Browsing by Author "Çap, Murat"

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COVID-19 Hastalarında Sistemik İnflamatuar Yanıt Sendromunun Ventriküler Repolarizasyon Parametreleri Üzerindeki Etkisi
(2025) Aslan, Burhan; Okşul, Metin; Bilge, Önder; Akın, Halil; Taştan, Ercan; Çap, Murat; Karahan, Mehmet Zülküf
Amaç: Malign ventriküler aritmi, COVID-19 hastalarında önemli bir mortalite nedenidir. Sistemik inflamatuar yanıt sendromu (SIRS) gelişen COVID-19 hastalarında malign ventriküler aritmi riskini öngören ventriküler repolarizasyon parametrelerini araştırmayı amaçladık. Gereç ve Yöntemler: Çalışmamıza 533 COVID-19 hastası dahil edildi ve hastalar iki gruba ayrıldı: SIRS gelişenler (n=197) ve gelişmeyenler (n=336). QRS, QT, QTc, Tp-e intervalleri, Tp-e/QTc, Tp-e/QT, QT/QRS (Kardiyak Elektrofizyolojik Denge İndeksi, İCEB) ve QTc/QRS (ICEBc) için EKG ölçümleri alındı ve bu değerler gruplar arasında karşılaştırıldı. Bulgular: Çalışma grubunun ortalama yaşı 62 olup, %49'u (261) kadındı. ICEBc, SIRS grubunda 5,1, SIRS olmayan grupta ise 4,98 olarak bulundu (p=0,004). QTc aralığı, SIRS grubunda 450 ms, SIRS olmayan grupta ise 427 ms olarak bulundu (p=0,001). Bu da SIRS grubunda önemli ölçüde daha yüksek bir QTc aralığı olduğunu göstermektedir. Çok değişkenli doğrusal regresyon analizi, ICEBc ile SIRS, yaş, cinsiyet ve C-reaktif protein (CRP) arasında anlamlı bir korelasyon olduğunu ortaya koymuştur. ROC analizi, ICEBc'nin hastane içi mortaliteyi QTc'den daha anlamlı bir öngörücü olduğunu göstermiştir (ICEBc: %64,5 duyarlılık, %50,4 özgüllük; QTc: %56,4 duyarlılık, %53,9 özgüllük). Sonuç: ICEBc ve QTc, SIRS gelişen COVID-19 hastalarında, SIRS gelişmeyen hastalara kıyasla anlamlı derecede yüksekti. SIRS hastalarında EKG'de malign aritmilerle ilişkili olduğu bilinen ICEBc, aritmik olayların öngörülmesine ve önlenmesine yardımcı olabilir. Ayrıca, ICEBc'nin QTc'den daha iyi bir hastane içi mortalite öngörücüsü olduğu bulunmuştur.
Early Systolic Lengthening Is Associated With Syntax Score in Patients With Non-St Acute Coronary Syndrome
(Kare Publ, 2024) Çap, Murat; Acar, Rezzan Deniz; Unkun, Tuba; Geçmen, Çetin; Kaymaz, Cihangir; Erdogan, Emrah; Bakal, Ruken
Background: Early systolic lengthening is a echocardiographic strain parameter previ- ously used to determine the lesion severity in patients with stable coronary artery dis- ease. In the present study, we aimed to evaluate the relationship between early systolic lengthening and anatomic SYNTAX score in troponin (−) and (+) groups among patients with non-ST-elevation acute coronary syndrome (ACS). Methods: A total of 95 patients diagnosed with non-ST-elevation ACS were included in the prospective, non-randomized, single-center study. The patients were categorized into 2 groups as troponin (+) and troponin (−). The patients were evaluated in terms of echocardiographic, clinical, and angiographic parameters. Results: The baseline characteristics, including age (58 ± 13 vs. 60 ± 10 respectively, P = .340), a history of hypertension (67.1% vs. 64%, respectively, P = .479), diabetes (28.6% vs. 32%, respectively, P = .467), global longitudinal strain (−14.37 ± 5.11 vs. −16.42 ± 3.93, respectively, P = .095), left ventricular ejection fraction (58.71 ± 8.73 vs. 57.20 ± 8.70, respectively, P = .263), and E/e’ (8.44 ± 2.13 vs. 8.33 ± 1.99, respectively, P = .785), were similar between troponin (+) and troponin (−) groups. Left ventricle end-systolic diam- eter (3.2 ± 0.78; 3.50 ± 0.74 vs. 3.2 ± 0.78, respectively, P = .031), left ventricle end-systolic volume (55.57 ± 32.17 vs. 38.28 ± 13.63, respectively, P = .013), left ventricle end-diastolic volume (115.31 ± 49.54 vs. 91.23 ± 20.57, respectively, P = .042), the rate of early systolic lengthening (65.7% vs. 28%, respectively, P = .001), the duration of early systolic lengthen- ing (24.02 ± 31 ms vs. 15.56 ± 30.19 ms, respectively, P = .009), and the SYNTAX score (16 ± 11 vs. 10 ± 10, respectively, P = .023) were higher in the troponin (+) group. Furthermore, a significant correlation was found between early systolic lengthening and SYNTAX score (r = 0.43, P < .001). Conclusion: The rate and duration of early systolic lengthening were higher in patients in the troponin (+) group. Early systolic lengthening is related to SYNTAX score in patients with non-ST-elevation ACS.
Turkish Real Life Atrial Fibrillation in Clinical Practice: Traffic Study
(Kare Publ, 2024) Arslan, Uğur; Mert, Kadir Ugur; Sen, Taner; Efe, Suleyman; Çap, Murat; Ozkalayci, Flora; Ulukoksal, Utku
Background: Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide and is associated with an increased risk of thromboembolism, ischemic stroke, impaired quality of life, and mortality. The latest research that shows the prevalence and incidence of AF patients in Türkiye was the Turkish Adults’ Heart Disease and Risk Factors study, which included 3,450 patients and collected data until 2006/07.The Turkish Real Life Atrial Fibrillation in Clinical Practice (TRAFFIC) study is planned to present current prevalence data, reveal the reflection of new treatment and risk approaches in our country, and develop new prediction models in terms of outcomes. Methods: The TRAFFIC study is a national, prospective, multicenter, observational registry. The study aims to collect data from at least 1900 patients diagnosed with atrial fibrillation, with the participation of 40 centers from Türkiye. The following data will be collected from patients: baseline demographic characteristics, medical history, vital signs, symptoms of AF, ECG and echocardiographic findings, CHADS2- VASC2 and HAS-BLED (1-year risk of major bleeding) risk scores, interventional treatments, antithrombotic and antiarrhythmic medications, or other medications used by the patients. For patients who use warfarin, international normalized ratio levels will be monitored. Follow-up data will be collected at 6, 12, 18, and 24 months. Primary endpoints are defined as systemic embolism or major safety endpoints (major bleeding, clinically relevant nonmajor bleeding, and minor bleeding as defined by the International Society on Thrombosis and Hemostasis). The main secondary endpoints include major adverse cardiovascular events (systemic embolism, myocardial infarc- tion, and cardiovascular death), all-cause mortality, and hospitalizations due to all causes or specific reasons. Results: The results of the 12-month follow-up of the study are planned to be shared by the end of 2023. Conclusion: The TRAFFIC study will reveal the prevalence and incidence, demographic characteristics, and risk profiles of AF patients in Türkiye. Additionally, it will provide insights into how current treatments are reflected in this population. Furthermore, risk prediction modeling and risk scoring can be conducted for patients with AF.