Browsing by Author "Yurtdas, Mustafa"

Now showing 1 - 20 of 20

Acute Myocardial Infarction in a Young Man; Fatal Blow of the Marijuana: a Case Report
(Korean Soc Cardiology, 2012) Yurtdas, Mustafa; Aydin, Mehmet Kasim
Marijuana is known to have been used for medicinal and recreational purposes for thousands of years. Although marijuana has some diverse effects on cardiovascular system, there is insufficient knowledge concerning acute myocardial infarction ( AMI) associated with marijuana and its underlying mechanism. We report the case of a 26 year-old young man suffering from ST-elevated AMI caused by marijuana abuse, which was successfully treating with percutaneous coronary intervention. It should be kept in mind that marijuana could be one of the most probable causes of AMI observed in apparently healthy young persons who use this drug.
Acute Serious Thrombocytopenia Associated With Intracoronary Tirofiban Use for Primary Angioplasty
(Hindawi Ltd, 2014) Yurtdas, Mustafa; Yaylali, Yalin Tolga; Aladag, Nesim; Ozdemir, Mahmut; Atay, Memis Hilmi
Tirofiban, a specific glycoprotein IIb/IIIa inhibitor, may cause extensive thrombocytopenia with an incidence of 0.2% to 0.5%. We report the case of a 50-year-oldman who developed thrombocytopenia after tirofiban use (both intracoronary and peripheral) over hours and the successful management of this complication after primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction.
Anomalous Origin of the Right Coronary Artery From the Left Anterior Descending Artery: Review of the Literature
(Via Medica, 2012) Yurtdas, Mustafa; Gulen, Oktay
Coronary artery anomalies that take place during fetal development are determined in approximately 1.3% of coronary angiograms. The right coronary artery originating from the left coronary system is an extremely rare variation of the single coronary artery anomaly in which the prognosis is usually benign provided that the anomalous vessel dose not pass between the aorta and the pulmonary artery. Anomalous right coronary artery anomaly has been rarely associated with other congenital cardiovascular anomalies such as transposition of the great vessels and tetralogy of Fallot. To date, a few attempts at classification have been made for coronary artery anomalies, but none of them seems comprehensive or practical for clinicians. The clinical significance of coronary anomalies is usually determined by underlying anatomic features of the wrong coronary origin and/or coronary atherosclerosis. Although coronary angiography is an important diagnostic method, new non-invasive methods such as coronary computed tomography angiography and cardiac magnetic resonance imaging have important roles to play in characterizing this coronary anomaly. It should be noted that the management strategy of these patients may vary based on clinical presentation, anatomical details and additional findings. (Cardiol J 2012; 19, 2: 122-129)
Assessment of the Elasticity Properties of the Ascending Aorta in Patients With Subclinical Hypothyroidism by Tissue Doppler Imaging
(Sbem-soc Brasil Endocrinologia & Metabologia, 2013) Yurtdas, Mustafa; Gen, Ramazan; Ozcan, Turkay; Aydin, Mehmet Kasim
Objective: We aimed to investigate whether aortic elastic properties were affected in subclinical hypothyroidism (SCH) by using tissue Doppler imaging (TDI). Subjects and methods: Forty-three patients with newly diagnosed SCH and forty-eight healthy controls were included to the study. Systolic and diastolic diameters of the ascending aorta were measured by M-mode transthoracic echocardiography, and the upper wall velocities of ascending aorta and mitral annulus velocities were measured by TDI. Aortic stiffness index (ASI) and aortic distensibility were computed using the formulas accepted in literature. Results: The clinical and demographic features of both groups were comparable. Aortic distensibility was significantly lower, and ASI was significantly higher in SCH patients than in controls. Systolic aortic upper wall velocity (Sao) was also significantly lower in SCH patients. Early (Eao) and late diastolic aortic upper wall (Aao) velocities did not differ between the two groups. Mitral annulus (Sm, Em, and Am) velocities were also similar between the groups. Sao was negatively correlated with ASI, and positively correlated with aortic distensibility. TSH level was positively correlated with ASI, total cholesterol and low-density lipoprotein-cholesterol, and negatively correlated with aortic distensibility and Sao. Conclusions: In this study, our results showed that SCH is associated with impaired elasticity of the ascending aorta. Elastic properties of the ascending aorta can be directly evaluated by the reproducibly measurement of the upper wall movements of the ascending aorta by TDI in SCH patients. Arq Bras Endocrinol Metab. 2013; 57(2): 132-8
