Browsing by Author "Zebitay, Ali Galip"

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Does Bilateral Uterine Artery Ligation Have Negative Effects on Ovarian Reserve Markers and Ovarian Artery Blood Flow in Women With Postpartum Hemorrhage
(Korean Soc Reproductive Medicine, 2019) Verit, Fatma Ferda; Cetin, Orkun; Keskin, Seda; Akyol, Hurkan; Zebitay, Ali Galip
Objective: Bilateral uterine artery ligation (UAL) is a fertility-preserving procedure used in women experiencing postpartum hemorrhage (PPH). However, the long-term effects of this procedure on ovarian function remain unclear. The aim of this study was to investigate whether bilateral UAL compromised ovarian reserve and ovarian blood supply. Methods: This prospective study included 49 women aged between 21 and 36 years who had undergone a cesarean section for obstetric indications. Of these, 25 underwent uterine bilateral UAL to control intractable atonic PPH. The control group consisted of 24 women who had not undergone bilateral UAL. Standard clinical parameters, the results of color Doppler screening, and ovarian reserve markers were assessed in all participants at 6 months after surgery. The clinical parameters included age, parity, cycle history, body mass index, and previous medication and/or surgery. Color Doppler screening findings included the pulsatility index (PI) and resistance index (RI) for both the uterine and ovarian arteries. The ovarian reserve markers included day 3 follicle-stimulating hormone (FSH) levels, antral follicle count, and anti-Mullerian hormone (AMH) levels. Results: There were no significant differences in the ovarian reserve markers of day 3 FSH levels, antral follicle count, and AMH levels between the study and control groups (p>0.05 for all). In addition, no significant differences were observed in the PI and RI indices of the uterine and ovarian arteries (p>0.05 for all). Conclusion: In this study, we showed that bilateral UAL had no negative effects on ovarian reserve or ovarian blood supply, so this treatment should be used as a fertility preservation technique to avoid hysterectomy in patients experiencing PPH.
Is Maternal Blood Procalcitonin Level a Reliable Predictor for Early Onset Neonatal Sepsis in Preterm Premature Rupture of Membranes
(Karger, 2017) Cetin, Orkun; Aydin, Zuhal Dilek; Verit, Fatma Ferda; Zebitay, Ali Galip; Karaman, Erbil; Elasan, Sadi; Yucel, Oguz
Background: This study is aimed at comparing the early diagnostic accuracy of maternal blood white blood cell (WBC) count, C-reactive protein (CRP) and procalcitonin in predicting early onset neonatal sepsis (EONS) among early preterm premature rupture of membrane (PPROM) pregnancies. Methods: A total of 57 consecutive pregnancies, complicated with PPROM, between 24 and 34 gestational weeks were recruited to the study at Suleymaniye Maternity Education and Research Hospital, Istanbul, Turkey between January 2012 and January 2013. All patients were hospitalized and followed up with expectant management. Maternal blood WBC count, CRP and procalcitonin levels were measured in the first 12 h of membrane rupture. EONS was diagnosed using clinical and laboratory findings, and obstetric and neonatal outcomes were noted. Results: The cutoff value for maternal blood CRP was >= 9.49 mg/dl. This value predicted EONS with 77.8% sensitivity, 80.0% specificity, 77.8% positive predictive value (PPV) and 80.0% negative predictive value (NPV). The cutoff value for maternal blood procalcitonin was 0.071 ng/ml. This value predicted EONS with 85.2% sensitivity, 86.7% specificity, 85.2% PPV and 86.7% NPV. Conclusion: Maternal blood procalcitonin levels were superior to maternal blood CRP and WBC count in predicting EONS. Consequently, the maternal blood procalcitonin level is a clinically useful, non-invasive and reliable biomarker in antenatal prediction of EONS. (C) 2016 S. Karger AG, Basel
Ne Erken Ne de Geç Gebelik: Adölesan, Reprodüktif Yaş ve İleri Yaş Gebeliklerin Perinatal Sonuçlarının Karşılaştırılması
(2015) Yücel, Oğuz; Kurdoğlu, Zehra; Çetin, Orkun; Verit, Fatma Ferda; Zebitay, Ali Galip; Aydın, Zuhal
İstanbul'un düşük gelir seviyeli bölümünde yer alan kliniğimizin adölesan, reprodüktif yaş ve ileri yaş gebeliklerinin (İYG) perinatal ve erken neonatal sonuçlarının karşılaştırılması.Gereç ve Yöntem: 1 Ocak 2007 ve 31 Ocak 2015 tarihleri arasında Süleymaniye Eğitim ve Araştırma Hastanesi'nde doğum yapan 306 adölesan, 301 reprodüktif yaş ve 303 ileri yaş gebe çalışmaya dahil edildi. Hastaların klinik, obstetrik ve erken dönem neonatal sonuçları retrospektif olarak değerlendirildi.Bulgular: Reprodüktif yaştaki gebeler ile karşılaştırıldığında, adölesan ve İYG'lerin daha kötü perinatal ve erken neonatal sonuçlara sebep olduğu görüldü. Adölesan ve İYG'lerin obstetrik sonuçları birbiri ile benzer bulundu. En kötü erken dönem neonatal sonuçlar, adölesan gebelik grubunda karşımıza çıktı.Sonuç: Adölesan ve İYG'leri yüksek riskli gebelik olarak tanımlanmalıdır. Çalışmamızın sonuçları dikkate alındığında, kadın doğum hekimleri, ebeler ve aile hekimleri bu iki gebe grubunda daha dikkatli davranmalıdırlar
Neither Early nor Late for Becoming Pregnant: Comparison of the Perinatal Outcomes of Adolescent, Reproductive Age, and Advanced Maternal Age Pregnancies
(Galenos Yayincilik, 2015) Cetin, Orkun; Verit, Fatma Ferda; Zebitay, Ali Galip; Aydin, Zuhal; Kurdoglu, Zehra; Yucel, Oguz
Objective: To compare perinatal and short-term neonatal outcomes of adolescent, reproductive age, and advanced maternal age (AMA) pregnancies in a low-income region of Istanbul. Materials and Methods: Three hundred six adolescents, 301 reproductive age, and 303 AMA pregnant women who delivered in Suleymaniye Education and Research Hospital between January 1st 2007, and January 31st 2015, were recruited to the study population. The clinical, obstetric and short-term neonatal outcomes of the women were analyzed retrospectively. Results: Adolescent and AMA pregnancies were associated with severe adverse perinatal and short-term neonatal outcomes compared with reproductiveage women. Adolescent and AMA pregnancies had quite similar risks in obstetric outcomes. Adolescent pregnancies were related with severe adverse shortterm neonatal outcomes when compared with advanced maternal age pregnancies. Conclusion: Adolescent and AMA pregnancies should be defined as high-risk pregnancies. Our research indicated that healthcare providers such as obstetricians, midwives, and family physicians should be alert in these populations.