Browsing by Author "Yurekturk, E."

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Analysis of Thyroid Hormones in Newborns with Hypoxic Ischaemic Encephalopathy
(Yuzuncu Yil Universitesi Tip Fakultesi, 2025) Aycan, N.; Yurekturk, E.; Başaranoǧlu, M.; Karaman, S.; Demir, D.Ç.; Tuncer, O.
Introduction: Thyroid hormone plays an essential role in brain development and fetal, neonatal, and adult brain function and may influence neuronal recovery after hypoxia and traumatic brain injury. We aimed to see whether there is a relationship between the effects of hypoxia at the cellular level and the stages of the disease. Materials and Methods: After ethics committee approval and informing the families, demographic characteristics, laboratory parameters, diffusion MRI images, and TSH and free T4 levels from thyroid function tests on postnatal days 5 and 21 were recorded retrospe ctively in newborns who were hospitalized with the diagnosis of hypoxic-ischemic encephalopathy in the neonatal intensive care unit of our hospital in the last two years. 81 HIE babies over 37 gestational weeks and 50 control babies of the same age participated in the stud y. Sarnat staging was performed according to the patient's clinical status. Results: There were no statistically significant differences between HIE and healthy babies regarding gender, mode of delivery, birth weight, and birth week. According to Sarnat scoring, while healthy infants had lower TSH levels on postnatal day 5 compared t o all types of hypoxic infants, moderate HIE newborns had higher TSH measurements compared with healthy, mild, and severe HIE neonates. fT4 level was statistically significantly higher in moderate HIE babies than in healthy, mild, and severe newborns. Conclusion: We demonstrated that thyroid hormones, known to have significant effects on energy catabolism and central nervous system development, varied over time in HIE infants at various stages. © Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Identification of Three Novel Pathogenic Itga2b and One Novel Pathogenic Itgb3 Mutations in Patients With Hereditary Glanzmann's Thrombasthenia Living in Eastern Turkey
(Wiley, 2020) Karaman, K.; Yurekturk, E.; Geylan, H.; Yasar, A. S.; Karaman, S.; Cetin, M.; Oner, A. F.
Investigation of the Relationship Among the Anatomical Level of the Lesion, Hydrocephalus and Chiari Type 2 Pathologies in Myelomeningocele Patients
(Elsevier (Singapore) Pte Ltd, 2025) Zengin, İ.; Akyol, M.E.; Yurekturk, E.; Cetin, E.
Objective: The coexistence of hydrocephalus and Chiari II malformation significantly increases mortality in patients with myelomeningocele (MMS). This study aimed to investigate the factors associated with the development of hydrocephalus and Chiari II malformation in patients with MMS. Methods: A total of 430 patients who were hospitalized and underwent surgery for MMS in the neurosurgery unit of our hospital were retrospectively evaluated. Data collected included gender, maternal age, lesion level, sac size, presence of hydrocephalus or Chiari II malformation, and the need for shunt placement. Univariate and multivariate statistical analyses were performed to examine the relationships between patient characteristics and the development of hydrocephalus and Chiari II malformation. Findings: Of the 430 patients, 227 (52.8 %) were female and 203 (47.2 %) were male. Hydrocephalus developed in 298 patients (69.3 %), while 218 (50.7 %) were diagnosed with Chiari II malformation. The most common lesion level was the lumbar region (61.4 %). In multivariate analysis, the risk of developing hydrocephalus was 8.58 times higher in patients with thoracic-cervicothoracic lesions and 2.65 times higher in those with thoracolumbar lesions. Gender and sac size were not significantly associated with the development of hydrocephalus (p = 0.181 and p = 0.077, respectively). Univariate analysis showed no significant association between lesion level and the development of Chiari II malformation (p = 0.971). Conclusion: In patients with MMS, lesion level is an independent risk factor for the development of hydrocephalus. Children with thoracic, cervicothoracic, and thoracolumbar lesions—especially those with Chiari II malformation—should be closely monitored for hydrocephalus development. © 2025 Elsevier B.V., All rights reserved.