Assessment of the Elasticity Properties of the Ascending Aorta in Patients With Subclinical Hypothyroidism by Tissue Doppler Imaging
(Sbem-soc Brasil Endocrinologia & Metabologia, 2013) Yurtdas, Mustafa; Ozcan, Turkay; Gen, Ramazan; Aydin, Mehmet Kasim
The Association of Glomerular Filtration Rate With Echocardiographic Parameters in Chronic Kidney Disease
(Elmer Press inc, 2021) Ozdemir, Mahmut; Asoglu, Ramazan; Dogan, Zeki; Aladag, Nesim; Akbulut, Tayyar; Yurtdas, Mustafa
Background: Cardiovascular disease (CVD) is the primary cause of mortality and morbidity in chronic kidney disease (CKD) patients. Aortic propagation velocity (APV), epicardial fat thickness (EFT) and carotid intima-media thickness (CIMT) measurements could provide additional information on assessing renal decline in CKD patients. The study aimed to evaluate EFT, AVP and CIMT in CKD patients and then investigate the association among those parameters.Methods: A total of 170 CKD consecutive subjects were enrolled in the study. Patients were divided into five groups according to their estimated glomerular filtration rate (eGFR) values. Each patient underwent complete transthoracic echocardiography examination. APV, EFT and CIMT were measured for analyses. A multivariate linear regression model was used for analysis to determine the independent predictors of eGFR.Results: The lowest APV was observed in stage IV-V, and the highest APV was observed in stage I-II (P < 0.001). Stage IV-V patients had the highest EFT and stage I-II patients had the lowest EFT (P < 0.001). Moreover, the lowest CIMT was observed in stage III, and the highest CIMT was observed in stage V (P < 0.001). eGFR was significantly and positively correlated with APV and negatively correlated with EFT and CIMT. In multivariate analyses, APV (odds ratio (OR): 0.289, P < 0.001), EFT (OR:-0.135, P < 0.001) and CIMT (OR: -0.388, P < 0.001) were independent predictors of eGFR.Conclusion: We found that APV decreased, and EFT and CIMT increased as CKD progress. The present study suggests that APV, EFT and CIMT might be incorporated with the examination of CKD patients in daily practice.
Association of Heart Rate Recovery With Microalbuminuria in Non-Obstructive Coronary Artery Disease
(Elmer Press inc, 2017) Yurtdas, Mustafa; Ozdemir, Mahmut; Aladag, Nesim; Yaylali, Yalin Tolga
Background: Non-obstructive coronary artery disease (CAD) is associated with significantly increased risk for myocardial infarction. Heart rate recovery (HRR), a measure of autonomic function, is a strong predictor of all-cause mortality. Microalbuminuria, a marker of early arterial disease, is an independent risk factor for cardiovascular disease and mortality. We aimed to investigate HRR and determine its relationship with microalbuminuria in patients with non-obstructive CAD. Methods: We prospectively studied 565 patients who underwent elective coronary angiography. All participants underwent urinary analysis and then an exercise test. Microalbuminuria was defined as an urinary albumin-to-creatinine ratio (UACR) of 30 -299 mg/g. The HRR was abnormal if <= 12 beats/min during the first minute after exercise. First, all patients were divided into two groups, patients with microalbuminuria (n = 152) and patients without microalbuminuria (n = 413). Then, all patients were re-divided into two groups, those with lower HRR (<= 12 beats/min, n = 126) and those with higher HRR (> 12 beats/min, n = 439). Results: Patients with microalbuminuria had lower HRR and patients with lower HRR had higher UACR. While UACR was negatively correlated with HRR in patients with microalbuminuria (r = -0.424; P < 0.001) and in patients with lower HRR (r = -0.192; P = 0.042), there was no correlation of UACR with HRR in neither patients with normoalbuminuria nor patients with higher HRR, respectively. In the all study population, there was a significant inverse association between UACR and HRR (r = -0.445, P < 0.001), and UACR independently predicted the presence of lower HRR (P < 0.001). Conclusions: Our findings showed that there was a significant inverse association between UACR and HRR in patients especially with microalbuminuria, and that albuminuria might predict cardiac autonomic imbalance evaluated by HRR in patients with non-obstructive CAD.
