Browsing by Author "Yuksek, N."

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Adenosine Deaminase in the Diagnosis of White Muscle Diseases in Lambs
(Polish Soc veterinary Sciences Editorial office, 2006) Altug, N.; Agaoglu, Z. T.; Yuksek, N.; Kaya, A.; Keles, I.
The aim of the study was to investigate the importance of ADA serum and its isoenzyme activity in diagnosing white muscle disease in lambs. The animal material used in the study was forty seven Akkaraman lambs - twenty seven of which had clinical signs of white muscle disease (white muscle disease group) and twenty healthy lambs (control group). Blood samples were taken and Se levels, CK, LDH, AST, ADA and ADA izoenzyme activity were determined. Following this, the animals in the white muscle disease group received I mg sodium selenit + 60 mg vitamin E intramuscularly as a single dose. Fourteen days following sodyum selenit + vitamin E application blood samples were again taken and the same analysis repeated. Apart from ADA2 activity, other enzyme activities were significantly high (p < 0.001), and serum Se concentrations were significantly low (p < 0.001) in animals of the white muscle disease group compared to the control group. When the parameters obtained from the white muscle disease group were compared before and after treatment it was indicated that all enzyme parameters decreased significantly (p < 0.001) after treatment. On the other hand, serum Se concentration increased (p < 0.01) after treatment in the diseased group. The results confirm that determining ADA serum and its isoenzymes, together with CK, LDH and AST values seems to be useful in diagnosing white muscle disease.
Assessment of Electrocardiographic Findings, Serum Nitric Oxide, Cardiac Troponins and Some Enzymes in Calves With Hyperkaliemia Related To Neonatal Diarrhoea
(Ecole Nationale veterinaire Toulouse, 2011) Ozkan, C.; Altug, N.; Yuksek, N.; Kaya, A.; Akgul, Y.
The aims of the present study were to characterize ECG changes in calves with hyperkaliemia due to neonatal diarrhoea and to determine concomitant variations of serum concentrations of NO and of sonic cardiac markers such as cardiac troponins I and T and serum enzyme AST, LDH, CK and CK-MB activities. For that, ECG examinations were performed and serum biochemical parameters were measured in 13 diarrhoeic calves developing hyperkaliemia before and 5 hours after intravenous electrolyte (NaCl and Na2HCO3) administration and also in 5 healthy control calves. Compared to controls, diarrhoeic and hyperkaliemic calves exhibited significant alterations in electrolyte concentrations (Increases of K, Mg and P concentrations coupled to decreases of Na and Cl concentrations), a significant blood accumulation of nitrogen compounds (BUN and creatinine) and significant increases in ALP, LDH, CK and GGT activities. Furthermore, the serum NO concentrations have greatly enhanced in some individuals. By contrast, the serum troponin concentrations and the heart specific CK-MB and AST activities were similar between the 2 groups whereas electrocardiography changes were evidenced in diarrhoeic calves: P wave anomalies were observed in sonic diseased calves and the mean amplitude and the mean duration of the QRS complex and the T wave were markedly increased. The fluid electrolyte therapy has restored the electrolyte balance and has globally improved the parameters of the cardiac function but has failed to counteract the blood azote accumulation and the release of ALP, LDH, CK and GOT enzymes and even has aggravated the decreases in total protein and albumin concentrations and the glycaemia variations. These results suggest that the diarrhoea-related hyperkaliemia has led to disturbances into the cardiac function without inducing severe myocardium lesions in calves but was coupled to acute renal failure.
Enhancement of the Glucose Metabolism and the Reverse Cholesterol Transport by a Peroxisome Proliferator Receptor Α (Pparα) Agonist Included in the Fasciolosis Treatment in Naturally Infested Sheep
(Ecole Nationale veterinaire Toulouse, 2013) Yuksek, N.; Altug, N.; Denizhan, V.; Ceylan, E.; Agaoglu, Z.
