Browsing by Author "Yur, Fatmaguel"

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Concentration of Products of Nitric Oxide Oxidation and Some Vitamins in Sheep With Naturally Acquired Babesiosis
(Tubitak Scientific & Technological Research Council Turkey, 2009) Mert, Handan; Yoeruek, Ibrahim; Deger, Yeter; Mert, Nihat; Dede, Semiha; Yur, Fatmaguel
The aim of the present study was to determine serum concentrations of the products of nitric oxide oxidation (nitrate and nitrite) and some vitamins (retinol acetate, alpha- and delta-tocopherol, and vitamin D 3) in sheep naturally infected with Babesia ovis. The investigation included 30 infected and 10 control sheep. Serum a- tocopherol levels were significantly lower (P < 0.05), and nitrate and nitrite concentrations were significantly higher (P < 0.05) in infected animals than in controls. It is thought that the elevated nitrate and nitrite levels of the sheep infected with babesiosis were due to the result of damage caused by Babesia. On the other hand, a significant decrease was observed in a- tocopherol levels in sheep with babesiosis because of damage and pathophysiological changes to erythrocytes.
Effects of Vitamin E and Selenium on Serum Trace and Major Elements in Horses
(Humana Press inc, 2008) Yur, Fatmaguel; Dede, Semiha; Deger, Yeter; Kilicalp, D.
The combined effects of vitamin E and selenium were studied in native Anatolian horses subject to strenuous exercise. The concentrations of copper, zinc, iron, calcium, potassium, and magnesium were determined in serum by atomic absorption spectrometry in two study groups (n=25 each), one of which served as untreated controls. After exercising the horses by running 1,500 m in about 7 min, only the copper level and the copper/zinc ratio significantly increased (p<0.05), but the concentrations of calcium, potassium, iron, and magnesium remained unchanged. In horses treated with vitamin E and selenium, the calcium and potassium levels decreased to levels lower than those of untreated controls before and after exercise. The iron levels were not changed by exercise or treatment alone but increased when the horses had been supplemented and exercised. The copper level and the copper/zinc ration increased as a result of exercise in both treated and untreated horses. These changes suggest that supplementation with vitamin E and selenium had an important effect on the serum concentrations of calcium, potassium, copper, iron, and the copper/zinc ratio.
Na+ Activity in Sheep With Natural Babesiosis
(veterinarni A Farmaceuticka Univerzita Brno, 2010) Yur, Fatmaguel; Yazar, Mete; Deger, Yeter; Dede, Semiha
The aim of this study was to determine the Na+/K(+)ATPase activity in the erythrocytes of sheep naturally infected with Babesia ovis before and after treatment. Seven diseased sheep and seven control animals were used for the study. Babesia infection was confirmed with Giemsa's staining of blood smears. Na+/K(+)ATPase activity in erythrocyte was determined colorimetrically by the release of inorganic phosphate from ATP in the presence and absence of ouabain. A marked decrease of Na+/K(+)ATPase activity (p < 0.05) was obtained in infected sheep (0.81 +/- 0.28 mu mol inorganic phosphate/h.mg protein) compared to control animals (3.63 +/- 0.72 mu mol Pi/h.mg protein). Beside this decline, Na+/K(+)ATPase activity of treated animals (1.29 +/- 0.81 mu mol Pi/h.mg protein) were significantly (p < 0.05) decreased compared to control animals. It can be concluded that decreased erythrocyte Na+/K(+)ATPase activity in babesia ovis may be due to the usage of new permeation pathways (NPPs) for the flux of ions instead of Na+/K+ pump.
Serum Selenium, Vitamin E, and Sialic Acids Concentrations in Lambs With White Muscle Disease
(Humana Press inc, 2008) Deger, Yeter; Mert, Handan; Mert, Nihat; Yur, Fatmaguel; Kozat, Sueleyman; Yoruk, Ibrahim H.; Sel, Tevhide
The aim of this study was to determine the serum concentrations of selenium, vitamin E, and total- and lipid-bound sialic acid (LBSA) in lambs with white muscle disease (WMD) before and after treatment with a commercial preparation containing selenite and vitamin E. Fifteen lambs with WMD and ten control animals were used as research materials. Blood samples were collected from both groups before- and 1 month after treatment for Se analysis by fluorimetry, whereas vitamin E and sialic acid were measured by HPLC and spectrophotometry, respectively. Compared to controls, in the diseased animals, there was a significant increase of serum total sialic acid (TSA) and LBSA, together with significant decreases of serum Se and vitamin E concentrations (p < 0.001). One month after treatment, a reversal of trend was observed with decreases of TSA and LBSA and increases of Se and vitamin E concentrations. The TSA and LBSA levels, however, remained significantly higher than those of the controls, p < 0.05 and 0.001, respectively. The Se and vitamin E concentrations of the treated animals were the same as those of controls. This is the first study on total and LBSA concentrations in lambs with WMD, showing that these markers can be used in the prognosis of the disease.