. Serum samples were seperated and analysed for biochemical parameters with autoanalyser and some vitamins with high performance liquid chromatography. Animals in infested group were treated with ecto-endoparasitic drug (moxidectin) and in 8 and 15 days after treatment blood samples were again collected to determine some vitamins and biochemical parameters. As a results, concentrations of retinol, sodium, potassium, calcium and albumin were lower (p<0.05) and activity of alanine aminotransferase was higher (p<0.05) in infected goats than in the controls. There was no statistically significant difference in the concentration of vit D-3, tocopherol, total protein, glucose and activity of aspartate aminotransferase and alkaline phosphatase between infected and control group.
Vitamin Levels in Lung Tissue of Rats With Bleomycin Induced Pulmonary Fibrosis
(Center Academic Publ Japan, 2009) Mert, Handan; Yoruk, Ibrahim; Ertekin, Ali; Dede, Semiha; Deger, Yeter; Yur, Fatmagul; Mert, Nihat
Bleomycin (BLM) is a chemotherapeutic agent against different carcinomas, one dose of which causes dependent pulmonary fibrosis. The present study was taken up in order to measure the retinyl ester. a-tocopherol and cholecalciferol (vitamin D-3) level in lung tissue in the rats following BLM-induced fibrosis. Fourteen rats were randomly divided into two groups as a control and a BLM group. On the day of the experiment. the BLM group rats were instilled with BLM (7.5 mg/kg) and the control group with sterile saline intratracheally. Fourteen days after instillation, rats in each group were sacrificed and the lungs were prepared for histopathological examination and determination of the vitamin levels with a HPLC system. The levels of retinyl ester, alpha-tocopherol and vitamin D-3 in the lungs of the BLM group were determined to be lower than in the controls. There was statistically significant difference for the alpha-tocopherol and vitamin D-3 concentrations compared to the control group (p<0.01, p<0.001.), respectively. According to these results in pulmonary fibrosis, vitamins were consumed by the lung tissue and their levels decreased.