The purpose of this study was to investigate the effects of PPAR alpha agonist on metabolic parameters in naturally Fasciola-infected sheep. Twenty sheep with fasciolosis were allotted in 2 equal groups according to the received treatment (triclabendazole/levamisole in the group I and triclabendazole/levamisole + PPAR alpha agonist (2-methyl-2-phenoxy-propionic acid) in the group II) and the haematological and biochemical parameters were assessed before the treatment and 7, 14 and 28 days after and were compared to control values determined from 10 healthy sheep. As expected, fasciolosis has induced an anaemia evidenced by low haematocrit and low haemoglobinemia coupled to eosinophilia and to a moderate lymphopenia, severe liver damage characterised by hepatocyte degenerescence (significant increases in serum AST and GDH activities) and bile duct obstruction (significant increases in serum GGT activity and in serum bile acid concentrations) leading to impairement in liver metabolic functions (hypoalbuminemia, marked decreases in serum glucose concentrations and in LDL associated cholesterol concentrations). All the heamatological and biochemical alterations were at least partially alleviated by the antihelminthic treatment except the serum triglyceride concentrations which have continued to decrease during the post-treatment period and the total cholesterol and HDL associated cholesterol concentrations which have markedly increased, particularly when sheep were also treated with the PPAR alpha agonist. These results clearly demonstrated the severe metabolic liver impairment occurring during fasciolosis in sheep and the beneficial effects of the PPAR alpha agonist on the correction of the negative energy balance, particularly by promoting the reverse cholesterol transport.
Evaluation of the Anesthetic Effects of Xylazine-Ketamine, Xylazine-Tiletamine and Tiletamine-Zolazepam Using Clinical and Laboratory Parameters in Rabbits
(Polskie Towarzystwo Nauk Weterynaryjnych, 2018) Karasu, A.; Altug, N.; Aslan, L.; Bakir, B.; Yuksek, N.
The aim of this study was to evaluate the anesthetic effects of xylazine-ketamine (XK), xylazine-tiletamine-zolazepam (XTZ) and tiletamine-zolazepam (TZ) using hematological and biochemical parameters in rabbits. ' A total of 18 rabbits were divided into three equal treatment groups (n = 6). The rabbits in the XK, XTZ, and TZ groups were administered xylazine (5 mg/kg) and ketamine (50 mg/kg), xylazine (5 mg/kg) and TZ ; (15 mg/kg), and TZ (15 mg/kg), respectively, via the intramuscular route. Following the injection, their reflexes ; were tested every 5 minutes. Heart rate, respiratory rate, and body temperature were determined before ; the injection (0 min) and at 5, 15, 30, 45, 60, 75, 90, and 120 min after injecting the anesthetic combinations. Furthermore, hematological and biochemical (alanine transaminase [ALT], aspartate transaminase [AST], alkaline phosphatase [ALP], bilirubin, blood urea nitrogen [BUN], and urea) analyses were also performed before, during, and after anesthesia administration. The duration of anesthesia and loss of reflexes were significantly longer in the XTZ group than in the other groups. However, in the TZ group, reflexes were remained. Respiratory rate and body temperature decreased in all the groups. Moreover, heart rate reduced only in the XK and XTZ groups, and the hematological parameters of all groups were comparable. Serum AST and ALP levels increased in the XTZ group compared to that in the XK and TZ groups, respectively. However, these increases were within the reference limits. The post-anesthesia serum BUN and urea levels significantly increased in the XTZ group (p < 0.05) compared to that in the other groups. Thus, although the XTZ combination provided satisfactory anesthetic effect in rabbits, it may be nephrotoxic. Therefore, its use for anesthesia induction in invasive renal procedures and experimental nephrotoxicity studies is not advisable. © 2018 Polskie Towarzystwo Nauk Weterynaryjnych. All rights reserved.
Evaluation of Total Antioxidant, Total Calcium, Selenium, Insulin, Free Triiodothyronine and Free Thyroxine Levels in Cows With Ketosis
(Islamic Azad Univ, Rasht, 2017) Kozat, S.; Yuksek, N.