The Comparison of the Treatment Strategies Preferred in Patients With St Segment Elevated Myocardial Infarction (Thrombolytic Therapy for Life)
(Elsevier Science inc, 2013) Ozdemir, Mahmut; Yurtdas, Mustafa; Sahin, Musa; Aladag, Nesim; Karadas, Sevdegul; Babat, Naci; Gumrukcuoglu, Hasan Ali
The Effects of Baseline Heart Rate Recovery Normality and Exercise Training Protocol on Heart Rate Recovery in Patients With Heart Failure
(Turkish Soc Cardiology, 2015) Yaylali, Yalin Tolga; Findikoglu, Gulin; Yurtdas, Mustafa; Konukcu, Sibel; Senol, Hande
Objective: It is unclear which exercise training protocol yields superior heart rate recovery (HRR) improvement in heart failure (HF) patients. Whether baseline HRR normality plays a role in the improvement is unknown. We hypothesized that an exercise training protocol and baseline HRR normality would be factors in altering HRR in HF patients. Methods: In this prospective, randomized, controlled and 3 group parallel study, 41 stable HF patients were randomly assigned to 3-times-weekly training sessions for 12 weeks, consisting of i) 30 minutes of interval training (IT) (n=17, 63.7 +/- 8.8 years old) versus ii) 30 minutes of continuous training (CT) (n=13, 59.6 +/- 6.8 years old) versus iii) no training (CON) (n=11, 60.6 +/- 9.9 years old). Each patient had cardiopulmonary exercise testing before and after the training program. Maximum heart rates attained during the test and heart rates at 1 and 2 min (HRR1 and HRR2) during the recovery phase were recorded. Paired samples t-test or Wilcoxon signed-rank test was used for comparisons before and after training. One-way ANOVA or Kruskal-Wallis variance analysis was used for comparisons among groups. Results: HRR1 was unchanged after training. HRR2 improved in the IT group after training, and post-training HRR2 values were significantly faster in the IT group than in controls. Both HRR1 and HRR2 was significantly faster, irrespective of exercise protocol in patients with abnormal baseline values after training. Conclusion: HRR1 did not improve after training. HRR2 improved only in the IT group. Both HRRs in patients with abnormal baseline values improved after both exercise protocols. IT might be superior to CT in improving HRR2. Baseline HRR might play a role in its response to exercise.
Fibrinogen To Albumin Ratio as a Powerful Predictor of the Exaggerated Morning Blood Pressure Surge in Newly Diagnosed Treatment-Naive Hypertensive Patients
(Taylor & Francis inc, 2020) Ozdemir, Mahmut; Yurtdas, Mustafa; Asoglu, Ramazan; Yildirim, Tarik; Aladag, Nesim; Asoglu, Emin
Background The exaggerated morning blood pressure surge (MS) is a risk factor for cardiovascular diseases. Inflammation is associated with the pathogenesis of hypertension. We aimed to investigate the association between fibrinogen, albumin, fibrinogen to albumin ratio (FAR), and exaggerated MS, and which of those variables is a better predictor for identifying an exaggerated MS in newly diagnosed treatment-naive hypertensive patients. Material and Methods The study included 249 treatment-naive patients who were newly diagnosed with hypertension in both clinical and ambulatory blood pressure (BP) monitoring measurements. Morning BP was defined as the mean of BPs measured during the first 2 hours after wake-up. The lowest BP was defined as the mean of 3 BP measurements focused on the lowest nighttime computations. The MS was calculated as the morning systolic BP minus the lowest systolic BP. Fibrinogen and albumin levels were measured from venous blood. FAR was obtained by dividing the fibrinogen to the albumin. Results Patients with higher-value MS had a higher fibrinogen, FAR, and a lower albumin than those with low-value MS. MS was positively correlated with fibrinogen and FAR, and negatively correlated with albumin (for all,p< .001). Fibrinogen, albumin, and FAR were independent predictors of exaggerated MS. FAR was a more powerful predictor than fibrinogen (p< .001) and albumin (p= .02) in determining exaggerated MS. Conclusion Patients with exaggerated MS had a higher fibrinogen and FAR, and a lower albumin level than those without exaggerated MS. FAR may be a better predictor than fibrinogen and albumin for determining exaggerated MS.
