Browsing by Author "Çilingir, B.M."

Now showing 1 - 6 of 6

A Case of Lung Adenocarcinoma Presenting as Miliary Appearance
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Çilingir, B.M.; Sunnetcioglu, A.; Özgökçe, M.; Bayram, I.
Multiple benign conditions may be the cause of miliary nodules, but the most common cause is metastatic disease. Even so miliary metastasis of lung cancer is rarely seen. The most common lung cancer with a miliary distribution is adenocarcinoma. It is often difficult to diagnose adenocarcinomas with a progressive course. Anamnesis, physical examination, imaging methods can give an idea but diagnosis should be confirmed histopathologically. As in our case, tissue biopsy should be performed for diagnosis. We aimed to present this case because we performed a tru cut biopsy which is rarely used for histopathologic diagnosis and the miliary nodules in the lung of adenocarcinoma is a rare condition. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Clinical Evaluation of Pulmonary Thromboembolism in Gynecologic Oncology Operations: Analysis of Nine Patients in a University Hospital
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Karaman, E.; Aydıner, B.; Çilingir, B.M.; Hacıoğlu, L.
To investigate the cases of pulmonary thromboembolism (PTE) and to analyze the risk factors in patients undergoing gynecologic oncology operations. Material and methods: The medical records of all patients who underwent gynecologic oncology surgery from January 2015 to September 2022 were collected from the hospital’s database. Cases with the di agnosis of PTE were retrieved and analyzed retrospectively. Dokuz cases of clinically apparent PTE were identified in the medical records. The mean age of the patients was 56.1 ±3.4. The mean BMI was 27.2±1.4. The majority of the cases were advanced stage ovarian malignancy who underwent a major surgery including pelvic-paraaortic lymphadenectomy (5/9). Dyspnea and shortness of breath was the main complaint. Tachypnea was the main finding in all cases. The leukocytosis and the thrombocytosis were notable in PTE cases. PTE remains as one of the fatal complications after gynecologic surgeries. In our case-cohort, increasing age, obesity and the complexity of surgery are significant predictors of pulmonary embolism in gynecologic oncology operations. Further multicenter studies stratifying risk factors are warranted to reach a proper prophylactic strategy and prevent PTE. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Could a New Measurement, a New Body Shape Index, Determine the Role of Obesity and Depression in Asthma Control
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Çilingir, B.M.; Ekin, S.; Yildiz, H.; Sunnetcioglu, A.; Günbatar, H.
Obesity is common in asthma. Depression is thought to be one of the risk factors that increase obesi ty. It is known that depression has an effect on poor asthma control. Body Mass Index (BMI) is mostly used to define obesity. In recent years, however, the ‘A Body Shape Index’ (ABSI) based on waist circumference (WC) measurement has been developed and th e higher ABSI corresponds to a more central body volume concentration. Our aim was to examine the effect of obesity and depression on asthma control in a way that questions the usability of ABSI, which is new in abdominal obesity measurement. A total of 99 asthmatic patients aged between 18-80 years who were followed up in Chest Diseases outpatient clinics were included in the study. Demographic and medical history of the patients were recorded. Waist circumference /BMI2/3 X Length(m) 2/3 was calculated for ABSI measurement. Beck Depression Scale (BDS) and Asthma Control Test (ACT) were applied. Pulmonary Function Test was applied to all patients by the same trained person. Obese and morbidly obese patients had poor asthma control. We found that the presence of depression caused poor asthma control in all BMI groups. The poorly controlled asthma group and the obese and morbidly obese patients had higher depression scores. BMI and waist circumference were higher in the poorly controlled asthma group (p=0.002, 0.033 respectively). However, there was no significant difference between the asthma groups in terms of ABSI (p=0.529). The findings of this study indicate that depressive symptoms, increased BMI and WC were significantly associated with poor asthma control. But ABSI is no superior to BMI in detecting asthma control and depressive mood. However, we should prompt our patients to treatment and exercise, especially for abdominal obesity. We should recommend that asthma patients with depression consult a psychiatrist. In this way, we can control our asthma patients more effectively by minimizing the existing risks. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Platelet Distribution With Is a Usable Parameter in Chronic Obstructive Pulmonary Disease Severity
(Yuzuncu Yil Universitesi Tip Fakultesi, 2020) Çilingir, B.M.; Sünnetçioğlu, A.
Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease with a high mortality and morbidity rate. The aim of our study was to investigate the relationship of hematological parameters including the MPV, PDW and RDW with the severity of COPD. We retrospectively enrolled patients with the diagnosis of COPD who were admitted to our Pulmonary Diseases Department. A total of 201 patients with COPD, diagnosed according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, were included in the study. Patients were divided into 4 groups according to the severity of COPD: group A (mild), group B (mild to moderate), group C (moderate to severe), and group D (severe). 159 healthy subjects without any risk factors or chronic diseases who were admitted to our outpatient clinics were included as control. There was statistically significant difference in PDW values between patients with COPD and controls (p =0. 001). There was no statistically significant difference in MPV values and RDW rates between patients with COPD and controls (p = 0.591, p = 0.677 respectively). Patients in the severe COPD group were older, more often were male, had higher hematocrit values. There were no statistically significant differences in MPV, PDW, and RDW values in the severity of COPD (p=0.639, p=0.082, p=0.662 respectively). PDW could be used an indicator of hypoxemia, underlying inflammation, and oxidative stress. It could be considered as a new marker in the determination of inflammation in COPD patients with rapid, inexpensive, easily measurable properties with routine CBC analysis. Morover, measurement of changes in PDW value during follow-up can be used to assess the inflammatory response. © 2020, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
Predictive Risk Factors for Intensive Care Unit Mortality in Acute Exacerbations of Copd Requiring Invasive Mechanical Ventilation
(Yuzuncu Yil Universitesi Tip Fakultesi, 2022) Sunnetcioglu, A.; Çilingir, B.M.; Çelikel, M.; Bedirhanoğlu, S.; Demirkiran, H.
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) frequently necessitate intensive care unit (ICU) admissions. The purpose of this study is to determine risk factors for ICU mortality in AECOPD who required invasive mechanical ventilation (IMV). Patients requiring IMV for AECOPD between January 2013 and March 2019 were retros pectively reviewed. Patients’ characteristics, comorbidities, and laboratory results were reviewed from the medical charts. Subjects’ acute physiology and chronic health evaluation (APACHE) II score, Glasgow Coma Scale (GCS), IMV (days), and mortality were recorded. As an output or dependent variable, ICU mortality was considered. Other variables were considered to independent factors or risk factors. Then, Logistic regression analysis was performed to determine risk factors for ICU mortality in AECOPD. The study, 134 patients were included. The mean duration of IMV were 11.6 ± 12.2 days. The ICU mortality were 51.4 %. On admission to ICU, patients had APACHE-II scores of 23.0 ± 6.2. Nonsurvivors had lower blood Mg levels ( 1.8 ± 0.2 mmol/L, p = 0.002), lower blood Ca levels (8.0 ± 0.7 mg/dL, p = 0.005), higher Uric Acid, (8.5±3.8 mg/dl, p = 004), higher CRP levels (87.2 ± 71.8 mg/dl, p = 0.048), higher leukocyte count (14.7 ± 10.2 103L, p= 0.040), higher serum lactate (2.3 ± 1.7 mmol, p = 0.003) compared to survivors. APACHI score and uric acid level were found statististically significant risk factors for ICU mortality. © 2022, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.
What Is the Case of More Accessibl E Treatment Options in Covid 19: Comparison of Hydroxychloroquine and Favipiravir Based on Laboratory Values
(Yuzuncu Yil Universitesi Tip Fakultesi, 2021) Çilingir, B.M.; Sunnetcioglu, A.; Yildiz, H.; Erçek, B.M.; Baykal, N.D.
Two of the drugs are frequently used in COVID-19 treatment algorithm because of their low cost, easy availabil ity and application; Hydroxychloroquine (HCQ) and Favipiravir. Our aim in this study is to compare the laboratory parameters of patients diagnosed with COVID-19 Pneumonia in whom HCQ and Favipiravir treatment was initiated, and to reveal the difference in the effectiveness of the treatments. 64 COVID-19 patients whose diagnoses were confirmed by real-time polymerase chain reaction test (RT-PCR) of nasopharyngeal swab samples and pneumonia image compatible with COVID-19 on Thorax CT were included in the study. Patients were divided into three groups: treated with HCQ, treated with favipiravir, and who were switched to favipiravir treatment when they did not benefit from HCQ. We compared the laboratory values on Day 1, Day 5 and at discharge. When compared in terms of laboratory values, there was no significant difference between the groups in which HCQ and Favipiravir was initiated. In the patient group who did not improve with HCQ and switched to favipiravi r treatment, lymphocyte levels increased and ferritin, CRP and d-dimer values decreased. The decrease in D-dimer and CRP values was statistically significant (p= 0.029, p= 0.048). PLT, Hemoglobin, RDW, MPV, NLR, PLR, INR values did not change significantly in any patient group. Our study with the most commonly used drugs in our country reveals that HCQ and Favipiravir are not superior to each other. When we changed the treatment with favipiravir in the group of patients receiving HCQ whose clinical an d / or laboratory values deteriorated, D-dimer and CRP values decreased during discharge. This finding shows how effective the timely treatment change is in the recovery of the patient by closely following the patient clinically and interpreting the laboratory values correctly. In COVID-19, we should direct the treatment of our patients by following the symptoms, risk factors and especially laboratory values. © 2021, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.