Ketosis is an important metabolic disease of high milk-producing cows. There are significant changes in many metabolite and hormonal concentrations in metabolic diseases. This study was carried out to assess the concentrations calcium (Ca), selenium (Se), total antioxidant (TAOC), insulin, free triiodothyronine (fT(3)) and free thyroxine (fT(4)) in cows with subclinical and clinical ketosis. This study included 20 dairy cows within the first two months of lactation, aged between 4-8 years. Cows with beta-hydroxybutyrate acid (BHBA) concentrations 1.20 mmol/L were considered healthy, whereas 1.20 and 1.50 mmol/L were considered subclinical and 1.60-2.20 mmol/L were classified as clinically ketotic. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), low density lipoprotein (LDH), glucose, Ca, plasma TAOC capacity and BHBA concentrations were performed spectrophotometrically. Serum insulin, free triiodothyronine and free thyroxine concentrations were measured using the chemi-luminescence method. Serum Se concentrations were measured using an Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). In conclusion, significant changes were noted in decreased concentrations of TAOC, Ca, Se, fT(3), fT(4) and insulin in cows with subclinical and clinical ketosis. The study identified important parameters, changes in the levels of these parameters will be important in determining the treatment and prognosis of the disease. Their use may also help reduce the economic losses suffered by dairy farmers as a result of the disease.
Genetic Chracterisation of Various Cat Breeds by Using Microsatellites in Turkey
(Blackwell Publishing, 2008) Eroglu, T.; Kurar, E.; Altunok, V.; Ozsensoy, Y.; Nizamlioglu, M.; Yuksek, N.
Haemobartonella Felis in Van Cats
(indian veterinary Journal, 2006) Yuksek, N.; Altug, N.; Agaoglu, Z.; Yuksel, H.; Kaya, A.; Tutuncu, M.
Selected Blood Serum Elements in Van (Turkey) Cats
(veterinarni A Farmaceuticka Univerzita Brno, 2007) Altunok, V.; Yazar, E.; Yuksek, N.
The Turkish Van cat originates from eastern Turkey. One of the characteristic features of Van cats is the colour of their eyes, which can be both eyes blue, both eyes amber or one eye blue and the other amber. Serum essential trace, macro and industrial element concentrations of Van cats (n = 47) according to sex, age, hair length and eye colour differences were investigated. Serum aluminium, arsenic, boron, barium, cobalt, chromium, copper, gallium, indium, iron, lead, lithium, manganese, nickel, selenium, silver, sulphur, strontium, vanadium and zinc were measured with ICP-OES plasma optical atomic emission spectrometer. In result, serum alummium, barium, copper, manganese and strontium levels in male cats were found higher (p < 0.05) than in female cats. Serum aluminium, copper, manganese, strontium and zinc amounts of blue-blue eyed cats were found higher (p < 0.05) than amber-amber, amber-blue and blue-amber eyed cats, and serum lithium of blue-amber eyed cats was higher (p < 0.05) than blue-blue eyed cats. There were no statistically significant differences (p > 0.05) found in the age and hair length groups. Our results indicate that several of the blood serum elements of Van cats may be related to their eye colours and sex differences.
Serum Potassium-Lowering Effects of Insulin Plus Dextrose and Adrenalin Treatment That Enhance Intracellular Potassium Transitions in Hyperkalemic Diarrheic Calves
(Univ Agriculture, Fac veterinary Science, 2016) Altug, N.; Yuksek, N.; Ozkan, C.; Basbugan, Y.; Keles, I.; Agaoglu, Z. T.; Akgul, Y.
The study examined the serum potassium-lowering effects of different treatment options for hyperkalemia in diarrheic calves (n=18). Calves were allocated into three treatment groups. All groups received isotonic sodium bicarbonate solution for a period of 90 minutes. The animals in group 1 received no further treatment, those in group 2 received a further dose of 50% dextrose and insulin, and those in group 3 received a further dose of adrenaline. High serum K levels in all groups significantly decreased after treatment (AT) than before treatment (BT). Serum potassium levels AT in groups 2 and 3 were found to be significantly lower than those in group 1. Increase in pH, bicarbonate and total carbon dioxide values were observed AT in all groups. However, bicarbonate and total carbon dioxide levels in the AT were not statistically significantly different from those in the adrenaline group compared with the groups 1. These parameters were significantly lower in the group 2. Moreover, the concentration of glucose in the groups 2 in contrast to the adrenalin group was higher than that in both the BT and group 1 AT. The insulin + dextrose combination and adrenaline applications in hyperkalemic calves had similar effects. However, the administration of adrenaline had a lower negative effect on metabolic acidosis treatment. (C) 2015 PVJ. All rights reserved