Heart Rate Recovery After Exercise and Its Relation With Neutrophil-To Ratio in Patients With Cardiac Syndrome X
(Lippincott Williams & Wilkins, 2014) Yurtdas, Mustafa; Yaylali, Yalin T.; Aladag, Nesim; Ozdemir, Mahmut; Ceylan, Yemlihan; Gencaslan, Murat; Akbulut, Tayyar
Objectives The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) are measures of systemic inflammation. Heart rate recovery (HRR) after exercise is influenced by autonomic function. The aim of this study was to ascertain whether HRR and the Duke Treadmill Score (DTS) values are related to NLR and PLR in patients with cardiac syndrome X (CSX). Methods A total of 350 participants were enrolled in the study. Complete blood counts and high-sensitivity C-reactive protein (hsCRP) were obtained. All participants underwent an exercise test. HRR and DTS were calculated after exercise. Abnormal HRR was defined as 12 beats/min or less. Results CSX and coronary artery disease (CAD) groups had higher NLR, PLR, and hsCRP, and lower HRR and DTS values than the control group (for all, P<0.05). In both CSX and CAD groups, HRR was positively correlated with DTS (r=0.468, P<0.001 and r=0.491, P<0.001, respectively) and negatively correlated with NLR (r=-0.519, P<0.001 and r=-0.612, P<0.001, respectively), PLR (r=-0.422, P<0.001 and r=-0.438, P<0.001, respectively), and hsCRP (r=-0.553, P<0.001 and r=-0.521, P<0.001, respectively). NLR and hsCRP were important two predictors of the presence of lower HRR in both CSX [NLR: odds ratio (OR), 0.395; 95% confidence interval (CI), 0.168-0.925; P=0.032 and hsCRP: OR, 0.748; 95% CI, 0.591-0.945; P=0.015], and CAD groups (NLR: OR, 0.115; 95% CI, 0.026-0.501; P=0.004 and hsCRP: OR, 0.637; 95% CI, 0.455-0.892; P=0.009). Conclusion CSX patients have higher NLR and PLR and slower HRR and lower DTS, similar to CAD patients, suggesting that CSX patients may be at a higher risk for developing cardiovascular events in the future. NLR may predict autonomic imbalance assessed by HRR in CSX. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Increased Plasma High-Sensitivity C-Reactive Protein and Myeloperoxidase Levels May Predict Ischemia During Myocardial Perfusion Imaging in Slow Coronary Flow
(Elsevier Science inc, 2014) Yurtdas, Mustafa; Yaylali, Yalin Tolga; Kaya, Yuksel; Ozdemir, Mahmut
Background and Aims. It is unclear whether changes in plasma levels of inflammatory markers could explain the link between ischemia and slow coronary flow (SCF). The aim of the study was to evaluate the plasma levels of high-sensitivity C-reactive protein (hsCRP), interleukin (IL)-6, and myeloperoxidase (MPO) during myocardial perfusion imaging (MPI) in SCF patients. Methods. The study population consisted of 53 SCF patients and 30 controls. Coronary flow rates were documented by TEVII frame count (TFC). Plasma levels of hsCRP, IL-6, MPO, and MPI were obtained in all participants. Results. hsCRP, IL-6 and MPO levels of SCF patients were higher than controls (hsCRP: 4.7 +/- 2.5 vs. 1.7 +/- 1.1 mg/L, p <0.001; IL-6: 8.2 +/- 4.3 vs. 5.2 +/- 2.1 pg/mL, p <0.001;. and MPO: 75.9 +/- 59.6 vs. 24.3 +/- 16.7 ng/mL, p <0.001). Twenty-one SCF patients exhibited myocardial perfusion defect (MPD) on MPI. In SCF patients, the highest hsCRP, IL-6 and MPO levels were observed in patients with both MPD and three-vessel slow flow. Mean TFCs were positively correlated with plasma levels of hsCRP (r = 0.424, p = 0.002), IL-6 (r = 0.367, p = 0.007), MPO (r = 0.430, p = 0.001), and reversibility score (r = 0.671, p <0.001) in SCF patients. HsCRP and MPO were the independent variables, which predicted positive MPI results (hsCRP: OR, 2.176; 95% CI, 1.200-3.943; p = 0.010, MPO: OR, 1.026; 95% CI, 1.007-1.046; p = 0.008). Conclusions. Inflammation may play a crucial role in both the pathogenesis and development of ischemia in SCF. Association of increased levels of inflammatory markers and ischemia suggests that endothelial inflammation may be largely responsible for clinical presentation. New combined treatment regimens should target endothelial activation and inflammation in SCF. (C) 2014 IMSS. Published by Elsevier Inc.
Increased Plasma Hscrp and Mpo Levels May Predict Ischemia During Mpi in Slow Coronary Flow
(Elsevier Science inc, 2013) Yurtdas, Mustafa; Yaylali, Yalin Tolga; Ozdemir, Mahmut; Kaya, Yuksel; Arin, Can Baba
Neutrophil-To Ratio May Predict Subclinical Atherosclerosis in Patients With Psoriasis
(Wiley, 2014) Yurtdas, Mustafa; Yaylali, Yalin T.; Kaya, Yuksel; Ozdemir, Mahmut; Ozkan, Ilker; Aladag, Nesim
Background: Systemic inflammation beyond the skin may provide an explanation of the increased cardiovascular risk observed in psoriasis. It was hypothesized that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are potential predictors of subclinical atherosclerosis measured by aortic velocity propagation (AVP) and carotid intima-media thickness (CIMT) in psoriasis. Methods: Fifty-one patients with psoriasis taking no antipsoriatic therapy and 37 age- and sex-matched healthy controls were prospectively enrolled. The Psoriasis Area and Severity Index (PASI) was calculated. Complete blood counts were obtained. Measurements of AVP and CIMT were performed. Results: The baseline clinical and demographic features, and white blood cell, platelet, neutrophil, lymphocyte, monocyte, and PLR were similar in both groups. NLR and high-sensitivity C-reactive protein (hs-CRP) were higher in the psoriasis group than the control group (P = 0.001, P < 0.001; respectively). The psoriasis group had lower AVP and higher CIMT values than those of controls (AVP: 48.9 +/- 18.1 vs. 64.3 +/- 14.5 cm/sec; P < 0.001, CIMT: 0.84 +/- 0.29 vs. 0.63 +/- 0.27 mm; P = 0.001, respectively). PASI was positively correlated with NLR and hs-CRP (r = 0.423, P = 0.002; r = 0.315, P = 0.024, respectively). There was an inverse association between AVP and CIMT (r = -0.749, P < 0.001). Binary logistic regression analysis demonstrated that NLR was the only variable able to predict lower AVP (= 41 cm/sec) and higher CIMT (>0.9 mm) values (P = 0.024 and 0.023; respectively). Conclusion: NLR is potentially an unrecognized predictor of subclinical atherosclerosis in patients with psoriasis. Future studies assessing the prognostic significance of NLR on cardiovascular event rates in psoriasis patients would be of great interest.
Neutrophil-To Ratio May Predict Subclinical Atherosclerosis in Patients With Psoriasis Reply
(Wiley-blackwell, 2014) Yurtdas, Mustafa; Yaylali, Yalin Tolga; Ozdemir, Mahmut; Aladag, Nesim; Ozkan, Ilker; Kaya, Yuksel
Nt-Pro Levels and Their Response To Exercise in Patients With Slow Coronary Flow
(Arquivos Brasileiros Cardiologia, 2012) Yurtdas, Mustafa; Ozcan, Ismail Turkay; Camsari, Ahmet; Cicek, Dilek; Tamer, Lulufer; Cin, Veli Gokhan; Akkus, Mehmet Necdet
Background: Natriuretic peptides are released by the heart in response to wall stress. Objective: The NT-Pro-BNP concentrations in slow coronary flow (SCF) patients were assessed before and after the exercise test and compared with the values of healthy controls. Methods: The study population was 34 patients with SCF [22 males (64.7%), aged 51.0 +/- 6.2 years], and 34 normal subjects with normal coronary arteries [21 males (61.8%), aged 53.2 +/- 6.6 years]. Coronary flow rates of all patients and control subjects were documented as Thrombolysis in Myocardial Infarction (TIMI) frame count. Blood samples were drawn at rest and after the exercise testing. Results: The baseline NT-Pro-BNP concentrations of the SCF patients were higher than those of the control subjects (NT-Pro-BNP: 49.7 +/- 14.2 pg/mL vs. 25.3 +/- 4.6 pg/mL p<0.0001, respectively), and this difference increased after exercise test between the groups (NT-Pro-BNP: 69.5 +/- 18.6 pg/mL vs. 30.9 +/- 6.4 pg/mL p<0.0001). In SCF group after exercise, NT-Pro-BNP concentration in 15 patients with angina was higher than those without angina (76.8 +/- 17.8 pg/mL vs. 63.8 +/- 17.5 pg/mL p=0.041). NT-Pro-BNP concentration in 11 patients with ST depression was also higher than those without ST depression (82.4 +/- 17.3 pg/mL vs. 63.3 +/- 16.1 pg/mL p=0.004). Median post-exercise increases in NT-Pro-BNP (Delta NT-Pro-BNP) were higher in the SCF group than in the control group (Delta NT-Pro-BNP: 19.8 +/- 7.7 pg/mL vs. 5.7 +/- 4.5 pg/mL p<0.0001). Conclusion: The results of this study suggest that there may be an important pathophysiologic link between the severity of SCF (microvascular or epicardial coronary artery dysfunction) and the level of circulating NT-Pro-BNP in SCF patients. (Arq Bras Cardiol 2012;99(6):1115-1122)
Percutaneous Closure of Secundum Atrial Septal Defects in Pediatric and Adult Patients: Short-, and Mid-Term Follow-Up Results
(Kare Publ, 2013) Kaya, Yuksel; Yurtdas, Mustafa; Ceylan, Yemlihan; Bulut, Mustafa Orhan; Soylemez, Nihat; Guvenc, Tolga Sinan; Ozkan, Mehmet
Objectives: We aimed to evaluate the shortand mid-term results of patients with atrial septal defect (ASD) who were treated with percutaneous closure. Study design: Seventy-nine patients with a diagnosis of secundum ASD (54 female and 25 male; mean age 26.2+/-17.2; range 3 to 71] years) were included in this study. All patients were evaluated by transthoracic (TTE) and/or transesophageal echocardiography (TEE). Amplatzer septal occluder (ASO) was used for percutaneous closure in all patients. In 76 patients, the procedure was performed under local anesthesia with TTE, while in the other 3 patients, it was performed with general anesthesia under the guidance of TEE. Patients were followed up at the 1st, 3rd, 6th and 12th months and annually thereafter. Mean followup period was 13.6+/-6.6 months. Results: Mean diameter of ASDs was 18.2+/-7.5 mm and stretched diameter was 20.7+/-8.04 mm during balloon dilatation, and mean diameter of implanted devices was 22.7+/-8.5 mm. Procedural time was 40.2+/-12.6, and fluoroscopy time was 10.9+/-4.1 minutes. The procedure was successfully performed in all patients (100%). One patient with cardiac tamponade died seven days after cardiac surgery. In two patients, the implanted devices embolized to the pulmonary circulation. Residual flow was found in three patients immediately after the procedure, without residual shunts one month after closure. Mild pericardial effusion in one patient and significant residual shunt due to device malposition in another were discovered at 1 and 6 months of the postprocedural follow- up period, respectively. Conclusion: Our findings showed that percutaneous closure of ASDs is successful in most patients with a low complication rate, and demonstrated that residual shunts do not develop in the majority of patients in the shortand mid- term.
Plasma Homocysteine Is Associated With Ischemic Findings Without Organic Stenosis in Patients With Slow Coronary Flow
(Elsevier Science Bv, 2013) Yurtdas, Mustafa; Ozcan, Ismail Turkay; Seyis, Ali Sabri; Camsari, Ahmet; Cicek, Dilek
Aim: To investigate the plasma concentrations of homocysteine (Hcy) in slow coronary flow (SCF) patients before and at the end of the exercise test and compare with the values of healthy controls. Methods: Study population consisted of 41 patients with SCF [68% men, aged 49 +/- 8 years], and 41 subjects with normal epicardial coronary arteries [56% men, aged 50 +/- 9 years]. Exercise test was performed in all study participants. Blood samples were drawn at rest and immediately at the end of exercise testing after 12 h of overnight fasting. Results: The baseline Hcy value of the SCF patients was higher than that of the control subjects (p < 0.0001), and this difference continued after exercise test between the groups (p < 0.0001). Median post-exercise increases in Hcy levels were higher in the SCF group than in the control group, without a significant difference (p = 0.088). In the SCF group after exercise, Hcy levels in 17 patients with angina and 18 patients with ST depression were higher than those without angina and ST depression (p < 0.0001 and p < 0.0001, respectively). In addition, Hcy values in patients with both angina and ST depression were greater than those with either angina (p < 0.05) or ST depression (p < 0.05). Conclusion: The results of this study show that there is an important pathophysiologic link between the increased levels of plasma Hcy, the degree of ischemic findings, and the severity of slow flow in SCF patients. (C) 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
The Relationship of the Degree of Coronary Stenosis and Percutaneous Coronary Revascularization With Heart Rate Recovery Index
(Elsevier Science inc, 2013) Yurtdas, Mustafa; Kaya, Yuksel; Aladag, Nesim; Ozdemir, Mahmut; Arin, Can Baba; Tuncer, Mustafa; Balci, Bahattin
Transradial Approach in the Diagnosis and Treatment of Coronary Artery Disease: a 2-Center Experience
(Tubitak Scientific & Technological Research Council Turkey, 2014) Yurtdas, Mustafa; Kaya, Yuksel; Gonullu, Edip
Background/aim: To document the safety, success, and complications of transradial coronary procedures. Materials and methods: This retrospective study consisted of 427 patients who had undergone transradial coronary angiography and/or angioplasty between June 2010 and May 2012. The main outcome measures were the procedural safety, success rate, and complications associated with transradial interventions. Results: Procedural success rate was 93.2% (398/427), with cannulation time of 2.1 +/- 1.4 min, diagnostic time of 5.6 +/- 2.1 min, fluoroscopy time of 9.5 +/- 6.6 min, and total procedure time of 47.1 +/- 20.2 min. The main causes for unsuccessful procedures were failed radial puncture (11 patients), serious radial artery spasm (12 patients), and distinct tortuosity (5 patients) and severe proximal stenosis (1 patient) of the right subclavian artery. Of 398 patients, 345 (86.7%) underwent both coronary angiography and angioplasty, while the remaining 53 (13.3%) had coronary angiography only. Major complication was recorded in only 1 patient (transient ischemic attack), whereas minor complications were observed in 76 patients (17 with symptomatic sinus bradycardia, 12 with venous thrombosis, 22 with hematoma, and 25 with radial artery occlusion). Conclusion: Our experience revealed that the transradial approach is a safe and feasible method for coronary procedures in patients with various manifestations of coronary disease.